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NICE Guideline: Assessment and Management of Chronic Pain in Over 16s

8 Apr, 2021 | 08:54h | UTC

Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain – National Institute for Health and Care Excellence

News release: NICE recommends range of effective treatments for people with chronic primary pain and calls on healthcare professionals to recognise and treat a person’s pain as valid and unique to them

 

Commentary | Distinguishing the real from the hyperglycemia: does COVID-19 induce diabetes?

9 Apr, 2021 | 03:28h | UTC

Distinguishing the real from the hyperglycaemia: does COVID-19 induce diabetes? – The Lancet Diabetes & Endocrinology

 

Large study finds 1 in 3 Covid-19 survivors have subsequent mental health and neurological conditions

8 Apr, 2021 | 09:14h | UTC

6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records – The Lancet Psychiatry

Commentaries: 1 in 3 Covid-19 patients are diagnosed with a neuropsychiatric condition in the next six months, large study finds – STAT AND A longer look at COVID-19 and neuropsychiatric outcomes – The Lancet Psychiatry AND Largest study to date suggests link between COVID-19 infection and subsequent mental health and neurological conditions – The Lancet AND Covid-19: One in three has neurological or psychiatric condition diagnosed after covid infection, study finds – The BMJ AND One in three survivors of severe Covid diagnosed with mental health condition – The Guardian AND Covid-19 linked to depression and dementia, study suggests – BBC AND Expert reaction to observational study looking at neurological and psychiatric outcomes 6 months after COVID-19 – Science Media Centre AND 1 in 3 COVID Survivors Struggle With Mental Health Issues Months Later – HealthDay

 

Commentary on Twitter (thread – click for more)

 

Cohort study: One in ten have long-term effects 8 months following mild COVID-19

8 Apr, 2021 | 09:12h | UTC

One in ten have long-term effects 8 months following mild COVID-19 – Karolinska Institutet

Original study: Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers – JAMA

 

Commentary on Twitter

 

Study: Outdoor transmission accounts for 0.1% of Covid-19 cases

8 Apr, 2021 | 09:11h | UTC

Outdoor transmission accounts for 0.1% of State’s Covid-19 cases – The Irish Times

Related: Systematic review: Outdoor transmission of SARS-CoV-2 and other respiratory viruses. “The odds of indoor transmission was very high compared to outdoors (18.7 times)”

 

Meta-Analysis: Primary prevention of variceal bleeding in people with esophageal varices due to liver cirrhosis

8 Apr, 2021 | 08:45h | UTC

Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network meta‐analysis – Cochrane Library

Summary: Treatment to prevent first bleeding from dilated veins in the oesophagus resulting from advanced scarring of the liver – Cochrane Library

Related Cochrane Review: M-A: Secondary prevention of variceal bleeding in adults with previous esophageal variceal bleeding due to decompensated liver cirrhosis

 

Perspective | Evidence isn’t Everything – Evidence-based medicine and statin decision-making

8 Apr, 2021 | 08:41h | UTC

Evidence isn’t Everything – Evidence-based medicine and statin decision-making

 

Commentary on Twitter

 

Podcast: Evaluation and Management of Chronic Diarrhea

8 Apr, 2021 | 08:38h | UTC

#267 Diarrhea Disemboweled Part 2: Chronic Diarrhea with Dr. Iris Wang – The Curbsiders

See also: #266 Diarrhea Disemboweled Part 1: Acute Diarrhea with Dr. Iris Wang – The Curbsiders

 

RCT: Among patients with peripheral artery disease, low-intensity exercise was significantly less effective than high-intensity exercise for improving 6-minute walk distance

7 Apr, 2021 | 01:31h | UTC

Effect of Low-Intensity vs High-Intensity Home-Based Walking Exercise on Walk Distance in Patients With Peripheral Artery Disease: The LITE Randomized Clinical Trial – JAMA (free for a limited period)

Commentary: No pain, no gain in exercise for peripheral artery disease – ‘You’ve got to walk with pain to reap benefits’ – Northwestern University

