Editor's Choice
M-A: Evaluation of the incremental value of a coronary artery calcium score beyond traditional cardiovascular risk assessment.
26 Apr, 2022 | 08:15h | UTCEvaluation of the Incremental Value of a Coronary Artery Calcium Score Beyond Traditional Cardiovascular Risk Assessment: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)
Invited Commentary: Addition of Coronary Artery Calcium Scores to Primary Prevention Risk Estimation Models—Primum Non Nocere – JAMA Internal Medicine (free for a limited period)
Author Interview: Incremental Value of a Coronary Artery Calcium Score
Commentary on Twitter
Coronary artery calcium scans provide a small gain in CVD risk assessment and may have a role in selected patients. Potential harms include false positives, incidental findings, radiation, and cost. No evidence suggests that this provides clinical benefit. https://t.co/7bASFf26NF
— JAMA Internal Medicine (@JAMAInternalMed) April 25, 2022
RCT: Uterine artery embolization vs. myomectomy for premenopausal women with uterine fibroids wishing to avoid hysterectomy.
26 Apr, 2022 | 08:08h | UTC
Why does the Omicron variant largely spare olfactory function? implications for the pathogenesis of anosmia in COVID-19.
26 Apr, 2022 | 08:05h | UTC
Cluster RCT: Supraglottic airway device vs. tracheal intubation in the initial airway management of out-of-hospital cardiac arrest.
26 Apr, 2022 | 08:12h | UTC
Cohort Study: Effectiveness of homologous vs. heterologous booster doses for an inactivated SARS-CoV-2 vaccine.
26 Apr, 2022 | 08:06h | UTCCommentaries:
COVID-19 vaccine booster strategy: striving for best practice – The Lancet Global Health
Covid-19: Mix and match booster vaccination approach offers best protection, study reports – The BMJ
Commentary on Twitter
Effectiveness of homologous and heterologous booster doses for an inactivated SARS-CoV-2 vaccine: a large-scale prospective cohort study https://t.co/0k7WlphoDV Heterologous booster provided ⬆️ protection than homologous one, especially when Coronavac vaccine had been used.
— Carlos del Rio (@CarlosdelRio7) April 25, 2022
WHO: Multi-country – acute, severe hepatitis of unknown origin in children.
25 Apr, 2022 | 01:13h | UTCMulti-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
Commentaries:
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
At least one child has died from mystery strain of severe hepatitis, WHO confirms – The Guardian
Related:
CDC Alerts Providers to Hepatitis Cases of Unknown Origin – Centers for Disease Control and Prevention AND Guidance: Recommendations for Adenovirus Testing and Reporting of Children with Acute Hepatitis of Unknown Etiology – Centers for Disease Control and Prevention
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
AHA Scientific Statement: Engaging families in adult cardiovascular care.
25 Apr, 2022 | 01:09h | UTCTop Things to Know: Engaging Families in Adult Cardiovascular Care – American Heart Association
Commentary on Twitter
https://twitter.com/ErinMichos/status/1517210340521648130
Under a Creative Commons Attribution‐NonCommercial‐NoDerivs License
NICE Guideline | Medicines associated with dependence or withdrawal symptoms: safe prescribing and withdrawal management for adults.
25 Apr, 2022 | 01:11h | UTC
Cohort Study: Association of the 2020 US presidential election with hospitalizations for acute cardiovascular conditions.
25 Apr, 2022 | 01:07h | UTCRelated:
Psychological Stress and Heart Disease: Fact or Folklore? – The American Journal of Medicine
Sudden Cardiac Death Triggered by an Earthquake – New England Journal of Medicine
Cardiovascular Events during World Cup Soccer – New England Journal of Medicine
Commentary from the author on Twitter (thread – click for more)
Found 42%⬆️in heart attacks days after 2020 US Presidential election ! Our study in 6,396,830 adults across California @JAMANetworkOpen https://t.co/4ikeNiWqkB with @MMeffordPhD & collaboration @HarvardChanSPH
Let's not underestimate the impact of emotional stress🔥on❤️
🧵 pic.twitter.com/GVohHz1iGU— Jamal Rana, MD (@JamalRanaMD) April 20, 2022
Echocardiography findings in COVID-19 patients admitted to intensive care units: a multi-national observational study.
