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RCT | AI improves nodule detection on chest radiographs in a health screening population

10 Feb, 2023 | 13:55h | UTC

AI Improves Nodule Detection on Chest Radiographs in a Health Screening Population: A Randomized Controlled Trial – Radiology

Editorial: AI Nodule Detection on Chest Radiographs Using Randomized Controlled Data: The Effect on Clinical Practice – Radiology

News Release: AI Improves Lung Nodule Detection on Chest X-Rays – RSNA News

 

SR | Mechanical plus oral antibiotic bowel preparation may prevent complications in elective colorectal surgery

10 Feb, 2023 | 13:53h | UTC

Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective colorectal surgery – Cochrane Library

Summary: Can combined mechanical and oral antibiotic bowel preparation reduce the risk of complications after scheduled colon or rectal resections compared with purely mechanical, purely oral antibiotic or no bowel preparation? – Cochrane Library

Related:

M-A: Strategies for antibiotic administration for bowel preparation among patients undergoing elective colorectal surgery – “the addition of oral antibiotics to intravenous antibiotics was associated with a reduction in the incidence of incisional surgical site infection by more than 50%”.

Meta-Analysis: Effects of Mechanical Bowel Preparation and Oral Antibiotics Before Elective Colorectal Surgery

 

Opinion | Interpreting the results from the first randomized controlled trial of colonoscopy: does it save lives?

10 Feb, 2023 | 13:54h | UTC

Interpreting the results from the first randomised controlled trial of colonoscopy: does it save lives? – BMJ Evidence Based Medicine

Original Study: RCT | Effect of colonoscopy screening on risks of colorectal cancer and related death.

 

RCT | Effectiveness of Mycophenolate Mofetil among patients with progressive IgA nephropathy

10 Feb, 2023 | 13:52h | UTC

Effectiveness of Mycophenolate Mofetil Among Patients With Progressive IgA Nephropathy: A Randomized Clinical Trial – JAMA Network Open

 

Commentary on Twitter

 

SHEA/IDSA/APIC Recommendations | Strategies to prevent healthcare-associated infections through hand hygiene

9 Feb, 2023 | 14:08h | UTC

SHEA/IDSA/APIC Practice Recommendation: Strategies to prevent healthcare-associated infections through hand hygiene: 2022 Update – Infection Control & Hospital Epidemiology

 

RCT | Sublobar resection noninferior to lobal resection for peripheral stage IA non–small-cell lung cancer

9 Feb, 2023 | 14:05h | UTC

Lobar or Sublobar Resection for Peripheral Stage IA Non–Small-Cell Lung Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Less lung tissue removal needed for early-stage cancer, study finds – Weill Cornell Medical College

Related:

Survival outcomes in a prospective randomized multicenter Phase III trial comparing patients undergoing anatomical segmentectomy versus standard lobectomy for non-small cell lung cancer up to 2 cm – Lung Cancer

A guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation.

Segmentectomy versus lobectomy in small-sized peripheral non-small-cell lung cancer (JCOG0802/WJOG4607L): a multicentre, open-label, phase 3, randomised, controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)

A Meta-Analysis Comparing Lobectomy versus Segmentectomy in Stage I Non-Small Cell Lung Cancer – The Korean Journal of Thoracic and Cardiovascular Surgery

 

Cohort Study | Adverse pregnancy outcomes and long-term risk of ischemic heart disease in mothers

9 Feb, 2023 | 14:02h | UTC

Adverse pregnancy outcomes and long term risk of ischemic heart disease in mothers: national cohort and co-sibling study – The BMJ

News Release: Five major adverse pregnancy outcomes associated with long term risks of ischemic heart disease – News Medical/BMJ

Commentary: Complications during pregnancy linked to a higher risk of heart disease, study finds – CNN

Related:

Risk and trajectory of premature ischemic CVD in women with a history of pre-eclampsia: a nationwide register-based study

Cohort Study | Pre-eclampsia is associated with increased risk of premature-onset obstructive coronary artery stenosis.

