Editor's Choice
Cohort Study | Laparoscopically confirmed endometriosis and risk of incident stroke.
26 Jul, 2022 | 13:25h | UTCLaparoscopically Confirmed Endometriosis and Risk of Incident Stroke: A Prospective Cohort Study – Stroke (free for a limited period)
News Release: Women with endometriosis may have higher risk of stroke – American Heart Association
Commentary: Endometriosis Linked to Greater Risk for Stroke – HealthDay
Commentary on Twitter
Just Published in #Stroke: Laparoscopically Confirmed Endometriosis and Risk of Incident Stroke: A Prospective Cohort Study @l_farland #AHAJournals https://t.co/e2gYhwtO9X pic.twitter.com/dOykgstzN3
— Stroke AHA/ASA (@StrokeAHA_ASA) July 21, 2022
Systematic Review | Antiplatelet agents for the treatment of deep venous thrombosis.
26 Jul, 2022 | 12:44h | UTCAntiplatelet agents for the treatment of deep venous thrombosis – Cochrane Library
Summary: Aspirin and similar drugs for the treatment of deep vein thrombosis (DVT) – Cochrane Library
Central venous catheter (CVC) management: evidence round-up.
26 Jul, 2022 | 12:41h | UTCCentral venous catheter (CVC) management: evidence round-up – Cochrane Library
Systematic Review | Heparin vs. 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults.
26 Jul, 2022 | 12:43h | UTCRelated: Central venous catheter (CVC) management: evidence round-up – Cochrane Library
Brief Review | Contraception in women with cardiovascular disease.
25 Jul, 2022 | 13:05h | UTCContraception in Women With Cardiovascular Disease – JAMA (free for a limited period)
Monkeypox virus infection in humans across 16 countries — April–June 2022.
25 Jul, 2022 | 13:09h | UTCCommentary: Largest monkeypox study to date highlights new symptoms – CIDRAP
Related: WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch
Commentary on Twitter
In this report, 528 cases of monkeypox across 16 countries are described. Rash, mucosallesions, fever, lethargy, and lymphadenopathy were common clinical findings. Few patients were hospitalized. https://t.co/SPTVK1vBRl pic.twitter.com/PNWDuAb7AG
— NEJM (@NEJM) July 21, 2022
WHO declares global public health emergency over Monkeypox virus outbreak.
25 Jul, 2022 | 13:11h | UTCWHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch
Measuring contraceptive method mix, prevalence, and demand satisfied by age and marital status in 204 countries and territories, 1970–2019: a systematic analysis for the Global Burden of Disease Study 2019.
25 Jul, 2022 | 13:07h | UTCCommentary: Global Study Shows Contraception Needs Often Unmet for Young Women – HealthDay
Commentary on Twitter
NEW—160 million women worldwide have unmet #contraception needs.
Study reveals large differences in types of contraceptives used across regions and age groups: https://t.co/bIcDBxcLMf pic.twitter.com/o95QCUUFPX
— The Lancet (@TheLancet) July 21, 2022
[PREPRINT] RCT | Inhaled fluticasone not beneficial for outpatients with Covid-19.
25 Jul, 2022 | 13:01h | UTCNews Release: Study finds no benefit to taking fluticasone furoate for COVID-19 symptoms – Duke Clinical Research Institute
Commentary: Asthma Drug Fluticasone Fails as Potential COVID-19 Treatment – HealthDay
Retrospective Cohort Study | Effectiveness of a fourth dose of mRNA COVID-19 vaccine against all-cause mortality in long-term care facility residents and in the oldest old.
25 Jul, 2022 | 13:03h | UTCRelated:
Cohort Study | Fatty liver disease is not associated with increased mortality in the elderly.
25 Jul, 2022 | 12:59h | UTCCommentary: Fatty liver disease may not affect mortality risk in elderly patients – ACP Gastroenterology
Cohort Study | Association of anesthesiologist staffing ratio with surgical patient morbidity and mortality.
