Editor's Choice
RCT: In patients with low-risk thyroid cancer, thyroidectomy without ablation radioiodine was noninferior to thyroidectomy with ablation radioiodine at 3 years.
10 Mar, 2022 | 10:59h | UTCThyroidectomy without Radioiodine in Patients with Low-Risk Thyroid Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: New research casts doubt on a cornerstone of thyroid cancer treatment – STAT
Commentary on Twitter
In RCT involving patients with low-risk differentiated thyroid cancer undergoing thyroidectomy, a follow-up strategy that did not involve the use of radioiodine was noninferior to the use of radioiodine in the response to treatment at 3 years. https://t.co/RaJL3tdE4T pic.twitter.com/8nIPw50nkg
— NEJM (@NEJM) March 9, 2022
RCT: In children with nonsevere, drug-susceptible tuberculosis, treatment for 4 months is noninferior to treatment for 6 months.
10 Mar, 2022 | 11:03h | UTCNews Release: Treatment length reduced for children with tuberculosis – University College London
Commentary on Twitter
https://twitter.com/NEJM/status/1501686991888392192
Meta-analysis of randomized trials: benefits and harms of direct oral anticoagulation and low molecular weight heparin for thromboprophylaxis in patients undergoing non-cardiac surgery.
10 Mar, 2022 | 10:48h | UTC
Commentary on Twitter
https://twitter.com/KariTikkinen/status/1501532156786577415
M-A: Comparative efficacy and tolerability of 32 oral and long-acting injectable antipsychotics for the maintenance treatment of adults with schizophrenia.
10 Mar, 2022 | 10:54h | UTCComparative efficacy and tolerability of 32 oral and long-acting injectable antipsychotics for the maintenance treatment of adults with schizophrenia: a systematic review and network meta-analysis – The Lancet (link to abstract – $ for full-text)
Perspective: Once viewed as a promising COVID-19 treatment, convalescent plasma falls out of favor.
10 Mar, 2022 | 10:47h | UTCOnce Viewed as a Promising COVID-19 Treatment, Convalescent Plasma Falls Out of Favor – JAMA
Perspective: What do we know about Covid’s impact on the brain?
10 Mar, 2022 | 10:46h | UTCWhat do we know about Covid’s impact on the brain? – The Guardian
Related: SARS-CoV-2 is associated with changes in brain structure in UK Biobank.
New WHO/ILO guide urges greater safeguards to protect health workers.
10 Mar, 2022 | 10:42h | UTCNew WHO/ILO guide urges greater safeguards to protect health workers – World Health Organization
Executive Summary: Caring for those who care: Guide for the development and implementation of occupational health and safety programmes for health workers – World Health Organization
Updated guideline summary introduces new recommendations for use of medications around total hip and knee replacement.
10 Mar, 2022 | 10:45h | UTCGuideline Summary (full guideline not available yet): 2022 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients with Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty – American College of Rheumatology
AAP Technical Report | Telehealth: Opportunities to improve access, quality, and cost in pediatric care.
10 Mar, 2022 | 10:41h | UTCTelehealth: Opportunities to Improve Access, Quality, and Cost in Pediatric Care – Pediatrics
News Release: New AAP report reviews telehealth’s potential to transform pediatric care – AAP News
RCT: Reliever-triggered inhaled glucocorticoid reduces severe exacerbations in black and latinx adults with moderate-to-severe asthma.
9 Mar, 2022 | 10:06h | UTCReliever-Triggered Inhaled Glucocorticoid in Black and Latinx Adults with Asthma – New England Journal of Medicine (link to abstract – $ for full-text)
RCT: The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure.
9 Mar, 2022 | 10:04h | UTC
ACR/Vasculitis Foundation Guideline for the management of Kawasaki Disease.
9 Mar, 2022 | 10:01h | UTC
ACS Best Practice Guidelines: Spine injury.
9 Mar, 2022 | 10:00h | UTCSpine Injury – American College of Surgeons
News Release: New guidelines will help trauma centers treat spinal injury patients
AAN Position Statement: Clinical guidance in neuropalliative care.
