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Endocrinology (all articles)

Review: Efficacy of Population‐wide Diabetes and Obesity Prevention Programs

5 May, 2019 | 21:51h | UTC

Efficacy of population‐wide diabetes and obesity prevention programs: An overview of systematic reviews on proximal, intermediate, and distal outcomes and a meta‐analysis of impact on BMI – Obesity Reviews (free)

 

Related Commentary on Twitter

https://twitter.com/trishgreenhalgh/status/1123478775881195520?s=03

 


Study: Predicting Individual Treatment Response in Diabetes

5 May, 2019 | 21:08h | UTC

Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an analysis using clinical trial data – The Lancet Endocrinology & Diabetes (free)

Commentaries: Predicting individual treatment response in diabetes – The Lancet Endocrinology & Diabetes (free) AND Simple clinical features can help personalise type 2 diabetes treatment – University of Exeter (free)

Related: Novel subgroups of adult-onset diabetes and their association with outcomes (link to abstract and commentaries)

 


WHO Study: Association between Characteristics at Birth, Breastfeeding and Obesity in 22 Countries

4 May, 2019 | 19:04h | UTC

Association between Characteristics at Birth, Breastfeeding and Obesity in 22 Countries: The WHO European Childhood Obesity Surveillance Initiative – Obesity Facts (free)

Commentary: Breastfeeding reduces child obesity risk by up to 25%, WHO finds – The Guardian (free)

 


GLP-1 Receptor Agonist Effective for Glucose Control in In Children and Adolescents with Type 2 Diabetes

4 May, 2019 | 16:45h | UTC

Liraglutide in Children and Adolescents with Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Liraglutide Effective for Glucose Control in Adolescents with Diabetes – NEJM Journal Watch (free) AND Liraglutide Lowers A1C in Youth With Type 2 Diabetes, Phase 3 Study Finds – AJMC (free)

 


Study: Basal Insulin Doses >0.5 IU/kg/d Have Diminishing Additional Impact on Improving Glycemic Measures

2 May, 2019 | 12:53h | UTC

When Basal Insulin is Not Enough: A Dose Response Relationship Between Insulin Glargine 100 Units/mL (U100) and Glycemic Control – Diabetes, Obesity and Metabolism (free)

Commentary: What’s the maximum effective basal insulin dose in T2D? – Univadis (free registration required)

 


Study: Benefits of Statins Questioned for Primary Prevention of Cardiovascular Disease

30 Apr, 2019 | 02:35h | UTC

Statins for the primary prevention of cardiovascular disease: an overview of systematic reviews – BMJ Open (free)

Commentary: NNT with statins is 400 for lower risk eligible patients, researchers estimate – Pulse (free)

 


Pediatric Obesity and Eating Disorders Symptoms: The Role of the Multidisciplinary Treatment

30 Apr, 2019 | 01:51h | UTC

Pediatric Obesity and Eating Disorders Symptoms: The Role of the Multidisciplinary Treatment. A Systematic Review – Frontiers in Pediatrics (free)

 


Systematic Review: Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention

26 Apr, 2019 | 02:05h | UTC

Long-Term Drug Therapy and Drug Discontinuations and Holidays for Osteoporosis Fracture Prevention: A Systematic Review – Annals of Internal Medicine (free)

See also: Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention: A Systematic Review – Agency for Healthcare Research and Quality (free) AND Full Report (free PDF) AND Evidence Summary (free PDF)

 


Cohort Study: Risk of Osteoporotic Fracture Similar with Denosumab vs. Alendronate

25 Apr, 2019 | 18:01h | UTC

Comparison of Risk of Osteoporotic Fracture in Denosumab vs Alendronate Treatment Within 3 Years of Initiation – JAMA Network Open (free)

Commentary: No difference in fracture risk with denosumab vs alendronate – Medicine Matters (free)

 


Meta-Analysis: Effects of Intensive Blood Pressure Lowering in Patients with Type 2 Diabetes

25 Apr, 2019 | 02:02h | UTC

Effects of intensive blood pressure lowering on mortality and cardiovascular and renal outcomes in type 2 diabetic patients: A meta-analysis – PLOS One (free)

 


Study: Long-Term Weight Loss with Metformin

24 Apr, 2019 | 06:24h | UTC

Long-Term Weight Loss with Metformin or Lifestyle Intervention in the Diabetes Prevention Program Outcomes Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Metformin may help patients maintain weight loss long-term – American College of Physicians (free) AND Metformin may help people at high diabetes risk to maintain weight loss – Medicine Matters (free) AND Metformin may help patients maintain long-term weight loss – 2 Minute Medicine (free)

 


Clinical Update: Metformin in 2019

23 Apr, 2019 | 01:50h | UTC

Metformin in 2019 – JAMA (free for a limited period)

 


Perspective: High-Fiber Diet Might Protect Against Range of Conditions

23 Apr, 2019 | 01:49h | UTC

High-Fiber Diet Might Protect Against Range of Conditions – JAMA (free for a limited period)

