Critical Care & Emergencies (all articles)
Case series of 12 patients with cerebral venous sinus thrombosis with thrombocytopenia after Ad26.COV2.S vaccination – all women younger than 60 years, with symptoms from 6 to 15 days after vaccination
3 May, 2021 | 05:43h | UTCSee also: Safety Monitoring of the Janssen (Johnson & Johnson) COVID-19 Vaccine — United States, March–April 2021 – Centers for Disease Control and Prevention AND Updated Recommendations from the Advisory Committee on Immunization Practices for Use of the Janssen (Johnson & Johnson) COVID-19 Vaccine After Reports of Thrombosis with Thrombocytopenia Syndrome Among Vaccine Recipients — United States, April 2021 – Centers for Disease Control and Prevention
Study: Patients with heart failure have a much higher incidence of pneumonia than matched individuals in the population. The development of pneumonia in these patients is associated with a 3- to 4-fold higher risk of cardiovascular and all-cause death.
3 May, 2021 | 05:18h | UTCCommentaries: Pneumonia in HF Patients Is Common, Lethal, and Preventable – TCTMD AND Outcomes of Pneumonia in Patients With Heart Failure – American College of Cardiology
ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding – RBC transfusion at a threshold of 7 g/dL; Erythromycin infusion is suggested before endoscopy; and endoscopy is suggested within 24 hours after presentation.
3 May, 2021 | 05:27h | UTC
ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury – antimicrobials, herbal and dietary supplements, and anticancer therapeutics are the most common classes of agents
3 May, 2021 | 05:22h | UTC
M-A: Delayed antibiotic prescribing for respiratory tract infections is a safe and effective strategy for most patients
30 Apr, 2021 | 08:33h | UTCCommentaries: Delayed Antibiotic Prescribing Safe for Respiratory Tract Infection – HealthDay
AHA/ASA Guidance: Diagnosis and Management of Cerebral Venous Sinus Thrombosis with Vaccine-Induced Thrombotic Thrombocytopenia – “No heparin products in any dose should be given.”
30 Apr, 2021 | 08:25h | UTCNews release: Guidance on treatment for rare blood clots and low platelets related to COVID-19 vaccine – American Heart Association
Study with 6.9 million people in England shows severe Covid-19 in young people can mostly be explained by obesity – At a BMI of more than 23 kg/m2, there was a linear increase in risk of severe COVID-19
30 Apr, 2021 | 08:22h | UTCCommentaries: Severe COVID in young people can mostly be explained by obesity – new study – The Conversation AND Obesity studies highlight severe COVID outcomes, even in young adults – CIDRAP AND Expert reaction to study looking at a potential link between body weight and risk of severe COVID-19, especially for younger adults – Science Media Centre
Commentary on Twitter (thread – click for more)
NEW—Study of health records of nearly 7 million people in England found that the risk of worse outcomes from #COVID19 starts rising in people with a BMI above 23kg/m2—considered to be in the healthy range.
Read in @TheLancetEndo: https://t.co/5ibn3yb1xO 1/2 pic.twitter.com/4MwnGq95Sz
— The Lancet (@TheLancet) April 29, 2021
Review: COVID-19-associated coagulopathy and antithrombotic agents – In non-critically ill hospitalized patients, therapeutic dose anticoagulation may improve clinical outcomes. In critically ill patients, this same treatment does not improve outcomes, and prophylactic dose anticoagulation is recommended
29 Apr, 2021 | 08:46h | UTCRelated: Full-dose Heparin best for moderate COVID-19 regardless of D-dimer — Data released from ACTIV-4a, ATTACC, and REMAP-CAP trials AND RCT: Intermediate-dose enoxaparin (1 mg/kg/d) not better than standard-dose prophylactic anticoagulation in patients with Covid-19 admitted to the intensive care unit
Commentary on Twitter
???State of the Art Review Article @TheLancetHaem by @MiddeldorpS
COVID-19-associated coagulopathy
Excellent explanation for the pathophysiology and great summary for the major RCTs and clinical guidelines https://t.co/NxP06KP2Hm pic.twitter.com/qHzyDsUZpt— Antibiotic Steward??Bassam Ghanem (@ABsteward) April 28, 2021
Ethics Commission Position Statement: Admission criteria and management of critical care patients in a pandemic context – “Age cannot be used as the sole criterion for admission nor denial of access to ICU settings”
29 Apr, 2021 | 08:36h | UTC
ACP Guideline: Appropriate Use of High-Flow Nasal Oxygen in Hospitalized Patients – “use high-flow nasal oxygen rather than noninvasive ventilation in hospitalized adults for the management of acute hypoxemic respiratory failure”
