Endocrinology (all articles)
“Lorcaserin in Obesity: Minimal Benefits and Ill-Defined Harms”
4 Feb, 2019 | 22:16h | UTCEBM Verdict: Lorcaserin in obesity: minimal benefits and ill-defined harms – BMJ Evidence Based Medicine (free)
Worldwide Dyslipidemia Guidelines
4 Feb, 2019 | 22:32h | UTCWorldwide Dyslipidemia Guidelines – Current Cardiovascular Risk Reports (free)
Related: JAMA Clinical Guidelines Synopsis: Management of Blood Cholesterol (free guideline and synopsis)
Cholesterol-Lowering Agents: PCSK9 Inhibitors Today and Tomorrow
4 Feb, 2019 | 22:19h | UTCCholesterol-Lowering Agents: PCSK9 Inhibitors Today and Tomorrow – Circulation Research (free for a limited period)
Meta-Analysis: Efficacy and Safety of Statin Therapy in Older People
3 Feb, 2019 | 15:43h | UTCCommentaries: Never too old for statin treatment? – The Lancet (free) AND Efficacy and safety of statin therapy in older people – expert comment – London School of Hygiene & Tropical Medicine (free) AND Expert reaction to meta-analysis looking at statins and cardiovascular events in all ages – Science Media Centre (free) AND Statin therapy reduces cardiovascular disease risk in older people – University of Oxford (free) AND Statins Lower Risk for CV Events in Elders, But Benefits for Primary Prevention Still in Question – NEJM Journal Watch (free)
“However, when stratified by history of vascular disease, a significant benefit among those aged 71 and older was limited to those with prior vascular disease.” (from NEJM Journal Watch)
AACE/ACE Comprehensive Type 2 Diabetes Management Algorithm 2019
1 Feb, 2019 | 02:50h | UTCAACE/ACE Comprehensive Type 2 Diabetes Management Algorithm 2019 – Endocrine Practice (Free PDF and Slide Presentations)
Related Guidelines: ADA 2019 Standards of Medical Care in Diabetes (free supplement) AND Diabetes Canada 2018 clinical practice guidelines for the prevention and management of diabetes in Canada (free)
Study: Patients with Type 2 Diabetes Safely Switched from Analog to Less Costly Human Insulin
30 Jan, 2019 | 01:13h | UTCImplementation of a Health Plan Program for Switching From Analogue to Human Insulin and Glycemic Control Among Medicare Beneficiaries With Type 2 Diabetes – JAMA (link to abstract – $ for full-text)
Commentary: Medicare Patients with Type 2 Diabetes Safely Switched From Analog to Human Insulin, JAMA Study Finds – AJMC (free)
Related: Meta-Analysis: Comparative Benefits and Harms of Basal Insulin Analogues for Type 2 Diabetes (link to abstract and commentaries) AND Retrospective Observational Study: Basal Insulin Analogs vs NPH Insulin for Type 2 Diabetes (link to abstract and commentaries)
“Patients with type 2 diabetes (T2D) enrolled in a CareMore Health Medicare Part D plan switched from analog to human insulin without significant loss of glycemic control while saving millions for themselves and for the health plan.: (from AJMC)
Consensus Statement: Targeted Treatment of Primary Aldosteronism
29 Jan, 2019 | 22:01h | UTC
European Practical and Patient-Centred Guidelines for Adult Obesity Management in Primary Care
29 Jan, 2019 | 00:07h | UTC
Systematic Review: Determinants of Weight Loss Maintenance
28 Jan, 2019 | 23:26h | UTCDeterminants of weight loss maintenance: a systematic review – Obesity Reviews (free)
Meta-Analysis: Low Glycemic Index Diets as an Intervention for Obesity
28 Jan, 2019 | 23:24h | UTC
Diabetes Guidelines: Key Messages for Family Physicians
27 Jan, 2019 | 20:41h | UTCOriginal Guideline: Diabetes Canada 2018 clinical practice guidelines for the prevention and management of diabetes in Canada (free) AND Quick Reference Guide (free PDF)
See also: ADA 2019 Standards of Medical Care in Diabetes (free supplement) AND Standards of Medical Care in Diabetes—2019 Abridged for Primary Care Providers (free PDF)
Hypothyroidism in the Elderly: Who Should Be Treated and How?
27 Jan, 2019 | 20:09h | UTCHypothyroidism in the Elderly: Who Should Be Treated and How? – Journal of the Endocrine Society (free)
Related: Meta-Analysis: Treating Subclinical Hypothyroidism is Not Associated with Quality of Life and Thyroid-Related Symptoms (link to abstract and commentaries) AND Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism (free study and commentary)
Cohort Study: Association of Fried Food Consumption with All Cause, Cardiovascular, and Cancer Mortality
24 Jan, 2019 | 21:40h | UTCCommentaries: Eating Fried Foods Linked To Heart Disease, Earlier Deaths In Women Over 50 – Kaiser Health News (free) AND Fried Foods Tied to Heart Disease in Women – The New York Times (10 articles per month are free)
Position Statement: Exercise Training for Patients with Type 2 Diabetes and Cardiovascular Disease
24 Jan, 2019 | 21:39h | UTCCommentaries: Physical activity reduces mortality in patients with diabetes: Exercise programs for diabetics are a cost effective treatment and should be reimbursed – European Society of Cardiology (free) AND Exercise Must Be a Prescription for Those With Type 2 Diabetes, European Cardiologists Say – AJMC (free) AND Exercise cuts mortality risk for people with type 2 diabetes, report says – UPI (free)
Fasting Diets are Going Mainstream — Ahead of the Science. Here’s Why.
