Family Medicine
Ranitidine absolved? FDA study finds Ranitidine does not convert to carcinogen NDMA, regardless of diet.
12 Jul, 2021 | 01:36h | UTCEditorial: Ranitidine and Risk of N-Nitrosodimethylamine (NDMA) Formation
Commentary: Ranitidine: FDA finds no evidence of elevated NDMA, regardless of diet
Commentaries on Twitter
Despite ranitidine (zantac) being pulled from market last year, a new study from the FDA did not find evidence that it increases concentrations of the carcinogenic metabolite people were worried about (i.e., it's probably safe). From @JAMA_current https://t.co/AdRic2GdXS
— Zack Williams, PhD (@QuantPsychiatry) June 28, 2021
In this crossover, randomized clinical trial, oral ranitidine did not significantly increase 24-hour urinary excretion of NDMA when administered with a noncured-meats diet or a cured-meats diet. https://t.co/EszRvfJOFJ
— JAMA (@JAMA_current) June 28, 2021
AHA Scientific Statement: Assessing and Addressing Cardiovascular Health in People Who Are Transgender and Gender Diverse.
12 Jul, 2021 | 01:43h | UTCNews release: Discrimination, stress linked to poorer heart health in transgender, gender diverse adults – American Heart Association
Clinical Practice Guideline for Postoperative Rehabilitation in Older Patients With Hip Fractures.
12 Jul, 2021 | 01:39h | UTCRelated: Guideline for the perioperative management of hip fractures 2020
RCT: Another study shows that non-antibiotic outpatient treatment in mild acute diverticulitis is safe.
12 Jul, 2021 | 01:29h | UTCEfficacy and Safety of Non-Antibiotic Outpatient Treatment in Mild Acute Diverticulitis (DINAMO-study): A Multicentre, Randomised, Open-Label, Non-Inferiority Trial – Annals of Surgery (link to abstract – $ for full-text)
Related: State of the Art Review: Management of colonic diverticulitis AND Treatment of Uncomplicated Acute Diverticulitis Without Antibiotics: A Systematic Review and Meta-analysis – Diseases of the Colon & Rectum AND Antibiotics Do Not Reduce Length of Hospital Stay for Uncomplicated Diverticulitis in a Pragmatic Double-Blind Randomized Trial – Clinical Gastroenterology and Hepatology AND Randomized Trial: Antibiotic Avoidance Associated with Similar Long-term Outcomes in Uncomplicated Diverticulitis
Commentary on Twitter
Another (final?) nail in the coffin for antibiotics in uncomplicated diverticulitis? DINAMO study from Spain – Outpatient treatment with antibiotics versus symptomatic Tx.
No difference in hospitalization rate or revisits to ER.https://t.co/wOc3tBGfxr @AnnalsofSurgery
— Ville Sallinen (@villesallinen) July 9, 2021
RCT: Traditional plaster casting immobilization not superior to removable brace in adults with an ankle fracture.
12 Jul, 2021 | 01:22h | UTCNews release: Cast no better than brace for broken ankles – University of Warwick
Review: most common joint procedures not backed by high quality evidence – “Urgent need exists to prioritize research into common orthopedic interventions”.
12 Jul, 2021 | 01:26h | UTCNews release: Most common joint procedures not backed by high quality evidence – The BMJ
Original study: Common elective orthopaedic procedures and their clinical effectiveness: umbrella review of level 1 evidence – The BMJ
Commentary on Twitter
This review of the 10 most common elective orthopaedic procedures suggests that most of these procedures recommended by national guidelines and used by surgeons have insufficient readily available, high quality evidence on their clinical effectivenesshttps://t.co/63B7XEXeyh
— The BMJ (@bmj_latest) July 10, 2021
RCT: CoronaVac showed efficacy of 83.5% for preventing symptomatic SARS-CoV-2 infection.
9 Jul, 2021 | 10:22h | UTCInvited commentary: CoronaVac: more data for regulators and policy makers
Commentary on Twitter
NEW—Interim analysis from phase 3 trial suggests efficacy of 2 doses of #CoronaVac is 83.5% against symptomatic #COVID19. More research is needed to confirm efficacy in the long term, in a more diverse group, and against emerging #variants of concern.
🔗 https://t.co/TN5b6wwclc pic.twitter.com/4zOvJFIIOH
— The Lancet (@TheLancet) July 8, 2021
Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization.
9 Jul, 2021 | 10:16h | UTCReduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization – Nature
Commentaries: Study highlights need for full Covid vaccination to protect against Delta variant – STAT AND How does the Delta variant dodge the immune system? Scientists find clues. – The New York Times
Commentary on Twitter (thread – click for more)
Just published @Nature
Delta variant protection by mRNA and AZ vaccines requires 2-doses, little neutralizing antibody (nAb) with 1-dose, and insufficient nAb with prior covidhttps://t.co/TOgJdMe0g6 pic.twitter.com/KWLb9rBZ44— Eric Topol (@EricTopol) July 8, 2021
CDC: Use of mRNA COVID-19 vaccine after reports of myocarditis among vaccine recipients – “Continued use of mRNA COVID-19 vaccines in all recommended age groups will prevent morbidity and mortality from COVID-19 that far exceed the number of cases of myocarditis expected”.
9 Jul, 2021 | 10:17h | UTC
Commentary on Twitter
In a new @CDCMMWR, the Advisory Committee on Immunization Practices recommends everyone 12 & older get a #COVID19 vaccine. The benefits of vaccination in preventing illness & death outweigh the rare risk of heart inflammation after vaccination. More: https://t.co/iPjbhU5jeV. pic.twitter.com/IggrZ4DX7L
— CDC (@CDCgov) July 6, 2021
After the pandemic: perspectives on the future trajectory of COVID-19.
