Critical Care & Emergencies (all articles)
The European guideline on management of major bleeding and coagulopathy following trauma
2 Mar, 2023 | 13:04h | UTC
Review | The golden grapes of wrath – Staphylococcus aureus bacteremia
1 Mar, 2023 | 13:46h | UTC
M-A | Which adverse events and which drugs are implicated in drug-related hospital admissions
28 Feb, 2023 | 13:59h | UTCSummary: This systematic review and meta-analysis aimed to provide an updated estimation of drug-related hospital admissions, the types and frequency of drug-induced harm, and the drugs involved. The review included 17 studies that examined acute admissions to emergency departments or inpatient wards resulting from drug-induced harm in the general population. These studies were published between January 2012 and December 2021. The estimated rates of admissions resulting from adverse drug reactions* (ADRs) and adverse drug events* (ADEs) were 8.3% and 13.9%, respectively. Almost half of the admissions related to ADRs and over two-thirds of those related to ADEs were possibly preventable. Gastrointestinal disorders, electrolyte disturbances, bleeding events, and renal and urinary disorders were the most frequently involved categories of drug-induced harm. The most frequently involved drug groups were nervous system drugs, followed by cardiovascular and antithrombotic agents.
*Adverse drug events (ADEs) and adverse drug reactions (ADRs) are two terms that are often used interchangeably, but they actually have different meanings. Adverse drug events (ADEs) refer to any negative effect that results from medication exposure and can be caused by a variety of factors, including medication errors, overdose, drug interactions, or allergic reactions. In contrast, adverse drug reactions (ADRs) are a specific type of ADE that occur as unintended effects of medication at normal therapeutic doses.
Guidelines | Efficacy and safety of non-steroidal anti-inflammatory drugs for the treatment of acute pain after orthopedic trauma
28 Feb, 2023 | 13:48h | UTC
The adult and pediatric palliative care: differences and shared issues
28 Feb, 2023 | 13:30h | UTC
Review | (Mal)nutrition in critical illness and beyond
28 Feb, 2023 | 13:28h | UTC(Mal)nutrition in critical illness and beyond: a narrative review – Anaesthesia
Cluster RCT | Effectiveness of an intensive care telehealth program to improve process quality
28 Feb, 2023 | 13:31h | UTC
Commentary on Twitter
📺 A structured, bundled telemedical quality improvement implemented in a local network of🇩🇪 hospitals improved quality of acute #ICU care vs to standard of care, increasing adherence to evidence-based performance indicators.
Open #FOAMc on @yourICM
📎 https://t.co/WV56tXoiHM pic.twitter.com/YQQvm2HUO5— Intensive Care Medicine (@yourICM) January 16, 2023
Guideline | Acute mechanical circulatory support
27 Feb, 2023 | 13:04h | UTC
Consensus Report | Sepsis-associated acute kidney injury
27 Feb, 2023 | 13:05h | UTCSepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup – Nature Reviews Nephrology (if the link is paywalled, try this one)
Commentary on Twitter
A Primer in @DiseasePrimers summarizes the epidemiology, mechanisms, diagnosis and treatment of pre-eclampsia, and discusses patient quality of life and open research questions for this condition. https://t.co/IO3uchSl8b pic.twitter.com/Y7Ij6jmy5a
— Nature Portfolio (@NaturePortfolio) February 25, 2023
Sepsis-induced coagulopathy: an update on pathophysiology, biomarkers, and current guidelines
27 Feb, 2023 | 12:36h | UTCSepsis-Induced Coagulopathy: An Update on Pathophysiology, Biomarkers, and Current Guidelines – Life
Related:
Review | How to manage coagulopathies in critically ill patients
Consensus Paper | Early management of isolated severe traumatic brain injury in a hospital without neurosurgical capabilities
24 Feb, 2023 | 13:49h | UTC
Commentary from the author on Twitter
Great to see our consensus published. Early management of isolated severe traumatic brain injury patients in a hospital without neurosurgical capabilities: a consensus and clinical recommendations of the World Society of Emergency Surgery (WSES).https://t.co/k9hwI82dOW pic.twitter.com/pIp5gFRnPa
— Deepak Sharma (@deepak_neuro) January 14, 2023
Review | When and how to use MIC in clinical practice?
24 Feb, 2023 | 13:28h | UTCWhen and How to Use MIC in Clinical Practice? – Antibiotics
Commentary on Twitter
https://twitter.com/ABsteward/status/1616852667124400129
Acute pain management pearls: a focused review for the hospital clinician
23 Feb, 2023 | 13:15h | UTCAcute Pain Management Pearls: A Focused Review for the Hospital Clinician – Healthcare
Bacteremia | ED presentations, evaluation, and management
22 Feb, 2023 | 12:25h | UTCBacteremia: ED Presentations, Evaluation, and Management – emDocs
Prevalence of long-term decision regret and associated risk factors in a large cohort of ICU surrogate decision makers
22 Feb, 2023 | 12:22h | UTC
Commentary on Twitter
One in five #ICU surrogate decision makers experience moderate to strong regret about life support decisions in ICU.
Read the full article: https://t.co/epCXB4QHRY@jlvincen @ISICEM #FOAMed #FOAMcc pic.twitter.com/0Q3X2uFYk0
— Critical Care (@Crit_Care) February 20, 2023
Guideline Synopsis | Management of thoracic aortic dissection
21 Feb, 2023 | 11:48h | UTCManagement of Thoracic Aortic Dissection – JAMA (free for a limited period)
Original Guidelines:
Review | How to manage coagulopathies in critically ill patients
21 Feb, 2023 | 11:43h | UTCHow to manage coagulopathies in critically ill patients – Intensive Care Medicine
Commentary on Twitter
Coagulopathies severe/frequent complication in #ICU: how to manage??
🩸 hemorrhagic coagulopathies: non‑malignant & malignant
🩸 thrombotic c.: sepsis‑induced & solid cancer‑associated
🩸 managing hemorrhagic c.
🩸(preventing &) managing thrombotic c.
🖇️ https://t.co/CKqzT7dcoH pic.twitter.com/SvpPNf0oGO— Intensive Care Medicine (@yourICM) February 18, 2023
Review | Neurological complications of sepsis
20 Feb, 2023 | 12:16h | UTCSummary: This article covers the latest developments in the prevention, diagnosis, and treatment of sepsis-associated encephalopathy (SAE) and ICU-acquired weakness (ICUAW). SAE diagnosis is clinical with supporting EEG and neuroimaging. Treatment involves early identification and treatment of infections and organ dysfunction. ICUAW is due to an overlap between critical illness polyneuropathy, critical illness myopathy, and muscle disuse atrophy. It affects all limbs and respiratory muscles and is associated with prolonged hospital stay, increased costs, and both short and long-term mortality. Recovery is typical in weeks or months, but severe cases may result in persistent functional impairments for ICU survivors.
Article: Neurological complications of sepsis – Current Opinion in Critical Care
RCT | Effect of non-invasive ventilation after extubation in critically ill patients with obesity
17 Feb, 2023 | 13:10h | UTCEffect of non-invasive ventilation after extubation in critically ill patients with obesity in France: a multicentre, unblinded, pragmatic randomised clinical trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Commentary on Twitter
NEW Research—Among critically ill adults with obesity undergoing extubation, the use of NIV was effective to reduce treatment-failure within 3 days
Read the RCT from Audrey De Jong & colleagues here: https://t.co/nMB3W8NAYX #SCCM2023 pic.twitter.com/iEHExPEhSN
— The Lancet Respiratory Medicine (@LancetRespirMed) January 21, 2023
RCT | Effect of early mobilization on long-term cognitive impairment in critical illness
17 Feb, 2023 | 13:07h | UTCEffect of early mobilisation on long-term cognitive impairment in critical illness in the USA: a randomised controlled trial – The Lancet Respiratory Medicine (free registration required)
Related:
M-A | The effect of early active mobilization at 6 months after critical illness
Early Active Mobilization during Mechanical Ventilation in the ICU – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
NEW Research—Early mobilisation might improve long-term cognitive impairment in ICU survivors after MV, but the increased risk of adverse events in the intervention group should be noted
Read the RCT from Bhakti Patel & colleagues here: https://t.co/DeqraodGXq #SCCM2023 pic.twitter.com/RMDhE7UxPM
— The Lancet Respiratory Medicine (@LancetRespirMed) January 21, 2023
M-A | The rate and assessment of muscle wasting during critical illness
17 Feb, 2023 | 12:55h | UTC
Commentary on Twitter
A Review published in @Crit_Care analyzes the data of ICU muscle wasting studies and reports that critically ill patients lose nearly 2% of skeletal muscle per day during the first week of ICU admission.https://t.co/qW5jzbWRSk
— BMC (@BioMedCentral) January 8, 2023
Acute pain management pearls: a focused review for the hospital clinician
17 Feb, 2023 | 12:42h | UTCAcute Pain Management Pearls: A Focused Review for the Hospital Clinician – Healthcare
RCT | Rivaroxaban shows promise compared to Enoxaparin in the acute phase of an acute coronary syndrome
16 Feb, 2023 | 15:20h | UTCInvited Commentary: Rivaroxaban for Patients With Acute Coronary Syndromes—Where Do We Stand? – JAMA Network Open
Commentary on Twitter
The H-REPLACE RCT: short-term rivaroxaban (5mg 2x/day) was noninferior to enoxaparin in safety + efficacy during 6-month follow-up among patients with acute coronary syndrome who missed the primary reperfusion window and before selective revascularization. https://t.co/TIHOwGSWjJ
— JAMA Network Open (@JAMANetworkOpen) February 10, 2023
Guideline | Diagnosis and management of subarachnoid hemorrhage caused by a ruptured aneurysm
16 Feb, 2023 | 15:23h | UTC
Regulations on palliative sedation: an international survey across eight European countries
16 Feb, 2023 | 15:17h | UTC