Family Medicine
M-A: Low prevalence of bacterial meningitis among well-appearing febrile infants aged 29-60 days with positive urinalysis results – “These results suggest that for these infants, the decision to use lumbar puncture should not be guided by urinalysis results alone”.
21 May, 2021 | 08:24h | UTC
Commentary on Twitter
This metanalysis found positive urinalysis alone is not an indication for LP in well looking febrile infants >28 days old. Prevalence among UA-positive infants: 0.4% vs UA-negative infants: 0.5%. https://t.co/dTzCiLHrSg
— JAMA Network Open (@JAMANetworkOpen) May 12, 2021
Systematic review: Cognitive behavioral therapy may improve outcomes for autism spectrum disorders.
21 May, 2021 | 08:21h | UTCCognitive Behavioral Therapy for Autism Spectrum Disorders: A Systematic Review – Pediatrics (link to abstract – $ for full-text)
Cohort study: 14% of adults aged 65 years or less who were infected with SARS-CoV-2 had at least one new type of clinical sequelae that required medical care after the acute phase of the illness.
20 May, 2021 | 08:59h | UTCEditorial: Unpacking post-covid symptoms – The BMJ
Commentary on Twitter (thread – click for more)
After covid infections, 14% of >266,000 people, age ≤ 65, developed at least 1 sequelae that required medical care #LongCovid Just out @bmj_latest @OptumLabs @mlipsitch Risk increased w/ pre-existing conditions but also found in healthy, age < 50 https://t.co/h8IlnRNp2v pic.twitter.com/e15uSj9BXN
— Eric Topol (@EricTopol) May 19, 2021
FDA In Brief: FDA advises against use of SARS-CoV-2 antibody test results to evaluate immunity or protection from COVID-19, including after vaccination.
20 May, 2021 | 08:55h | UTC
Commentary on Twitter (thread – click for more)
Today, we issued a safety communication notifying the public and providers that results from SARS-CoV-2 antibody tests should not be used to evaluate immunity or protection from #COVID19 at any time – especially after receiving a #COVID19 vaccination. https://t.co/KlywV04WYO pic.twitter.com/TPdIVxWzSh
— U.S. FDA (@US_FDA) May 19, 2021
Systematic review and meta-analysis of observational studies suggest low-dose aspirin may be of benefit for patients with Covid-19 – the finds require further investigation in randomized studies.
20 May, 2021 | 08:54h | UTC
One year after hospital discharge due to SARS-CoV-2 Infection, the prevalence of long-term cough, chest pain, dyspnea, and fatigue was 2.5%, 6.5%, 23.3%, and 61.2%, respectively
20 May, 2021 | 08:57h | UTCPrevalence of Post-COVID-19 Cough One Year After SARS-CoV-2 Infection: A Multicenter Study – Lung
SPRINT Trial final report: targeting a systolic BP of less than 120 mm Hg in patients at increased CV risk is associated with improved CV and mortality outcomes but increases the risk of serious adverse events.
20 May, 2021 | 08:36h | UTC
Characteristics associated with Multisystem Inflammatory Syndrome among adults with SARS-CoV-2 infection
20 May, 2021 | 08:52h | UTCCommentary: COVID-related inflammatory syndrome looks different in adults – CIDRAP
M-A: Psychologic treatment of depression compared with pharmacotherapy and combined treatment in primary care – Psychotherapy has comparable effects to those of pharmacotherapy, and combined treatment might be better than either psychotherapy or pharmacotherapy alone.
20 May, 2021 | 08:34h | UTC
Commentary on Twitter
https://twitter.com/pimcuijpers/status/1391999860505825286
24-week randomized controlled trial: Mixed tree nut snacks resulted in similar weight loss and increased satiety compared to refined carbohydrate snacks in a weight loss and maintenance program.
20 May, 2021 | 08:28h | UTCCommentary: Mixed tree nut snacks result in significant weight loss and improved satiety – News Medical
ERS clinical practice guidelines for the diagnosis of asthma in children aged 5–16 years.
20 May, 2021 | 08:21h | UTC
WHO and UNICEF launch new tools for the promotion of adolescent mental health.