25 Apr, 2022 | 01:00h | UTC
Commentary on Twitter
Echocardiography in #COVID19 #ICU pts, ECHO-COVID study
♥︎ systolic dysfunction in ⅓: 23% LV (similar to septic cardiomyopathy), 22.5% RV (due to P overload)
♥︎ ACP in 17% (due to hypercapnia, PE, MV)
♥︎ ACP/age associated with in-ICU mortality
📖 https://t.co/NUlAZh9hHw pic.twitter.com/t17pNolFqy— Intensive Care Medicine (@yourICM) April 21, 2022
RCT: Segmentectomy resulted in better outcomes than lobectomy in small-sized peripheral non-small-cell lung cancer.
25 Apr, 2022 | 01:03h | UTCSegmentectomy versus lobectomy in small-sized peripheral non-small-cell lung cancer (JCOG0802/WJOG4607L): a multicentre, open-label, phase 3, randomised, controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Cohort Study: COVID-19 vaccination during early pregnancy was not associated with increased risk of congenital fetal anomalies.
25 Apr, 2022 | 00:59h | UTCCommentaries:
COVID vaccine in early pregnancy not tied to birth defects – CIDRAP
No Sign That COVID Vaccine in Pregnancy Raises Birth Defect Risk – HealthDay
SARS-CoV-2 reinfections: overview of efficacy and duration of natural and hybrid immunity.
25 Apr, 2022 | 00:56h | UTCRelated Study:
Rates of COVID-19 Among Unvaccinated Adults With Prior COVID-19 – JAMA Network Open AND Commentaries: COVID-19 infection granted patients strong and long-lasting protection from reinfection – Providence Health & Services AND COVID-19 infection may offer similar immunity as vaccination – CIDRAP
RCT: Early surgery vs. exercise and education for meniscal tears in young adults.
25 Apr, 2022 | 00:51h | UTCEarly Surgery or Exercise and Education for Meniscal Tears in Young Adults – NEJM Evidence
Commentary:
Early Surgery Not Superior for Meniscal Tears in Young Adults – HealthDay
Commentary on Twitter
https://twitter.com/nejmevidence/status/1486005957654052866
Systematic Review: The performance of wearable sensors in the detection of SARS-CoV-2 infection.
25 Apr, 2022 | 00:55h | UTC
Commentary on Twitter
A missed opportunity for Covid early detection and tracking, inexpensively, passively, at scalehttps://t.co/4cDxlps7AM systematic review of wearable sensors (smartwatch or fitness bands worn or owned by > 80 million Americans) @LancetDigitalH pic.twitter.com/sy1rArB5fE
— Eric Topol (@EricTopol) April 22, 2022
Under a (CC BY 4.0) License
WHO recommends highly successful COVID-19 therapy (nirmatrelvir-ritonavir) and calls for wide geographical distribution and transparency from originator.
22 Apr, 2022 | 09:36h | UTCSee also:
A living WHO guideline on drugs for covid-19 – The BMJ
Therapeutics and COVID-19: living guideline – World Health Organization
Related:
Commentary on Twitter
🔥 Our latest @WHO living guidance on drugs for #COVID19, with new recommendations for nirmatrelvir-ritonavir & updated recommendation for remdesivir in non-severe illness.@bmj_latest: https://t.co/KuJjwzeTPV@WHO: https://t.co/n3iQx3pdmY
@theMAGICapp: https://t.co/dA7YYzeAZ1 pic.twitter.com/LvAhJf70UY
— Arnav Agarwal (@ArnavAgarwalMD) April 21, 2022
CDC alerts providers to hepatitis cases of unknown origin.
22 Apr, 2022 | 09:34h | UTCCommentaries:
CDC issues health advisory about acute hepatitis in children – CNN
CDC Issues Alert for Hepatitis in Children With Adenovirus Infection – WebMD
Related:
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Policy stringency and mental health during the COVID-19 pandemic: a longitudinal analysis of data from 15 countries.
