Critical Care & Emergencies (all articles)
Japanese doctors perform world’s first living donor lung transplant to a Covid-19 patient
12 Apr, 2021 | 01:12h | UTCJapanese doctors perform world’s first living donor lung transplant to a Covid-19 patient – CNN
Comprehensive Review | Pneumonia
9 Apr, 2021 | 03:14h | UTCPneumonia – Nature Reviews Disease Primers (free for a limited period)
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Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19
12 Apr, 2021 | 01:24h | UTC
Commentary on Twitter
NEW Research— Early administration of inhaled budesonide reduced the likelihood of needing urgent medical care and reduced time to recovery after early #COVID19
RCT from Mona Bafadhel & colleagues https://t.co/6cJogJs7rp pic.twitter.com/C1dhmTcexP
— The Lancet Respiratory Medicine (@LancetRespirMed) April 10, 2021
[Preprint] CoronaVac is 50% effective for reducing symptomatic SARS-CoV-2 infection after the first dose in the setting of high P.1 variant transmission in Brazil
9 Apr, 2021 | 03:36h | UTC
Commentary on Twitter (thread – click for more)
New 50% efficacy study of Brazil-predominant vaccine CoronaVac (by Sinovac) in Manaus ?? among healthcare workers when #P1 ~75% dominant. Not a trial, but the study found a 1st dose >=14-days efficacy of 50% on symptomatic #COVID19, ~32% if +asymptomatic. https://t.co/YMmZ3mmSDI pic.twitter.com/jwx5R627ys
— Eric Feigl-Ding (@DrEricDing) April 8, 2021
Commentary | Distinguishing the real from the hyperglycemia: does COVID-19 induce diabetes?
9 Apr, 2021 | 03:28h | UTC
The NIH COVID-19 Treatment Guidelines Panel’s Statement on the Emergency Use Authorization of Anti-SARS-CoV-2 Monoclonal Antibodies for the Treatment of COVID-19
9 Apr, 2021 | 03:35h | UTC
Review: Care for the organ transplant recipient on the intensive care unit
8 Apr, 2021 | 08:36h | UTCCare for the organ transplant recipient on the intensive care unit – Journal of Critical Care
Study finds low risk of venous thromboembolism in outpatients with Covid-19 – researchers advise against the use of anticoagulants outside clinical trials
8 Apr, 2021 | 08:59h | UTCCommentaries: VTE Related to SARS-CoV-2 Infection Less Of a Problem in Outpatients – TCTMD AND No Increase Seen in Outpatient VTE for SARS-CoV-2-Positive Patients – Physician’s Weekly
Commentary on Twitter (thread – Click for more)
Interesting report on VTE incidence in COVID-19 patients, starting with counting outside of the hospital. See https://t.co/XJvbrfHm6d … 1/n
— Geert-Jan Geersing (@gjgeersing) April 7, 2021
ACP Guidance: Appropriate Use of Short-Course Antibiotics in Common Infections
6 Apr, 2021 | 01:12h | UTCSummary for Patients: Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians
Guidance on syndrome of Thrombosis and Thrombocytopenia occurring after coronavirus Vaccination
7 Apr, 2021 | 01:48h | UTC
Commentary on Twitter
*CLINICIANS*
New guidance for suspected cases of thrombosis-thrombocytopaenia syndrome following COVID-19 vaccination. This is a very rare event but worth bookmarking as it also guides you on what is NOT likely to be a case.MT @Maherjane https://t.co/PHjFlB079y
— Trisha Greenhalgh ? #CovidIsAirborne (@trishgreenhalgh) April 6, 2021
Large study showed no association between blood group types and increased risk of Covid-19
7 Apr, 2021 | 01:41h | UTC
Commentary on Twitter
This case-control study found blood type A was not associated with higher nor type O with lower COVID-19 susceptibility or severity. Blood types were not prognostically useful. https://t.co/P8VpvQWuwE
— JAMA Network Open (@JAMANetworkOpen) April 6, 2021
Diagnostic Test Interpretation: Evaluation of Hypokalemia
6 Apr, 2021 | 01:07h | UTCEvaluation of Hypokalemia – JAMA (free for a limited period)
Consensus Statement: Perioperative management of patients with pulmonary hypertension undergoing non-cardiothoracic, non-obstetric surgery
6 Apr, 2021 | 00:54h | UTC
M-A: Colchicine administration for percutaneous coronary intervention
6 Apr, 2021 | 00:58h | UTCColchicine administration for percutaneous coronary intervention: A meta-analysis of randomized controlled trials – The American Journal of Emergency Medicine (link to abstract – $ for full-text)
Related: Efficacy and safety of low-dose colchicine in patients with coronary disease: a systematic review and meta-analysis of randomized trials – European Heart Journal (link to abstract – $ for full-text)
M-A: High versus low PEEP levels for mechanically ventilated adult patients with acute lung injury and ARDS
5 Apr, 2021 | 01:19h | UTC
Cohort Study: Selected patients with Covid-19 can be safely discharged on home oxygen, with low mortality and readmission rates
5 Apr, 2021 | 01:52h | UTCVideo: Home Oxygen Instructions for Discharged Patients With COVID-19
Commentaries: Covid-19: Ambulatory Management with Home Oxygen Results in Low Mortality, Low Readmissions – Physician’s Weekly AND Mortality, readmission low with COVID-19 discharge on home oxygen – HealthDay
