Editor's Choice
RCT | Continuous vs. intermittent meropenem administration shows similar mortality and drug-resistance in sepsis patients
19 Jun, 2023 | 14:11h | UTCContinuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis: The MERCY Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Do Prolonged Infusions of β-Lactam Antibiotics Improve Outcomes in Critically Ill Patients With Sepsis? – JAMA (free for a limited period)
See also: Visual Abstract
Commentary: Trial finds no difference between continuous, intermittent meropenem for sepsis patients – CIDRAP
Commentary on Twitter
Continuous administration of meropenem, compared with intermittent administration, does not improve clinically relevant outcomes in critically ill patients with #sepsis. https://t.co/eJ9zdGI4k2 #CCR23 pic.twitter.com/8n2eR9qBPe
— JAMA (@JAMA_current) June 16, 2023
RCT | Mild hypercapnia after cardiac arrest shows no improvement in neurological outcomes vs. normocapnia
16 Jun, 2023 | 14:15h | UTCMild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: New data supports current management of CO2 levels in cardiac arrest patients – UCD Dublin
Perspective | Benefits and pitfalls of social media in cardiology
16 Jun, 2023 | 14:13h | UTC
Commentary on Twitter
Medical #education has entered the #DigitalTransformation era 🤖
What is the role of #SoMe and multimedia platforms in #cardiology❓
Here is our view from the @JACCJournals #JACCCaseReports #SoMe Editors ❤️#CardioTwitter #MedEd #CardioEd
➡️Link to full paper below🧵 pic.twitter.com/0W77HzoJ6Q
— Alessandro Beneduce (@ABeneduceMD) June 9, 2023
Brief Review | Why is cuff size so important and other factors that affect accurate blood pressure measurement
16 Jun, 2023 | 14:12h | UTC
RCT | Multiple electrolytes solution reduces acute kidney injury in pediatric septic shock compared to saline
16 Jun, 2023 | 14:10h | UTCMultiple Electrolytes Solution Versus Saline as Bolus Fluid for Resuscitation in Pediatric Septic Shock: A Multicenter Randomized Clinical Trial – Critical Care Medicine (link to abstract – $ for full-text)
Systematic Review | Tranexamic acid likely decreases red blood cell transfusion need in hip fracture surgery
16 Jun, 2023 | 14:09h | UTC
RCT | Prehospital use of tranexamic acid in severe trauma cases shows no superiority over placebo
15 Jun, 2023 | 15:16h | UTCPrehospital Tranexamic Acid for Severe Trauma – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Shining a new light on tranexamic acid for trauma care – Monash University
Commentary on Twitter
Late breaking at #CCR23: In the PATCH-Trauma trial involving adults with major trauma, treatment with tranexamic acid did not result in a greater number of patients surviving with a favorable functional outcome at 6 months than placebo. https://t.co/i8fu34ReCB pic.twitter.com/GEOtRphOBb
— NEJM (@NEJM) June 14, 2023
Consensus Statement | Concussion in sport
15 Jun, 2023 | 15:14h | UTC
Perspective | Observational studies must be reformed before the next pandemic
15 Jun, 2023 | 15:12h | UTCObservational studies must be reformed before the next pandemic – Nature Medicine
Evidence-based clinical practice guideline for deprescribing opioid analgesics
15 Jun, 2023 | 15:08h | UTC
RCT | Cannabis-based medicines show no significant relief for moderate-to-severe cancer pain
15 Jun, 2023 | 15:10h | UTCCannabis‐based medicines and medical cannabis for adults with cancer pain – Cochrane Library
Summary: Cannabis-based medicines for cancer pain – Cochrane Library
Review | Fluid therapy for critically ill adults with sepsis
14 Jun, 2023 | 14:51h | UTCFluid Therapy for Critically Ill Adults With Sepsis: A Review – JAMA (free for a limited period)
Audio clinical review: Fluid Therapy for Critically Ill Adults With Sepsis – JAMA
Perspective | Inside the nascent industry of AI-designed drugs
14 Jun, 2023 | 14:50h | UTCInside the nascent industry of AI-designed drugs – Nature (if the link is paywalled, try this one)
Opinion | Threats by artificial intelligence to human health and human existence
14 Jun, 2023 | 14:47h | UTCThreats by artificial intelligence to human health and human existence – BMJ Global Health
News Release: Doctors and public health experts join calls for halt to AI R&D until it’s regulated – BMJ Newsroom
RCT | Ultrasonography noninferior to radiography for pediatric distal forearm fracture diagnosis
14 Jun, 2023 | 14:45h | UTCUltrasonography or Radiography for Suspected Pediatric Distal Forearm Fractures – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Ultrasound breaks new ground for forearm fractures in children – Griffith University
RCT | 0.01% atropine effective in reducing progression of myopia in children over 3 years
14 Jun, 2023 | 14:41h | UTCNews Release: Eye drops slow nearsightedness progression in kids – Ohio State University
See also: Visual Abstract
Related:
RCT | Effect of low-concentration atropine eyedrops vs. placebo on myopia incidence in children
Crossover RCT | Spectacle lenses with highly aspherical lenslets for slowing myopia.