 

Commentary on Twitter

 

Short review | Assessment and management of dysphagia and achalasia

7 Apr, 2021 | 01:13h | UTC

Assessment and management of dysphagia and achalasia – Clinical Medicine Journal

 

Commentary on Twitter

 

UK regulator confirms that people should continue to receive the COVID-19 vaccine AstraZeneca

8 Apr, 2021 | 09:05h | UTC

UK regulator confirms that people should continue to receive the COVID-19 vaccine AstraZeneca – GOV.UK

Original report: MHRA issues new advice, concluding a possible link between COVID-19 Vaccine AstraZeneca and extremely rare, unlikely to occur blood clots – Medicines and Healthcare products Regulatory Agency

Commentary: Expert reaction to statements from MHRA and EMA in relation to the AstraZeneca vaccine and rare blood clots and low blood platelets – Science Media Centre

 

Commentary on Twitter

 

WHO Interim statement: A causal relationship between the AstraZeneca COVID-19 vaccine and the occurrence of blood clots with low platelets is considered plausible but is not confirmed

8 Apr, 2021 | 09:09h | UTC

Interim statement of the COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety on AstraZeneca COVID-19 vaccine – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

AstraZeneca’s COVID-19 vaccine: EMA finds possible link to very rare cases of unusual blood clots with low blood platelets. The benefits of the vaccine continue to outweigh the risks for people who receive it.

8 Apr, 2021 | 09:07h | UTC

AstraZeneca’s COVID-19 vaccine: EMA finds possible link to very rare cases of unusual blood clots with low blood platelets – European Medicines Agency

Commentaries: In rare instances, AstraZeneca’s Covid-19 vaccine linked to blood clots, regulators say – STAT AND Expert reaction to statements from MHRA and EMA in relation to the AstraZeneca vaccine and rare blood clots and low blood platelets – Science Media Centre

 

JCVI statement on use of the AstraZeneca COVID-19 vaccine: “JCVI currently advises that it is preferable for adults aged <30 years to be offered an alternative COVID-19 vaccine, if available.”

8 Apr, 2021 | 09:02h | UTC

JCVI statement on use of the AstraZeneca COVID-19 vaccine: 7 April 2021 – GOV.UK

Commentaries: Covid: Under-30s offered alternative to Oxford-AstraZeneca jab – BBC AND Expert reaction to statements from MHRA and EMA in relation to the AstraZeneca vaccine and rare blood clots and low blood platelets – Science Media Centre

 

Consensus Document: Management of the complications of long term indwelling catheters

7 Apr, 2021 | 01:20h | UTC

British Association of Urological Surgeons (BAUS) and Nurses (BAUN) Consensus Document: Management of the Complications of Long Term Indwelling Catheters – BJU International

 

Video: Coronavirus Variants and Vaccines

8 Apr, 2021 | 09:00h | UTC

Coronavirus Variants and Vaccines – JAMA

 

Study finds low risk of venous thromboembolism in outpatients with Covid-19 – researchers advise against the use of anticoagulants outside clinical trials

8 Apr, 2021 | 08:59h | UTC

Incidence of 30-Day Venous Thromboembolism in Adults Tested for SARS-CoV-2 Infection in an Integrated Health Care System in Northern California – JAMA Internal Medicine

Commentaries: VTE Related to SARS-CoV-2 Infection Less Of a Problem in Outpatients – TCTMD AND No Increase Seen in Outpatient VTE for SARS-CoV-2-Positive Patients – Physician’s Weekly

 

Commentary on Twitter (thread – Click for more)

https://twitter.com/gjgeersing/status/1379740743951134721

 

CDC Updated Guidance: “It is possible for people to be infected through contact with contaminated surfaces or objects, but the risk is generally considered to be low”

7 Apr, 2021 | 02:00h | UTC

Science Brief: SARS-CoV-2 and Surface (Fomite) Transmission for Indoor Community Environments – Centers for Disease Control and Prevention

