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M-A | Nonpharmacological interventions to lengthen sleep duration in healthy children.

19 Sep, 2022 | 12:44h | UTC

Nonpharmacological Interventions to Lengthen Sleep Duration in Healthy Children: A Systematic Review and Meta-analysis – JAMA Pediatrics (free for a limited period)

Editorial: Children’s Sleep and Our Power to Improve It – JAMA Pediatrics (free for a limited period)

Commentary: Data Demonstrates the Best Intervention for Pediatric Sleep Health is Earlier Bedtime – HCP Live

 

Commentary on Twitter

 

The Lancet Commission on lessons for the future from the COVID-19 pandemic – “a massive global failure.”

16 Sep, 2022 | 13:03h | UTC

Homepage: The Lancet COVID-19 Commission

The Lancet Commission on lessons for the future from the COVID-19 pandemic

Editorial: COVID-19: the case for prosociality

News Release: New report details “massive global failures” of COVID-19 response, calls for improved multilateral cooperation to end pandemic and effectively manage future global health threats – The Lancet

Infographic: COVID-19 response: a massive global failure

Commentaries:

WHO responds to The Lancet COVID-19 Commission – World Health Organization

Covid-19: Commission describes “massive global failures” of pandemic response – The BMJ

Covid-19 death toll is a tragedy and ‘massive global failure at multiple levels,’ Lancet commission says – CNN

Lancet Commission on COVID-19 response: ‘Massive global failure’ – CIDRAP

 

Guideline Synopsis | AHA/ACC Guideline for the management of heart failure.

16 Sep, 2022 | 13:01h | UTC

Management of Heart Failure – JAMA (free for a limited period)

Original Article: #ACC22 – 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure.

 

The Lancet Commission | Towards the elimination of chronic obstructive pulmonary disease.

16 Sep, 2022 | 13:02h | UTC

Homepage: Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission – The Lancet

Commission: Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission

Editorial: COPD: from an end-stage disease to lifelong lung health

Invited Commentary: Classification of COPD: fostering prevention and precision medicine in the Lancet Commission on COPD

Commentary: Proposed classification of COPD according to major risk factors – News Medical

 

AHA Scientific Statement | Management of patients at risk for and with left ventricular thrombus.

16 Sep, 2022 | 13:00h | UTC

Management of Patients at Risk for and With Left Ventricular Thrombus: A Scientific Statement From the American Heart Association – Circulation

 

RCT | Among neonates with probable bacterial infection, switching from intravenous to oral antibiotics (amoxicillin–clavulanic acid) was noninferior to a full course of intravenous antibiotics and resulted in shorter hospitalization (median duration of 3.4 vs. 6.8 days).

16 Sep, 2022 | 12:59h | UTC

Efficacy and safety of switching from intravenous to oral antibiotics (amoxicillin–clavulanic acid) versus a full course of intravenous antibiotics in neonates with probable bacterial infection (RAIN): a multicentre, randomised, open-label, non-inferiority trial – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)

Commentary: Dutch team devise less painful ‘drip and drink’ antibiotics treatment for babies – Dutch News

 

Commentaries on Twitter

(Thread – click for more)

 

Study | The specificity and positive predictive value of high-sensitivity cardiac troponin I for the diagnosis of myocardial infarction are reduced in older individuals.

16 Sep, 2022 | 12:57h | UTC

Influence of Age on the Diagnosis of Myocardial Infarction – Circulation

 

RCT | Short-term outcomes of laparoscopy-assisted vs. open surgery for patients with low rectal cancer.

16 Sep, 2022 | 12:58h | UTC

Short-term Outcomes of Laparoscopy-Assisted vs Open Surgery for Patients With Low Rectal Cancer: The LASRE Randomized Clinical Trial – JAMA Oncology

 

Commentary on Twitter

https://twitter.com/JAMAOnc/status/1570532915393744896

 

RCT | In patients with acute pancreatitis, early aggressive hydration resulted in a higher incidence of fluid overload without improvement in clinical outcomes.

