Critical Care & Emergencies (all articles)
COVID-19 Vaccine Janssen: EMA finds possible link to very rare cases of unusual blood clots with low blood platelets
21 Apr, 2021 | 07:07h | UTCCommentary: Johnson & Johnson vaccine: EU regulator says blood clot very rare side effect – BBC
Commentary on Twitter
https://twitter.com/hildabast/status/1384535676482297865
Vaccine-induced Immune Thrombotic Thrombocytopenia: Frequently Asked Questions
21 Apr, 2021 | 07:09h | UTC
M-A: Corticosteroids in COVID-19 and non-COVID-19 ARDS
20 Apr, 2021 | 06:11h | UTC
Guideline Synopsis: Management of Acute Coronary Syndromes in Patients Without Persistent ST-Segment Elevation
21 Apr, 2021 | 06:41h | UTCManagement of Acute Coronary Syndromes in Patients Without Persistent ST-Segment Elevation – JAMA (free for a limited period)
Original guideline: #ESCCongress – 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation AND Summary: The ‘Ten Commandments’ for the 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation – European Heart Journal
Outcome of acute kidney injury: how to make a difference?
20 Apr, 2021 | 05:26h | UTCOutcome of acute kidney injury: how to make a difference? – Annals of Intensive Care
RCT: No benefit from second intravenous immunoglobulin dose in patients with Guillain-Barré syndrome with poor prognosis
18 Apr, 2021 | 21:21h | UTCSecond intravenous immunoglobulin dose in patients with Guillain-Barré syndrome with poor prognosis (SID-GBS): a double-blind, randomised, placebo-controlled trial – The Lancet Neurology (link to abstract – $ for full-text)
Study Commentary | What if the EHR Age-Adjusts D-dimer for You?
18 Apr, 2021 | 21:04h | UTCWhat if the EHR Age-Adjusts D-dimer for You? – Journal Feed
Original study: Multi-center implementation of automated age-adjusted D-dimer results reduces unnecessary PE imaging – The American Journal of Emergency Medicine (link to abstract – $ for full-text)
Hemodialysis Emergencies: Core Curriculum 2021
16 Apr, 2021 | 06:13h | UTCHemodialysis Emergencies: Core Curriculum 2021 – American Journal of Kidney Diseases
Commentary on Twitter
Hemodialysis Emergencies: Core Curriculum 2021https://t.co/BOQrsABOU3 (FREE)@KeikoGNeph @Mike_J_Choi @MedStarGUH #Hemodialysis pic.twitter.com/KYZRCqm5OA
— AJKD (@AJKDonline) March 26, 2021
Advances in Clinical Cardiology 2020: A Summary of Key Clinical Trials
16 Apr, 2021 | 06:14h | UTCAdvances in Clinical Cardiology 2020: A Summary of Key Clinical Trials – Advances in Therapy
Evolving changes in mortality of 13,301 critically ill adult patients with COVID-19 over 8 months
16 Apr, 2021 | 06:35h | UTC
Commentary on Twitter
Our paper on covid-19 pandemic trends in the first 8 months in the pandemic at @yourICM. Patients are getting younger, less frail, and mortality decreased over time. Very poor outcomes for elder frail patients. https://t.co/DHJvr22zFl
— Fernando Zampieri (@f_g_zampieri) April 14, 2021
M-A: Treatment with hydroxychloroquine is associated with increased mortality in COVID-19 patients
16 Apr, 2021 | 06:30h | UTC
Commentaries on Twitter
The use of hydroxychloroquine in COVID19 will be remembered as one of the worst examples of medicine going against its core principle:
First Do No Harm. https://t.co/PGq4D5pJ1H— Maurizio Cecconi (@DrMCecconi) April 15, 2021
What collaboration can achieve
Just out in @NatureComms our meta-analysis of 14 unpublished & 14 published RCTs on Hydroxychloroquine/ Choloroquine
Thanks so much to the great team – and special thanks for rapidly sharing the data of unpublished trials!https://t.co/Dg1DmAx1Kq
— Lars G. Hemkens (@LGHemkens) April 15, 2021
Perspective | Ivermectin is the new Hydroxychorloquine
16 Apr, 2021 | 06:28h | UTCIvermectin is the new Hydroxychorloquine – Science-Based Medicine
Were pregnant women more affected by COVID-19 in the second wave of the pandemic?