19 May, 2021 | 08:33h | UTCNews release: WHO and UNICEF launch new tools for the promotion of adolescent mental health – World Health Organization
WHO/UNICEF Helping Adolescents Thrive programme
Helping Adolescents Thrive Toolkit
Magnificent Mei and Friends: Comic 1
The mental and brain health of children and adolescents
Commentary on Twitter (thread – click for more)
📢 NEW RELEASE : The Helping Adolescents Thrive Toolkit, developed by WHO & @UNICEF, provides guidance for people working in the health, social services, education & justice sectors on how to promote & protect adolescent mental health.
Download 👉https://t.co/gtAK7WeQC7 pic.twitter.com/x7lq6m51Ze
— World Health Organization (WHO) (@WHO) May 18, 2021
Perspective | Facebook calls links to depression inconclusive. These researchers disagree.
19 May, 2021 | 08:30h | UTCFacebook Calls Links To Depression Inconclusive. These Researchers Disagree – NPR
Related: Cohort study: Preschoolers’ extensive electronic media use linked to emotional/behavioral issues AND Analysis: Smartphones, Social Media Use and Youth Mental Health AND [Abstract Only] Study: Associations Between Time Spent Using Social Media and Mental Health Problems Among Youth AND Association of Screen Time and Depression in Adolescence AND The Adverse Effects of Social Media use on Young People’s Mental Health May be Caused by Exposure to Cyberbullying, Loss of Sleep, and Reduced Physical Activity AND Research: This Is Your Brain Off Facebook AND Cohort Study: Social Media Use and Adolescent Mental Health AND Supplement: Children, Adolescents and Screens: What We Know and What We Need To Learn
The catastrophization effects of an MRI report on the patient and surgeon and the benefits of ‘clinical reporting’: results from an RCT and blinded trials.
19 May, 2021 | 08:25h | UTCRelated: You cannot unsee your MRI report AND Direct communication between radiologists and patients improves the quality of imaging reports – European Radiology
Commentary on Twitter
https://twitter.com/hjluks/status/1392151713700794374
Large cohort study confirms the renal toxicities of anti-inflammatories, suggesting Ibuprofen may be the safest option among them.
19 May, 2021 | 08:28h | UTCComparative Risks of Nonsteroidal Anti-Inflammatory Drugs on CKD – Clinical Journal of the American Society of Nephrology (link to abstract – $ for full-text)
Commentary: Study: Ibuprofen Found Safest NSAID for the Kidney – MPR
Commentary on Twitter
Comparative Risks of Nonsteroidal Anti-Inflammatory Drugs on CKD
Read this new @CJASN study and listen to the accompanying podcast:https://t.co/GL1ITzh4O4 pic.twitter.com/lZGeFqfrDZ
— American Society of Nephrology (@ASNKidney) April 29, 2021
SARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacy.
18 May, 2021 | 07:52h | UTC
#ACC21 – The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030 – “The Lancet women and cardiovascular disease Commission outlines 10 ambitious recommendations to improve health outcomes for millions of women”.
18 May, 2021 | 07:32h | UTCHomepage: The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030 – The Lancet (free registration required)
Infographic: Women and cardiovascular disease
Video: The Lancet women and cardiovascular disease Commission
News release: Experts call for urgent action to reduce global burden of cardiovascular disease in women by 2030 – The Lancet
Commentary on Twitter (thread – click for more)
Cardiovascular disease is responsible for 35% of deaths in women yearly—yet remains:
❣️Understudied
❣️Under-recognised
❣️Underdiagnosed
❣️UndertreatedNEW @TheLancet Commission outlines 10 recommendations to improve health outcomes for millions of women: https://t.co/DDB97FFunC pic.twitter.com/WjV3aqqLV9
— The Lancet (@TheLancet) May 17, 2021
WHO study estimates long working hours causing 745.000 deaths a year from heart disease and stroke.
18 May, 2021 | 07:29h | UTCNews Release: Long working hours increasing deaths from heart disease and stroke: WHO, ILO – World Health Organization
Commentary: Long working hours killing 745,000 people a year, study finds – BBC
Commentary on Twitter (thread – click for more)
🆕 WHO & @ilo analysis shows that working 55 hours or more per week impacts #WorkersHealth & increases risk of cardiovascular diseases.
Long working hours led to 745 000 deaths from #stroke & ischemic heart disease in 2016, a 2⃣9⃣% rise ↗️ since 2000.
👉 https://t.co/T3nuPX3nH7 pic.twitter.com/UW5XxbjWqo
— World Health Organization (WHO) (@WHO) May 17, 2021
Opinion | E-Cigarettes and the U.S. Menthol Ban: A Missed Opportunity to Protect Youth.