RCT | Effect of text messaging parents of school-aged children on outdoor time to control myopia.
RCT | Myopia control effect of repeated low-level red-light therapy in children.
M-A | Oseltamivir fails to lower hospitalization risk in adult and adolescent influenza patients
13 Jun, 2023 | 14:12h | UTC
Commentary on Twitter
In this systematic review and meta-analysis of 15 RCTs, oseltamivir was not associated with reduced risk of first hospitalization compared with placebo or standard of care among influenza-infected adult and adolescent outpatients. https://t.co/UEqsbA2JQZ
— JAMA Internal Medicine (@JAMAInternalMed) June 12, 2023
Viewpoint | Detecting selection bias in observational studies—when interventions work too fast
13 Jun, 2023 | 14:09h | UTCDetecting Selection Bias in Observational Studies—When Interventions Work Too Fast – JAMA Internal Medicine (free for a limited period)
Commentary from the author on Twitter
Our paper in @JAMAInternalMed helps recognize confounding/biases in obs studies.https://t.co/qhptGVAIev
Look at image on left-a randomized study in which K better than V (slow separation of curves, plausible).
On right-retrospective obs study of VRD vs KRd.Early separation!! pic.twitter.com/mma9vGpueQ
— Manni Mohyuddin (@ManniMD1) June 12, 2023
Review | Wastewater monitoring can anchor global disease surveillance systems
13 Jun, 2023 | 14:07h | UTCWastewater monitoring can anchor global disease surveillance systems – The Lancet Global Health
Related:
Use of Wastewater for Mpox Outbreak Surveillance in California – New England Journal of Medicine
Opinion: Wastewater analysis can be a powerful public health tool—if it’s done sensibly.
CDC unveils its latest weapon in Covid-19 detection: wastewater.
[Preprint] Wastewater genomic testing can effectively track COVID-19 variants of concern.
Human Waste Could Be The Next Big Weapon in Controlling COVID-19 – TIME
Next steps for wastewater testing to help end this pandemic — and prevent the next one – STAT
The myriad ways sewage surveillance is helping fight COVID around the world – Nature
It’s time to begin a national wastewater testing program for Covid-19 – STAT
Coronavirus: Testing sewage an ‘easy win’ – BBC
Saving time and money in biomedical publishing: the case for free-format submissions with minimal requirements
13 Jun, 2023 | 14:08h | UTCCommentary: Revealed: the millions of dollars in time wasted making papers fit journal guidelines – Nature
Review | Diagnosis and management of depression in adolescents
13 Jun, 2023 | 14:05h | UTCDiagnosis and management of depression in adolescents – Canadian Medical Association Journal
News Release: How to diagnose and manage depression in adolescents: A new review for clinicians – Canadian Medical Association Journal
IDSA 2023 Guidance on the treatment of antimicrobial resistant gram-negative infections
12 Jun, 2023 | 13:58h | UTCRelated:
RCT | Noninferior survival rates with hearts donated after circulatory death versus brain death
12 Jun, 2023 | 13:57h | UTCTransplantation Outcomes with Donor Hearts after Circulatory Death – New England Journal of Medicine (link to abstract – $ for full-text)
Video summary: Outcomes with Donor Hearts after Circulatory Death | NEJM
News Release: Multicenter Trial Finds Using Circulatory Death Donors is Safe and Effective for Heart Transplantation – Northwestern Medicine
Commentary: Transplantation Outcomes With Donor Hearts After Circulatory Death – American College of Cardiology
Commentary on Twitter
In a randomized trial, survival at 6 months after transplantation with hearts donated after circulatory death was noninferior to that with hearts donated after brain death. https://t.co/IymsknTqSE#cardiology pic.twitter.com/oYAS10fVJt
— NEJM (@NEJM) June 7, 2023
2ry Analysis of a RCT | Metformin linked to 41% reduction in long COVID incidence in outpatient treatment
12 Jun, 2023 | 13:55h | UTCNews Release: Study shows metformin lowers the risk of getting long COVID – University of Minnesota Medical School
Commentary on Twitter
These data not persuasive. There are 6 different arms. 3 drugs. This is not the primary endpoint. No adjustment for multiple testing.
Even USFDA would not accept these data for regulatory approval, and they are basically working for Pharma at this pthttps://t.co/FZoxo9shtG
— Vinay Prasad MD MPH (@VPrasadMDMPH) June 9, 2023
Pre-clinical Study | Taurine deficiency and aging, a correlation found in mice, monkeys, and worms
12 Jun, 2023 | 13:53h | UTCTaurine deficiency as a driver of aging – Science
Invited Commentary: Taurine linked with healthy aging – Science
News Release: Taurine May Be a Key to Longer and Healthier Life – Columbia University
Commentary on Twitter
Taurine deficiency may be a driver for aging, finds a new Science study in several animal models. The results warrant clinical trials to examine taurine’s effect on healthy lifespan in humans.
📄: https://t.co/iJfI4rne7o#SciencePerspective: https://t.co/EdOKecgoqF pic.twitter.com/dekChiKRN3
— Science Magazine (@ScienceMagazine) June 8, 2023