Primary Care–Based Cardiovascular Disease Risk Management After Adverse Pregnancy Outcomes: a Narrative Review – Journal of General Internal Medicine

Pregnancy Complications and Risk of Cardiovascular Disease Later in Life: A Nationwide Cohort Study – Journal of the American Heart Association

AHA Scientific Statement | Adverse Pregnancy Outcomes and Cardiovascular Disease Risk

Consensus statement: Cardiovascular health after menopause transition, pregnancy disorders, and other gynecologic conditions

Cohort Study: Preeclampsia and Cardiovascular Disease

Cohort Study: Cardiovascular Disease After Hypertensive Disorders of Pregnancy Largely Explained by Conventional Cardiovascular Risk Factors

All Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease

Gestational Hypertension and Future Risk of Cardiovascular Disease

Research: Conjoint Associations of Gestational Diabetes and Hypertension With Diabetes, Hypertension, and Cardiovascular Disease in Parents

 

RCT | Pegylated Interferon Lambda reduces hospitalizations in predominantly vaccinated outpatients with Covid-19

9 Feb, 2023 | 14:03h | UTC

Early Treatment with Pegylated Interferon Lambda for Covid-19 – New England Journal of Medicine

News Release: Single-dose treatment reduces risk of COVID-19 hospitalization by half for high-risk patients in a largely vaccinated population – University Health Network

 

[Not published yet] Dual blood thinners under prescribed after minor or warning stroke, especially in women

9 Feb, 2023 | 14:01h | UTC

Dual blood thinners under prescribed after minor or warning stroke, especially in women – American Heart Association

Related:

Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ

Dual Antiplatelet Therapy Versus Aspirin in Patients With Stroke or Transient Ischemic Attack: Meta-Analysis of Randomized Controlled Trials – Stroke

Efficacy and Safety of Using Dual Versus Monotherapy Antiplatelet Agents in Secondary Stroke Prevention: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials – Circulation

Multiple versus fewer antiplatelet agents for preventing early recurrence after ischaemic stroke or transient ischaemic attack – Cochrane Library

 

Case-control study | Effectiveness of a Meningococcal Group B vaccine (4CMenB) in children

9 Feb, 2023 | 13:59h | UTC

Effectiveness of a Meningococcal Group B Vaccine (4CMenB) in Children – New England Journal of Medicine

Commentaries:

NEJM: Effectiveness of pediatric meningococcal B vaccine – MedicalResearch.com

4CMenB Vaccination Effective Against Invasive Meningococcal Disease in Children Under 5 – HealthDay

 

Commentary on Twitter

 

Cohort Study | Outcomes of Meningococcal B disease in children after implementation of routine 4CMenB vaccination

9 Feb, 2023 | 13:57h | UTC

Outcomes of meningococcal serogroup B disease in children after implementation of routine infant 4CMenB vaccination in England: an active, prospective, national surveillance study – The Lancet Child & Adolescent Health

 

Commentary on Twitter

 

RCT | BCG vaccine not effective for preventing COVID-19 and other respiratory tract infections in older adults

9 Feb, 2023 | 13:53h | UTC

Bacillus Calmette-Guérin vaccine for prevention of COVID-19 and other respiratory tract infections in older adults with comorbidities: a randomized controlled trial – Clinical Microbiology and Infection

News Release: Tuberculosis vaccine does not protect elderly against COVID-19, finds large Dutch study – University Medical Center Utrecht

 

Commentary on Twitter

 

RCT | Pregnancy and neonatal safety of PrEP for HIV prevention initiated during pregnancy vs. afterwards

9 Feb, 2023 | 13:55h | UTC

Pregnancy and neonatal safety outcomes of timing of initiation of daily oral tenofovir disoproxil fumarate and emtricitabine pre-exposure prophylaxis for HIV prevention (CAP016): an open-label, randomised, non-inferiority trial – The Lancet HIV (link to abstract – $ for full-text)

 

Guidance on the use of convalescent plasma to treat immunocompromised patients with COVID-19