18 May, 2021 | 07:28h | UTCE-Cigarettes and the U.S. Menthol Ban: A Missed Opportunity to Protect Youth – Think Global Health
Commentary on Twitter (thread – click for more)
📢📢📢 @US_FDA should ban flavors in all nicotine-containing products, not just menthol cigarettes. More than 8 out of 10 current youth e-cigarette users in the U.S. vape non-tobacco flavors.
IHME researchers for @ThinkGlobalHlth 🧵⤵️ https://t.co/d56mDCvTY3
— Institute for Health Metrics and Evaluation (IHME) (@IHME_UW) May 17, 2021
Systematic review: Treatment of gastro-esophageal reflux disease to help manage asthma in adults and children may result in reduced use of rescue medications, but the benefits on the number of exacerbations and hospital utilization remain uncertain.
18 May, 2021 | 07:27h | UTC
NICE Guideline Update | Headaches in over 12s: diagnosis and management.
18 May, 2021 | 07:14h | UTCHeadaches in over 12s: diagnosis and management – National Institute for Health and Care Excellence
Setting the record straight: There is no ‘Covid heart’.
17 May, 2021 | 08:47h | UTCSetting the record straight: There is no ‘Covid heart’ – STAT
Commentary on Twitter
Why the issue of Covid-19 induced cardiac problems was massively overblown and why screening low-risk patients with MRI and other fancy tests is neither necessary nor wise. https://t.co/HkJFOJ6oeM
— Raffaele Rasoini (@RasoiniR) May 14, 2021
#ACC21 – RCT: No significant differences in cardiovascular events or major bleeding between patients receiving 81 mg vs. 325 mg of aspirin daily.
17 May, 2021 | 08:31h | UTCComparative Effectiveness of Aspirin Dosing in Cardiovascular Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: High- and Low-Dose Aspirin Equivalent in ASCVD: ADAPTABLE – TCTMD AND Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-Term Effectiveness – ADAPTABLE – American College of Cardiology
Video: Aspirin Dosing: A Patient-centric Trial Assessing Benefits And Long-term Effectiveness Trial
#ACC21 – RCT: Tailored, earlier heart failure rehabilitation program has physical and emotional benefits for older patients.
17 May, 2021 | 08:23h | UTCCommentaries: Tailored, earlier heart failure rehab has physical, emotional benefits for patients – National institutes of Health AND REHAB-HF: Tailored Cardiac Rehab Program Improved Function and Quality of Life in Older HF Patients – American College of Cardiology AND Rehabilitation Therapy in Older Acute Heart Failure Patients – REHAB-HF – American College of Cardiology
Commentaries on Twitter
#REHAB-HF #ACC21 innovative intensive rehab improved physical function
-attention to SDOH environment assessment & involvement of family/care givers
-q2 wk trouble shooting discussion
-corrected balance/mobility first to get pts on treadmill w confidence https://t.co/rOmsc6qdq3 pic.twitter.com/V8TugBipUT— Ritu Thamman MD (@iamritu) May 16, 2021
REHAB-HF trial results found novel #CVRehab program tailored to address specific physical impairments in frail/older patients w/ acute #HeartFailure improved physical function & quality of life; did not significantly reduce hospitalizations. https://t.co/f98IdMvqj4 #ACC21 #cvGeri pic.twitter.com/zY8E1WBNmf
— American College of Cardiology (@ACCinTouch) May 16, 2021
2 recent meta-analysis highlight the benefits of short term (30 days) dual antiplatelet therapy with aspirin + clopidogrel in patients within 24 hours of high-risk transient ischemic attack or mild-moderate ischemic stroke.
17 May, 2021 | 08:16h | UTCMeta-analysis 1: Dual Antiplatelet Therapy Versus Aspirin in Patients With Stroke or Transient Ischemic Attack: Meta-Analysis of Randomized Controlled Trials – Stroke
Meta-analysis 2: Efficacy and Safety of Using Dual Versus Monotherapy Antiplatelet Agents in Secondary Stroke Prevention: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials – Circulation (link to abstract – $ for full-text)
Commentary: Dual vs. Monotherapy Antiplatelet Agents in Secondary Stroke Prevention – American College of Cardiology
Related Guideline: Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ


