Editor's Choice | Page 58 of 113 | Links Medicus Content Curation & Alerts in Medicine

Patients who are on mechanical ventilation may benefit from surgical treatment of unstable chest wall injuries, but non-ventilated patients demonstrated little benefit from surgical intervention. https://t.co/MlQ9qIrKon

— JAMA Surgery (@JAMASurgery) September 21, 2022

A quality improvement study showed that a clinic–based aspirin deimplementation intervention can reduce inappropriate aspirin prescribing and bleeding in patients receiving warfarin for anticoagulation.

22 Sep, 2022 | 13:14h | UTC

Assessment of an Intervention to Reduce Aspirin Prescribing for Patients Receiving Warfarin for Anticoagulation – JAMA Network Open

News Release: Stopping aspirin when on a blood thinner lowers risk of bleeding, study finds – Michigan Medicine

Commentary on Twitter

An anticoagulation clinic–based #aspirin deimplementation intervention was associated with improved guideline-concordant aspirin use and fewer bleeding complications. https://t.co/kxKFZOdhae #Research

— JAMA Network Open (@JAMANetworkOpen) September 19, 2022

RCT | Helmet noninvasive ventilation no better than usual respiratory support for acute hypoxemic respiratory failure due to COVID-19.

22 Sep, 2022 | 13:11h | UTC

Effect of Helmet Noninvasive Ventilation vs Usual Respiratory Support on Mortality Among Patients With Acute Hypoxemic Respiratory Failure Due to COVID-19: The HELMET-COVID Randomized Clinical Trial – JAMA

Commentary on Twitter

Helmet noninvasive ventilation did not significantly reduce 28-day mortality vs usual respiratory support among patients with acute hypoxemic respiratory failure due to #COVID19 #pneumonia. https://t.co/LCuuY9UqZA #Research pic.twitter.com/NgdzwCVJ4V

— JAMA (@JAMA_current) September 20, 2022

Understanding post-COVID-19 interstitial lung disease: a new fibroinflammatory disease entity.

22 Sep, 2022 | 13:09h | UTC

Understanding post-COVID-19 interstitial lung disease (ILD): a new fibroinflammatory disease entity – Intensive Care Medicine

Commentary on Twitter

Post #COVID19 interstitial lung disease?
🦠 PC-ILD fibroinflammatory disease
🦠 etiopathogenesis
Identifying risk factors & understanding immunopathomechanisms critical to facilitate early intervention to prevent, slow or arrest lung damage progression.
📎https://t.co/OEM2W9bAEd pic.twitter.com/m4w4qUXl9r

— Intensive Care Medicine (@yourICM) September 8, 2022

Study shows that the leading causes of hospitalization of adults with diabetes are changing.

22 Sep, 2022 | 13:08h | UTC

Trends in leading causes of hospitalisation of adults with diabetes in England from 2003 to 2018: an epidemiological analysis of linked primary care records – The Lancet Diabetes & Endocrinology

Commentaries:

The changing character of diabetes complications – The Lancet Diabetes & Endocrinology (free registration required)

Reasons for hospital admissions in people with type 2 diabetes are changing – MedicalXpress

Pulmonary artery denervation for pulmonary arterial hypertension: a sham-controlled randomized trial.

21 Sep, 2022 | 13:21h | UTC

Pulmonary Artery Denervation for Pulmonary Arterial Hypertension: A Sham-Controlled Randomized Trial – JACC: Cardiovascular Interventions

Commentaries:

Pulmonary Artery Denervation in Idiopathic PAH Ups 6-Minute Walk Test – TCTMD

Pulmonary Artery Denervation for Pulmonary Arterial Hypertension – PADN-CFDA – American College of Cardiology

Commentary on Twitter

#TCT2022 #JACCINT LBCT SimPub: PADN-CFDA trial included 128 pts w/ #cvPAH. At 6-month follow-up, PADN assoc. w/ a ⬆️ improvement in 6MWD, PVR, RV function, & ⬇️ NT-proBNP. Clinical worsening was ⬇️ & satisfactory clinical response was ⬆️ in the PADN group. https://t.co/3IVaUwCgOT pic.twitter.com/bylhcA4GrQ

— JACC Journals (@JACCJournals) September 18, 2022

Guideline Synopsis | Management of major depressive disorder.

21 Sep, 2022 | 13:23h | UTC

The Management of Major Depressive Disorder: Synopsis of the 2022 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline – Annals of Internal Medicine

ASCO Guideline | Integrative medicine for pain management in oncology.

