Editor's Choice
WHO outlines 40 research priorities on antimicrobial resistance
26 Jun, 2023 | 00:50h | UTCNews release: WHO outlines 40 research priorities on antimicrobial resistance – World Health Organization
Report: Global research agenda for antimicrobial resistance in human health – World Health Organization
Commentary on Twitter
🔥WHO published its 1st global research agenda for the world’s scientists to address the most urgent human health priorities to combat antimicrobial resistance
It outlines 40 research topics on drug-resistant bacteria,fungi& Mycobacterium TB
H/t @paimadhuhttps://t.co/AOVObnJK5Q pic.twitter.com/owZJwMIDXK— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) June 22, 2023
WHO Report | Water, sanitation, hygiene, waste and electricity services in health care facilities
23 Jun, 2023 | 13:41h | UTC
Commentary on Twitter (thread – click for more)
Better access to water, sanitation, hygiene & waste services in health facilities improve quality care and help prevent millions of deaths annually.
New WHO & @UNICEF Global Progress Report 2023 outlines how:
➡️ https://t.co/moyBs6yibC pic.twitter.com/Rv0P8DjzjA— World Health Organization (WHO) (@WHO) June 13, 2023
Report | Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000–2021
23 Jun, 2023 | 13:40h | UTCNews Release: Sickle cell disease is 11 times more deadly than previously recorded – Institute for Health Metrics and Evaluation
Commentary on Twitter (thread – click for more)
Ahead of #WorldSickleCellDay #WSCD23 we are publishing the first detailed global estimates on the burden of #sicklecell disease
Read it #openaccess https://t.co/pVlWZ6s1G4
The authors show that mortality linked to #sicklecell disease is higher than previously described🧵 pic.twitter.com/WplWr0gXqJ
— The Lancet Haematology (@TheLancetHaem) June 16, 2023
RCT | Single-Dose VLA1553 Chikungunya vaccine shows high immunogenicity and seems safe
23 Jun, 2023 | 13:38h | UTCNews Release: First phase 3 trial of a chikungunya vaccine candidate finds it is generally safe and provokes an immune response – The Lancet
Commentary on Twitter
New: First phase 3 trial of a chikungunya vaccine candidate finds it is generally safe and provokes an immune response. https://t.co/YSzV5oxXRc pic.twitter.com/rGL7A5eLAr
— The Lancet (@TheLancet) June 13, 2023
RCT | Time-lapse-based embryo selection does not improve pregnancy rates in IVF treatments
23 Jun, 2023 | 13:37h | UTCClinical outcomes of uninterrupted embryo culture with or without time-lapse-based embryo selection versus interrupted standard culture (SelecTIMO): a three-armed, multicentre, double-blind, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
News Release: New IVF Method: more expensive, not more effective – Amsterdam UMC
Commentary on Twitter (thread – click for more)
Time-lapse monitoring is increasingly used to culture and select embryos for transfer in IVF. Yet there is insufficient evidence for superior clinical results.
A study evaluated whether the embryo selection method can increase clinical results. 🧵https://t.co/DFqgCFHZ55
— The Lancet (@TheLancet) May 3, 2023
Review | Evaluation and management of diabetes-related foot infections
23 Jun, 2023 | 13:36h | UTCEvaluation and Management of Diabetes-related Foot Infections – Clinical Infectious Diseases
Related: Guideline Series | Prevention and management of diabetes-related foot disease
Scientific Advisory | Expedited CT scanning with iodinated contrast when necessary favored over renal concerns in emergencies
22 Jun, 2023 | 15:19h | UTCRelated:
Radiographic Contrast Media and the Kidney – Clinical Journal of the American Society of Nephrology
Contrast-Associated Acute Kidney Injury – Journal of Clinical Medicine
Choosing Wisely | Recommendations for advance care planning
22 Jun, 2023 | 15:18h | UTCSee complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
Review | Nonsurgical management of major hemorrhage
22 Jun, 2023 | 15:16h | UTCNonsurgical management of major hemorrhage – Canadian Medical Association Journal
ERAS Guideline | Perioperative care for emergency laparotomy
22 Jun, 2023 | 15:14h | UTCGuidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS) Society Recommendations – World Journal of Surgery
Part 1: Preoperative: Diagnosis, Rapid Assessment and Optimization
Part 2: Emergency Laparotomy: Intra- and Postoperative Care
Part 3: Organizational Aspects and General Considerations for Management of the Emergency Laparotomy Patient
Editorial | How to become a good surgeon
22 Jun, 2023 | 15:12h | UTCHow to become a good surgeon – Advances in Ophthalmology Practice and Research
RCT | LMWH does not increase live birth rates in women with thrombophilia and recurrent miscarriage
21 Jun, 2023 | 13:39h | UTCHeparin for women with recurrent miscarriage and inherited thrombophilia (ALIFE2): an international open-label, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter (thread – click for more)
New study: Many women with recurrent miscarriage are tested for inherited thrombophilia. If confirmed positive, daily subcutaneous low-molecular-weight heparin (LMWH) is given.
