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Critical Care & Emergencies (all articles)

Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients

12 Apr, 2021 | 01:23h | UTC

Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients – Critical Care

 

Commentary on Twitter

 

Another study shows intravenous radiocontrast use is not associated with reduced kidney function

12 Apr, 2021 | 00:44h | UTC

Association of Intravenous Radiocontrast With Kidney Function: A Regression Discontinuity Analysis – JAMA Internal Medicine

Commentaries: Radiocontrast Exposure Safe for Kidney Function – HCP Live AND Exposure to contrast on CTPA doesn’t cause long-term kidney injury – AuntMinnie

Related: ACR/NKF Consensus Statement: “The Risk of Acute Kidney Injury Developing in Patients with Reduced Kidney Function Following Exposure to Intravenous Iodinated Contrast Media has Been Overstated” (Guideline and commentaries)

 

Commentary on Twitter (thread – click for more)

 

M-A: Treatment for bleeding esophageal varices in people with decompensated liver cirrhosis

12 Apr, 2021 | 00:39h | UTC

Treatment for bleeding oesophageal varices in people with decompensated liver cirrhosis: a network meta‐analysis – Cochrane Library

Summary: Treatment for bleeding from enlarged veins in the oesophagus (food pipe) in people with advanced scarring of the liver – Cochrane Library

Related Cochrane Reviews: M-A: Secondary prevention of variceal bleeding in adults with previous esophageal variceal bleeding due to decompensated liver cirrhosis AND Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network meta‐analysis – Cochrane Library

 

Japanese doctors perform world’s first living donor lung transplant to a Covid-19 patient

12 Apr, 2021 | 01:12h | UTC

Japanese doctors perform world’s first living donor lung transplant to a Covid-19 patient – CNN

 

Comprehensive Review | Pneumonia

9 Apr, 2021 | 03:14h | UTC

Pneumonia – Nature Reviews Disease Primers (free for a limited period)

Try this link if the above is paywalled.

 

Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19

12 Apr, 2021 | 01:24h | UTC

Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial – The Lancet Respiratory Medicine

Commentary: Early treatment with inhaled budesonide to prevent clinical deterioration in patients with COVID-19 – The Lancet Respiratory Medicine

 

Commentary on Twitter

 

[Preprint] CoronaVac is 50% effective for reducing symptomatic SARS-CoV-2 infection after the first dose in the setting of high P.1 variant transmission in Brazil

9 Apr, 2021 | 03:36h | UTC

Effectiveness of CoronaVac in the setting of high SARS-CoV-2 P.1 variant transmission in Brazil: A test-negative case-control study – medRxiv

 

Commentary on Twitter (thread – click for more)

 

Commentary | Distinguishing the real from the hyperglycemia: does COVID-19 induce diabetes?

9 Apr, 2021 | 03:28h | UTC

Distinguishing the real from the hyperglycaemia: does COVID-19 induce diabetes? – The Lancet Diabetes & Endocrinology

 

The NIH COVID-19 Treatment Guidelines Panel’s Statement on the Emergency Use Authorization of Anti-SARS-CoV-2 Monoclonal Antibodies for the Treatment of COVID-19

9 Apr, 2021 | 03:35h | UTC

The COVID-19 Treatment Guidelines Panel’s Statement on the Emergency Use Authorization of Anti-SARS-CoV-2 Monoclonal Antibodies for the Treatment of COVID-19 – NIH COVID-19 Treatment Guidelines

 

Review: Care for the organ transplant recipient on the intensive care unit

8 Apr, 2021 | 08:36h | UTC

Care for the organ transplant recipient on the intensive care unit – Journal of Critical Care

 

Study finds low risk of venous thromboembolism in outpatients with Covid-19 – researchers advise against the use of anticoagulants outside clinical trials

8 Apr, 2021 | 08:59h | UTC

Incidence of 30-Day Venous Thromboembolism in Adults Tested for SARS-CoV-2 Infection in an Integrated Health Care System in Northern California – JAMA Internal Medicine

Commentaries: VTE Related to SARS-CoV-2 Infection Less Of a Problem in Outpatients – TCTMD AND No Increase Seen in Outpatient VTE for SARS-CoV-2-Positive Patients – Physician’s Weekly

 

Commentary on Twitter (thread – Click for more)

https://twitter.com/gjgeersing/status/1379740743951134721

 

ACP Guidance: Appropriate Use of Short-Course Antibiotics in Common Infections

6 Apr, 2021 | 01:12h | UTC

Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians – Annals of Internal Medicine

Summary for Patients: Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians

News release: ACP best practice advice: Shorter course of antibiotics may be appropriate for some common infection – American College of Physicians

 

Guidance on syndrome of Thrombosis and Thrombocytopenia occurring after coronavirus Vaccination

7 Apr, 2021 | 01:48h | UTC

Guidance produced from the Expert Haematology Panel (EHP) focussed on syndrome of Thrombosis and Thrombocytopenia occurring after coronavirus Vaccination – British Society of Haematology