22 Apr, 2022 | 09:28h | UTC
UK drug regulator advises patients and doctors against the use of Pregabalin during pregnancy due to a possible increased risk of congenital malformations.
22 Apr, 2022 | 09:31h | UTCSee also: Pregabalin and risks in pregnancy – Medicines and Healthcare products Regulatory Agency
Source: Avoid prescribing pregabalin during pregnancy if possible, says UK drug regulator – The BMJ ($)
Commentary on Twitter
The Medicines and Healthcare Products Regulatory Agency (@MHRAgovuk) has strengthened its warning about avoiding pregabalin during pregnancy after new data showed an increased risk of major congenital malformations associated with the drug https://t.co/ghGvqCqA0C
— The BMJ (@bmj_latest) April 22, 2022
One-year follow-up of a RCT: In ICU patients with severe hypoxemia, there was no difference in long-term mortality and health-related quality of life with lower vs. higher oxygenation targets.
22 Apr, 2022 | 09:32h | UTCOriginal Study: Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure – New England Journal of Medicine
Commentary on Twitter
Lower (8 kPa) vs higher oxygenation (12 kPa) targets: no longterm survival benefit nor HRQoL improvement at 1y in #ICU pts with severe hypoxaemia (HOT-ICU trial cohort). Substantial impairments in several EQ-5D-5L dimensions in survivors in both groups.
🖇️ https://t.co/P48Cd5sIWK pic.twitter.com/JBFEIqDdcB— Intensive Care Medicine (@yourICM) April 20, 2022
RCT: Calorie restriction combined with time-restricted eating (eating from 8:00 am to 4:00 pm) did not significantly decrease weight loss compared to calorie restriction alone at 12 months (net difference, −1.8 kg; 95% CI, −4.0 to 0.4; P=0.11).
21 Apr, 2022 | 10:31h | UTCCalorie Restriction with or without Time-Restricted Eating in Weight Loss- New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Time-Restricted Eating No Better Than Cutting Calories for Obesity – HealthDay
Commentary on Twitter
As compared with calorie restriction, time-restricted eating does not produce additional benefits with regard to reduction of body weight, body fat, and metabolic risk factors. https://t.co/Ygx4zbC6QP pic.twitter.com/TGE5Pva3yS
— NEJM (@NEJM) April 20, 2022
RCT: Intramuscular AZD7442 (Tixagevimab–Cilgavimab) for prevention of Covid-19.
21 Apr, 2022 | 10:29h | UTC
Commentary on Twitter
AZD7442 (tixagevimab/cilgavimab) found to have about 76% efficacy in preventing symptomatic Covid-19 infection. https://t.co/8tmvz3xI4I pic.twitter.com/fOegZjBRA6
— NEJM (@NEJM) April 20, 2022
[News release – not published yet] New guidelines from WHO recommend a simpler, safer treatment for cryptococcal disease in people living with HIV.
21 Apr, 2022 | 10:28h | UTCRelated Study: Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis – New England Journal of Medicine (link to abstract – $ for full-text)
Cohort study: COVID-19 infection granted patients strong and long-lasting protection from reinfection.
21 Apr, 2022 | 10:20h | UTCNews Release: COVID-19 infection granted patients strong and long-lasting protection from reinfection – Providence Health & Services
Original Study: Rates of COVID-19 Among Unvaccinated Adults With Prior COVID-19 – JAMA Network Open
Commentary: COVID-19 infection may offer similar immunity as vaccination – CIDRAP
Commentary on Twitter
This US cohort study found that unvaccinated individuals with prior symptomatic #COVID19 had 85% lower risk against recurrent COVID-19 compared to unvaccinated individuals without prior infection, for up to 9 months, through November, 2021. https://t.co/1qHCFmGqXG
— JAMA Network Open (@JAMANetworkOpen) April 20, 2022
SARS-CoV-2 vaccination and myocarditis in a Nordic cohort study of 23 million residents.
21 Apr, 2022 | 10:23h | UTCEditorial: Communicating the Benefits of Vaccination in Light of Potential Risks