Family Medicine
USPSTF Statement: Insufficient evidence to recommend Vitamin D deficiency screening
14 Apr, 2021 | 01:47h | UTCVitamin D Deficiency in Adults: Screening – U.S. Preventive Services Task Force
Evidence Report: Screening for Vitamin D Deficiency in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force
Editorial: The USPSTF 2021 Recommendations on Screening for Asymptomatic Vitamin D Deficiency in Adults: The Challenge for Clinicians Continues – JAMA AND Why USPSTF Still Finds Insufficient Evidence to Support Screening for Vitamin D Deficiency – JAMA Network Open
JAMA Patient Page: Screening for Vitamin D Deficiency in Adults
Study shows practitioners overestimate the probability of disease before and after testing
14 Apr, 2021 | 01:44h | UTCAccuracy of Practitioner Estimates of Probability of Diagnosis Before and After Testing – JAMA Internal Medicine (free for a limited period)
Commentary: Physicians, Probabilities, and Populations—Estimating the Likelihood of Disease for Common Clinical Scenarios – JAMA Internal Medicine (free for a limited period)
Commentary on Twitter
How good are doctors at diagnosis?
This is the most relevant paper I have written. Not perfect but addresses a huge issue I think could change medicine if acknowledged
…it has changed how I think about diagnosishttps://t.co/4ZtoD3F4rF @JAMAInternalMed @drjohnm
1/n— Dan Morgan (@dr_dmorgan) April 12, 2021
M-A: Effectiveness of treatments for acute and subacute mechanical non-specific low back pain
14 Apr, 2021 | 01:39h | UTC
Commentary on Twitter
Just published in BJSM ???
Effectiveness of treatments for acute and subacute mechanical non-specific low back pain: a systematic review with network meta-analysis
?????https://t.co/bx06RPLTbT pic.twitter.com/RzHkwN2nTp
— Physio Meets Science (@PhysioMeScience) April 13, 2021
Case Report: Thrombotic Thrombocytopenia after Johnson & Johnson Vaccine
15 Apr, 2021 | 07:02h | UTCThrombotic Thrombocytopenia after Ad26.COV2.S Vaccination – New England Journal of Medicine
Related: U.S. regulators pause Johnson & Johnson vaccine rollout over rare (1 in a million) cases of blood clots AND 4 Things to Know About the J&J Covid Vaccine Pause – Kaiser Health News AND Why Johnson & Johnson shots were paused — and why that’s so confusing – Vox AND Is it the adenovirus vaccine technology, used by AstraZeneca and Johnson & Johnson, causing blood clots? There’s no evidence yet – The Conversation
Observational study: Impact of the influenza vaccine on COVID-19 infection rates and severity
15 Apr, 2021 | 06:47h | UTCCommentary: Flu shot associated with fewer, less severe COVID cases – University of Michigan
Physical inactivity is associated with a higher risk for severe COVID-19 outcomes: a study in 48 440 adult patients
15 Apr, 2021 | 06:49h | UTCCommentaries: Exercise may strongly protect against poor COVID-19 outcomes – CIDRAP AND One Good Way to Help Beat COVID: Exercise – HealthDay
New studies suggest SARS-CoV-2 variant B.1.1.7 is not more deadly, just more transmissible
14 Apr, 2021 | 02:12h | UTCCommentaries: Expert reaction to two papers looking at the transmissibility and severity of the B.1.1.7 variant – Science Media Centre AND UK coronavirus variant not more deadly, just spreads more easily, studies find – LiveScience
Cohort study: Higher cumulative exposure to Thiazide diuretics linked to an increased risk of skin cancer in people older than 65 years
13 Apr, 2021 | 05:08h | UTCCommentaries: Thiazides May Up Risk for Skin Cancer in Older Adults – HealthDay AND Some blood pressure medication linked to higher risk of skin cancer, study finds – CTV News
Related study: Case-Control Study: Possible Association of Hydrochlorothiazide Use and Risk of Melanoma
Diagnosis and management of leukocytoclastic vasculitis
14 Apr, 2021 | 01:26h | UTCDiagnosis and management of leukocytoclastic vasculitis – Internal and Emergency Medicine
