Editor's Choice
RCT | Prolonged higher dose methylprednisolone vs. conventional dexamethasone in COVID-19 pneumonia
4 May, 2023 | 13:53h | UTC
RCT | Best endovascular treatment first strategy yields better outcomes for chronic limb ischemia vs. vein bypass first strategy
3 May, 2023 | 15:39h | UTCCommentary: BASIL-2 Supports Endo-First Strategy for CLTI With Infrapopliteal Disease – TCTMD
M-A | Efficacy of osteoporosis interventions on fracture prevention in postmenopausal women
3 May, 2023 | 15:37h | UTC
Cluster RCT | Eat, sleep, console approach vs. usual care for neonatal opioid withdrawal
3 May, 2023 | 15:35h | UTCEat, Sleep, Console Approach or Usual Care for Neonatal Opioid Withdrawal – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: “Eat, Sleep, Console” reduces hospital stay and need for medication among opioid-exposed infants – NIH News Releases
Commentary on Twitter
In this randomized trial, infants who were treated with the Eat, Sleep, Console model for neonatal opioid withdrawal syndrome had a significantly shorter hospital stay than those in the usual-care group. Full results of the ESC-NOW trial: https://t.co/13j7a5DhZd#PAS2023 pic.twitter.com/so5jqIVwpi
— NEJM (@NEJM) April 30, 2023
M-A | Direct oral anticoagulants versus warfarin across the spectrum of kidney function in patients with AF
3 May, 2023 | 15:32h | UTCDirect Oral Anticoagulants Versus Warfarin Across the Spectrum of Kidney Function: Patient-Level Network Meta-Analyses From COMBINE AF – Circulation (free for a limited period)
Commentary on Twitter
Direct Oral Anticoagulants versus Warfarin Across the Spectrum of Kidney Function: Patient-Level Network Meta-Analyses from COMBINE AF @jlharrington_md #AHAJournals https://t.co/6Rzlt09m9W pic.twitter.com/2oknvnken8
— Circulation (@CircAHA) April 18, 2023
Big little lies: a compendium and simulation of p-hacking strategies
3 May, 2023 | 15:30h | UTCBig little lies: a compendium and simulation of p-hacking strategies – Royal Society Open Science
Differential diagnosis, prevention, and treatment of mpox (Monkeypox): a review for dermatologists
3 May, 2023 | 15:27h | UTC
SR | Fecal microbiota transplantation effective in recurrent C. difficile treatment
3 May, 2023 | 15:29h | UTCCommentaries:
Fecal microbiota transplant: Effective solution for recurrent C. difficile infections – News Medical
Related:
Commentary on Twitter
💩 Stool transplantation for treatment of repeated Clostridioides difficile infection
🔎 #SystematicReview looked at the evidence from 6 clinical trials
🌟 'More effective than antibiotics for treating recurring, life-threatening gut infections' https://t.co/NHSZYWccoN pic.twitter.com/q8kRVExvMg— The Cochrane Library (@CochraneLibrary) April 28, 2023
Supportive care management recommendations for mucocutaneous manifestations of monkeypox infection
3 May, 2023 | 15:26h | UTC
Scientific Statement | Role of natriuretic peptides in the diagnosis and management of heart failure
2 May, 2023 | 14:05h | UTC
AHA Scientific Statement | Hypertension in patients treated with in-center maintenance hemodialysis
2 May, 2023 | 14:02h | UTCTop Things to Know: HTN in Patients Treated with In-Center Maintenance Hemodialysis: Current Evidence and Future Opportunities – American Heart Association
Commentary on Twitter
❤️ New AHA statement reviews current evidence on defining, diagnosing & treating HTN in patients on maintenance hemodialysis + highlights research opportunities including studies on BP targets & treatment strategies. @HyperAHA
Read more: https://t.co/Cn5ktruTQA pic.twitter.com/7OTr3eQmrm
— AHA Science (@AHAScience) April 26, 2023
ChatGPT’s responses to patient questions rated higher for quality and empathy than physicians
2 May, 2023 | 14:00h | UTCChatGPT’s responses to patient questions rated higher for quality and empathy than physicians
Comparing Physician and Artificial Intelligence Chatbot Responses to Patient Questions Posted to a Public Social Media Forum – JAMA Internal Medicine (free for a limited period)
Commentaries:
How Chatbots and Large Language Model Artificial Intelligence Systems Will Reshape Modern Medicine: Fountain of Creativity or Pandora’s Box? – JAMA Internal Medicine (free for a limited period)
Commentary on Twitter (thread – click for more)
Here's what's under appreciated about Chat GPT paper🧵
PCP panel can be 2 to 5k
Doc in clinic 40 hours++ already
Doc not good at typing
Chat GPT can reply instantly
Chat GPT never fatigues
Can keep replying
Can reply day&night
Can read chart
Can type pleasantries, doc too busy 4— Vinay Prasad MD MPH (@VPrasadMDMPH) April 30, 2023
RCT | An herbal-based injection reduced 28-day mortality in patients with sepsis
2 May, 2023 | 13:58h | UTC
Commentary on Twitter
Among patients with sepsis, treatment with Xuebijing injection, compared with the placebo group, resulted in lower 28-day mortality. https://t.co/tHwnq6mKu8
— JAMA Internal Medicine (@JAMAInternalMed) May 1, 2023
Review | Suicide in young people: screening, risk assessment, and intervention
2 May, 2023 | 13:56h | UTCSuicide in young people: screening, risk assessment, and intervention – The BMJ
RCT | Craniotomy and decompressive craniectomy yield comparable outcomes in acute subdural hematoma
2 May, 2023 | 13:51h | UTCDecompressive Craniectomy versus Craniotomy for Acute Subdural Hematoma – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: International study recommends replacing skull section after treatment for a brain bleed – University of Cambridge
Commentary on Twitter
Presented at #AANS2023: In an international trial involving 450 patients with acute subdural hematoma, craniotomy (replacing bone flap) and decompressive craniectomy (removing bone flap) yielded similar disability results at 12 months. https://t.co/KoNebwQIsi#neurosurgery pic.twitter.com/t9E9YZeHyq
— NEJM (@NEJM) April 23, 2023
RCT | Hypotension-avoidance and hypertension-avoidance strategies resulted in similar outcomes in noncardiac surgery
2 May, 2023 | 13:54h | UTCHypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery: An International Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Hypotension-Avoidance No Better than Hypertension-Avoidance for Reducing Post-Op Adverse Events – HCP Live
Commentary on Twitter
Finally published-POISE-3 showed no diff in effects on major vasc complic between 2 alternative BP mgmt strategies. Probably easiest to continue current regimen.
Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery https://t.co/GIR4jAL07H— Steven Cohn, MD (@preopconsult) April 24, 2023
Video | Bayesian way
2 May, 2023 | 13:50h | UTC
M-A | Low-dose triple and quadruple antihypertensives outperform monotherapy in blood pressure reduction
28 Apr, 2023 | 13:23h | UTCEfficacy and Safety of Low-Dose Triple and Quadruple Combination Pills vs Monotherapy, Usual Care, or Placebo for the Initial Management of Hypertension: A Systematic Review and Meta-analysis – JAMA Cardiology (free for a limited period)
Commentary: Low-Dose Polypills Top Other Approaches for Initial BP Control: Meta-analysis – TCTMD
AHA Scientific Statement | Assessing popular diets in relation to 2021 American Heart Association dietary recommendations
28 Apr, 2023 | 13:21h | UTCTop Things to Know: Popular Dietary Patterns: Alignment with AHA 2021 Dietary Guidance – American Heart Association
Commentary on Twitter
A 🆕 scientific statement evaluates how well 10 popular eating patterns align with AHA nutrition guidance, offering a valuable tool for both clinicians and consumers to understand and adopt heart-healthy dietary patterns.
Read more 👉 https://t.co/PbGRqhF05p pic.twitter.com/sropKchRWx— AHA Science (@AHAScience) April 27, 2023
Cohort Study | Risk of multiple morbidities across the lifespan in people with Down syndrome or intellectual disabilities
28 Apr, 2023 | 13:19h | UTC
Commentary from the author on Twitter (thread – click for more)
Our new report on Multiple morbidity across the lifespan in people with Down syndrome or intellectual disability is out today https://t.co/wkakUfjetn pic.twitter.com/fVyKZZPdOW
— Andre Strydom (@drandrestrydom) April 27, 2023
Global burden of chronic respiratory diseases and risk factors, 1990–2019
28 Apr, 2023 | 13:17h | UTCNews Release: Chronic respiratory disease is third leading cause of death globally with air pollution killing 1.3 million people – IHME
Commentary on Twitter (thread – click for more)
Modifiable risk factors like air pollution were responsible for roughly 70% of chronic respiratory disease (#CRD) deaths, finds new global burden of disease study published in @eClinicalMed @TheLancet 🧵
»https://t.co/uUVZFdNWVV pic.twitter.com/kgMXOePlfS
— Institute for Health Metrics and Evaluation (IHME) (@IHME_UW) April 25, 2023
RCT | Molecular point-of-care testing for gastroenteritis reduced isolation time but increased antibiotic use
28 Apr, 2023 | 13:15h | UTC
M-A | Corticosteroids in community-acquired bacterial pneumonia
26 Apr, 2023 | 14:29h | UTCCorticosteroids in Community-Acquired Bacterial Pneumonia: a Systematic Review, Pairwise and Dose-Response Meta-Analysis – Journal of General Internal Medicine (if the link is paywalled, try this one)
Related:
RCT | Hydrocortisone reduces mortality in severe community-acquired pneumonia
ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia
ASCO Guideline Update | Management of anxiety and depression in adult survivors of cancer
26 Apr, 2023 | 14:27h | UTCCommentary: ASCO Updates Guideline for Management of Anxiety and Depression in Adult Cancer Survivors – ASCO Daily News
Related: Anxiety and depression in adult cancer patients: ESMO Clinical Practice Guideline – ESMO Open
Commentary on Twitter
Just issued: Guideline update on the management of anxiety and depression in adult #CancerSurvivors. Read more ➡️ https://t.co/gxv0I86jHX #survonc #supponc #psyonc pic.twitter.com/hwnNgTuqSo
— ASCO (@ASCO) April 20, 2023
ESMO Guideline | Anxiety and depression in adult cancer patients
26 Apr, 2023 | 14:26h | UTCAnxiety and depression in adult cancer patients: ESMO Clinical Practice Guideline – ESMO Open