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Critical Care & Emergencies (all articles)

Review: Prevention and management of thrombosis in hospitalized patients with COVID-19 pneumonia.

26 Nov, 2021 | 08:44h | UTC

Prevention and management of thrombosis in hospitalised patients with COVID-19 pneumonia – The Lancet Respiratory Medicine

 

Promises and challenges of personalized medicine to guide ARDS therapy.

25 Nov, 2021 | 10:25h | UTC

Promises and challenges of personalized medicine to guide ARDS therapy – Critical Care

 

Basics of extracorporeal membrane oxygenation.

25 Nov, 2021 | 10:09h | UTC

Basics of Extracorporeal Membrane Oxygenation – Surgical Clinics of North America

 

Review: Noninvasive ventilation and oxygenation strategies.

25 Nov, 2021 | 10:08h | UTC

Noninvasive Ventilation and Oxygenation Strategies – Surgical Clinics of North America

 

Review: COVID-19-associated Invasive Fungal Infection.

24 Nov, 2021 | 08:48h | UTC

COVID-19-associated Invasive Fungal Infection – Open Forum Infectious Diseases

Related:

Taskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis.

M-A: Incidence and mortality of COVID‐19‐associated pulmonary aspergillosis – The incidence and mortality in the ICU were estimated to be 10.2% and 54.9%, respectively.

Consensus Guideline: Defining and managing COVID-19-associated pulmonary aspergillosis

Bacterial and fungal superinfections in critically ill patients with COVID-19

Invasive Fungal Disease complicating COVID-19: when it rains it pours

A national strategy to diagnose COVID-19 associated invasive fungal disease in the ICU

Epidemiology of invasive pulmonary aspergillosis among COVID-19 intubated patients

 

Commentary on Twitter

 

Chest Pain: Who needs additional testing beyond ECG and Troponin?

24 Nov, 2021 | 08:28h | UTC

Chest Pain: Who Needs Additional Testing Beyond ECG and Troponin? – JACC: Case Reports

 

A prospective cohort study showed a 3.1% risk for recurrent venous thromboembolism at 90 days in patients with subsegmental pulmonary embolism managed without anticoagulation.

24 Nov, 2021 | 08:31h | UTC

Risk for Recurrent Venous Thromboembolism in Patients With Subsegmental Pulmonary Embolism Managed Without Anticoagulation: A Multicenter Prospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

M-A: Colchicine doesn’t lessen COVID-19 severity or stave off risk of death.

23 Nov, 2021 | 08:55h | UTC

News release: Gout drug colchicine doesn’t lessen COVID-19 severity or stave off risk of death – BMJ

Original Study: Efficacy and safety of colchicine in COVID-19: a meta-analysis of randomised controlled trials – RMD Open

Related:

RECOVERY Trial: In patients admitted to hospital with COVID-19, Colchicine did not reduce 28-day mortality, duration of hospital stay, or risk of progressing to invasive mechanical ventilation or death.

[Preprint] PRINCIPLE RCT: Colchicine does not improve time to recovery in outpatients with Covid-19 at higher risk of complications.

COLCORONA RCT: Colchicine for community-treated patients with COVID-19 – findings suggest it may lower death and hospital admission rates, but further studies are required.

[Preprint] RECOVERY Trial: Colchicine does not improve outcomes in patients admitted to hospital with COVID-19.

 

The COVID-19 Patient in the Surgical Intensive Care Unit.

23 Nov, 2021 | 08:46h | UTC

The COVID-19 Patient in the Surgical Intensive Care Unit – Surgical Clinics of North America

 

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections.

23 Nov, 2021 | 08:45h | UTC

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections – Infectious Diseases Society of America

 

Commentary on Twitter

 

Bowel Perforation: ED presentations, evaluation, and management.

23 Nov, 2021 | 08:19h | UTC

Bowel Perforation: ED presentations, evaluation, and management – emDocs

 

Non-invasive respiratory support in the management of acute COVID-19 pneumonia: considerations for clinical practice and priorities for research – “The two randomized controlled trials indicate superiority of non-invasive ventilation over high-flow nasal oxygen in reducing the need for intubation”.

21 Nov, 2021 | 23:15h | UTC

Non-invasive respiratory support in the management of acute COVID-19 pneumonia: considerations for clinical practice and priorities for research – The Lancet Respiratory Medicine

Related: [Preprint] RCT: non-invasive respiratory strategies in acute respiratory failure in patients with COVID-19 – CPAP reduced the composite outcome of intubation or death within 30 days; high-flow nasal oxygenation was not associated with better outcomes.

 

Commentary on Twitter

 

M-A: Convalescent plasma does not reduce mortality in COVID-19.

21 Nov, 2021 | 23:09h | UTC

Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials – BMC Infectious Diseases

Related:

RCT: Another study shows convalescent plasma does not improve outcomes in critically ill patients with Covid-19.

RCT: Convalescent plasma does not improve outcomes and may be harmful to hospitalized patients with COVID-19.

NIH study shows no significant benefit of convalescent plasma for COVID-19 outpatients with early symptoms.