21 Sep, 2022 | 13:22h | UTC

Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology–ASCO Guideline – Journal of Clinical Oncology

Commentary: New SIO-ASCO practice guideline addresses the use of integrative therapies for cancer pain management – News Medical

Observational study suggests an increased risk of adverse events with the use of perioperative Gabapentin for pain management.

21 Sep, 2022 | 13:20h | UTC

Perioperative Gabapentin Use and In-Hospital Adverse Clinical Events Among Older Adults After Major Surgery – JAMA Internal Medicine (free for a limited period)

Invited Commentary: Perioperative Gabapentin Use in Older Adults: Revisiting Multimodal Pain Management – JAMA Internal Medicine (free for a limited period)

Commentary on Twitter

Study suggests that careful risk-benefit assessment is needed before prescribing #gabapentin for perioperative #PainManagement to older patients. https://t.co/GDxupdEjeT #Research

— JAMA Internal Medicine (@JAMAInternalMed) September 19, 2022

M-A | Efficacy and safety of unrestricted visiting policy for critically ill patients.

21 Sep, 2022 | 13:18h | UTC

Efficacy and safety of unrestricted visiting policy for critically ill patients: a meta-analysis – Critical Care

Commentary on Twitter

https://twitter.com/arianna_gazzato/status/1568138556756860928

RCT | Effects of an exercise program on brain health outcomes for children with overweight or obesity.

21 Sep, 2022 | 13:17h | UTC

Effects of an Exercise Program on Brain Health Outcomes for Children With Overweight or Obesity: The ActiveBrains Randomized Clinical Trial – JAMA Network Open

News Release: Study finds schoolchildren who exercise perform better academically – University of Granada

Commentary: Exercise Improves Brain Health in Overweight, Obese Youth – HealthDay

Commentary on Twitter

Intelligence, cognitive flexibility and academic performance improved following a 20-week RCT based on aerobic + resistance training among children with overweight or obesity. @ortegaporcel @profithugr @canalUGR and collaborators. #OpenAccess #Research https://t.co/XYddOoO7e7 pic.twitter.com/rZpjJxe3tr

— JAMA Network Open (@JAMANetworkOpen) August 30, 2022

Brief Review | Everything you need to know about deresuscitation.

21 Sep, 2022 | 13:19h | UTC

Everything you need to know about deresuscitation – Intensive Care Medicine

Commentary on Twitter

Fluid administration among most common interventions in #ICU… but high potential for harm! Here everything you need to know about deresuscitation
☔️ Why deresuscitation?
☔️ What is it?
☔️ When to start/stop?
☔️ How to deresuscitate?
☔️ So what's next?
🖇️ https://t.co/Qmvm3aOQPA pic.twitter.com/u3ZfNMa2W7

— Intensive Care Medicine (@yourICM) August 7, 2022

Long-term follow-up of a RCT | Percutaneous coronary intervention vs. bypass surgery for multivessel coronary artery disease.

20 Sep, 2022 | 13:34h | UTC

Everolimus-Eluting Stents or Bypass Surgery for Multivessel Coronary Artery Disease: Extended Follow-up Outcomes of Multicenter Randomized Controlled BEST Trial – Circulation

Commentary: 10-Year Data From BEST Trial Find No Significant Safety or MACE Differences Between PCI With EES Versus CABG – Cardiac Interventions Today

Original Study: Trial of Everolimus-Eluting Stents or Bypass Surgery for Coronary Disease – New England Journal of Medicine

Long-term follow-up of a RCT | Outcomes after catheter-based renal artery denervation for resistant hypertension.

20 Sep, 2022 | 13:33h | UTC

Long-term outcomes after catheter-based renal artery denervation for resistant hypertension: final follow-up of the randomised SYMPLICITY HTN-3 Trial – The Lancet (free registration required)

Commentary: SYMPLICITY HTN-3’s Late Surprise: Sustained BP Drop at 3 Years Despite Earlier Miss – TCTMD

Original Study: A Controlled Trial of Renal Denervation for Resistant Hypertension – New England Journal of Medicine

RCT | Myopia control effect of repeated low-level red-light therapy in children.

20 Sep, 2022 | 13:31h | UTC

Myopia Control Effect of Repeated Low-Level Red-Light Therapy in Chinese Children: A Randomized, Double-Blind, Controlled Clinical Trial – Ophthalmology

Commentary: Repeated Low-Level Red-Light Therapy Reduces Myopia Progression in Children – HCP Live

Brief Review | Source control in the management of sepsis and septic shock.