29 Apr, 2021 | 08:34h | UTC
M-A: Administration of vasopressor medications through a peripheral intravenous catheter is associated with low risk of adverse events
29 Apr, 2021 | 08:19h | UTCRelated Meta-Analysis: Complication of vasopressor infusion through peripheral venous catheter (study and commentary on Twitter)
Review: Systemic and organ-specific immune-related manifestations of COVID-19 – over 70 different systemic and organ-specific immune-related disorders have been reported
28 Apr, 2021 | 08:42h | UTCSystemic and organ-specific immune-related manifestations of COVID-19 – Nature Reviews Rheumatology
How the UK found the first effective Covid-19 treatment — and saved a million lives (about the RECOVERY trial and the effects of Dexamethasone)
28 Apr, 2021 | 08:36h | UTCHow the UK found the first effective Covid-19 treatment — and saved a million lives – Vox
Related: Covid-19: The Inside Story of the RECOVERY Trial AND Covid: The London bus trip that saved maybe a million lives – BBC
Overview of SARS-CoV-2 infection in adults living with HIV – Low CD4 cell counts, or untreated HIV infection is associated a more severe clinical course
28 Apr, 2021 | 08:32h | UTCOverview of SARS-CoV-2 infection in adults living with HIV – The Lancet HIV
Commentary on Twitter
New Review: Overview of SARS-CoV-2 infection in adults living with HIV: https://t.co/xXTntfIYPF pic.twitter.com/6w6MUSbo3n
— The Lancet HIV (@TheLancetHIV) April 27, 2021
American Academy of Orthopedic Surgeons Clinical Practice Guideline Summary for Limb Salvage or Early Amputation
28 Apr, 2021 | 08:14h | UTC
NICE publishes updated clinical guideline on the diagnosis and management of atrial fibrillation
27 Apr, 2021 | 09:33h | UTCGuideline: Atrial fibrillation: diagnosis and management – National Institute for Health and Care Excellence
ACP Guideline: Appropriate Use of Point-of-Care Ultrasonography in Patients With Acute Dyspnea in Emergency Department or Inpatient Settings
27 Apr, 2021 | 09:31h | UTC
Appropriate Clinical Use of Lactate Measurements
27 Apr, 2021 | 09:15h | UTCAppropriate Clinical Use of Lactate Measurements – Anesthesiology
Commentary on Twitter
Elevated lactate can result from many pathophysiologic processes. Understanding the mechanism of lactate production, metabolism, and the basics of lactic acidosis will enable the appropriate use of laboratory tests and interpretation. https://t.co/aoA2aLl3mg pic.twitter.com/t4WLxAXe5k
— Anesthesiology journal (@_Anesthesiology) March 12, 2021
The Utility of Chest CT imaging in suspected or diagnosed COVID-19 Patients – a review of literature
27 Apr, 2021 | 08:30h | UTC
Clinical Manifestation, Evaluation, and Rehabilitative Strategy of Dysphagia Associated With COVID-19
27 Apr, 2021 | 08:29h | UTC
Clinical review of 43 patients with COVID-19-associated Acute Transverse Myelitis and 3 patients with Acute Transverse Myelitis reported post-vaccination
27 Apr, 2021 | 08:32h | UTCCommentary: Rare neurological condition linked to COVID-19 cases in 21 countries – Houston Methodist
SARS-CoV-2 and Stroke Characteristics – higher rate of large vessel occlusions and stroke in young patients
25 Apr, 2021 | 22:01h | UTC
Commentary on Twitter
SARS-CoV-2 and #Stroke Characteristics: A Report From the Multinational COVID-19 Stroke Study Group #COVID19 #AHACOVID19 #AHAJournals @cgriessenauer @ArKatsanos https://t.co/Errp6MjQMV pic.twitter.com/QX5tAGQOXU
— Stroke AHA/ASA (@StrokeAHA_ASA) April 21, 2021
Multicenter cohort study shows survival among ECMO-assisted patients is strongly associated with center experience
25 Apr, 2021 | 22:05h | UTCInvited commentary: COVID-19 and ECMO: a call for close cooperation and more investigation – The Lancet Respiratory Medicine
Commentary on Twitter
#ECMO network & outcomes during #COVID19 #pandemic in Paris:
➡️17 #ICUs
➡️6 mobile teams
➡️302 pts
➡️46% 90d survival, strongly associated with center experience.
Early #ECLS in high VV volume center advocated: centralize & regulate indications!@TheLancet https://t.co/PqAYWY82Hs pic.twitter.com/ironyGdyFa— M Velia Antonini (@FOAMecmo) April 21, 2021
Analysis of 1060 Cases of Drug-Induced Acute Pancreatitis – a large proportion of cases were caused by antineoplastic (16.89%), antibiotic (12.08%), and anticonvulsant (9.72%) drugs
25 Apr, 2021 | 20:55h | UTCAnalysis of 1060 Cases of Drug-Induced Acute Pancreatitis – Gastroenterology
NIH Updates COVID-19 Treatment Guidelines – adds recommendations on colchicine, fluvoxamine, and monoclonal antibodies
23 Apr, 2021 | 08:46h | UTCNIH Coronavirus Disease 2019 (COVID-19)
Treatment Guidelines – National Institutes of Health