Family Medicine
M-A | Elevated HbA1c in gestational diabetes mellitus tied to 1.7-fold rise in large for gestational age incidence
13 Jun, 2023 | 13:39h | UTC
2ry Analysis of a RCT | Metformin linked to 41% reduction in long COVID incidence in outpatient treatment
12 Jun, 2023 | 13:55h | UTCNews Release: Study shows metformin lowers the risk of getting long COVID – University of Minnesota Medical School
Commentary on Twitter
These data not persuasive. There are 6 different arms. 3 drugs. This is not the primary endpoint. No adjustment for multiple testing.
Even USFDA would not accept these data for regulatory approval, and they are basically working for Pharma at this pthttps://t.co/FZoxo9shtG
— Vinay Prasad MD MPH (@VPrasadMDMPH) June 9, 2023
Guideline | Prevention and therapy of preterm birth
12 Jun, 2023 | 13:45h | UTCPrevention and Therapy of Preterm Birth. Guideline of the DGGG, OEGGG and SGGG
SR | Effectiveness of anticholinergic drugs for treating people with overactive bladder syndrome
12 Jun, 2023 | 13:41h | UTC
Review | Pregnancy as an early cardiovascular moment: peripartum cardiovascular health
12 Jun, 2023 | 13:36h | UTCPregnancy as an Early Cardiovascular Moment: Peripartum Cardiovascular Health – Circulation Research
Commentary on Twitter
@CircRes Alert! Compendium on Early #CVD#Pregnancy as an Early #Cardiovascular Moment: #Peripartum Cardiovascular Health https://t.co/tqOWn9AU0O
Authored by Drs. @heartdocsadiya, NA Cameron, and KJ Lindley pic.twitter.com/KlOXura8Y2
— Circulation Research (@CircRes) June 10, 2023
Cohort Study | Almost a third of bipolar disorder patients non-adherent to 20% or more of prescriptions
12 Jun, 2023 | 13:29h | UTC
RCT | Multivitamin supplementation may improve memory in aged adults
7 Jun, 2023 | 14:12h | UTCMultivitamin Supplementation Improves Memory in Older Adults: A Randomized Clinical Trial – The American Journal of Clinical Nutrition (link to abstract – $ for full-text)
News Releases:
Multivitamin Improves Memory in Older Adults, Study Finds – Columbia University
Related Research: Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial – Alzheimer’s & Dementia
SR | Limited evidence for vitamin and mineral supplements in delaying dementia in people with mild cognitive impairment
7 Jun, 2023 | 14:09h | UTC
Commentary on Twitter
? How does vitamin and mineral supplementation affect #cognitivefunction and progression to #dementia in people with mild cognitive impairment (MCI)?
Get the current evidence picture in this #systematicreview on @CochraneLibrary: https://t.co/YUsbjELIZq@NIH_ODS #NSHFD pic.twitter.com/hRl27Tm7op— Cochrane CAM (@CochraneCAM) May 31, 2023
AHA Scientific Advisory | Digital technologies in cardiac rehabilitation
7 Jun, 2023 | 14:23h | UTCTop Things to Know: Digital Technologies in CR – American Heart Association
JACC Scientific Statement | Remote monitoring for heart failure management at home
7 Jun, 2023 | 14:00h | UTC
Commentary on Twitter
New #JACC Scientific Statement spanning remote monitoring to integrated mgmt of #HeartFailure.
Updates in physiology of congestion, monitoring signals, & #DigitalHealth tech will support clinical teams to connect circles of care/self-care of #HF at home! https://t.co/TyaXT1P1hg pic.twitter.com/0u5STreIDQ
— JACC Journals (@JACCJournals) June 6, 2023
M-A | Advance care planning for frail elderly: are we missing a golden opportunity?
