Critical Care & Emergencies (all articles)
EASL guideline: management of patients with decompensated cirrhosis
13 Apr, 2018 | 01:29h | UTCEASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis (free PDF)
Review: how to tackle congestion in acute heart failure
13 Apr, 2018 | 01:04h | UTCReview: How to tackle congestion in acute heart failure – Korean Journal of Internal Medicine (free)
Cluster-randomised crossover trial: effects of antibiotic cycling and mixing on antibiotic resistance in the ICU
13 Apr, 2018 | 01:06h | UTCThe effects of antibiotic cycling and mixing on antibiotic resistance in intensive care units: a cluster-randomised crossover trial – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Commentaries: Antibiotic cycling, mixing don’t affect resistance, study says – CIDRAP (free) AND Antibiotic cycling no better than mixing for reducing Gram-negative resistance in the ICU – Univadis (free registration required)
Systematic review: diagnostic and management of life-threatening Adult-Onset Still Disease
13 Apr, 2018 | 00:55h | UTC
Systematic review: alpha-blockers as medical expulsive therapy for ureteral stones
12 Apr, 2018 | 01:56h | UTCAlpha-blockers as medical expulsive therapy for ureteral stones – Cochrane Library (link to abstract – $ for full-text)
Summary: Alpha-blockers for ureteral stones in adult patients with symptoms of stone disease – Cochrane Library (free)
Guideline on management of the acute asthma attack in children
12 Apr, 2018 | 01:05h | UTC
Consensus statement: improving the safety of opioid use for acute noncancer pain in hospitalized adults
12 Apr, 2018 | 00:55h | UTCCommentary: New guidance for safe opioid prescribing for hospitalized patients with acute pain – Beth Israel Deaconess Medical Center, via EurekAlert (free)
Retrospective cohort: whole-body CT scans do not reduce mortality in children with blunt trauma
12 Apr, 2018 | 00:36h | UTCAssociation of Whole-Body Computed Tomography With Mortality Risk in Children With Blunt Trauma – JAMA Pediatrics (link to abstract – $ for full-text)
Commentaries: Whole-Body CT Scans Don’t Appear to Improve Survival in Kids with Blunt Trauma – NEJM Physician’s First Watch (free) AND CT Pan-Scan: No Mortality Benefit in Kids With Blunt Trauma – Medscape (free registration required) AND Whole body CT doesn’t cut mortality in peds blunt trauma – MedicalXpress (free)
Consensus statement: endovascular therapy of acute ischemic stroke
11 Apr, 2018 | 02:03h | UTCRelated guideline: 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association / American Stroke Association (free PDF)
Randomized controlled trial: acupuncture versus titrated morphine in acute renal colic
11 Apr, 2018 | 01:19h | UTCSource: EvidenceAlerts
Retrospective longitudinal analysis: excess oxygen may increase mortality in ARDS
11 Apr, 2018 | 01:17h | UTCOxygen Exposure Resulting in Arterial Oxygen Tensions Above the Protocol Goal Was Associated With Worse Clinical Outcomesin Acute Respiratory Distress Syndrome – Critical Care Medicine (link to abstract – $ for full-text)
Commentary: ARDS mortality rises with excess oxygen – Univadis (free registration required)
Meta-analysis: acute chest pain evaluation using coronary CT angiography
6 Apr, 2018 | 01:43h | UTCAcute chest pain evaluation using coronary computed tomography angiography compared with standard of care: a meta-analysis of randomised clinical trials – Heart (link to abstract – $ for full-text)
See commentary in: Articles of the month (March 2018) – First10EM (free)
Se related meta-analysis published recently with similar results: Outcomes of non-invasive diagnostic modalities for the detection of coronary artery disease: network meta-analysis of diagnostic randomised controlled trials – The BMJ (free)
“Bottom line: In the RCTs we have to date, CCTA demonstrate no benefit, but leads to an increase in unnecessary invasive procedures” (from First10EM).
Meta-analysis: effects of oxygen therapy in patients with suspected acute myocardial infarction
6 Apr, 2018 | 01:39h | UTCEffects of supplemental oxygen therapy in patients with suspected acute myocardial infarction: a meta-analysis of randomised clinical trials – Heart (link to abstract – $ for full-text)
Related guideline: BTS Guideline for oxygen use in healthcare and emergency settings – British Thoracic Society (free)
“These findings from eight RCTs support departing from the usual practice of administering oxygen in normoxaemic patients”.