Related: Catching COVID from surfaces is very unlikely. So perhaps we can ease up on the disinfecting – The Conversation AND Coronavirus is in the air — there’s too much focus on surfaces – Nature AND COVID-19 rarely spreads through surfaces. So why are we still deep cleaning? – Nature

 

Identifying and managing functional cardiac symptoms

7 Apr, 2021 | 01:15h | UTC

Identifying and managing functional cardiac symptoms – Clinical Medicine Journal

 

ACP Guidance: Appropriate Use of Short-Course Antibiotics in Common Infections

6 Apr, 2021 | 01:12h | UTC

Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians – Annals of Internal Medicine

Summary for Patients: Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians

News release: ACP best practice advice: Shorter course of antibiotics may be appropriate for some common infection – American College of Physicians

 

Cohort study: Risk of suicide attempt in patients with recent diagnosis of mild cognitive impairment or dementia

7 Apr, 2021 | 01:08h | UTC

Risk of Suicide Attempt in Patients With Recent Diagnosis of Mild Cognitive Impairment or Dementia – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Recent Diagnosis of Cognitive Impairment, Dementia May Increase Suicide Risk – Psychiatric News Alert AND Suicide Attempts Spike Soon After Dementia Diagnosis – HealthDay

 

Systematic review: Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men

7 Apr, 2021 | 01:10h | UTC

Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men – Cochrane Library

 

Differences in susceptibility of circulating SARS-CoV-2 variants B.1.1.7 and B.1.351 to neutralization by convalescent plasma or vaccinee (Sinopharm or Sinovac) serum

7 Apr, 2021 | 01:57h | UTC

Susceptibility of Circulating SARS-CoV-2 Variants to Neutralization – New England Journal of Medicine

Related studies: Another study indicates SARS-CoV-2 variant B.1.351, but not variant B.1.1.7, has partial resistance to neutralizing antibodies generated by natural infection or mRNA vaccination – Nature Medicine AND Pfizer coronavirus vaccine found to be moderately less effective against B.1.351 variant AND SARS-CoV-2 variants B.1.351 and P.1 can escape from therapeutic antibodies and evade antibodies induced by infection or mRNA vaccination AND B.1.351 strain of SARS-CoV-2 neutralization titer reduced 8- to 9-fold for Pfizer and AstraZeneca vaccinees. Convalescent plasma and therapeutic antibodies were less effective against this variant as well. AND RCT: Oxford/AstraZeneca vaccine does not protect against mild-to-moderate Covid-19 due to the B.1.351 variant AND New study of Coronavirus variants predicts virus evolving to escape current vaccines, treatments AND Moderna COVID-19 vaccine may be less effective against variant found in South Africa

 

Commentary on Twitter

https://twitter.com/hildabast/status/1379597338956603400

 

Guidance on syndrome of Thrombosis and Thrombocytopenia occurring after coronavirus Vaccination

7 Apr, 2021 | 01:48h | UTC

Guidance produced from the Expert Haematology Panel (EHP) focussed on syndrome of Thrombosis and Thrombocytopenia occurring after coronavirus Vaccination – British Society of Haematology

Related: Exceedingly rare side effects reported with AstraZeneca vaccine in the UK – 22 cases of cerebral venous sinus thrombosis with low levels of platelets out of 18 million vaccinated individuals

 

Commentary on Twitter

https://twitter.com/trishgreenhalgh/status/1379414362700517385

 

Epidemiology of Multisystem Inflammatory Syndrome in Children: A Step Closer to Understanding Who, Where, and When

7 Apr, 2021 | 01:52h | UTC

Editorial: Epidemiology of Multisystem Inflammatory Syndrome in Children: A Step Closer to Understanding Who, Where, and When – JAMA Pediatrics

Original study: Trends in Geographic and Temporal Distribution of US Children With Multisystem Inflammatory Syndrome During the COVID-19 Pandemic – JAMA Pediatrics

Commentaries: New findings in COVID-related kids’ syndrome, Kawasaki disease – CIDRAP AND Most kids with serious inflammatory illness had mild COVID – Associated Press

 

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