22 Jul, 2022 | 11:46h | UTCAssociation of Anesthesiologist Staffing Ratio With Surgical Patient Morbidity and Mortality – JAMA Surgery (free for a limited period)
Author Interview: Anesthesiologist Staffing Ratio and Surgical Patient Morbidity and Mortality – JAMA
News Release: Surgery risks go up depending upon the anesthesiologist’s workload – University of Michigan
Commentaries:
Understaffing in Anesthesiology Linked to Patient Deaths, Complications — Higher morbidity, mortality rates tied to anesthesia docs covering 3 to 4 overlapping surgeries – MedPage Today (free registration required)
Overworked Anesthesiologists Can Put Surgical Patients at Risk – HealthDay
Guideline Synopsis | Therapy for mild to moderate asthma.
22 Jul, 2022 | 11:48h | UTCTherapy for Mild to Moderate Asthma – JAMA (free for a limited period)
Original Guideline: 2022 GINA Report, Global Strategy for Asthma Management and Prevention
Perspective | Achieving diagnostic excellence for cancer: symptom detection as a partner to screening.
22 Jul, 2022 | 11:44h | UTCAchieving Diagnostic Excellence for Cancer: Symptom Detection as a Partner to Screening – JAMA (free for a limited period)
RCT | In patients undergoing cardiac surgery with cardiopulmonary bypass, using a 4% albumin solution for volume expansion did not reduce adverse events compared to ringer acetate.
21 Jul, 2022 | 13:32h | UTCEffect of 4% Albumin Solution vs Ringer Acetate on Major Adverse Events in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Albumin vs Crystalloid Fluid for Resuscitation in Cardiac Surgery: New Evidence and Arguments in the Timeless Debate – JAMA (free for a limited period)
Commentary: Trial does not support albumin as primer, volume replacement solution in CABG – Healio (free registration required)
Commentary on Twitter
https://twitter.com/JAMA_current/status/1549424077298868225
Comprehensive review finds little evidence that depression is caused by an imbalance of serotonin in the brain.
21 Jul, 2022 | 13:29h | UTCNews Release: No evidence that depression is caused by low serotonin levels, finds comprehensive review – University College London
Commentary from the authors: Depression is probably not caused by a chemical imbalance in the brain – new study – The Conversation
Other commentaries:
Expert reaction to a review paper on the ‘serotonin theory of depression’ – Science Media Centre
Little evidence that chemical imbalance causes depression, UCL scientists find – The Guardian
Cohort Study | Effectiveness of the Pfizer vaccine against Omicron in children 5 to 11 years of age.
21 Jul, 2022 | 13:28h | UTC
Single-arm phase 1–2 trial of AAVS3 gene therapy in patients with Hemophilia B.
21 Jul, 2022 | 13:23h | UTCPhase 1–2 Trial of AAVS3 Gene Therapy in Patients with Hemophilia B – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Novel gene therapy could reduce bleeding risk for hemophilia patients – University College London
Commentary: Hemophilia B Gene Therapy Produces Durable Response for 90% of Participants – AJMC
Commentary on Twitter
Nine of 10 patients with hemophilia B who received a liver-directed adeno-associated viral vector containing a hyperactive variant of factor IX maintained factor IX activity for up to 42 months. Thrombosis developed in 1 patient. https://t.co/yId8HWS1u2 pic.twitter.com/CdDeizSMK6
— NEJM (@NEJM) July 20, 2022
RCT | Pembrolizumab plus chemotherapy in advanced triple-negative breast cancer.
21 Jul, 2022 | 13:25h | UTCPembrolizumab plus Chemotherapy in Advanced Triple-Negative Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Among patients with triple-negative breast cancer and high expression of PD-L1, pembrolizumab plus chemotherapy resulted in longer overall survival than chemotherapy alone. https://t.co/5urffgHdFb pic.twitter.com/2GlmJuYZJz
— NEJM (@NEJM) July 20, 2022
Analysis | Fiber intake for optimal health: how can healthcare professionals support people to reach dietary recommendations?
21 Jul, 2022 | 13:17h | UTC
Retrospective cohort study | Impact of ethnicity on the accuracy of measurements of oxygen saturations.
