Editor's Choice
Guideline: Sleep-related breathing disorders in adults.
28 Jun, 2022 | 11:21h | UTCPartial update of the German S3 Guideline Sleep-Related Breathing Disorders in Adults – Somnologie
Rheumatic heart disease is a neglected disease relative to its burden worldwide: findings from Global Burden of Disease 2019.
28 Jun, 2022 | 11:17h | UTC
RCT: Two-day vs. seven-day course of levofloxacin in acute COPD exacerbation.
28 Jun, 2022 | 11:19h | UTCCommentary: Antibiotics in COPD Exacerbations – 2 days vs 7 days – RebelEM
Long COVID symptoms in SARS-CoV-2-positive children aged 0–14 years and matched controls in Denmark: a national, cross-sectional study.
28 Jun, 2022 | 11:16h | UTCNews Release: Largest study reports long COVID symptoms in children up to age 14 – Lancet
Commentaries:
Difficult questions about long COVID in children – The Lancet Child & Adolescent Health
Kids do get long COVID, but it seems uncommon, data reveal – CIDRAP
Cardiovascular damage in COVID-19: What we know two years later.
28 Jun, 2022 | 11:11h | UTCCardiovascular Damage in COVID-19: What We Know Two Years Later – Current Cardiology Reports
Epilepsy: what are the best medications?
28 Jun, 2022 | 11:14h | UTCEpilepsy: what are the best medications? – Evidently Cochrane
Original Study: Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data – Cochrane Library
Cohort Study: Association of receipt of the fourth BNT162b2 dose with omicron infection and COVID-19 hospitalizations among residents of long-term care facilities.
28 Jun, 2022 | 11:08h | UTCCommentary: Fourth Dose of BNT162b2 Prevents Severe COVID-19 in Nursing Home Residents – HealthDay
Commentary on Twitter
Cohort study found that vaccination with a fourth BNT162b2 dose vs 3 doses given 4 months or earlier, was associated with lower risk of hospitalizations by 64-67% and deaths by 72%, among residents of long-term care facilities during massive Omicron surge. https://t.co/LTZ4umgSDh
— JAMA Internal Medicine (@JAMAInternalMed) June 23, 2022
Infertility, recurrent pregnancy loss, and risk of stroke: pooled analysis of individual patient data of 618 851 women.
27 Jun, 2022 | 11:59h | UTCNews Release: Infertility and pregnancy loss may increase women’s risk of stroke – BMJ Newsroom
Commentary on Twitter
Infertility and pregnancy loss are associated with an increased risk of non-fatal and fatal stroke in later life, finds study.
Early monitoring of women who have experienced miscarriage or stillbirth could lower the risk, the researchers suggest https://t.co/fYrNfpz6fC
— The BMJ (@bmj_latest) June 24, 2022
Systematic Review: Antibiotics for uncomplicated diverticulitis.
27 Jun, 2022 | 11:56h | UTCAntibiotics for uncomplicated diverticulitis – Cochrane Library
Summary: Antibiotics for uncomplicated diverticulitis – Cochrane Library
Related:
Efficacy and Safety of Non-Antibiotic Outpatient Treatment in Mild Acute Diverticulitis (DINAMO-study): A Multicentre, Randomised, Open-Label, Non-Inferiority Trial – Annals of Surgery (link to abstract – $ for full-text)
Elective surgical management of diverticulitis – Current Problems in Surgery
Management of Colonic Diverticulitis – Agency for Healthcare Research and Quality
Commentary on Twitter
The benefits of antibiotics in diverticulitis are uncertain with respect to complications, emergency✂️, recurrence, elective colonic resections&long‐term complications. This may be because diverticulitis is❌an infectious disorder, but an inflammatory onehttps://t.co/0HmAllw5Af
— John Damianos, M.D. (@john_damianosMD) June 26, 2022
2022 AHA/ACC key data elements and definitions for cardiovascular and noncardiovascular complications of COVID-19.
27 Jun, 2022 | 12:01h | UTCNews Release: New ACC/AHA Data Standards Address CV, Noncardiovascular Complications of COVID-19 – American College of Cardiology
Epidemiology of myocarditis and pericarditis following mRNA vaccination by vaccine product, schedule, and interdose interval among adolescents and adults in Ontario, Canada.
27 Jun, 2022 | 11:51h | UTCCommentary: Young Men’s Myocarditis Risk 5 Times Higher With Moderna vs Pfizer Vax — But Canadian study finds that 8-week interval before second dose attenuates some of the risk – MedPage Today (free registration required)
[Press Release – not published yet]: RCT: Sanofi-GSK report its vaccine targeted against ancestral and Beta strains had an overall efficacy of 72% against the Omicron variant.
