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Critical Care & Emergencies (all articles)

Study: Pulmonary embolism detected in 6% of patients with COPD admitted to the hospital with acute worsening of respiratory symptoms

15 Jan, 2021 | 08:37h | UTC

Prevalence of Pulmonary Embolism Among Patients With COPD Hospitalized With Acutely Worsening Respiratory Symptoms – JAMA (link to abstract – $ for full-text)

 

Cohort study: Piperacillin/tazobactam linked to increased risk of acute kidney injury when compared to cefepime or meropenem

15 Jan, 2021 | 08:24h | UTC

Risk of acute kidney injury and Clostridioides difficile infection with piperacillin/tazobactam, cefepime and meropenem with or without vancomycin – Clinical Infectious Diseases

 

Commentary on Twitter

 

Systematic review: Oral hygiene care with chlorhexidine mouthwash or gel in critically ill patients probably reduces the incidence of developing ventilator-associated pneumonia

15 Jan, 2021 | 08:09h | UTC

Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia – Cochrane Library

Summary: Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia – Cochrane Library

 

No ICU beds? Expect double the number of Covid-19 deaths

14 Jan, 2021 | 02:05h | UTC

No ICU beds? Expect double the number of Covid-19 deaths. – Vox

 

Guideline: Malignant hyperthermia 2020

14 Jan, 2021 | 01:45h | UTC

Malignant hyperthermia 2020: Guideline from the Association of Anaesthetists – Anaesthesia

 

A randomized trial of albumin infusion to prevent intradialytic hypotension in hospitalized hypoalbuminemic patients

14 Jan, 2021 | 01:42h | UTC

A randomized trial of albumin infusion to prevent intradialytic hypotension in hospitalized hypoalbuminemic patients – Critical Care

 

Confirmed reinfection with SARS-CoV-2 variant VOC-202012/01

13 Jan, 2021 | 02:30h | UTC

Confirmed Reinfection with SARS-CoV-2 Variant VOC-202012/01 – Clinical Infectious Diseases

 

Commentary on Twitter

 

Six RCTs to answer one question: what is the role of tocilizumab in COVID-19?

13 Jan, 2021 | 02:28h | UTC

Six RCTs to answer one question: what is the role of tocilizumab in COVID-19? – PulmCrit

Related (study and commentaries): Randomized trial: Arthritis drugs improve survival in critically ill patients with Covid-19

 

HEAR or HEART Pathway – Can We Drop Troponin?

13 Jan, 2021 | 01:59h | UTC

HEAR or HEART Pathway – Can We Drop Troponin? – Journal Feed

Original Study: Identification of very low-risk acute chest pain patients without troponin testing – Emergency Medicine Journal

 

Observational study: Surgical decompression within 24 h of acute spinal cord injury is associated with improved sensorimotor recovery

13 Jan, 2021 | 01:49h | UTC

The influence of timing of surgical decompression for acute spinal cord injury: a pooled analysis of individual patient data – The Lancet Neurology (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Blood plasma treatment has limited effect for sickest COVID-19 patients

12 Jan, 2021 | 02:07h | UTC

Blood plasma treatment has limited effect for sickest COVID-19 patients – Imperial College London

See also: Expert reaction to REMAP-CAP recruitment of severely ill COVID-19 patients into convalescent plasma trial being paused after initial analysis suggested it did not improve outcomes – Science Media Centre AND Trial of COVID-19 blood plasma finds no benefit in severely ill patients – Reuters

 

Randomized trial: Plasma therapy administered early is beneficial in high-risk elderly patients

12 Jan, 2021 | 02:05h | UTC

Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults – New England Journal of Medicine

Commentaries: Early convalescent plasma may lower risk of severe COVID in seniors – CIDRAP AND Covid-19: Early Plasma Treatment Improved Outcomes in Older Patients – Physician’s Weekly

 

Commentaries on Twitter

 

Randomized trial: Renin–angiotensin system inhibitors can be safely continued in patients admitted to hospital with COVID-19

12 Jan, 2021 | 01:59h | UTC

Continuation versus discontinuation of renin–angiotensin system inhibitors in patients admitted to hospital with COVID-19: a prospective, randomised, open-label trial – The Lancet Respiratory Medicine

Commentary: Commonly used blood pressure medications safe for COVID-19 patients, study finds – University of Pennsylvania School of Medicine

 

 

Cohort study: Prevalence and risk factors for delirium in critically ill patients with COVID-19

12 Jan, 2021 | 01:55h | UTC

Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study – The Lancet Respiratory Medicine