Commentaries on Twitter
Is “HOME O2” safe in #COVID19? @JAMANetworkOpen
N=621 #COVID Pts D/Ced on O2 instead of being kept in hosp. 20% BMI>30, 33% HTN/DM. Only 1.2% 30-d Mort rate & only 8.5% returned for hosp admission. Safe is done right!https://t.co/clZAzEqWwy#medtwitter #CriticalCare #Nurse pic.twitter.com/EInhCdcN6f— WesElyMD (@WesElyMD) April 3, 2021
Cohort study finds #COVID19 patients discharged with home oxygen from the LA safety net public hospital system using an innovative program had similar outcomes to patients not requiring home oxygen. @BradSpellberg @LACUSCMedCenter https://t.co/kZrxVKHB5F
— JAMA Network Open (@JAMANetworkOpen) April 1, 2021
Cohort study: High thrombotic risk in cancer patients receiving immunotherapy
5 Apr, 2021 | 01:08h | UTCHigh thrombotic risk in cancer patients receiving immunotherapy – Medical University of Vienna
Original study: Incidence, risk factors, and outcomes of venous and arterial thromboembolism in immune checkpoint inhibitor therapy – Blood
Early outcomes after lung transplantation for severe COVID-19: a series of the first consecutive cases from four countries
5 Apr, 2021 | 01:49h | UTCCommentary: Criteria for selecting COVID-19 patients for lung lung transplantation – Medical University of Vienna
Commentary on Twitter
NEW Research—Lung transplantation is the only option for survival in some patients with severe, unresolving #COVID19-associated #ARDS
From Ankit Bharat & colleagues https://t.co/7u52IJSOIn, including a fantastic video abstract https://t.co/2cjfTLXR8R
— The Lancet Respiratory Medicine (@LancetRespirMed) April 1, 2021
Exceedingly rare side effects reported with AstraZeneca vaccine in the UK – 22 cases of cerebral venous sinus thrombosis with low levels of platelets out of 18 million vaccinated individuals
5 Apr, 2021 | 01:45h | UTCCovid-19: Seven UK blood clot deaths after AstraZeneca vaccine – BBC
Original report: Coronavirus vaccine – weekly summary of Yellow Card reporting – Medicines and Healthcare products Regulatory Agency
Related opinion: Undermining the AstraZeneca jab is a dangerous act of political folly – The Guardian
“Based on current experience, the expected benefits of both COVID-19 vaccines in preventing COVID-19 and its serious complications far outweigh any known side effects”
Many hospitalized Covid-19 patients are given antibiotics. That’s a problem
5 Apr, 2021 | 01:33h | UTCMany hospitalized Covid-19 patients are given antibiotics. That’s a problem – STAT
RCT: Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury – waiting too long can be deleterious
2 Apr, 2021 | 09:17h | UTCComparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial – The Lancet (link to abstract – $ for full-text)
Effects of the COVID-19 pandemic on maternal and perinatal outcomes: a systematic review and meta-analysis
2 Apr, 2021 | 09:23h | UTCCommentaries: Covid-19 led to a global increase in stillbirths, maternal mortality, and depression, review finds – CNN AND COVID-19 pandemic and health-care disruptions: count the most vulnerable – The Lancet Global Health
Commentary on Twitter
NEW—Pregnancy outcomes worsened during the #COVID19 pandemic worldwide, with an increase in maternal deaths, stillbirth, ruptured ectopic pregnancies, and maternal depression.
New review of 40 studies from 17 countries in @LancetGH: https://t.co/GWBohu6b6k pic.twitter.com/4RzgtShYeH
— The Lancet (@TheLancet) April 1, 2021
Rapid point-of-care tests for diagnosing COVID-19 infection: the latest Cochrane evidence
2 Apr, 2021 | 09:21h | UTCOriginal review and commentaries: Systematic review: Rapid, point‐of‐care antigen and molecular‐based tests for diagnosis of SARS‐CoV‐2 infection
Therapeutics and COVID-19 | WHO guideline update advises Ivermectin should only be used to treat COVID-19 within clinical trials
1 Apr, 2021 | 04:02h | UTCSummary and Infographic: Drug treatments for covid-19: living systematic review and network meta-analysis – The BMJ
Original guideline: Therapeutics and COVID-19: living guideline – World Health Organization
News release: WHO advises that ivermectin only be used to treat COVID-19 within clinical trials – World Health Organization
Commentary: WHO joins Europe, Merck in recommending against ivermectin for COVID-19 – Reuters
Commentary on Twitter
?Our updated @WHO #LivingGuidance on #COVID19 now adding recommandation on #ivermectin to previous recs on #steroids #remdesivir #lopinavir #Hydroxychloroquine
?https://t.co/eV7BtVrvAf
?https://t.co/G3Eu18Vg0s#MichaelJacobs @Bram_Rochwerg @PerVandvik @diazjv @bmj_latest https://t.co/qdrBQIZK8e pic.twitter.com/s9TkO1afYs— Thomas Agoritsas, MD PhD (@ThomasAgoritsas) March 31, 2021
ERAS Guidelines for Perioperative Care for Emergency Laparotomy: Part 1—Preoperative: Diagnosis, Rapid Assessment and Optimization
1 Apr, 2021 | 03:35h | UTC