9 Feb, 2023 | 13:50h | UTC

Guidance on the use of convalescent plasma to treat immunocompromised patients with COVID-19 – Clinical Infectious Diseases

 

Retrospective Cohort | Survivors of sepsis are at increased risk of late cardiovascular events

8 Feb, 2023 | 12:46h | UTC

Cardiovascular Events Among Survivors of Sepsis Hospitalization: A Retrospective Cohort Analysis – Journal of the American Heart Association

Editorial: Describing Sepsis as a Risk Factor for Cardiovascular Disease – Journal of the American Heart Association

News Release: Sepsis increased risk of heart failure and rehospitalization after hospital discharge – American Heart Association

Commentaries:

Sepsis Emerges as Powerful CVD Risk Factor in Large US Analysis – TCTMD

Cardiovascular Hospitalization Increased After Sepsis Hospitalization – HealthDay

 

RCT | Gefitinib plus MTX not better than MTX alone to treat tubal ectopic pregnancy

8 Feb, 2023 | 12:43h | UTC

Combination of gefitinib and methotrexate to treat tubal ectopic pregnancy (GEM3): a multicentre, randomised, double-blind, placebo-controlled trial – The Lancet

 

Commentary from the author on Twitter (thread – click for more)

Under a Creative Commons Attribution (CC BY 4.0) license

 

Review | Liberation from mechanical ventilation in the cardiac intensive care unit

8 Feb, 2023 | 12:45h | UTC

Liberation From Mechanical Ventilation in the Cardiac Intensive Care Unit – JACC: Advances

 

Review | Management of menopausal symptoms

8 Feb, 2023 | 12:44h | UTC

Management of Menopausal Symptoms: A Review – JAMA (free for a limited period)

Audio Clinical Review: Treatment of Menopausal Symptoms – JAMA

 

RCT | Methylprednisolone vs. immunoglobulins equally effective in PIMS temporally associated with SARS-CoV-2

8 Feb, 2023 | 12:42h | UTC

Methylprednisolone versus intravenous immunoglobulins in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): an open-label, multicentre, randomised trial – The Lancet Child & Adolescent Health

 

Review | Autonomic dysfunction and postural orthostatic tachycardia syndrome in post-acute COVID-19 syndrome

8 Feb, 2023 | 12:38h | UTC

Autonomic dysfunction and postural orthostatic tachycardia syndrome in post-acute COVID-19 syndrome – Nature Reviews Cardiology

 

Commentary on Twitter

 

Video | Malaria — Epidemiology, treatment, and prevention

8 Feb, 2023 | 12:37h | UTC

Malaria — Epidemiology, Treatment, and Prevention | NEJM

 

Research shows ad libitum meal energy intake is influenced by energy density, eating rate and hyper-palatable foods

8 Feb, 2023 | 12:36h | UTC

Ad libitum meal energy intake is positively influenced by energy density, eating rate and hyper-palatable food across four dietary patterns – Nature Food (free for a limited period)

News Release: Research shows impact of ‘hyper-palatable’ foods across four diets – University of Kansas

 

Commentary from one of the authors on Twitter (thread – click for more)

 

RCT | Outcomes in children of women with type 2 diabetes exposed to metformin vs. placebo during pregnancy

8 Feb, 2023 | 12:32h | UTC

Outcomes in children of women with type 2 diabetes exposed to metformin versus placebo during pregnancy (MiTy Kids): a 24-month follow-up of the MiTy randomised controlled trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

 

Crossover RCT | Effects of SGLT2 inhibition on sodium in patients with chronic syndrome of inappropriate antidiuresis

8 Feb, 2023 | 12:34h | UTC

Treatment Effect of the SGLT2 Inhibitor Empagliflozin on Chronic Syndrome of Inappropriate Antidiuresis: Results of a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial – Journal of the American Society of Nephrology

 

Commentary on Twitter

 

Guideline | Assessment and management of complex fractures

7 Feb, 2023 | 14:19h | UTC

Fractures (complex): assessment and management – National Institute for Health and Care Excellence

 

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