Editor's Choice
RCT | Effect of prescriber notifications of patient’s fatal overdose on opioid prescribing at 4 to 12 months
10 Jan, 2023 | 14:50h | UTC
Commentary on Twitter
Letters notifying clinicians of a patient's fatal overdose reduced opioid prescribing up to one year after receiving the letter. https://t.co/cEU1inH9lE
— JAMA Network Open (@JAMANetworkOpen) January 6, 2023
Diagnostic accuracy study | Home waking salivary cortisone to screen for adrenal insufficiency
10 Jan, 2023 | 14:47h | UTCHome Waking Salivary Cortisone to Screen for Adrenal Insufficiency – NEJM Evidence
Commentary: At-home saliva test to diagnose adrenal insufficiency makes a difference to patients’ health – News Medical
Commentary on Twitter
This prospective study tested use of home waking salivary cortisone levels to predict adrenal insufficiency. Salivary cortisone had diagnostic accuracy similar to that of a standard adrenocorticotropin (ACTH) stimulation test. https://t.co/EYEBppBN7y#EndoTwitter #MedTwitter pic.twitter.com/RsKvnCHrUQ
— NEJM Evidence (@NEJMEvidence) January 6, 2023
Restoring mortality data in the FOURIER trial of evolocumab in patients with CVD: a reanalysis based on regulatory data
10 Jan, 2023 | 14:49h | UTCCommentaries:
Yet Another Story on Re-Analyzing a Major Trial – Sensible Medicine
Study Alleges Mortality Miscount in FOURIER Trial; TIMI Group Disagrees – TCTMD
Nature announces support for authors from over 70 countries to publish open access
10 Jan, 2023 | 14:46h | UTC
Commentary on Twitter
From today, primary research from authors from 70+ countries classified by the World Bank as low-income or lower-middle-income economies accepted for publication in @NatureMedicine or Nature research journals can be published Gold OA at no cost: https://t.co/izXuU2jLDZ
— Nature Medicine (@NatureMedicine) January 9, 2023
M-A | Association of hearing aids and cochlear implants with cognitive decline and dementia
10 Jan, 2023 | 14:43h | UTCAssociation of Hearing Aids and Cochlear Implants With Cognitive Decline and Dementia: A Systematic Review and Meta-analysis – JAMA Neurology (link to abstract – $ for full-text)
Commentary: Review Links Hearing Aid Devices With Reduced Cognitive Decline – HealthDay
Related: Dementia and hearing-aid use: a two-way street – Age and Ageing
WHO Interim Guidance | Surveillance, case investigation and contact tracing for mpox (monkeypox)
10 Jan, 2023 | 14:45h | UTC
Dementia and hearing-aid use: a two-way street
10 Jan, 2023 | 14:42h | UTCDementia and hearing-aid use: a two-way street – Age and Ageing
Related: Association of Hearing Aids and Cochlear Implants With Cognitive Decline and Dementia: A Systematic Review and Meta-analysis – JAMA Neurology (link to abstract – $ for full-text)
2022 Articles of import and impact in psychiatry
10 Jan, 2023 | 14:40h | UTC2022 Articles of Import and Impact – The American Journal of Psychiatry
We are back with our activities! Expect some changes in the alerts to better cover some specialties and subspecialties that have had fewer articles until now; also, expect a broader coverage of journals. If you enjoy our selection of articles, it would mean a lot to us if you sent our Telegram channels links to your friends (doctors or medical students). Happy 2023!
9 Jan, 2023 | 15:07h | UTCAll Channels (175 specialties and subspecialties)
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ACP Guideline | Pharmacologic treatment of primary osteoporosis or low bone mass to prevent fractures in adults
9 Jan, 2023 | 14:59h | UTCSummary for Patients: Pharmacologic Treatment of Primary Osteoporosis or Low Bone Mass to Prevent Fractures in Adults
WHO updates recommendations on HPV vaccination schedule
9 Jan, 2023 | 14:57h | UTCNews Release: WHO updates recommendations on HPV vaccination schedule – World Health Organization
Guideline: Human papillomavirus vaccines: WHO position paper, December 2022 – World Health Organization
Commentaries:
WHO supports 1-dose HPV vaccine strategy – CIDRAP
Commentary on Twitter
🆕 WHO has revised its recommendations on possible schedules for human papillomavirus (#HPV) vaccines & now recommends:
👉1 or 2-doses for girls & women aged 9-20
👉2 doses with a 6-month interval for women 21+https://t.co/m0KZyH6sPR pic.twitter.com/W4PeS4raV9— World Health Organization (WHO) (@WHO) December 21, 2022
11 clinical trials that will shape medicine in 2023
9 Jan, 2023 | 14:54h | UTC11 clinical trials that will shape medicine in 2023 – Nature
WHO | Increase in invasive Group A streptococcal infections among children in Europe, including fatalities
9 Jan, 2023 | 14:53h | UTC
RCT | VV116 vs. Nirmatrelvir–Ritonavir for oral treatment of Covid-19
9 Jan, 2023 | 14:50h | UTCVV116 versus Nirmatrelvir–Ritonavir for Oral Treatment of Covid-19 – New England Journal of Medicine
Commentaries:
Study could pave way for new antiviral, as China grapples with Covid wave – STAT
Chinese oral COVID-19 drug equally effective with Paxlovid: study
VV116 Noninferior to Nirmatrelvir-Ritonavir for COVID-19 – HealthDay
Commentary on Twitter
In a Chinese trial involving participants with symptomatic mild-to-moderate Covid-19, VV116 (an oral analogue of remdesivir) was noninferior to nirmatrelvir–ritonavir with respect to the time to sustained clinical recovery.