9 Jul, 2021 | 10:18h | UTCAfter the pandemic: perspectives on the future trajectory of COVID-19 – Nature
Will COVID become a disease of the young? – “A growing share of infections among unvaccinated youths in countries with high vaccination rates is putting the spotlight on the role of young people in the pandemic”.
9 Jul, 2021 | 10:14h | UTCWill COVID become a disease of the young? – Nature
Podcast | Heavy menstrual bleeding, anticoagulation & coagulopathy in menstruating patients.
9 Jul, 2021 | 09:56h | UTC
M-A: Little benefit from muscle relaxants for adults with non-specific low back pain.
9 Jul, 2021 | 10:02h | UTCCommentary: New analysis finds muscle relaxant drugs to be largely ineffective for low back pain – News Medical
Related studies: M-A: Effectiveness of treatments for acute and subacute mechanical non-specific low back pain AND RCT: Little benefit from osteopathic manipulative treatment on activity limitations in patients with nonspecific subacute and chronic low back pain AND M-A: Little benefit from antidepressants for low back pain AND Meta-analysis: Little benefit from antidepressants for the treatment of back pain and osteoarthritis AND ACP/AAFP Guideline: Nonpharmacologic and pharmacologic management of acute pain from non–low back, musculoskeletal injuries in adults
Commentaries on Twitter
Muscle relaxants are largely ineffective for #lowback #pain. They might increase the risk of side effects.
Published today in @bmj_latest ⬇️
Proud to be a part of this excellent team led by @AidanCashin
Paper: https://t.co/4p7gd7PJIe pic.twitter.com/3CLvL7JUfI
— Hayley Leake (@HayleyLeake) July 8, 2021
This systematic review found very low certainty evidence that muscle relaxant drugs for the treatment of acute low back pain might provide a small and not clinically meaningful improvement in pain intensity at two weeks or less @Pain_NeuRa https://t.co/HGwN4Oekrq
— The BMJ (@bmj_latest) July 8, 2021
Systematic Review: Altered dietary salt intake for people with chronic kidney disease.
9 Jul, 2021 | 09:52h | UTCAltered dietary salt intake for people with chronic kidney disease – Cochrane Library
Summary: Altered dietary salt intake for adults with chronic kidney disease – Cochrane Library
Commentary on Twitter
https://twitter.com/CochraneUK/status/1410873135709278210
Systematic review: Prophylactic drug management for febrile seizures in children.
9 Jul, 2021 | 09:51h | UTCProphylactic drug management for febrile seizures in children – Cochrane Library
Summary: Prophylactic drug management for febrile seizures in children
Prospective national cohort in Chile showed CoronaVac effectiveness was 65.9% for symptomatic Covid-19, 87.5% for hospitalization, 90.3% for ICU admission, and 86.3% for death.
8 Jul, 2021 | 09:22h | UTCEffectiveness of an Inactivated SARS-CoV-2 Vaccine in Chile – New England Journal of Medicine
Related: Phase 1/2 RCT: CoronaVac is well tolerated and safe and induces strong humoral responses in children and adolescents aged 3–17 years. AND WHO approval of Chinese CoronaVac COVID vaccine will be crucial to curbing pandemic. AND Brazilian town experiment shows mass vaccination can wipe out COVID-19.
Commentary on Twitter
https://twitter.com/hildabast/status/1412890823948079105
Mounting evidence suggests Sputnik COVID vaccine is safe and effective.
8 Jul, 2021 | 09:14h | UTCMounting evidence suggests Sputnik COVID vaccine is safe and effective – Nature
Schooling during COVID-19: Recommendations from the European Technical Advisory Group for schooling during COVID-19.
8 Jul, 2021 | 09:11h | UTC
COVID and schools: the evidence for reopening safely.
8 Jul, 2021 | 09:12h | UTCCOVID and schools: the evidence for reopening safely – Nature
Review: Dietary recommendations for prevention of atherosclerosis.
8 Jul, 2021 | 09:03h | UTCDietary recommendations for prevention of atherosclerosis – Cardiovascular Research
News Release: What should I eat to avoid heart disease? – European Society of Cardiology
Commentary: Plant-Based Diet Best for Your Heart – HealthDay
Study Commentary: Decreased Antibiotic Use for Acute Otitis Media and Acute Sinusitis Following Implementation of Childhood PCV13 Immunization.
8 Jul, 2021 | 08:54h | UTC
A narrative review of evidence to guide deprescribing among older adults.
8 Jul, 2021 | 08:51h | UTCRelated: Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens. (several resources on the subject)
M-A: Are antimicrobial stewardship interventions effective and safe in long-term care facilities?
8 Jul, 2021 | 08:52h | UTC
M-A: Continuation of antidepressants vs. sequential psychological interventions to prevent relapse in depression.
8 Jul, 2021 | 08:50h | UTCContinuation of Antidepressants vs Sequential Psychological Interventions to Prevent Relapse in Depression: An Individual Participant Data Meta-analysis – JAMA Psychiatry (link to abstract – $ for full-text)
Commentaries: Cognitive Therapy While Tapering Antidepressants May Be Alternative to Maintenance Medication – Psychiatric News Alert AND Psychotherapy Can Prevent Relapse When Discontinuing Antidepressants – Mad in America
Commentary on Twitter
Sequential delivery of a psychological intervention while tapering antidepressants may be a potential alternative to long-term medication use in recurrent #depression, regardless of clinical risk factors @JosefienUMH, @Claudib123 https://t.co/UURRmv6qQO
— JAMA Psychiatry (@JAMAPsych) May 19, 2021
Clinical guidelines for female lower urinary tract symptoms.
8 Jul, 2021 | 08:44h | UTCClinical Guidelines for Female Lower Urinary Tract Symptoms – International Journal of Urology