Opinion | More kids are being diagnosed with ADHD for borderline (yet challenging) behaviors. Our new research shows why that’s a worry
13 Apr, 2021 | 05:14h | UTCOriginal study: Overdiagnosis of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents: A Systematic Scoping Review – JAMA Network Open
Commentary on Twitter
More kids are being diagnosed with ADHD for borderline (yet challenging) behaviours. Our new research shows why that’s a worry https://t.co/mWzLgroPor via @ConversationEDU
— Rae Thomas (@rthomasEBP) April 12, 2021
U.S. regulators pause Johnson & Johnson vaccine rollout over rare (1 in a million) cases of blood clots
14 Apr, 2021 | 02:16h | UTCJoint CDC and FDA Statement on Johnson & Johnson COVID-19 Vaccine – U.S. Food & Drug Administration
Commentaries: Covid-19: US suspends Johnson and Johnson vaccine rollout over blood clots – BMJ AND CDC and FDA recommend US pause use of Johnson & Johnson’s Covid-19 vaccine over blood clot concerns – CNN AND US halts J&J COVID vaccine after reports of blood clots – CIDRAP AND U.S. urges pause on use of Johnson & Johnson Covid-19 vaccine after rare blood clotting cases – CIDRAP
RCT: Inhaled budesonide shortens recovery time in non-hospitalized patients with COVID-19
13 Apr, 2021 | 05:30h | UTCOriginal study (preprint): Inhaled budesonide for COVID-19 in people at higher risk of adverse outcomes in the community: interim analyses from the PRINCIPLE trial – medRxiv
Commentary: Covid: Asthma drug ‘speeds up recovery at home’ – BBC
Related study: Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19 (study and commentaries)
Characteristics and Disease Severity of US Children and Adolescents Diagnosed With COVID-19
14 Apr, 2021 | 01:59h | UTCCommentary: CDC: 1 in 3 children hospitalized with COVID-19 requires treatment in ICU – UPI AND 12% of Children with COVID Are Hospitalized: Study – WebMD
Commentary on Twitter
Of 2430 pediatric patients who were hospitalized with COVID-19, 756 (31.1%) experienced severe COVID-19. Severe disease was more common in patients with chronic conditions, in male patients, and in children aged 2-11 years vs children aged 12-18 years. https://t.co/3fmlCFsmo8
— COVID Reference (@CovidReference) April 10, 2021
Infectivity of severe acute respiratory syndrome coronavirus 2 in children compared with adults
13 Apr, 2021 | 05:27h | UTCCommentary: Children may be less infectious in spreading SARS-CoV-2 to others – News Medical
Cohort Study: Effects of fluoroquinolones on outcomes of patients with aortic dissection or aneurysm
13 Apr, 2021 | 05:05h | UTCRelated: Another study suggests fluoroquinolone use may increase the risk of development of aortic aneurysms (study and commentaries) AND Link between fluoroquinolones, aorta problems may not be as strong as thought AND Study: Oral Fluoroquinolones and Risk of Mitral and Aortic Regurgitation AND FDA Warns About Increased Risk of Aortic Dissection and Ruptures of Aortic Aneurism with Fluoroquinolones AND Meta-analysis: Fluoroquinolones and the Risk of Aortopathy AND Study: Oral Fluoroquinolone and the Risk of Aortic Dissection AND Research: Fluoroquinolone use and risk of aortic aneurysm and dissection
Clinical Review: Screening and management of atrial fibrillation in primary care
13 Apr, 2021 | 05:09h | UTCScreening and management of atrial fibrillation in primary care – The BMJ
AHA/ASA Scientific Statement: Perioperative Neurological Evaluation and Management to Lower the Risk of Acute Stroke in Patients Undergoing Noncardiac, Nonneurological Surgery
12 Apr, 2021 | 00:50h | UTC
Commentary on Twitter
NEW GUIDELINE – now codifies what has been discussed for a while "If history of stroke exists, consider delaying elective surgery at least 6 mo
and preferably 9 mo from time of incident stroke." @SPAQIedu @LeeAFleisher @preopconsult @afedwardMD https://t.co/0ewdlPGVlj— Kurt Pfeifer (@KurtPfeifer) April 9, 2021