This is despite an absence of evidence that such treatment is beneficial 🧵 https://t.co/0IuFhvjlZr
— The Lancet (@TheLancet) June 2, 2023
Acute heart failure: differential diagnosis and treatment
21 Jun, 2023 | 13:37h | UTCAcute heart failure: differential diagnosis and treatment – European Heart Journal Supplements
Qualitative Study | International perspectives on modifications to the surgical safety checklist
21 Jun, 2023 | 13:36h | UTCInternational Perspectives on Modifications to the Surgical Safety Checklist – JAMA Network Open
Invited Commentary: Modifications of the World Health Organization’s Surgical Safety Checklist—Ways Forward to Ensure Sustainable Implementation – JAMA Network Open
Commentary on Twitter
Qualitative study: >10 years after the surgical safety checklist was developed, systems should consider checklist modification to improve safety, teamwork & buy-in. https://t.co/5xisRqzWkf @N8turl3y @MaryEBrindle @ucalgarymed @ariadnelabs
— JAMA Network Open (@JAMANetworkOpen) June 7, 2023
Cohort Study | Dengue patients at high risk of cholecystitis and pancreatitis within 30 days
21 Jun, 2023 | 13:34h | UTC
Brief Review | Selection bias due to conditioning on a collider
21 Jun, 2023 | 13:32h | UTCSelection bias due to conditioning on a collider – The BMJ
RCT | Use of lumbar drains improves 6-month outcomes in patients with aneurysmal subarachnoid hemorrhage
20 Jun, 2023 | 12:55h | UTCSee also: Visual Abstract
Commentary on Twitter
In this trial, among patients with aneurysmal subarachnoid hemorrhage, lumbar drainage improved clinical neurological outcomes at 6 months. https://t.co/SZjuQoGoku pic.twitter.com/szKcZaPL9K
— JAMA Neurology (@JAMANeuro) June 18, 2023
RCT | In chronic subdural hematoma, dexamethasone fails to match surgery for functional outcomes
20 Jun, 2023 | 12:53h | UTCDexamethasone versus Surgery for Chronic Subdural Hematoma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Dexamethasone Compared to Burr-Hole Drainage for Chronic Subdural Hematoma – HealthDay
RCT | No superior recovery with minithoracotomy over sternotomy in mitral valve repair
20 Jun, 2023 | 12:51h | UTCMinithoracotomy vs Conventional Sternotomy for Mitral Valve Repair: A Randomized Clinical Trial – JAMA (free for a limited period)
See also: Visual Abstract
Opinion | Strategic masking to protect patients from all respiratory viral infections
20 Jun, 2023 | 12:50h | UTCStrategic Masking to Protect Patients from All Respiratory Viral Infections – New England Journal of Medicine (link to abstract – $ for full-text)
RCT | Thrice-weekly oral iron shows non-inferiority and fewer gastrointestinal effects in treating iron-deficiency anemia
20 Jun, 2023 | 12:48h | UTCA randomized controlled trial of thrice-weekly versus thrice-daily oral ferrous fumarate treatment in adult patients with iron-deficiency anemia – Ann Hematol (if the link is paywalled, try this one)
ESICM guidelines on ARDS: definition, phenotyping and respiratory support strategies
19 Jun, 2023 | 14:18h | UTCSee also: Caring for Patients With Acute Respiratory Distress Syndrome: Summary of the 2023 ESICM Practice Guidelines – JAMA (free for a limited period)
Commentary on Twitter
#ARDS @ESICM guidelines
🫁 definition
🫁 phenotyping
🫁 #HFNO
🫁 CPAP/NIV
🫁 low tidal volume MV
🫁 PEEP & recruitment maneuvers
🫁 prone positioning
🫁 neuromuscular blocking agents
🫁 extracorporeal life support #ECMO #ECLS #ECCO2r#FOAMcc on @yourICM
🖇️ https://t.co/xGtI2y0vZw pic.twitter.com/H1z7EBxLLo— Intensive Care Medicine (@yourICM) June 16, 2023
RCT | High-dose hemodiafiltration reduces mortality risk in kidney failure patients compared to conventional high-flux hemodialysis
19 Jun, 2023 | 14:17h | UTCEffect of Hemodiafiltration or Hemodialysis on Mortality in Kidney Failure – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
#ERA23: In patients with kidney failure undergoing kidney-replacement therapy, the use of high-dose hemodiafiltration resulted in lower mortality than conventional high-flux hemodialysis. Full results of the CONVINCE trial: https://t.co/NRtQnHm9vo
— NEJM (@NEJM) June 16, 2023
RCT | Video laryngoscopy improves first-attempt intubation, severe complications unchanged
19 Jun, 2023 | 14:15h | UTCVideo versus Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Study shows video laryngoscope increases successful intubation on first attempt – Vanderbilt University Medical Center
RCT | Testosterone replacement does not appear to increase cardiovascular events in hypogonadal men at high risk
19 Jun, 2023 | 14:13h | UTCCardiovascular Safety of Testosterone-Replacement Therapy – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Presented today at #ENDO2023: In the TRAVERSE study, a randomized trial involving men with hypogonadism and preexisting or a risk of cardiovascular disease, testosterone therapy was noninferior to placebo with respect to major adverse cardiac events. https://t.co/V3FTTsOLd1
— NEJM (@NEJM) June 16, 2023