M-A: Convalescent plasma is safe but does not improve outcomes in the treatment of COVID-19.

RECOVERY Trial: No benefit from convalescent plasma in patients admitted to hospital with COVID-19.

 

Clinical Guideline Highlights for the Hospitalist: Management of Upper Gastrointestinal and Ulcer Bleeding.

21 Nov, 2021 | 22:44h | UTC

Clinical Guideline Highlights for the Hospitalist: Management of Upper Gastrointestinal and Ulcer Bleeding – Journal of Hospital Medicine (free for a limited period)

Original Guideline: ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding – RBC transfusion at a threshold of 7 g/dL; Erythromycin infusion is suggested before endoscopy; and endoscopy is suggested within 24 hours after presentation.

 

RECOVERY Trial: Aspirin as an add-on therapy did not reduce mortality in patients hospitalized with COVID-19.

19 Nov, 2021 | 11:01h | UTC

Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial – The Lancet

Invited Commentary: Studying the coagulopathy of COVID-19 – The Lancet

 

Commentary from the author on Twitter (thread – click for more)

 

Consensus and expert recommendations: basic ultrasound head-to-toe skills for intensivists in the general and neuro intensive care unit population.

19 Nov, 2021 | 10:37h | UTC

Basic ultrasound head-to-toe skills for intensivists in the general and neuro intensive care unit population: consensus and expert recommendations of the European Society of Intensive Care Medicine

 

Commentary on Twitter

 

[Preprint] M-A: Inhaled corticosteroids in COVID-19 outpatients.

18 Nov, 2021 | 08:48h | UTC

Inhaled Corticosteroids for Outpatients with Covid-19: A Meta-Analysis – medRxiv

Commentary: Favourable meta-analysis of inhaled corticosteroids in COVID-19 outpatients – News Medical

Related:

PRINCIPLE RCT: Inhaled budesonide improves time to recovery from COVID-19 in people at high risk of complications in the community.

Position Paper: Recommendations for the use of topical inhalant budesonide in COVID-19.

RCT: Inhaled budesonide shortens recovery time in non-hospitalized patients with COVID-19

Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19

 

Commentary on Twitter

 

Observational study in patients with stroke with large-vessel occlusion presenting in the extended window suggests non-contrast CT is as good as CT perfusion or MRI to select patients for thrombectomy.

18 Nov, 2021 | 08:41h | UTC

Noncontrast Computed Tomography vs Computed Tomography Perfusion or Magnetic Resonance Imaging Selection in Late Presentation of Stroke With Large-Vessel Occlusion – JAMA Neurology

Commentary: Noncontrast CT a cost-friendly alternative to select late-stroke patients for thrombectomy – Health Imaging

 

Commentary on Twitter

 

M-A: In patients with anterior circulation acute stroke and evidence of reversible cerebral ischemia across the 6–24 h time window, thrombectomy was associated with higher rates of independence in activities of daily living at 90 days than best medical therapy alone.

18 Nov, 2021 | 08:43h | UTC

Thrombectomy for anterior circulation stroke beyond 6 h from time last known well (AURORA): a systematic review and individual patient data meta-analysis – The Lancet (link to abstract – $ for full-text)

 

Editorial: Twenty recommendations to individualize interventions in the early resuscitation of patients with sepsis.

18 Nov, 2021 | 08:38h | UTC

Twenty recommendations to individualize interventions in the early resuscitation of patients with sepsis – Critical Care

Related: Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

 

Demystifying the EEG report for intensivists.

18 Nov, 2021 | 08:36h | UTC

Demystifying the EEG Report – NeuroEMCrit

 

RCT: Intravenous immunoglobulins do not improve outcomes in patients with COVID-19-associated moderate-to-severe acute respiratory distress syndrome.

16 Nov, 2021 | 08:48h | UTC

Intravenous immunoglobulins in patients with COVID-19-associated moderate-to-severe acute respiratory distress syndrome (ICAR): multicentre, double-blind, placebo-controlled, phase 3 trial – The Lancet Respiratory Medicine

 

Commentary on Twitter

 

Review: Vaccine-induced immune thrombotic thrombocytopenia.

16 Nov, 2021 | 08:46h | UTC

Vaccine-induced immune thrombotic thrombocytopenia – The Lancet Haematology

Related:

Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance.

Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.

Review: Clinical characteristics and pharmacological management of COVID-19 vaccine–induced immune thrombotic thrombocytopenia with cerebral venous sinus thrombosis.

Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.

Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)

 

Commentary on Twitter

 

2021 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations.

16 Nov, 2021 | 08:37h | UTC

2021 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Neonatal Life Support; Education, Implementation, and Teams; First Aid Task Forces; and the COVID-19 Working Group – Circulation (for an HTML version click here)

Top Things to Know: International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations (CoSTR) – American Heart Association

 

M-A: Prediction of extubation outcome in critically ill patients.

16 Nov, 2021 | 08:27h | UTC

Prediction of extubation outcome in critically ill patients: a systematic review and meta-analysis – Critical Care

 

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