Critical Care & Emergencies (all articles)
RCT: Azithromycin provides no benefit for community treatment of patients with suspected COVID-19
7 Mar, 2021 | 20:15h | UTC
Commentary on Twitter
The PRINCIPLE trial publishes its first peer reviewed paper, showing results from the study of azithromycin as a treatment for Covid-19 in the community. @TheLancet #UrgentCovidResearch #PRINCIPLETrial
?https://t.co/qKRI5PVpQk pic.twitter.com/BVQztDSvSC— OxPrimaryCareSci (@OxPrimaryCare) March 5, 2021
[Preprint] Genomics and epidemiology of a novel SARS-CoV-2 lineage P.1 – “P.1 may be 1.4–2.2 times more transmissible and 25-61% more likely to evade protective immunity elicited by previous infection with non-P.1 lineages”
7 Mar, 2021 | 20:05h | UTCGenomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil – medRxiv
Commentary: Brazil variant can reinfect virus survivors; COVID-19 vaccine antibodies pass into breast milk – Reuters
Diagnosis of non-consensus transient ischemic attacks with focal, negative, and non-progressive symptoms: population-based validation by investigation and prognosis
7 Mar, 2021 | 19:32h | UTC
Commentary on Twitter
Some patients present with symptoms that are considered not definitive for TIA (isolated dysarthria, vertigo, etc). Are these patients at risk for later stroke? Fascinating results in @TheLancet from the Oxford Vascular Study@ESOstroke @WorldStrokeOrg https://t.co/l0tJXseE3Y
— Seemant Chaturvedi (@ChaturvediNeuro) March 5, 2021
[Preprint] Increased risk of hospitalization associated with infection with SARS-CoV-2 Lineage B.1.1.7 in Denmark
7 Mar, 2021 | 19:46h | UTC
Commentary on Twitter (thread – click for more)
?~64% MORE SEVERE—The already more contagious #B117 variant from ?? is now found to increase risk of #COVID19 hospitalization by 64% versus other strains, says Denmark’s ?? CDC. Denmark sequences every cases—their data is the best, & now most worrisome.? https://t.co/F6w2JYEUnM pic.twitter.com/mngJoTBZtl
— Eric Feigl-Ding (@DrEricDing) March 4, 2021
Therapy options for adrenal insufficiency and recommendations for the management of adrenal crisis
7 Mar, 2021 | 19:00h | UTC
Prevention of Clostridioides difficile in hospitals: A position paper of the International Society for Infectious Diseases
7 Mar, 2021 | 18:58h | UTC
RCT: Ivermectin does not improve time to resolution of symptoms among adults with mild COVID-19
5 Mar, 2021 | 08:53h | UTCCommentaries: Ivermectin: Yet Another Fad Runs Into The Brick Wall Known As “Actual Science” – Brief-19 AND Ivermectin doesn’t speed recovery from mild COVID-19, study shows – CIDRAP
Scientific Statement: Invasive management of acute myocardial infarction complicated by cardiogenic shock
5 Mar, 2021 | 08:33h | UTC
Respiratory microbiome in mechanically ventilated patients: a narrative review
5 Mar, 2021 | 08:14h | UTC
Commentary on Twitter
Respiratory microbiome on mechanical ventilation:
➡️definition
➡️state of the art: lung bacterial microbiota in #ICU, invasive mechanical ventilation, #ARDS, lung nosocomial infections & VAP, lung mycobiota, virome
➡️perspectives & clinical applicationshttps://t.co/fO7ggoJNUk pic.twitter.com/0W8hLNkuSO— Intens Care Med (@yourICM) February 9, 2021
RCT: Mixed findings with Terlipressin plus Albumin for the treatment of Type 1 hepatorenal syndrome
4 Mar, 2021 | 08:35h | UTCTerlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome – New England Journal of Medicine (link to abstract – $ for full-text)
RCT: Albumin provides no benefit to hospitalized patients with decompensated cirrhosis
4 Mar, 2021 | 08:37h | UTCA Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Albumin provides no benefit to hospitalized patients with advanced liver disease – University College London
RCT: Inspiratory muscle training with an electronic resistive loading device improves prolonged weaning outcomes
4 Mar, 2021 | 08:10h | UTCInspiratory Muscle Training With an Electronic Resistive Loading Device Improves Prolonged Weaning Outcomes in a Randomized Controlled Trial – Critical Care Medicine (link to abstract – $ for full-text)
Commentaries on Twitter
In 101 patients on MV, inspiratory muscle training vs T-piece led to better maximal inspiratory pressure, weaning success, and 60d-survival.
