Critical Care & Emergencies (all articles)
Research: Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria
8 Mar, 2018 | 20:31h | UTCColistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria: an open-label, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
“Combination therapy was not superior to monotherapy”.
Perioperative stroke: pathophysiology and management
8 Mar, 2018 | 20:24h | UTCPerioperative stroke: pathophysiology and management – Synapse (free)
Source: Critical Care Reviews Newsletter
Management of Traumatic Brain Injury Patients
8 Mar, 2018 | 20:24h | UTCManagement of traumatic brain injury patients – Synapse (free)
Source: Critical Care Reviews Newsletter
Points of Concern in Post Acute Kidney Injury Management
8 Mar, 2018 | 20:21h | UTCPoints of Concern in Post Acute Kidney Injury Management – Nephron (free)
Source: Critical Care Reviews Newsletter
Review: Infections Complicating Cirrhosis
8 Mar, 2018 | 20:20h | UTCInfections complicating cirrhosis – Liver International (free)
Source: Critical Care Reviews Newsletter
Update: non-invasive ventilation in chronic obstructive pulmonary disease
8 Mar, 2018 | 20:20h | UTCSource: Critical Care Reviews Newsletter
Reviews: Post-Contrast Acute Kidney Injury
8 Mar, 2018 | 20:18h | UTCSource: Critical Care Reviews Newsletter
Practical recommendations for managing in-flight medical emergencies
2 Mar, 2018 | 02:08h | UTCNews release: Responding to inflight medical emergencies can be stressful for doctors – CMAJ News (free)
Related video: Managing medical emergencies at 36,000 ft: A guide to Air Canada’s in-flight emergency medical kit (free)
Balanced Crystalloids vs Saline in Hospitalized Patients
2 Mar, 2018 | 02:10h | UTCBalanced Crystalloids versus Saline in Critically Ill Adults – New England Journal of Medicine (free)
Related article: Balanced Crystalloids versus Saline in Noncritically Ill Adults – New England Journal of Medicine (free)
Commentary: Balanced Crystalloids May Be Better Than Saline for Critically Ill Patients – NEJM Physician’s First Watch (free)
“Balanced crystalloids may be superior to saline in critically ill patients — but not in patients hospitalized outside an ICU” (from Physician’s First Watch)
Hydrocortisone plus Fludrocortisone Reduces Deaths in Septic Shock
2 Mar, 2018 | 02:08h | UTCHydrocortisone plus Fludrocortisone for Adults with Septic Shock – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Hydrocortisone-fludrocortisone cuts deaths in septic shock – The Hospitalist (free)
Research: Impact of treatment delay on mortality in ST-segment elevation myocardial infarction (STEMI)
2 Mar, 2018 | 02:06h | UTCCommentaries: 3% rise in deaths for every 10 min delay in restoring blood flow after heart attack – OnMedica (free) AND Treatment Delay and Mortality in STEMI With Shock – American College of Cardiology, Latest in Cardiology (free)
Guideline: Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy
2 Mar, 2018 | 02:04h | UTCRelated guidelines: Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO) (free) AND Management of febrile neutropaenia: ESMO Clinical Practice Guidelines (free) AND Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update (free)
Policy Statement: Pediatric Medication Safety in the Emergency Department
2 Mar, 2018 | 02:00h | UTCPolicy Statement: Pediatric Medication Safety in the Emergency Department – American Academy of Pediatrics (free)
Commentaries: Recommendations Issued on Reducing Pediatric Medication Errors in the ED – NEJM Physician’s First Watch (free) AND Policy statement outlines ways to improve pediatric medication safety – 2 Minute Medicine (free)
Guidelines for Burn Care Under Austere Conditions
2 Mar, 2018 | 01:57h | UTCSee also: Guideline for Burn Care Under Austere Conditions: Special Care Topics (free)
Source: Critical Care Reviews Newsletter
Systematic Review: Interventions for paracetamol (acetaminophen) overdose
2 Mar, 2018 | 01:01h | UTCInterventions for paracetamol (acetaminophen) overdose – Cochrane Library (free)
Original article: Interventions for paracetamol (acetaminophen) overdose – Cochrane Library (link to abstract – $ for full-text)
Research: Effect of the Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department Patients
2 Mar, 2018 | 00:57h | UTCEffect of the Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department Patients: The PROPER Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentaries: Pulmonary Embolism Rule-out Criteria non-inferior to usual care for patients at low-risk for pulmonary embolism – 2 Minute Medicine (free) AND EM Nerd-The Case of the Diagnostic Absurdity (free) AND Using PERC & Sending Home Pulmonary Emboli For Fun and Profit – Emergency Literature of Note (free)
An Evidence-Based Approach to Pressors in Shock
1 Mar, 2018 | 22:12h | UTCAn Evidence-Based Approach to Pressors in Shock: Part I – emDocs (free)
An Evidence-Based Approach to Pressors in Shock: Part II – emDocs (free)
Meta-analysis: Hemodynamic effects of acute hyperoxia
1 Mar, 2018 | 22:08h | UTCHemodynamic effects of acute hyperoxia: systematic review and meta-analysis – Critical Care (free)
Review: Approach to Hemoptysis in the Modern Era
1 Mar, 2018 | 21:54h | UTCApproach to Hemoptysis in the Modern Era – Canadian Respiratory Journal (free)
Systematic Review: Interventions to prevent hemodynamic instability during renal replacement therapy in critically ill patients
27 Feb, 2018 | 17:24h | UTC
EM Cases: Emergency Radiology Controversies
27 Feb, 2018 | 17:16h | UTCEM Cases: Emergency Radiology Controversies – emDocs (free)
Review: Takotsubo Syndrome
27 Feb, 2018 | 16:39h | UTCTakotsubo syndrome – Indian Heart Journal (free)
Related articles: Stress cardiomyopathy of the critically ill: Spectrum of secondary, global, probable and subclinical forms – Indian Heart Journal (free) AND Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy – New England Journal of Medicine (free) AND The challenge of Takotsubo syndrome: heterogeneity of clinical features – Swiss Medical Weekly (free) AND Clinical Management of Takotsubo Cardiomyopathy – Circulation Journal (free)
Should we measure the central venous pressure to guide fluid management?
27 Feb, 2018 | 16:34h | UTCSource: Critical Care Reviews Newsletter
Reproducibility of clinical research in critical care: a scoping review
27 Feb, 2018 | 16:27h | UTCReproducibility of clinical research in critical care: a scoping review – BMC Medicine (free)
“Reproducibility in Critical Care trials from NEJM, Lancet, JAMA. Bottom line:
-Attempt to reproduce previous findings: 42%
-Original studies reported larger effects
-Inconsistency with the original: 56%” (via @otavio_ranzani see Tweet)
Meta-Analysis: Association of Vegetation Size With Embolic Risk in Patients With Infective Endocarditis
27 Feb, 2018 | 16:25h | UTCAssociation of Vegetation Size With Embolic Risk in Patients With Infective Endocarditis: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Infective Endocarditis Vegetation Size vs. Embolic Risk – American College of Cardiology, Latest in Cardiology (free) AND Larger Endocarditis Vegetations More Likely to Embolize, Kill – MedPage Today (free registration required)