Observational study: time to endovascular treatment and outcome in acute ischemic stroke
6 Apr, 2018 | 01:30h | UTCTime to Endovascular Treatment and Outcome in Acute Ischemic Stroke: MR CLEAN Registry Results – Circulation (link to abstract – $ for full-text)
Commentary: Time to endovascular therapy predicted functional outcome after stroke in registry study – ACP Hospitalist (free)
“Every hour of delay from stroke onset to the start of endovascular therapy resulted in a 5.3% decreased probability of functional independence” (from ACP Hospitalist)
Randomized controled trial: outcomes of goal-directed haemodynamic therapy in surgical patients
5 Apr, 2018 | 18:39h | UTCSource: Critical Care Reviews Newsletter
Position Statement: Panton–Valentine leukocidin-positive Staphylococcus aureus
5 Apr, 2018 | 18:36h | UTCSource: Critical Care Reviews Newsletter
Meta-analysis: videolaryngoscopy vs direct laryngoscopy for emergency orotracheal intubation
5 Apr, 2018 | 18:37h | UTCSource: Critical Care Reviews Newsletter
Review: hyperchloraemia in sepsis
5 Apr, 2018 | 18:32h | UTCHyperchloraemia in sepsis – Annals of Intensive Care (free)
Source: Critical Care Reviews Newsletter
Review: perioperative gastrointestinal problems in the ICU
5 Apr, 2018 | 18:34h | UTCPerioperative gastrointestinal problems in the ICU – Anesthesiology Intensive Therapy (free PDF)
Source: Critical Care Reviews Newsletter
Narrative review: diagnosis and management of acute ischemic stroke
3 Apr, 2018 | 17:54h | UTCReview: Diagnosis and Management of Acute Ischemic Stroke – Mayo Clinic Proceedings (free)
Related guideline: 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association / American Stroke Association (free PDF) AND Summary for ED-relevant care: 2018 AHA/ASA Ischemic Stroke Updates – emDocs (free)
Narrative review: mechanisms and management of acute pancreatitis
3 Apr, 2018 | 17:54h | UTCReview: Mechanisms and Management of Acute Pancreatitis – Gastroenterology Research and Practice (free)
Source: Critical Care Reviews Newsletter
Meta-analysis: effects of telestroke on thrombolysis times and outcomes
3 Apr, 2018 | 15:25h | UTCEffects of Telestroke on Thrombolysis Times and Outcomes: A Meta-analysis – Prehospital Emergency Care (link to abstract – $ for full-text)
Source: EvidenceAlerts
Cost-effectiveness analysis: MRI after a normal CT for cervical clearance in blunt trauma
3 Apr, 2018 | 15:24h | UTCCost-effectiveness of Magnetic Resonance Imaging in Cervical Clearance of Obtunded Blunt Trauma After a Normal Computed Tomographic Finding – JAMA Surgery (link to abstract – $ for full-text)
Commentaries: Neck injury follow-up MRI may cost patients thousands in unnecessary exams – HealthImaging (free) AND No Benefit for MRI After Normal Cervical CT in Blunt Trauma – Physician’s Briefing (free)
Meta-Analysis: A Comparison of the Quick-SOFA and Systemic Inflammatory Response Syndrome Criteria in Sepsis
30 Mar, 2018 | 04:29h | UTCRelated meta-analysis and commentaries: Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text) AND For mortality prediction, qSOFA has poor sensitivity, moderate specificity, review finds – ACP Hospitalist (free) AND Systemic inflammatory response syndrome criteria may be more sensitive than quick sequential organ failure assessment for predicting mortality in patients with suspected infection – 2 Minute Medicine (free)
“The SIRS was significantly superior to the qSOFA for sepsis diagnosis, and the qSOFA was slightly better than the SIRS in predicting hospital mortality. The association of both criteria could provide a better model to initiate or escalate therapy in patients with sepsis”.
The Effect of Door-to-Diuretic Time on Clinical Outcomes in Patients With Acute Heart Failure
30 Mar, 2018 | 04:09h | UTCCommentaries: Quicker Diuretics Not Associated With Better Outcomes in Acute Heart Failure – TCTMD (free) AND Door-to-Diuretic Time in Acute Heart Failure – American College of Cardiology, Latest in Cardiology (free) AND Door-to-diuretic time didn’t affect mortality from heart failure in Korean registry – ACP Hospitalist (free)
“Overall, there isn’t strong evidence of benefit from early use of diuretics and “the overriding consideration should remain ‘get it right’ rather than ‘do it fast,’” the editorial concluded”. (from ACP)