23 Jan, 2019 | 12:43h | UTCFasting diets are going mainstream — ahead of the science. Here’s why. – Vox (free)
New Canada’s Dietary Guidelines
23 Jan, 2019 | 01:25h | UTCCanada’s Dietary Guidelines – Government of Canada (free)
Homepage: Canada’s Food Guide (free resources)
Related Commentary on Twitter
New food guide: https://t.co/Yx15RSJ8ab My initial response, pretty solid! Like this image. And like that they are keeping message simple. @GovCanHealth #Canadasfoodguide. pic.twitter.com/Ab8Leqi19A
— Timothy Caulfield (@CaulfieldTim) January 22, 2019
Randomized Trial: Effect of a Low Free Sugar Diet vs Usual Diet on Nonalcoholic Fatty Liver Disease
22 Jan, 2019 | 23:21h | UTCEffect of a Low Free Sugar Diet vs Usual Diet on Nonalcoholic Fatty Liver Disease in Adolescent Boys: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentaries: Study shows low-sugar diet effective in boys with nonalcoholic fatty liver disease – University of California (free) AND Low free sugar diet reduces hepatic steatosis in nonalcoholic fatty liver disease in adolescent males – 2 Minute Medicine (free) AND To Fight Fatty Liver, Avoid Sugary Foods and Drinks – The New York Times (10 articles per month are free)
Meta-Analysis: Association of Aspirin Use for Primary Prevention with Cardiovascular Events and Bleeding Events
22 Jan, 2019 | 22:18h | UTCAssociation of Aspirin Use for Primary Prevention With Cardiovascular Events and Bleeding Events: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)
Commentaries: Expert reaction to study looking at aspirin use in healthy people, and cardiovascular events and bleeding – Science Media Centre (free) AND Aspirin Modest at Best in Primary CV Prevention – MedPage Today (free registration required) AND When to take (or not take) aspirin to prevent heart trouble – CNN (free)
Related: Meta-Analysis: Efficacy and Safety of Aspirin for Primary Prevention of Cardiovascular Events (link to abstract and commentaries) AND Aspirin Did Not Prevent Deaths or Disability in Healthy Older Adults (free study and commentaries)
Meta-Analysis: Interventions for Obesity Among Schoolchildren
21 Jan, 2019 | 12:29h | UTCInterventions for obesity among schoolchildren: A systematic review and meta-analyses – PLOS One (free)
Consensus Statement: Fertility, Pregnancy and Lactation After Bariatric Surgery
20 Jan, 2019 | 15:14h | UTCRelated Review: Pregnancy After Bariatric Surgery: Impact on Pregnancy Management and Outcome (free)
Evidence‐based Guidelines for Screening of Diabetic Retinopathy
20 Jan, 2019 | 15:12h | UTCEvidence‐based Danish guidelines for screening of diabetic retinopathy – Acta Ophthalmologica (free)
“There is solid evidence to support a flexible, individualized screening regimen. In particular, it is possible to prolong screening intervals to 24–48 months for patients with no or mild nonproliferative diabetic retinopathy”.
Cohort Study: Common Conditions Associated with Hereditary Hemochromatosis Genetic Variants
18 Jan, 2019 | 01:03h | UTCCommentaries: Haemochromatosis: disorder that causes body to absorb too much iron from food may be major cause of disease – The Conversation (free) AND Haemochromatosis is linked to more disease than previously thought – The BMJ Opinion (free) AND Health impact of genetic ‘iron-overdose disease’ may have been underestimated – NHS News (free)
The EAT–Lancet Commission on Healthy Diets from Sustainable Food Systems
18 Jan, 2019 | 01:04h | UTCFood in the Anthropocene: the EAT–Lancet Commission on healthy diets from sustainable food systems – The Lancet (free articles – registration required)
Summary: EAT-Lancet Commission Brief for Everyone (free)
Commentaries: New Diet Guidelines to Benefit People and the Planet: More Greens for All, Less Meat for Some – The New York Times (10 articles per month are free) AND New ‘planetary health diet’ can save lives and the planet, major review suggests – CNN (free) AND A bit of meat, a lot of veg – the flexitarian diet to feed 10bn – BBC (free)
Related Commentary on Twitter
Feeding a population of 10 billion people by 2050 with a healthy & sustainable diet will be impossible without transforming eating habits, improving food production & reducing food waste—new @EATForum–@TheLancet Commission #EATLancet #foodcanfixit https://t.co/TsRQiyhA09 pic.twitter.com/v2KtYu9pdS
— The Lancet (@TheLancet) January 16, 2019
Summary: Hypertriglyceridemia Management According to the 2018 AHA/ACC Guideline
18 Jan, 2019 | 00:57h | UTC
Meta-Analysis: Efficacy and Safety of Aspirin for Primary Prevention of Cardiovascular Events
18 Jan, 2019 | 00:55h | UTCEfficacy and safety of aspirin for primary prevention of cardiovascular events: a meta-analysis and trial sequential analysis of randomized controlled trials – European Heart Journal (link to abstract – $ for full-text)
Commentary: Daily Aspirin Use May Do More Harm Than Good for Healthy People – Diagnostic and Interventional Cardiology (free)
Related Study: Aspirin Did Not Prevent Deaths or Disability in Healthy Older Adults (free study and commentaries)