Phase 2 RCT: A fourth dose of an mRNA Covid-19 vaccine increases cellular and humoral immunity against SARS-CoV-2.

Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial – The Lancet Infectious Diseases

Commentaries:

What a second booster dose of mRNA COVID-19 vaccines tells us – The Lancet Infectious Diseases

Covid: Fourth-dose jab trial shows good boost – BBC

Commentary on Twitter (thread – click for more)

The results of the @CovBoost fourth dose booster substudy are now online in @TheLancetInfDis

We demonstrated fourth doses of covid vaccines were safe and well tolerated and boost antibody levels above their peak following a third dosehttps://t.co/zGi0iNCAcL

— Alasdair Munro (@apsmunro) May 10, 2022