27 Jun, 2022 | 11:52h | UTCPress Release: Sanofi-GSK first to report a successful efficacy study against Omicron with COVID-19 Beta-containing vaccine – Sanofi
Commentaries: Bivalent COVID Vax Gets Phase III Win Against Omicron, Companies Say — Sanofi, GSK boast of 72% efficacy against Omicron variant – MedPage Today (free registration required)
Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19.
27 Jun, 2022 | 11:49h | UTC
Commentary on Twitter
NEW Personal View—Use of pragmatic and explanatory trial designs in acute care research: lessons from #COVID19
From Jonathan Casey & colleagues https://t.co/3vJs5j6Q1Q pic.twitter.com/hEUFYxNKRf
— The Lancet Respiratory Medicine (@LancetRespirMed) June 14, 2022
Perspective | What Omicron’s BA.4 and BA.5 variants mean for the pandemic.
27 Jun, 2022 | 11:48h | UTCWhat Omicron’s BA.4 and BA.5 variants mean for the pandemic – Nature
M-A: The role of resistance exercise training for improving cardiorespiratory fitness in healthy older adults.
27 Jun, 2022 | 11:42h | UTC
Vaccinations may have prevented almost 20 million COVID-19 deaths worldwide.
27 Jun, 2022 | 11:46h | UTCNews Release: Vaccinations may have prevented almost 20 million COVID-19 deaths worldwide – Imperial College London
Original Study: Global impact of the first year of COVID-19 vaccination: a mathematical modelling study – The Lancet Infectious Diseases
Commentaries:
Covid-19 vaccines prevented nearly 20 million deaths in a year, study estimates – STAT
COVID-19 vaccines saved an estimated 20 million lives in 1 year – CIDRAP
Commentary on Twitter (thread – click for more)
🆕 @TheLancetInfDis
In the 1st year of Covid vaccinations, ~20 million deaths were prevented worldwide (data from 185 countries)
Another ~600,000 lives would have been saved if the @WHO 40% target been achievedhttps://t.co/BWig83xlnN @azraghani @imperialcollege @MRC_Outbreak pic.twitter.com/lF8biBJIlK— Eric Topol (@EricTopol) June 23, 2022
Cohort Study: The risk of stroke is substantially higher in the first year of initiation of oral contraceptives or hormone replacement therapy.
27 Jun, 2022 | 11:44h | UTCOral Contraceptives, Hormone Replacement Therapy, and Stroke Risk – Stroke (link to abstract – $ for full-text)
Commentary: Flash of Greater Stroke Risk at Initiation of Oral Contraceptives — Risk with hormone replacement therapy lingers in the long run, though – MedPage Today (free frustration required)
M-A: Hypothermic vs. normothermic temperature control after cardiac arrest.
24 Jun, 2022 | 11:51h | UTCHypothermic versus Normothermic Temperature Control after Cardiac Arrest – NEJM Evidence
Related:
ERC-ESICM guidelines on temperature control after cardiac arrest in adults – Intensive Care Medicine (if the link is paywalled, try this one)
Systematic Review: Parenteral Vitamin C in patients with severe infection.
24 Jun, 2022 | 11:49h | UTCParenteral Vitamin C in Patients with Severe Infection: A Systematic Review – NEJM Evidence
Related:
New COVID drugs face delays as trials grow more difficult.
24 Jun, 2022 | 11:47h | UTCNew COVID drugs face delays as trials grow more difficult – Nature
An update on refractory hypertension.
24 Jun, 2022 | 11:44h | UTCAn Update on Refractory Hypertension – Current Hypertension Reports
Research must do no harm: new guidance addresses all studies relating to people.
24 Jun, 2022 | 11:46h | UTCResearch must do no harm: new guidance addresses all studies relating to people – Nature
See Guidance: Research Ethics – Nature Portfolio
Perspective | Four areas of health innovation boosted by the pandemic.
24 Jun, 2022 | 11:36h | UTCFour areas of health innovation boosted by the pandemic – Nature Medicine
Commentary on Twitter
Leading researchers speak with @NatureMedicine about how the COVID-19 pandemic has spurred research on wearables, genomic surveillance, behavioral interventions and drug discovery. https://t.co/k3Svb0xBVB
— Nature Portfolio (@NaturePortfolio) June 17, 2022
Is shorter always better? The pros and cons of treating Gram-negative bloodstream infections with 7 days of antibiotics.
24 Jun, 2022 | 11:38h | UTC
Cohort Study: COVID-19 trajectories among 57 million adults in England.
24 Jun, 2022 | 11:34h | UTCNews Release: Most comprehensive analysis of COVID-19 data reveals previously unattributed deaths – Health Data Research UK
Commentary from one of the authors on Twitter (thread – click for more)
📣 COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records
Proud to share this work with @johanhilge @SpirosDenaxas @BHFDataScience @HDR_UK + team in @LancetDigitalHhttps://t.co/DY96ClN0c3
🧵
— Chris Tomlinson (@tomlincr) June 9, 2022