Editor's Choice
IDSA updates guidelines on the treatment and management of patients with COVID-19.
13 May, 2022 | 11:35h | UTC
Cohort Study: Health outcomes in people 2 years after surviving hospitalization with COVID-19.
13 May, 2022 | 11:32h | UTC
Clinical features of, and risk factors for, severe or fatal COVID-19 among people living with HIV admitted to hospital: analysis of data from the WHO Global Clinical Platform of COVID-19.
13 May, 2022 | 11:28h | UTCInvited Commentary: A collision of pandemics: HIV and COVID-19 – The Lancet HIV
Commentaries on Twitter
New: Clinical features of, and risk factors for, severe or fatal COVID-19 among people living with HIV admitted to hospital: analysis of data from the WHO Global Clinical Platform of COVID-19 by Silvia Bertagnolio and colleagues https://t.co/hAyuWi7fMN #openaccess pic.twitter.com/VmjeYMLPHu
— The Lancet HIV (@TheLancetHIV) May 11, 2022
Clinical features of, and risk factors for, severe or fatal COVID-19 among PLWH admitted to hospital…. https://t.co/KKVKwroy4Z Compared with individuals without HIV, PLWH (96% living in Africa) had 15% ⬆️ odds of severe COVID-19 and were 38% more likely to die in hospital.
— Carlos del Rio (@CarlosdelRio7) May 12, 2022
[Preprint] Long Covid: A systematic review and meta-analysis of 120,970 patients.
13 May, 2022 | 11:30h | UTCLong Covid: A Systematic Review and Meta-Analysis of 120,970 Patients – Preprints with The Lancet
Commentary on Twitter
A systematic #LongCovid review of nearly 200 studies and over 120,000 participants, reinforces the high frequency of symptoms > 6 months, not linked to severity of acute illness, and potential for marked disabilityhttps://t.co/9NYQT1P79G pic.twitter.com/WFzBqghbGI
— Eric Topol (@EricTopol) May 6, 2022
Limiting resident-physician work hours may improve patient safety outcomes.
12 May, 2022 | 10:30h | UTCNews Release: Limiting resident-physician work hours improved patient safety outcome – Brigham and Women’s Hospital
New guideline for low-risk, recurrent abdominal pain in the emergency department.
12 May, 2022 | 10:31h | UTCNews Release: New guideline for low-risk, recurrent abdominal pain in the emergency department – Society for Academic Emergency Medicine
Opinion: Why preprints are good for patients.
12 May, 2022 | 10:25h | UTCWhy preprints are good for patients – Nature Medicine
Commentary on Twitter
.@PeterHorby on how rapid communication saved lives. "In the month between the public announcement of the [RECOVERY dexamethasone] result and the publication of the peer-reviewed manuscript, over 700,000 [new] COVID-19 cases were reported globally."https://t.co/5m3VVxjBBX
— Natalie E. Dean, PhD (@nataliexdean) May 11, 2022
Systematic Review: Antibiotic prophylaxis for preventing bacterial endocarditis following dental procedures.
12 May, 2022 | 10:24h | UTC
Commentary on Twitter
Have a look at the evidence on antibiotics for preventing bacterial endocarditis in people undergoing dental treatment. Summary here: https://t.co/7uxnkbgt8t. Full review here: https://t.co/3Au3EsHZIU pic.twitter.com/RLsF3fHiZa
— Cochrane Oral Health (@CochraneOHG) May 11, 2022
Capsid inhibition with Lenacapavir in multidrug-resistant HIV-1 infection.
12 May, 2022 | 10:20h | UTCCapsid Inhibition with Lenacapavir in Multidrug-Resistant HIV-1 Infection – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Lenacapavir for HIV Infection in a Multidrug-Resistant Study Cohort – ContagionLive
RCT: Evaluation of mRNA-1273 Covid-19 vaccine in children 6 to 11 years of age.
12 May, 2022 | 10:22h | UTC
Commentary on Twitter
Two 50-μg doses of mRNA-1273 vaccine were found to be safe and effective in inducing immune responses and preventing Covid-19 in children 6 to 11 years of age. https://t.co/A5SBK4zK6E pic.twitter.com/7x4JgOwK57
— NEJM (@NEJM) May 11, 2022
Cohort Study: Impact of modifiable healthy lifestyle adoption on lifetime gain from middle to older age.
12 May, 2022 | 10:14h | UTC
Commentary on Twitter
https://twitter.com/EricTopol/status/1524446562545405952
Epidemiological update: Hepatitis of unknown etiology in children.
12 May, 2022 | 10:12h | UTCRelated:
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentary on Twitter (thread – click for more)
Update: #Hepatitis of unknown aetiology in children – 11 May 2022
Approximately 106 cases have been identified in 14 EU/EEA countries and 450 cases are reported worldwide.
The cause of the disease is still under investigation.
Read more: https://t.co/B0lLm7I0dV— ECDC Outbreaks (@ECDC_Outbreaks) May 11, 2022
USPSTF recommends against screening for COPD in asymptomatic adults.
11 May, 2022 | 11:26h | UTCEditorial: Screening for Chronic Obstructive Pulmonary Disease: Challenges and Opportunities – JAMA
Evidence Report: Screening for Chronic Obstructive Pulmonary Disease: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA
Patient Page: Screening for Chronic Obstructive Pulmonary Disease – JAMA
Author Interview: USPSTF Recommendation: Screening for Chronic Obstructive Pulmonary Disease – JAMA
Commentary: USPSTF Continues to Recommend Against COPD Screening in Asymptomatic Adults – AJMC
Commentary on Twitter
The 🇺🇸 USPSTF, again, recommends against screening for #COPD jn asymptomatic adults: ‘using a reaffirmation process, the USPSTF concludes with moderate certainty that screening for COPD in asymptomatic adults has no net benefit’. https://t.co/msBtDBKngx
— John Hurst (@ProfHurst) May 10, 2022
Use of novel strategies to develop guidelines for management of pyogenic osteomyelitis in adults: a WikiGuidelines group consensus statement.