16 Apr, 2021 | 06:24h | UTCWere pregnant women more affected by COVID-19 in the second wave of the pandemic? – The Lancet
Pandemic Boosts an Old Idea—Bringing Acute Care to the Patient
15 Apr, 2021 | 06:51h | UTCPandemic Boosts an Old Idea—Bringing Acute Care to the Patient – JAMA
Related studies: Cohort Study: Selected patients with Covid-19 can be safely discharged on home oxygen, with low mortality and readmission rates AND Association of a Bundled Hospital-at-Home and 30-Day Postacute Transitional Care Program With Clinical Outcomes and Patient Experiences – JAMA Internal Medicine
Case Report: Thrombotic Thrombocytopenia after Johnson & Johnson Vaccine
15 Apr, 2021 | 07:02h | UTCThrombotic Thrombocytopenia after Ad26.COV2.S Vaccination – New England Journal of Medicine
Related: U.S. regulators pause Johnson & Johnson vaccine rollout over rare (1 in a million) cases of blood clots AND 4 Things to Know About the J&J Covid Vaccine Pause – Kaiser Health News AND Why Johnson & Johnson shots were paused — and why that’s so confusing – Vox AND Is it the adenovirus vaccine technology, used by AstraZeneca and Johnson & Johnson, causing blood clots? There’s no evidence yet – The Conversation
New studies suggest SARS-CoV-2 variant B.1.1.7 is not more deadly, just more transmissible
14 Apr, 2021 | 02:12h | UTCCommentaries: Expert reaction to two papers looking at the transmissibility and severity of the B.1.1.7 variant – Science Media Centre AND UK coronavirus variant not more deadly, just spreads more easily, studies find – LiveScience
Study: Protocoled time-limited trials among critically ill patients with advanced medical illnesses were associated with reduction of nonbeneficial ICU treatments
13 Apr, 2021 | 05:16h | UTCEvaluation of Time-Limited Trials Among Critically Ill Patients With Advanced Medical Illnesses and Reduction of Nonbeneficial ICU Treatments – JAMA Internal Medicine (free for a limited period)
Commentary: Time-Limited Trials and Potentially Nonbeneficial Treatment in the ICU—Willing to Wait for It – JAMA Internal Medicine AND Time-limited trials may decrease the length of stay of critically ill patients in the intensive care unit – 2 Minute Medicine
Author interview: Time-Limited Trials Among Patients With Advanced Illness to Reduce Nonbeneficial ICU Treatments
Related review: Time-limited trial of intensive care treatment: an overview of current literature – Intensive Care Medicine
IDSA Guidance on the Treatment of ESBL Enterobacterales, Carbapenem-Resistant Enterobacterales, and Pseudomonas
13 Apr, 2021 | 05:11h | UTC
Long-term mortality of elderly patients after intensive care unit admission for COVID-19
14 Apr, 2021 | 02:09h | UTC
Commentary on Twitter
Long-term outcome of elderly (≥ 80y) #COVID19 pts admitted to #ICU: 6-month mortality ➡️ 72% (likely underestimated) at upper end of recent literature on older critical pts. Data supporting more informed goals-of-care decisions for this #SARSCoV2 cohort?https://t.co/mIKNxNpdC8 pic.twitter.com/OQS5SN5FXR
— Intensive Care Medicine (@yourICM) April 13, 2021
RCT: Inhaled budesonide shortens recovery time in non-hospitalized patients with COVID-19
13 Apr, 2021 | 05:30h | UTCOriginal study (preprint): Inhaled budesonide for COVID-19 in people at higher risk of adverse outcomes in the community: interim analyses from the PRINCIPLE trial – medRxiv
Commentary: Covid: Asthma drug ‘speeds up recovery at home’ – BBC
Related study: Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19 (study and commentaries)
Cohort Study: Effects of fluoroquinolones on outcomes of patients with aortic dissection or aneurysm
13 Apr, 2021 | 05:05h | UTCRelated: Another study suggests fluoroquinolone use may increase the risk of development of aortic aneurysms (study and commentaries) AND Link between fluoroquinolones, aorta problems may not be as strong as thought AND Study: Oral Fluoroquinolones and Risk of Mitral and Aortic Regurgitation AND FDA Warns About Increased Risk of Aortic Dissection and Ruptures of Aortic Aneurism with Fluoroquinolones AND Meta-analysis: Fluoroquinolones and the Risk of Aortopathy AND Study: Oral Fluoroquinolone and the Risk of Aortic Dissection AND Research: Fluoroquinolone use and risk of aortic aneurysm and dissection
M-A: Post-extubation oxygenation strategies in acute respiratory failure – NPPV or HFNC may reduce the risk of endotracheal reintubation but not mortality
12 Apr, 2021 | 00:42h | UTC
AHA/ASA Scientific Statement: Perioperative Neurological Evaluation and Management to Lower the Risk of Acute Stroke in Patients Undergoing Noncardiac, Nonneurological Surgery
12 Apr, 2021 | 00:50h | UTC
Commentary on Twitter
NEW GUIDELINE – now codifies what has been discussed for a while "If history of stroke exists, consider delaying elective surgery at least 6 mo
and preferably 9 mo from time of incident stroke." @SPAQIedu @LeeAFleisher @preopconsult @afedwardMD https://t.co/0ewdlPGVlj— Kurt Pfeifer (@KurtPfeifer) April 9, 2021
Cohort study: Postoperative in-hospital mortality of patients with COVID-19 infection was more than double that in patients without COVID-19
13 Apr, 2021 | 05:21h | UTCRelated: Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery AND Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk
[Press release – not published yet] Phase 3 prevention trial showed 81% reduced risk of symptomatic SARS-CoV-2 infections with subcutaneous administration of monoclonal antibodies
13 Apr, 2021 | 05:26h | UTCCommentaries: Regeneron says antibody cocktail prevented Covid when given as simple injection, not an IV – STAT AND Regeneron’s Covid mAb as a prophylactic injection: Reduced risk of symptomatic infection by 81% – Endpoint News