 


Meta-Analysis of Randomized Trials: Comparative Outcomes of Heart Failure Among Existent Classes of Anti-diabetic Agents

22 Apr, 2019 | 22:25h | UTC

Comparative outcomes of heart failure among existent classes of anti-diabetic agents: a network meta-analysis of 171,253 participants from 91 randomized controlled trials – Cardiovascular Diabetology (free)

 


Clinical Management of Intermittent Fasting in Patients with Diabetes Mellitus

22 Apr, 2019 | 22:18h | UTC

Clinical Management of Intermittent Fasting in Patients with Diabetes Mellitus – Nutrients (free)

The authors acknowledge the almost non-existent evidence on this issue and suggest practical recommendations for the care of these patients.

 


Consensus Report: Nutrition Therapy for Adults With Diabetes or Prediabetes

22 Apr, 2019 | 02:22h | UTC

Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report – Diabetes Care (free PDF)

 


Consensus on Postoperative Recommendations After Transsphenoidal Surgery

22 Apr, 2019 | 01:58h | UTC

Consensus on Postoperative Recommendations After Transsphenoidal Surgery – Experimental and Clinical Endocrinology & Diabetes (free)

 


Latest Updates on Lipid Management

21 Apr, 2019 | 21:14h | UTC

Latest Updates on Lipid Management – High Blood Pressure & Cardiovascular Prevention (free)

 


Meta-analysis: Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes

20 Apr, 2019 | 16:07h | UTC

Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis – JAMA Network Open (free)

Commentaries: Evidence Supporting Niacin Use for Cardiovascular Disease Prevention Evaluated – MPR (free) AND Niacin: Time to Revisit That FDA Indication – MedPage Today (free registration required)

 

Related Commentary on Twitter

 


Meta-Analysis: Effect of Community-based Programs on Diabetes Prevention in Low- and Middle-income Countries

20 Apr, 2019 | 13:53h | UTC

The effect of community-based programs on diabetes prevention in low- and middle-income countries: a systematic review and meta-analysis – Globalization and Health (free)

 


Small Randomized Trial Suggests Metformin May be Effective for Left Ventricular Hypertrophy in Patients with Coronary Artery Disease Without Diabetes

19 Apr, 2019 | 08:37h | UTC

A randomized controlled trial of metformin on left ventricular hypertrophy in patients with coronary artery disease without diabetes: the MET-REMODEL trial – European Heart Journal (free)

Commentaries: Diabetes drug Metformin may fight heart disease, study says – UPI (free) AND Diabetic drug shown to reduce the risk of heart disease in non-diabetic patients – University of Dundee (free) AND Metformin reduces left ventricular mass in nondiabetic patients with CAD – Cardiovascular Business (free)

 


Another Observational Study Showing Association of Statin Use with Risk of New‐Onset Diabetes Mellitus

19 Apr, 2019 | 08:25h | UTC

Time‐ and Dose‐Dependent Association of Statin Use With Risk of Clinically Relevant New‐Onset Diabetes Mellitus in Primary Prevention: A Nationwide Observational Cohort Study – Journal of the American Heart Association (free)

Editorial: Perils of Observational Data Analyses (free)

Commentary: Statins for primary prevention: do benefits outweigh DM risk? – Univadis (free registration required)

Related: Cohort Study: Statin Use Associated with a 38% Higher Risk of Incident Type 2 Diabetes (free study and commentaries)

 


Randomized Trial: SGLT2 inhibitor Reduces Progression of Kidney Disease in Patients with Type 2 Diabetes and Nephropathy

16 Apr, 2019 | 02:52h | UTC

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy – New England Journal of Medicine (free for a limited period)

Commentary: Canagliflozin may offer renal protection in people with type 2 diabetes and CKD – Medicine Matters (free)

“among 1000 patients treated for 2.5 years, 21.2 individuals would need to be treated to prevent the composite primary outcome.” (from Medicine Matters)

 


Randomized Trial: Statins Safe and Effective for Patients with Rheumatoid Arthritis

16 Apr, 2019 | 02:50h | UTC

Trial of atorvastatin for the primary prevention of cardiovascular events in patients with rheumatoid arthritis (TRACE RA): A multicenter, randomized, placebo controlled trial – Arthritis & Rheumatology (free)

Commentaries: Statins safe for rheumatoid arthritis patients – University of Dundee (free) AND Statins safe for preventing cardiovascular events in rheumatoid arthritis patients, study suggests – Wiley (free)

 


Cohort Study: Gestational Diabetes Associated with Incident Diabetes in Childhood and Youth

16 Apr, 2019 | 02:03h | UTC

Gestational diabetes associated with incident diabetes in childhood and youth: a retrospective cohort study – Canadian Medical Association Journal (free)

Commentary: Maternal gestational diabetes linked to diabetes in children – CMAJ (free)

 


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