Related: Exceedingly rare side effects reported with AstraZeneca vaccine in the UK – 22 cases of cerebral venous sinus thrombosis with low levels of platelets out of 18 million vaccinated individuals

 

Commentary on Twitter

https://twitter.com/trishgreenhalgh/status/1379414362700517385

 

Large study showed no association between blood group types and increased risk of Covid-19

7 Apr, 2021 | 01:41h | UTC

Association of Sociodemographic Factors and Blood Group Type With Risk of COVID-19 in a US Population – JAMA Network Open

 

Commentary on Twitter

 

Diagnostic Test Interpretation: Evaluation of Hypokalemia

6 Apr, 2021 | 01:07h | UTC

Evaluation of Hypokalemia – JAMA (free for a limited period)

 

Consensus Statement: Perioperative management of patients with pulmonary hypertension undergoing non-cardiothoracic, non-obstetric surgery

6 Apr, 2021 | 00:54h | UTC

Perioperative management of patients with pulmonary hypertension undergoing non-cardiothoracic, non-obstetric surgery: a systematic review and expert consensus statement – British Journal of Anaesthesia

 

M-A: Colchicine administration for percutaneous coronary intervention

6 Apr, 2021 | 00:58h | UTC

Colchicine administration for percutaneous coronary intervention: A meta-analysis of randomized controlled trials – The American Journal of Emergency Medicine (link to abstract – $ for full-text)

Related: Efficacy and safety of low-dose colchicine in patients with coronary disease: a systematic review and meta-analysis of randomized trials – European Heart Journal (link to abstract – $ for full-text)

 

M-A: High versus low PEEP levels for mechanically ventilated adult patients with acute lung injury and ARDS

5 Apr, 2021 | 01:19h | UTC

High versus low positive end‐expiratory pressure (PEEP) levels for mechanically ventilated adult patients with acute lung injury and acute respiratory distress syndrome – Cochrane Library

Summary: Effects of higher versus lower levels of pressure in the lungs at the end of each breath during mechanical ventilation in patients with acute respiratory distress syndrome (ARDS) – Cochrane Library

 

Cohort Study: Selected patients with Covid-19 can be safely discharged on home oxygen, with low mortality and readmission rates

5 Apr, 2021 | 01:52h | UTC

Mortality and Readmission Rates Among Patients With COVID-19 After Discharge From Acute Care Setting With Supplemental Oxygen – JAMA Network Open

Video: Home Oxygen Instructions for Discharged Patients With COVID-19

Commentaries: Covid-19: Ambulatory Management with Home Oxygen Results in Low Mortality, Low Readmissions – Physician’s Weekly AND Mortality, readmission low with COVID-19 discharge on home oxygen – HealthDay

 

Commentaries on Twitter

 

Cohort study: High thrombotic risk in cancer patients receiving immunotherapy

5 Apr, 2021 | 01:08h | UTC

High thrombotic risk in cancer patients receiving immunotherapy – Medical University of Vienna

Original study: Incidence, risk factors, and outcomes of venous and arterial thromboembolism in immune checkpoint inhibitor therapy – Blood

 

Early outcomes after lung transplantation for severe COVID-19: a series of the first consecutive cases from four countries

5 Apr, 2021 | 01:49h | UTC

Early outcomes after lung transplantation for severe COVID-19: a series of the first consecutive cases from four countries – The Lancet Respiratory Medicine

Commentary: Criteria for selecting COVID-19 patients for lung lung transplantation – Medical University of Vienna

 

Commentary on Twitter

 

Exceedingly rare side effects reported with AstraZeneca vaccine in the UK – 22 cases of cerebral venous sinus thrombosis with low levels of platelets out of 18 million vaccinated individuals

5 Apr, 2021 | 01:45h | UTC

Covid-19: Seven UK blood clot deaths after AstraZeneca vaccine – BBC

Original report: Coronavirus vaccine – weekly summary of Yellow Card reporting – Medicines and Healthcare products Regulatory Agency

Related opinion: Undermining the AstraZeneca jab is a dangerous act of political folly – The Guardian

“Based on current experience, the expected benefits of both COVID-19 vaccines in preventing COVID-19 and its serious complications far outweigh any known side effects”

 

Many hospitalized Covid-19 patients are given antibiotics. That’s a problem

5 Apr, 2021 | 01:33h | UTC

Many hospitalized Covid-19 patients are given antibiotics. That’s a problem – STAT

 

RCT: Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury – waiting too long can be deleterious

2 Apr, 2021 | 09:17h | UTC

Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial – The Lancet (link to abstract – $ for full-text)

 

Effects of the COVID-19 pandemic on maternal and perinatal outcomes: a systematic review and meta-analysis

2 Apr, 2021 | 09:23h | UTC

Effects of the COVID-19 pandemic on maternal and perinatal outcomes: a systematic review and meta-analysis – The Lancet Global Health

Commentaries: Covid-19 led to a global increase in stillbirths, maternal mortality, and depression, review finds – CNN AND COVID-19 pandemic and health-care disruptions: count the most vulnerable – The Lancet Global Health

 

Commentary on Twitter

 

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