Thanks to @CritCareReviews https://t.co/8RR9e8nDVm— Peter Nydahl (@NydahlPeter) January 2, 2021
Inspiratory muscle training in patients on prolonged weaning increases muscle strength and is associated with a higher 60d survival rate and successful weaning. Another contribution from Brazilian physiotherapy! Kudos to @brunoguimaraesp and team! https://t.co/LEw7vGSZey
— Angelo Roncalli (@curso_vm) December 25, 2020
NIH halts trial of COVID-19 convalescent plasma in emergency department patients with mild symptoms
3 Mar, 2021 | 08:55h | UTC
COVID-19 research in critical care: the good, the bad, and the ugly
3 Mar, 2021 | 08:49h | UTCCOVID-19 research in critical care: the good, the bad, and the ugly – Intensive Care Medicine
Commentary on Twitter
Challenges, achievements, directions of critical care research in #pandemic, from early small #COVID19 studies (incomplete/inconsistent data), to large-scale registries, through overlapping/competing & underpowered trials, often with poor LMIC involvement.https://t.co/EyEui4pKPi pic.twitter.com/jUDXAVaD5z
— Intens Care Med (@yourICM) March 1, 2021
More transmissible and evasive SARS-CoV-2 variant growing rapidly in Brazil
3 Mar, 2021 | 08:53h | UTCOriginal study (preprint): Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil
Commentaries: Covid Brazil variant ‘may spread more easily’ – BBC AND Brazil coronavirus variant: what is it and why is it a concern? An expert explains – The Conversation
Using Bayesian Methods to Augment the Interpretation of Critical Care Trials. An Overview of Theory and Example Reanalysis of the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial
3 Mar, 2021 | 08:36h | UTC
Commentary on Twitter
I love this paper on Bayes.
Aren’t trials just like medical tests: they update our prior knowledge or beliefs?
If you can discuss a trial using its p-wave or confidence intervals, why not its posterior probabilities given *justified* priors.
(Yes, I am enthralled!) https://t.co/w1ym9jgQD5
— John Mandrola, MD (@drjohnm) March 1, 2021
RCT: High flow oxygen does not change the risk of mortality in patients with a suspected acute coronary syndrome
3 Mar, 2021 | 08:37h | UTC
Commentary on Twitter
Supplementary high flow oxygen given for ischaemic symptoms to patients with suspected acute coronary syndrome was not associated with a change in 30 day mortality, finds new #BMJResearchhttps://t.co/CDhfFyVL88
— The BMJ (@bmj_latest) March 2, 2021
M-A: Role of Cilostazol in prevention of vasospasm following aneurysmal subarachnoid hemorrhage
3 Mar, 2021 | 08:16h | UTCRole of Cilostazol in prevention of vasospasm following aneurysmal subarachnoid hemorrhage – A systematic review, meta-analysis and trial sequential analysis – World Neurosurgery (link to abstract – $ for full-text)
Studies: Secondary infections in patients with severe COVID-19
2 Mar, 2021 | 02:05h | UTCSecondary Infections in Patients with Severe COVID-19 – NEJM Journal Watch
Scaling up COVID-19 rapid antigen tests: promises and challenges
2 Mar, 2021 | 02:09h | UTCScaling up COVID-19 rapid antigen tests: promises and challenges – The Lancet Infectious Diseases
Review: Cardiovascular biomarkers in patients with COVID-19
2 Mar, 2021 | 02:07h | UTC
Commentary on Twitter
Cardiovascular #biomarkers in patients with #COVID19 – review article by @escardio Study Group on Biomarkers in Cardiology of the Acute Cardiovascular Care Association #ACVC_ESC https://t.co/9Mcx24fX8y#EHJACVC #cardiotwitter #medtwitter pic.twitter.com/y7kD2Oylrj
— European Society of Cardiology Journals (@ESC_Journals) March 1, 2021
Serious bradycardia and Remdesivir for COVID-19: a new safety concern
2 Mar, 2021 | 02:06h | UTC
Commentary on Twitter
⛔A new safety concern⛔
New ? post-marketing study @CMIJournal suggests that the use of remdesivir is significantly associated with an increased risk of reporting serious bradycardia compared with HCQ,LPV/RTV, tocilizumab or glucocorticoids #IDTwitter https://t.co/npLMchifEM— Antibiotic Steward? Bassam Ghanem (@ABsteward) February 27, 2021
Consensus Document: Venous thromboembolism prophylaxis in the trauma intensive care unit
2 Mar, 2021 | 01:52h | UTC
Guideline: Treatment of methicillin-resistant Staphylococcus aureus (MRSA)
2 Mar, 2021 | 01:50h | UTC
Commentary on Twitter
We're delighted to publish the first update of UK #MRSA guidelines in more than a decade. Please share with your contacts & colleagues .
Treatment of methicillin-resistant Staphylococcus aureus (MRSA): updated guidelines from the UKhttps://t.co/3o3OVIdLuB #JACAMRNews #IDtwitter pic.twitter.com/GGlv1C1T1g
— JAC-AMR (@jac_amr) February 4, 2021
Cohort study: Recovery of consciousness and functional outcome in moderate and severe traumatic brain injury
2 Mar, 2021 | 01:34h | UTCRecovery of Consciousness and Functional Outcome in Moderate and Severe Traumatic Brain Injury – JAMA Neurology (free for a limited period)
Editorial: Holding Out Hope After Traumatic Brain Injury (free for a limited period)
Commentary on Twitter
In this study in @JAMANeuro:
most individuals who became comatose after moderate/severe traumatic brain injury recovered consciousness and ~50% regained functional independence, cautioning early decisions to withdraw/withhold treatment in these patients. https://t.co/jIz38AwCXO— Saleh Almenawer, MD (@SAlmenawer) March 1, 2021