Commentaries: Sedation in mechanically ventilated patients with COVID-19 – The Lancet Respiratory Medicine AND Large study finds higher burden of acute brain dysfunction for COVID-19 ICU patients – Vanderbilt University Medical Center

 

Artificial intelligence in telemetry: What clinicians should know

12 Jan, 2021 | 01:21h | UTC

Artificial intelligence in telemetry: what clinicians should know – Intensive Care Medicine

 

Commentary on Twitter

 

[Preprint] Randomized trial: Arthritis drugs improve survival in critically ill patients with Covid-19

10 Jan, 2021 | 20:56h | UTC

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 – Preliminary report – medRxiv

Commentaries: Covid-19: Arthritis drugs improve survival in intensive care patients, shows study – The BMJ AND Arthritis drugs could help save lives of Covid patients, research finds – The Guardian AND Expert comment – Two potentially life-saving drugs for critically ill COVID-19 patients – London School of Hygiene & Tropical Medicine

 

Commentary on Twitter

 

Randomized trial: Neutralizing monoclonal antibody not efficacious among hospitalized patients with covid-19

10 Jan, 2021 | 20:55h | UTC

A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19 – New England Journal of Medicine

Commentaries: Covid-19: Trial of LY-CoV555 Stopped for Futility – Physician’s Weekly AND Results of NIH-sponsored ACTIV-3 trial published – NIH News Releases AND Bamlanivimab Flops in Hospitalized COVID-19 Patients – MedPage Today (free registration required)

 

[Press release – results not published yet] International trials of blood thinners in critically ill COVID-19 patients pause due to futility

10 Jan, 2021 | 20:44h | UTC

International trials of blood thinners in critically ill COVID-19 patients pause due to futility – NIH News Releases

 

Commentary on Twitter

 

Randomized trial: Ultra-early tranexamic acid does not improve outcomes after subarachnoid hemorrhage

10 Jan, 2021 | 21:02h | UTC

Ultra-early tranexamic acid after subarachnoid haemorrhage (ULTRA): a randomised controlled trial – The Lancet (link to abstract – $ for full-text)

 

 

Meta-analysis: Effectiveness of bundle interventions on ICU delirium

10 Jan, 2021 | 20:16h | UTC

Effectiveness of Bundle Interventions on ICU Delirium: A Meta-Analysis – Critical Care Medicine

Commentary: ICU bundles do not appear to improve delirium but may help other outcomes – ACP Hospitalist

 

Commentary on Twitter

 

NICE Guideline: Do not use Vitamin D to prevent or treat COVID 19

18 Dec, 2020 | 10:03h | UTC

COVID-19 rapid guideline: vitamin D – National Institute for Health and Care Excellence

News release: NICE, PHE and SACN publish rapid COVID-19 guidance on vitamin D

Commentaries: Covid and vitamin D: ‘Not enough evidence’ for treatment – BBC AND Covid-19: Evidence is lacking to support vitamin D’s role in treatment and prevention – The BMJ

 

Commentary on Twitter

https://twitter.com/onisillos/status/1339485382501666816

 

“Racial Bias in Pulse Oximetry Measurement”. In two large cohorts, Black patients had nearly three times the frequency of occult hypoxemia that was not detected by pulse oximetry as White patients

18 Dec, 2020 | 10:01h | UTC

Racial Bias in Pulse Oximetry Measurement – New England Journal of Medicine

Commentary: Devices Used In COVID-19 Treatment Can Give Errors For Patients With Dark Skin – NPR

 

Commentary on Twitter (thread – click for more)

 

COVID 5 times deadlier than flu for hospital patients, study finds

18 Dec, 2020 | 09:53h | UTC

COVID 5 times deadlier than flu for hospital patients, study finds – CIDRAP

Original study: Comparative evaluation of clinical manifestations and risk of death in patients admitted to hospital with covid-19 and seasonal influenza: cohort study – The BMJ

 

Commentary on Twitter

 

Brazilian guidelines for the management of brain-dead potential organ donors

17 Dec, 2020 | 09:00h | UTC

Brazilian guidelines for the management of brain-dead potential organ donors. The task force of the AMIB, ABTO, BRICNet, and the General Coordination of the National Transplant System – Annals of Intensive Care

 

Randomized trial: Dexamethasone for chronic subdural hematoma resulted in fewer favorable outcomes and more adverse events than placebo at 6 months

17 Dec, 2020 | 09:02h | UTC

Trial of Dexamethasone for Chronic Subdural Hematoma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Dexamethasone should be avoided in patients with chronic subdural haematoma – University of Cambridge AND Dexamethasone for Chronic Subdural Hematoma? – NEJM Journal Watch

 

Commentary on Twitter

 

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