15 Sep, 2022 | 13:15h | UTC

Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis – New England Journal of Medicine (link to abstract – $ for full-text)

 

RCT | Effects of cocoa extract and a multivitamin on cognitive function.

15 Sep, 2022 | 13:14h | UTC

Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial – Alzheimer’s & Dementia

Commentary: Daily multivitamins improved the brain function of seniors in a trial — but plenty of questions remain – STAT

 

Cohort Study | Patients diagnosed with diabetes by oral glucose tolerance test without elevated HbA1c had similar cardiovascular and renal disease risks as those without diabetes.

15 Sep, 2022 | 13:12h | UTC

Risk of Macrovascular and Microvascular Disease in Diabetes Diagnosed Using Oral Glucose Tolerance Test With and Without Confirmation by Hemoglobin A1c: The Whitehall II Cohort Study – Circulation

Commentary: Patients diagnosed by OGTT without elevated HbA1c had similar CV, renal disease risks as those without diabetes – ACP Diabetes

 

Commentary on Twitter

 

New research estimates the overall disease burden of genetic risk factors.

15 Sep, 2022 | 13:13h | UTC

News Release: New research estimates the overall disease burden of genetic risk factors – University of Helsinki

Original Study: Genetic risk factors have a substantial impact on healthy life years – Nature Medicine

 

Commentaries on Twitter

 

RCT | Effect of different itraconazole dosing regimens on cure rates, treatment duration, safety, and relapse rates in adult patients with tinea corporis/cruris.

15 Sep, 2022 | 13:10h | UTC

Effect of Different Itraconazole Dosing Regimens on Cure Rates, Treatment Duration, Safety, and Relapse Rates in Adult Patients With Tinea Corporis/Cruris: A Randomized Clinical Trial – JAMA Dermatology (free for a limited period)

 

Commentary on Twitter

 

Cohort Study | Long-term outcomes among men undergoing active surveillance for prostate cancer.

15 Sep, 2022 | 13:11h | UTC

Long-term Outcomes Among Men Undergoing Active Surveillance for Prostate Cancer in Sweden – JAMA Network Open

Invited Commentary: Exploring the Long-term Outcomes of Active Surveillance Among Men With Prostate Cancer—Best for Whom? – JAMA Network Open

 

RCT | Robotic vs. laparoscopic surgery for middle and low rectal cancer.

15 Sep, 2022 | 13:09h | UTC

Robotic versus laparoscopic surgery for middle and low rectal cancer (REAL): short-term outcomes of a multicentre randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentaries:

Robotic Surgery Tops Laparoscopic Surgery for Middle and Low Rectal Cancer — Randomized trial shows fewer positive circumferential resection margins with robotic technique – MedPage Today (free registration required)

 

Commentaries on Twitter

 

M-A | Role of pessaries in the treatment of pelvic organ prolapse.

15 Sep, 2022 | 13:08h | UTC

Role of Pessaries in the Treatment of Pelvic Organ Prolapse: A Systematic Review and Meta-analysis – Obstetrics & Gynecology (free for a limited period)

 

USPSTF Statement | The current evidence is insufficient to recommend routine screening for prediabetes and type 2 diabetes in children and adolescents.

14 Sep, 2022 | 13:23h | UTC

Screening for Prediabetes and Type 2 Diabetes in Children and Adolescents: US Preventive Services Task Force Recommendation Statement – JAMA

Editorials:

Recommendations for Screening Children and Adolescents for Prediabetes and Type 2 Diabetes – JAMA

Broader Screening for Youth-Onset Type 2 Diabetes—We Just Are Not There Yet – JAMA Network Open

Evidence Report: Screening for Prediabetes and Type 2 Diabetes in Children and Adolescents: Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Patient Page: Screening for Type 2 Diabetes in Children and Adolescents – JAMA

Author Interview: USPSTF Recommendation: Screening for Prediabetes and Diabetes in Children and Adolescents – JAMA

 

Study | Vitamin D3 and omega-3 fatty acids not helpful in reducing the risk of frailty.