7 Jun, 2023 | 13:53h | UTC
Guideline Series | Prevention and management of diabetes-related foot disease
7 Jun, 2023 | 13:41h | UTCDefinitions and criteria for diabetes-related foot disease (IWGDF 2023 update)
Guidelines on the classification of foot ulcers in people with diabetes (IWGDF 2023 update)
Guidelines on offloading foot ulcers in persons with diabetes (IWGDF 2023 update)
RCT | Immediate vs. delayed sequential bilateral cataract surgery: non-inferior in safety, higher cost-effectiveness
6 Jun, 2023 | 14:41h | UTCSafety, effectiveness, and cost-effectiveness of immediate versus delayed sequential bilateral cataract surgery in the Netherlands (BICAT-NL study): a multicentre, non-inferiority, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
News Release: Cataract surgery: two-sided treatment better than one-by-one approach – Maastricht University
RCT | Tirzepatide outperforms insulin glargine in HbA1c reduction and weight loss in type 2 diabetes
6 Jun, 2023 | 14:39h | UTC
Commentary on Twitter
The SURPASS-AP-Combo trial shows that addition of #tirzepatide as 2L or 3L therapy is non-inferior & superior to insulin glargine for glycemic outcomes at 40 weeks in an Asia-Pacific (mostly Chinese) population w/ type 2 #diabetes. https://t.co/RDh2WSJ1wZ pic.twitter.com/nm6pPpVdxH
— Nature Medicine (@NatureMedicine) June 2, 2023
Adrenaline auto-injector prescription for patients at risk of anaphylaxis: BSACI guidance for primary care
6 Jun, 2023 | 14:28h | UTC
Podcast | Insulin, type 2 diabetes, and hypoglycemia
6 Jun, 2023 | 14:25h | UTC#397: Insulin, Type 2 Diabetes, Fanny Packs, and Hypoglycemia with Dr. Jeff Colburn – The Curbsiders
Podcast | Hypopigmented and depigmented skin lesions in pediatrics
6 Jun, 2023 | 14:24h | UTC#84: Hypopigmented & Depigmented Skin Lesions: An En-LIGHT-ening Review – The Cribsiders
Podcast | Ascend your understanding of pelvic inflammatory disease
6 Jun, 2023 | 14:23h | UTC#83: Ascend Your Understanding of Pelvic Inflammatory Disease (PID) – The Cribsiders
Brief Review | What BP target is appropriate for pregnant patients with mild chronic hypertension?
6 Jun, 2023 | 14:20h | UTC
Adrenal failure: an evidence-based diagnostic approach
6 Jun, 2023 | 14:16h | UTCAdrenal Failure: An Evidence-Based Diagnostic Approach – Diagnostics
Systematic Review | Impact of physical therapies on pain, function, and life quality in myofascial pain syndrome
6 Jun, 2023 | 14:07h | UTC
RCT | Noninferiority shown between DOACs and LMWH for recurrent VTE prevention in cancer patients
5 Jun, 2023 | 13:50h | UTCSummary: This unblinded, pragmatic, noninferiority randomized clinical trial aimed to assess the efficacy of direct oral anticoagulants (DOACs) against low-molecular-weight heparin (LMWH) in preventing recurrent venous thromboembolism (VTE) in patients with cancer. The study included 671 patients from 67 oncology centers, with a new clinical or radiological diagnosis of VTE.
Participants were randomly assigned to receive either a DOAC or LMWH for 6 months, and treating physicians selected and prescribed the drugs based on considerations like availability and drug-drug interactions. The primary outcome was the rate of recurrent VTE at 6 months. Findings revealed that the DOAC group had a recurrent VTE rate of 6.1% as compared to 8.8% in the LMWH group, showing noninferiority. Both groups had statistically similar rates of major bleeding and severe adverse events.
This pragmatic study included patients with advanced cancer and brain metastases, impaired performance status, and reduced liver or kidney function, making it more representative of routine oncology practice. Moreover, patient adherence to DOAC treatment was significantly higher than to LMWH. Nevertheless, the study had limitations, including the lack of blinding and underrepresentation of certain racial and ethnic groups.
In conclusion, this trial suggests that DOACs were noninferior to LMWH for preventing recurrent VTE in patients with cancer over a 6-month follow-up period, supporting the use of DOACs in this population for VTE prevention. Further research is needed to confirm these results and investigate long-term outcomes.
Article: Direct Oral Anticoagulants vs Low-Molecular-Weight Heparin and Recurrent VTE in Patients With Cancer: A Randomized Clinical Trial – JAMA (free for a limited period)
See also: Visual abstract
Commentary on Twitter
Among adults with cancer and VTE, direct oral anticoagulants were noninferior to low-molecular-weight heparin for preventing recurrent VTE over 6-month follow-up. #ASCO23 https://t.co/DP5RvlSYxe pic.twitter.com/rBJ99plopK
— JAMA (@JAMA_current) June 2, 2023
Review | Prevention of venous thromboembolism in patients with cancer
5 Jun, 2023 | 13:48h | UTCPrevention of venous thromboembolism in patients with cancer – The BMJ
Cohort Study | Overweight or obesity in early and middle adulthood linked to higher gastrointestinal cancer risk
5 Jun, 2023 | 13:34h | UTCEditorial: Obesity and Gastrointestinal Cancer: A Life Course Perspective – JAMA Network Open
Commentary: Association Between Overweight/Obesity and Risk of Gastrointestinal Cancer – The ASCO Post
Cohort Study | Cannabis use disorder linked to increased risk of depression and bipolar disorder
5 Jun, 2023 | 13:26h | UTCCannabis Use Disorder and Subsequent Risk of Psychotic and Nonpsychotic Unipolar Depression and Bipolar Disorder – JAMA Psychiatry (link to abstract – $ for full-text)
Author Interview: Cannabis Use Disorder and Subsequent Risk of Unipolar Depression and Bipolar Disorder
Commentary: Expert reaction to study of cannabis use disorder, bipolar disorder, and depression – Science Media Centre