9 Mar, 2022 | 09:56h | UTCClinical Guidance in Neuropalliative Care: An AAN Position Statement – Neurology
RCT: In patients with trauma-related hemorrhagic shock receiving prehospital care, there was no benefit from resuscitation with blood products compared to 0.9% sodium chloride.
9 Mar, 2022 | 09:55h | UTCInvited commentary: Prehospital blood transfusion: who benefits? – The Lancet Haematology
Commentary on Twitter
NEW research—resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care: results of #RePHILL, a randomised, controlled, phase 3 trial #openaccess #EmergencyMedicine 🚑🩸https://t.co/Ci0lMMCryX pic.twitter.com/iWEtV12N1r
— The Lancet Haematology (@TheLancetHaem) March 8, 2022
Cohort Study: One-year trajectory of cognitive changes in older survivors of COVID-19 in Wuhan, China.
9 Mar, 2022 | 09:51h | UTC
WHO says COVID boosters needed, reversing previous call.
9 Mar, 2022 | 09:49h | UTCWHO says COVID boosters needed, reversing previous call – Associated Press
Commentary on Twitter
Who needs a booster? The @WHO reverses its position and supports "urgent and broad" 3-shot vaccination https://t.co/y5pyY9bJr7 @AP The evidence has supported that move for several months.
"Fully vaccinated" = 3-shots
(or confirmed infection-acquired immunity + 1 shot)— Eric Topol (@EricTopol) March 8, 2022
Safety of mRNA vaccines administered during the initial 6 months of the US COVID-19 vaccination program.
9 Mar, 2022 | 09:46h | UTCCommentaries:
Large US study confirms most mRNA COVID-19 vaccine side effects are mild and temporary – Lancet
Covid vaccines not linked to deaths, major US study finds – BBC
Most mRNA COVID vaccine adverse events mild, transient – CIDRAP
SARS-CoV-2 is associated with changes in brain structure in UK Biobank.
9 Mar, 2022 | 09:53h | UTCSARS-CoV-2 is associated with changes in brain structure in UK Biobank – Nature
Commentary:
Brain changes after COVID revealed by imaging – Nature
Scans reveal how Covid may change the brain – BBC
RCT: Azithromycin is not effective for the prevention of recurrent wheeze following severe respiratory syncytial virus bronchiolitis.
8 Mar, 2022 | 08:49h | UTCCommentaries:
Commentary on Twitter
This RCT tested oral azithromycin vs placebo to reduce recurrent wheeze (RW) in 1-18-month-olds hospitalized with acute severe RSV bronchiolitis. Azithromycin did not reduce occurrence of RW and may increase risk of RW in some groups. #AAAAI22 #Asthma #EBM https://t.co/jYcBuiQ8aY pic.twitter.com/u65NbQaIlX
— NEJM Evidence (@NEJMEvidence) February 28, 2022
AHA Scientific Statement: Cardio-oncology drug interactions.
8 Mar, 2022 | 09:53h | UTC
Doing more can be worse: ten common errors in the ICU.
8 Mar, 2022 | 08:51h | UTCDoing More Can Be Worse: Ten Common Errors in the ICU – ICU Management & Practice
How long does protective immunity against COVID-19 last after infection or vaccination? Two immunologists explain.
8 Mar, 2022 | 08:56h | UTC
Study shows the number of covid-19 infections missed by lateral flow tests “substantial enough to be of clinical importance”.
8 Mar, 2022 | 08:57h | UTCOriginal Study: SARS-CoV-2 antigen lateral flow tests for detecting infectious people: linked data analysis – The BMJ
Commentaries:
RCT: Screening for atrial fibrillation in older adults using a single-lead ECG did not increase detection rates at one year.
8 Mar, 2022 | 09:51h | UTCScreening for Atrial Fibrillation in Older Adults at Primary Care Visits: the VITAL-AF Randomized Controlled Trial – Circulation (link to abstract – $ for full-text)
Related:
Clinical Review: Screening and management of atrial fibrillation in primary care