[Press release – not published yet] Phase 3 prevention trial showed 81% reduced risk of symptomatic SARS-CoV-2 infections with subcutaneous administration of monoclonal antibodies
13 Apr, 2021 | 05:26h | UTCCommentaries: Regeneron says antibody cocktail prevented Covid when given as simple injection, not an IV – STAT AND Regeneron’s Covid mAb as a prophylactic injection: Reduced risk of symptomatic infection by 81% – Endpoint News
Cohort study: SARS-CoV-2 infection rates of antibody-positive vs. antibody-negative health-care workers – previous infection was associated with 84% lower risk of (re)infection
12 Apr, 2021 | 01:30h | UTCCommentary: Correlates of protection from SARS-CoV-2 infection – The Lancet
Commentary on Twitter
?SIREN STUDY? @TheLancet
Previous SARS-CoV-2 infection
provides protection similar to or even better than currently used vaccines
?84% risk reduction(RR) for reinfection
?93% RR for those w symptomatic infections
?B.1.1.7 circulate during the studyhttps://t.co/uQ3M9yahAv pic.twitter.com/leQCNbmHQO— Antibiotic Steward??Bassam Ghanem (@ABsteward) April 10, 2021
Perspective | They Tested Negative for Covid. Still, They Have Long Covid Symptoms.
13 Apr, 2021 | 05:23h | UTCThey Tested Negative for Covid. Still, They Have Long Covid Symptoms. – Kaiser Health News
Commentary on Twitter
Scary: Many people have tested negative for SARSCoV2, yet they developed Long Covid. What's to blame? Haphazard testing protocols, delays & difficulties accessing tests & poor quality of many of the tests on the market. All have have left people without proof of infection. https://t.co/KH3QYkbbKW pic.twitter.com/MVuRhWoHle
— delthia ricks ? (@DelthiaRicks) April 12, 2021
Another study shows intravenous radiocontrast use is not associated with reduced kidney function
12 Apr, 2021 | 00:44h | UTCCommentaries: Radiocontrast Exposure Safe for Kidney Function – HCP Live AND Exposure to contrast on CTPA doesn’t cause long-term kidney injury – AuntMinnie
Related: ACR/NKF Consensus Statement: “The Risk of Acute Kidney Injury Developing in Patients with Reduced Kidney Function Following Exposure to Intravenous Iodinated Contrast Media has Been Overstated” (Guideline and commentaries)
Commentary on Twitter (thread – click for more)
Our new paper in @JAMAInternalMed: is IV contrast nephrotoxic? Lots of studies say no, but have ⬆️risk of confounding: people who get contrast ≠ people who don't get it. We used a natural experiment to try to overcome this bias https://t.co/XWEEohAvK0 1/5
— Robert Goulden (@EMrobg) April 5, 2021
RCT: Effect of High-frequency (10-kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy
9 Apr, 2021 | 03:18h | UTCAuthor Interview: Effect of High-Frequency (10 kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy
Commentary on Twitter
Thrilled to see our publication out today in @JAMANeuro using #SCS to treat #diabetic #pain. 86% of patients with over 50% pain relief at 6 months with better sleep and walking! #progress #needherscience #neuromodulation @UAMSneurosurg @UAMSPain @uamshealth https://t.co/TJQPHsHvSa
— Dr. Erika Petersen (@ErikaPetersenMD) April 5, 2021
Short Review | How to use antihistamines
9 Apr, 2021 | 03:13h | UTCHow to use antihistamines – Canadian Medical Association Journal
Comprehensive Review | Pneumonia
9 Apr, 2021 | 03:14h | UTCPneumonia – Nature Reviews Disease Primers (free for a limited period)
Try this link if the above is paywalled.
Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19
12 Apr, 2021 | 01:24h | UTC
Commentary on Twitter
NEW Research— Early administration of inhaled budesonide reduced the likelihood of needing urgent medical care and reduced time to recovery after early #COVID19
RCT from Mona Bafadhel & colleagues https://t.co/6cJogJs7rp pic.twitter.com/C1dhmTcexP
— The Lancet Respiratory Medicine (@LancetRespirMed) April 10, 2021