20 Sep, 2022 | 13:32h | UTC

Source control in the management of sepsis and septic shock – Intensive Care Medicine (if the link is paywalled, try this one)

Commentary on Twitter

Source control to eliminate origin of infection, control contamination, restore premorbid anatomy/function in #sepsis & septic shock
🧫 think outside (abdominal) box
🧫 have multidisciplinary approach
🧫 first do NO (additional) harm#FOAMcc on @yourICM
🖇 https://t.co/GrA0oR5lf0 pic.twitter.com/ZyPaFF3qFH

— Intensive Care Medicine (@yourICM) September 15, 2022

Preliminary results of a RCT | Once-only colonoscopy vs. two rounds of fecal immunochemical testing 2 years apart for colorectal cancer screening.

20 Sep, 2022 | 13:29h | UTC

Once-only colonoscopy or two rounds of faecal immunochemical testing 2 years apart for colorectal cancer screening (SCREESCO): preliminary report of a randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentary: Two Rounds of FIT vs Single Colonoscopy as a One-time CRC Screening – Medscape (free registration required)

Network M-A | Associations between statins and adverse events in secondary prevention of cardiovascular disease.

20 Sep, 2022 | 13:30h | UTC

Associations between statins and adverse events in secondary prevention of cardiovascular disease: Pairwise, network, and dose-response meta-analyses of 47 randomized controlled trials – Frontiers in Cardiovascular Medicine

RCT | Cerebral embolic protection during transcatheter aortic-valve replacement did not significantly reduce the incidence of periprocedural stroke.

19 Sep, 2022 | 12:49h | UTC

Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

PROTECTED TAVR: No Less Stroke With Embolic Protection, but Some See Hope – TCTMD

Stroke PROTECTion With SEntinel During Transcatheter Aortic Valve Replacement – PROTECTED TAVR – American College of Cardiology

Presumed Clinical Benefits of TAVR Cerebral Protection Remain Unproven — Large trial comes up short in proving a definitive benefit to debris filters – MedPage Today (free registration required)

News Release: Cerebral Embolic Protection During Transcatheter Aortic-Valve Replacement – Cedars-Sinai

Commentary on Twitter

In a randomized trial involving patients with aortic stenosis, the use of a cerebral protection device during TAVR did not decrease the risk of periprocedural stroke, but there were fewer disabling strokes. #TCT2022 https://t.co/wBgNlgmIty pic.twitter.com/EViLG19shX

— NEJM (@NEJM) September 17, 2022

RCT | Multiple doses of prophylactic intravenous antibiotics are no better than a single dose in implant-based breast reconstruction.

19 Sep, 2022 | 12:48h | UTC

Effectiveness of Single vs Multiple Doses of Prophylactic Intravenous Antibiotics in Implant-Based Breast Reconstruction: A Randomized Clinical Trial – JAMA Network Open

Commentary on Twitter

Multiple-dose antibiotic prophylaxis was not superior to a single-dose regimen in preventing surgical site infection and implant removal after implant-based breast reconstruction in this RCT. https://t.co/p7GbNRMPfW #OAResarch

— JAMA Network Open (@JAMANetworkOpen) September 16, 2022

Cohort Study | Seven healthy lifestyle habits linked to reduced risk of dementia in people with diabetes.

19 Sep, 2022 | 12:45h | UTC

Association of Combined Healthy Lifestyle Factors With Incident Dementia in Patients With Type 2 Diabetes – Neurology (link to abstract – $ for full-text)

News Release: Seven healthy lifestyle habits may reduce dementia risk for people with diabetes – American Academy of Neurology

Commentary: Lifestyle Factors May Cut Dementia Risk in Patients With Diabetes – HealthDay

Cluster RCT | Effects of real-time prescription benefit recommendations on patient out-of-pocket costs.

19 Sep, 2022 | 12:47h | UTC

Effects of Real-time Prescription Benefit Recommendations on Patient Out-of-Pocket Costs: A Cluster Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

Invited Commentary: Real-time Prescription Benefit Tools—The Promise and Peril – JAMA Internal Medicine (free for a limited period)

Commentary on Twitter

Real-time Prescription Benefits (RTPB) uses patient out-of-pocket (OOP) cost to recommend lower-cost med alternatives to prescribers. In a RCT, RTPB reduced med OOP costs by 11%, though recommendations were only made for a small proportion of orders. https://t.co/xXviGvnbKw pic.twitter.com/naeciB3CDg

— JAMA Internal Medicine (@JAMAInternalMed) September 12, 2022

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