11 May, 2022 | 11:23h | UTCCommentary: A new approach to medical guidelines, taking inspiration from Wikipedia – University of Michigan
Commentary on Twitter
This consensus statement & systematic review uses a WikiGuidelines methodology for clinical guideline development (precluding recommendations based on low-quality data/opinion), addressing 7 questions regarding osteomyelitis management. @BradSpellberg https://t.co/MVjkzC5rdf
— JAMA Network Open (@JAMANetworkOpen) May 10, 2022
Study suggests tailoring diabetes screening by race and ethnicity may lead to earlier diagnosis.
11 May, 2022 | 11:19h | UTCCommentary: Tailoring diabetes screening by race, ethnicity may lead to earlier diagnosis – ACP Internist
Original Study: Diabetes Screening by Race and Ethnicity in the United States: Equivalent Body Mass Index and Age Thresholds – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary from the author on Twitter (thread – click for more)
1/In her 40s, my mother, an Indian American, was diagnosed with diabetes, though she was not indicated for screening
This led me to ask…do we appropriately screen for diabetes by race/ethnicity?
Now answered in @AnnalsofIM with⭐️mentor @kardiologykazihttps://t.co/xTM9WmIbaL pic.twitter.com/IK5v76KMxh
— Rahul Aggarwal (@RahulAggarwalMD) May 9, 2022
AHA: Call to action for cardiovascular disease in women: epidemiology, awareness, access, and delivery of equitable health care.
11 May, 2022 | 11:22h | UTCNews Release: Investment, action urged to improve access, quality and equity in women’s heart health – American Heart Association
Phase 2 RCT: A fourth dose of an mRNA Covid-19 vaccine increases cellular and humoral immunity against SARS-CoV-2.
11 May, 2022 | 11:14h | UTCCommentaries:
What a second booster dose of mRNA COVID-19 vaccines tells us – The Lancet Infectious Diseases
Covid: Fourth-dose jab trial shows good boost – BBC
Commentary on Twitter (thread – click for more)
The results of the @CovBoost fourth dose booster substudy are now online in @TheLancetInfDis
We demonstrated fourth doses of covid vaccines were safe and well tolerated and boost antibody levels above their peak following a third dosehttps://t.co/zGi0iNCAcL
— Alasdair Munro (@apsmunro) May 10, 2022
[Preprint] Modeling transmission of SARS-CoV-2 Omicron in China.
11 May, 2022 | 11:16h | UTCModeling transmission of SARS-CoV-2 Omicron in China – Nature Medicine
Commentary on Twitter
https://twitter.com/EricTopol/status/1524050859054616576
RCT: Doxycycline vs. azithromycin for treating anorectal Chlamydia trachomatis infection in women.
11 May, 2022 | 11:15h | UTCDoxycycline versus azithromycin for the treatment of anorectal Chlamydia trachomatis infection in women concurrent with vaginal infection (CHLAZIDOXY study): a multicentre, open-label, randomised, controlled, superiority trial – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Commentary: Doxycycline Bests Azithromycin for Anogenital Chlamydia in Women — Open-label randomized trial set out to duplicate results from prior studies in men – MedPage Today (free registration required)
Related:
M-A: Interventions to reduce falls in hospitals.
11 May, 2022 | 11:12h | UTCInterventions to reduce falls in hospitals: a systematic review and meta-analysis – Age and Ageing
Metabolic Alkalosis Pathogenesis, Diagnosis, and Treatment: Core Curriculum 2022.
10 May, 2022 | 11:31h | UTC
Commentary on Twitter
Metabolic Alkalosis Pathogenesis, Diagnosis, and Treatment: Core Curriculum 2022https://t.co/5ujfpBDwBz (FREE) pic.twitter.com/e1RvYVAzC8
— AJKD (@AJKDonline) May 8, 2022
ECRI and ISMP Public Statement | Medication errors are complex; criminal charges will not improve care.
10 May, 2022 | 11:29h | UTCSee also:
The simple thing hospitals can do to prevent dangerous drug mistakes – CNN
Legionnaires’ Disease: Update on diagnosis and treatment.
10 May, 2022 | 11:06h | UTCLegionnaires’ Disease: Update on Diagnosis and Treatment – Infectious Diseases and Therapy
Commentary on Twitter
Legionellosis is becoming increasingly important as a public health problem throughout the world; although it is an underreported disease!
Fantastic 🆕💥Review Article @InfectDis_Ther
Legionnaires’ Disease: Update on Diagnosis and Treatment #IDTwitter https://t.co/OvmZZZRz6n pic.twitter.com/vCu7MZdnKs— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) May 7, 2022
Under a http://creativecommons.org/licenses/by-nc/4.0/ license
Review: First-generation oral antivirals against SARS-CoV-2.
10 May, 2022 | 11:08h | UTCFirst-generation Oral Antivirals Against SARS-CoV-2 – Clinical Microbiology and Infection
Podcast: Inpatient Covid Management.
10 May, 2022 | 11:03h | UTC#332 Inpatient Covid Management with Dr. Nathan Erdmann. – The Curbsiders