21 Jul, 2022 | 13:15h | UTCRelated:
Racial Bias in Pulse Oximetry Measurement – New England Journal of Medicine
FDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias – STAT
Pulse Oximeter Accuracy and Limitations: FDA Safety Communication – U.S. Food & Drug Administration
With monkeypox spreading globally, many experts believe the virus can’t be contained.
21 Jul, 2022 | 13:12h | UTCWith monkeypox spreading globally, many experts believe the virus can’t be contained – STAT
Related:
Diagnosis, Prevention, and Treatment of Monkeypox – JAMA
7 of your most pressing monkeypox vaccine questions, answered – Vox
How contagious is monkeypox—and should you get a vaccine? Here’s the latest. – National Geographic
Prevention and Treatment of Monkeypox – Drugs
Monkeypox soars in Europe, with more than 4,000 cases – CIDRAP
No room for complacency – World Health Organization
Multi-country monkeypox outbreak: situation update – World Health Organization
Monkeypox Genital Lesions – New England Journal of Medicine
Monkeypox vaccination begins — can the global outbreaks be contained? – Nature
Incubation period for monkeypox: Estimates from the Netherlands.
‘Discriminatory and stigmatizing’: Scientists push to rename monkeypox viruses – STAT
Rename monkeypox strains to remove geographic stigma, researchers say – Science
2022 Monkeypox and Orthopoxvirus Outbreak Global Map – Centers for Disease Control and Prevention
As monkeypox threat grows, scientists debate best vaccine strategy – Science
Monkeypox is a new global threat. African scientists know what the world is up against – Science
Experts highlight sexual aspect of monkeypox spread – CIDRAP
What to Know About Monkeypox – JAMA
Multi-country monkeypox outbreak in non-endemic countries: Update – World Health Organization
Monkeypox outbreaks: 4 key questions researchers have – Nature
Study reports first use of antivirals in monkeypox patients – Lancet
Surveillance, case investigation and contact tracing for Monkeypox – World Health Organization
Laboratory testing for the monkeypox virus: Interim guidance – World Health Organization
A Novel International Monkeypox Outbreak – Annals of Internal Medicine
EU health agency warns monkeypox could become endemic in Europe if outbreak continues – STAT
Monkeypox cases increase across Europe, North America – CIDRAP
Multi-country monkeypox outbreak in non-endemic countries – World Health Organization
Monkeypox goes global: why scientists are on alert – Nature
Monkeypox: What do we know about the outbreaks in Europe and North America? – The BMJ
Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – STAT
Monkeypox: Time to worry or one to ignore? – BBC
UK, Spain, Portugal report more monkeypox cases – CIDRAP
U.S. monkeypox case reported, as Spain, Portugal report infections in growing outbreak – STAT
Monkeypox – United Kingdom of Great Britain and Northern Ireland – World Health Organization
Monkeypox cases confirmed in England – latest updates – UK Health Security Agency
Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – Health Policy Watch
European outbreak of monkeypox: what you need to know – The Conversation
Rare monkeypox outbreak in U.K., Europe and U.S.: What is it and should we worry – NPR
Monkeypox cases under investigation in Canada as outbreak spreads in Europe, U.S. – CBC News
Open-label RCT | Moderate-intensity statin plus ezetimibe is noninferior to high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease.
20 Jul, 2022 | 12:32h | UTCLong-term efficacy and safety of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease (RACING): a randomised, open-label, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
AHA Scientific Statement | Polygenic risk scores for cardiovascular disease.
20 Jul, 2022 | 12:31h | UTC
High-sensitivity cardiac troponin and the 2021 AHA/ACC Guidelines for the evaluation and diagnosis of acute chest pain.
20 Jul, 2022 | 12:29h | UTCHigh-Sensitivity Cardiac Troponin and the 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guidelines for the Evaluation and Diagnosis of Acute Chest Pain – Circulation (free for a limited period)
Commentary on Twitter
#Primer HS Cardiac Troponin & Guidelines for Evaluation and Diagnosis of Acute Check Pain #AHAJournals https://t.co/avcm6LEbgb pic.twitter.com/zs8yRe6u1y
— Circulation (@CircAHA) July 13, 2022