14 Sep, 2022 | 13:20h | UTC

News Release: Vitamin D3 and omega-3 fatty acids not helpful in reducing risk of frailty – Brigham and Women’s Hospital

Original Study: Effect of Vitamin D3 and Omega-3 Fatty Acid Supplementation on Risk of Frailty: An Ancillary Study of a Randomized Clinical Trial – JAMA Network Open

Invited Commentary: There Is No Magic Pill to Prevent Frailty—You Still Have to Eat Your Vegetables – JAMA Network Open

 

Commentary on Twitter

 

Cohort Study | Risk factors for heart disease and stroke are largely similar in men and women globally.

14 Sep, 2022 | 13:18h | UTC

News Release: Risk factors for heart disease and stroke are largely similar in men and women globally, finds study – McMaster University

Original Study: Metabolic, behavioural, and psychosocial risk factors and cardiovascular disease in women compared with men in 21 high-income, middle-income, and low-income countries: an analysis of the PURE study – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

https://twitter.com/TheLancet/status/1569636002762817536

 

RCT | Extended duration thromboprophylaxis (continued for 56 days postoperatively) is not beneficial after surgical resection of colorectal cancer.

14 Sep, 2022 | 13:22h | UTC

Efficacy and safety of extended duration to perioperative thromboprophylaxis with low molecular weight heparin on disease-free survival after surgical resection of colorectal cancer (PERIOP-01): multicentre, open label, randomised controlled trial – The BMJ

 

Cohort Study | Prospective associations of daily step counts and intensity with cancer and cardiovascular disease incidence and mortality and all-cause mortality.

14 Sep, 2022 | 13:17h | UTC

Prospective Associations of Daily Step Counts and Intensity With Cancer and Cardiovascular Disease Incidence and Mortality and All-Cause Mortality – JAMA Internal Medicine

Commentaries:

Higher Step Counts Equal Better CV Health: UK Biobank – TCTMD

Pace as important as 10,000 steps for health, finds new research – University of Sidney

How Many Steps a Day (and How Fast) to Lengthen Your Life? – HealthDay

 

M-A of randomized trials | In patients hospitalized with community-acquired pneumonia, corticosteroids reduce the need for mechanical ventilation without significant effects on mortality, treatment failure, or adverse events.

14 Sep, 2022 | 13:16h | UTC

Effect of corticosteroids on mortality and clinical cure in community-acquired pneumonia: A systematic review, meta-analysis, and meta-regression of randomized control trials – CHEST Journal (link to abstract – $ for full-text)

Related: Corticosteroids for CAP, influenza and COVID-19: when, how and benefits or harm? – European Respiratory Review

 

Perspective | Redefining critical illness.

14 Sep, 2022 | 13:13h | UTC

Redefining critical illness – Nature Medicine

 

Review | Multisystem inflammatory syndrome in children (MIS-C) and neonates (MIS-N) associated with COVID-19: optimizing definition and management.

14 Sep, 2022 | 13:15h | UTC

Multisystem inflammatory syndrome in children (MIS-C) and neonates (MIS-N) associated with COVID-19: optimizing definition and management – Pediatrics Research

 

Commentary on Twitter

Under a http://creativecommons.org/licenses/by/4.0/ License

 

RCT | Dexamethasone is not effective for the treatment of dyspnea in patients with cancer and increases the risk of adverse events.

13 Sep, 2022 | 13:22h | UTC

Effect of dexamethasone on dyspnoea in patients with cancer (ABCD): a parallel-group, double-blind, randomised, controlled trial – The Lancet Oncology (free for a limited period)

 

Commentary on Twitter

 

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