Read the full study: https://t.co/zckTB3Rvb9 pic.twitter.com/0TVF7hEXjP
— NEJM (@NEJM) December 28, 2022
Guideline | Treatment of hypercalcemia of malignancy in adults
9 Jan, 2023 | 14:46h | UTCNews Release: Experts provide first framework for treating hypercalcemia of malignancy in adults – News Medical
The WHO estimates of excess mortality associated with the COVID-19 pandemic
9 Jan, 2023 | 14:48h | UTCThe WHO estimates of excess mortality associated with the COVID-19 pandemic – Nature
Commentary: Pandemic’s Two-Year Global Death Toll May Be Close to 15 Million – HealthDay
Scientists tie third clinical trial death to experimental Alzheimer’s drug
9 Jan, 2023 | 14:47h | UTCScientists tie third clinical trial death to experimental Alzheimer’s drug – Science
Related: RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns.
ESC/AHA/ACC/WHF Joint Opinion | Randomized trials fit for the 21st century
9 Jan, 2023 | 14:44h | UTCCommentaries:
It’s Time to Revamp How Clinical Trials Are Done, Say Cardiology Societies – TCTMD
Commentary on Twitter
Together with @ACCinTouch @escardio & @worldheartfed, we are positioned to push, guide and support the remodeling of #RCTs for the 21st century. #RedesignRCTs
Read the joint statement in @circaha: https://t.co/hoypaSp10m pic.twitter.com/vwMGx0tksz
— AHA Science (@AHAScience) December 16, 2022
Happy Holidays! We will return with our activities on January 9, 2023. Any breakthrough articles during this break will be delivered at the beginning of the year.
19 Dec, 2022 | 03:46h | UTCWHO manual on sugar-sweetened beverage taxation policies to promote healthy diets.
16 Dec, 2022 | 13:52h | UTCNews Release: WHO calls on countries to tax sugar-sweetened beverages to save lives – World Health Organization
Related:
M-A: Outcomes following taxation of sugar-sweetened beverages.
Public Policies to Reduce Sugary Drink Consumption in Children and Adolescents – Pediatrics
Cutting back on sugar-sweetened beverages: What works? – Cochrane Library
Sugar-sweetened beverage taxes: Lessons to date and the future of taxation – PLOS Medicine
Banning the promotion of soft drinks could be more effective than a sugar tax – The Conversation
Sugar tax: why health experts want it but politicians and industry are resisting – The Guardian
Commentary on Twitter
Sugar is addictive and keeps you hooked on unhealthy drinks like sodas & energy drinks.
Break the cycle today for a healthier life! https://t.co/M1GQE4136I pic.twitter.com/06aVCYmeK5— World Health Organization (WHO) (@WHO) December 13, 2022
RCT | Chlorthalidone (12.5-25 mg) and Hydrochlorothiazide (25-50 mg) are similarly effective for the prevention of CVD in hypertensive patients.
16 Dec, 2022 | 13:49h | UTCChlorthalidone vs. Hydrochlorothiazide for Hypertension–Cardiovascular Events – New England Journal of Medicine (link to abstract – $ for full-text)
Related (news release and commentaries before publication): RCT | Chlortalidone and Hydrochlorothiazide resulted in similar reductions of CVD in older patients with hypertension.
Commentary on Twitter
Patients 65 years or older with hypertension who switched from chlorthalidone to hydrochlorothiazide did not have fewer major cardiovascular events or non–cancer-related deaths than those who continued receiving hydrochlorothiazide. https://t.co/9xAiSZzxio pic.twitter.com/bIVOOiVDve
— NEJM (@NEJM) December 14, 2022
Updated Guidance | Acute, periprocedural and long-term antithrombotic therapy in older adults.
16 Dec, 2022 | 13:51h | UTCCommentary: Antithrombotic Therapy in Older Adults: Key Points – American College of Cardiology
Cohort Study | Association between bariatric surgery and alcohol use–related hospitalization and all-cause mortality.
16 Dec, 2022 | 13:44h | UTCAssociation Between Bariatric Surgery and Alcohol Use–Related Hospitalization and All-Cause Mortality in a Veterans Affairs Cohort – JAMA Surgery (link to abstract – $ for full-text)
RCTs | Vaccines for Zaire Ebola virus disease.
16 Dec, 2022 | 13:46h | UTCRandomized Trial of Vaccines for Zaire Ebola Virus Disease – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Ebola vaccine regimens safe, immunogenic in adults and children – NIH News Releases
Commentaries:
Ebola vaccine strategies show safety and immune response – CIDRAP
Commentary on Twitter
In two randomized trials of Ebola vaccines, safety and immune responses in adults and children were assessed for three regimens with two different vaccines. All three induced immune responses lasting at least 1 year. https://t.co/JUMN8Ieygv pic.twitter.com/NajlnA2B7y
— NEJM (@NEJM) December 14, 2022
RCT | Effect of an intermittent calorie-restricted diet on Type 2 DM remission.
16 Dec, 2022 | 13:43h | UTCEffect of an Intermittent Calorie-restricted Diet on Type 2 Diabetes Remission: A Randomized Controlled Trial – The Journal of Clinical Endocrinology & Metabolism (link to abstract – $ for full-text)
Commentaries:
Expert reaction to study looking at intermittent fasting and type 2 diabetes – Science Media Centre
Intermittent Fasting Can Achieve Remission in Type 2 Diabetes – HealthDay
Commentary on Twitter
Can an intermittent fasting (IF) diet reverse Type 2 diabetes?
A small randomized trial says yes, w/ 47% of IF-assigned participants achieving remission for at least 1 year vs 3% of controls (odds ratio of 31; yes, too good to be true)https://t.co/Ths3LrNL8u
Worth further study pic.twitter.com/VwOqMeAAJr— Eric Topol (@EricTopol) December 14, 2022