Evidence-based Medicine

“Genetic testing, telemedicine, end-of-life care, and human subjects research are among issues examined in new edition of ACP Ethics Manual” (from News Release)

Perspective: Unethical Experiments’ Painful Contributions to Today’s Medicine

15 Jan, 2019 | 00:32h | UTC

Unethical experiments’ painful contributions to today’s medicine – CNN (free)

Survey: Association of Patient Comorbid Conditions with Cancer Clinical Trial Participation

13 Jan, 2019 | 21:16h | UTC

Association of Patient Comorbid Conditions With Cancer Clinical Trial Participation – JAMA Oncology (free for a limited period)

Editorial: Drivers of Clinical Trial Participation—Demographics, Disparities, and Eligibility Criteria (free for a limited period)

Audio Interview: Association of Patient Comorbid Conditions With Cancer Clinical Trial Participation (free)

Study: Assessment of Pharmaceutical Company and Device Manufacturer Payments to Gastroenterologists and Their Participation in Clinical Practice Guideline Panels

10 Jan, 2019 | 19:18h | UTC

Assessment of Pharmaceutical Company and Device Manufacturer Payments to Gastroenterologists and Their Participation in Clinical Practice Guideline Panels – JAMA Network Open (free)

Invited Commentary: The Call for Greater Transparency in Conflicts of Interest (free)

Perspective: Are Medical Editors Responsible if Articles they Publish Cause Harm?

10 Jan, 2019 | 00:08h | UTC

Are medical editors responsible if articles they publish cause harm? – CMAJ News (free)

Association Between Surrogate End-points and Overall Survival in Oncology

9 Jan, 2019 | 22:45h | UTC

A systematic review of trial-level meta-analyses measuring the strength of association between surrogate end-points and overall survival in oncology – European Journal of Cancer (free for a limited period)

“we found most surrogates in oncology had low or modest correlation with OS, which suggests that caution should be used when making conclusions based on surrogate markers.”

Perspective: Will the World Embrace Plan S, the Radical Proposal to Mandate Open Access to Science Papers?

8 Jan, 2019 | 21:02h | UTC

Will the world embrace Plan S, the radical proposal to mandate open access to science papers? – Science (free)

Study: Parachute use to Prevent Death and Major Trauma When Jumping from Aircraft

8 Jan, 2019 | 05:11h | UTC

Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial – The BMJ (free)

Linked Opinion: We jumped from planes without parachutes (and lived to tell the tale) – The BMJ Opinion (free)

Commentaries: Researchers Show Parachutes Don’t Work, But There’s A Catch – NPR (free) AND Evidence-Based Satire – The Health Care Blog (free)

Related Commentary on Twitter

Parachute use compared with a backpack control did not reduce death or major traumatic injury. The authors say that this largely resulted from their ability to only recruit participants jumping from stationary aircraft on the ground #XmasBMJ @rwyeh https://t.co/CUZSqrW28n pic.twitter.com/G9jsNuxXIu

— The BMJ (@bmj_latest) December 14, 2018

Ann Robinson’s research reviews, 7 January 2019

7 Jan, 2019 | 21:20h | UTC

Ann Robinson’s research reviews, 7 January 2019 – The BMJ (free)

Ann Robinson reviews the latest research from the top medical journals.

Guideline: Control of Confounding and Reporting of Results in Causal Inference Studies

7 Jan, 2019 | 13:41h | UTC

Control of Confounding and Reporting of Results in Causal Inference Studies. Guidance for Authors from Editors of Respiratory, Sleep, and Critical Care Journals – Annals of the American Thoracic Society (free) (via @Abraham_RMI)

Random-Effects Meta-analysis: Summarizing Evidence with Caveats

7 Jan, 2019 | 07:06h | UTC

Guide to Statistics and Methods: Random-Effects Meta-analysis: Summarizing Evidence With Caveats – JAMA (free for a limited period)

Study: Publication Overlap in Systematic Reviews of Non–Vitamin K Oral Anticoagulants in Atrial Fibrillation

4 Jan, 2019 | 20:52h | UTC

Overview of Systematic Reviews of Non–Vitamin K Oral Anticoagulants in Atrial Fibrillation: Evidence of Publication Overlap – Circulation: Cardiovascular Quality and Outcomes (free)

Editorial: Replication, Duplication, and Waste in a Quarter Million Systematic Reviews and Meta-Analyses (free)

Congratulations on the Promotion. But Did Science Get a Demotion?

4 Jan, 2019 | 20:35h | UTC

Congratulations on the Promotion. But Did Science Get a Demotion? – The New York Times (10 articles per month are free)

“The incentives of grant funding and career advancement, even the potential for fame, can influence researchers”

Guidance for Industry: Clinical Trial Endpoints for the Approval of Cancer Drugs and Biologics

3 Jan, 2019 | 11:34h | UTC

Clinical Trial Endpoints for the Approval of Cancer Drugs and Biologics: Guidance for Industry – U.S. Food and Drug Administration (free PDF)

Commentary: FDA Issues Guidance on Endpoints for Cancer Clinical Trials – The ASCO Post (free)

The 2018 Altmetric Top 100 Articles

14 Dec, 2018 | 00:04h | UTC

The 2018 Altmetric Top 100 Articles (free)

“In the past year, Altmetric has tracked over 25 million mentions of 2.8 million research outputs. This page highlights the top 100 most-mentioned scholarly articles published in the past year – those which have truly captured the public imagination.”

“What These Medical Journals Don’t Reveal: Top Doctors’ Ties to Industry”

14 Dec, 2018 | 00:01h | UTC

What These Medical Journals Don’t Reveal: Top Doctors’ Ties to Industry – The New York Times (10 articles per month are free)

BMJ Investigation: How Cow’s Milk Protein Allergy is Extending the Reach of Infant Formula Manufacturers

13 Dec, 2018 | 19:26h | UTC

Overdiagnosis and industry influence: how cow’s milk protein allergy is extending the reach of infant formula manufacturers – The BMJ (free)

Commentaries: Disentangling ourselves from “Big Formula” – The BMJ (free) AND Infant formula companies are behind the guidelines on milk allergy, and their sales are soaring – The Conversation (free)

Related: Europe’s Bold Open-Access Plan Detailed (free report and commentaries)

Study: Patient Organizations and Conflicts of Interest

Open Access 2018: A Year of Funders and Universities Drawing Lines in the Sand

Zackary Berger’s Weekly Research Reviews – 14 January 2019

Opinion: The Scandal of Surrogates and the Missing Survival Data in Cancer Trials

American College of Physicians Ethics Manual: Seventh Edition