Critical Care & Emergencies (all articles)
Guideline Summary: 2018 IDSA Guidelines for Clostridium Difficile Infection
5 Oct, 2018 | 01:24h | UTCRelated Guidelines: Clinical Practice Guidelines for Clostridium difficileInfection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) – Clinical Infectious Diseases (free) AND The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines – GUT (free)
The Global Burden of Sepsis: Barriers and Potential Solutions
28 Sep, 2018 | 01:06h | UTCThe global burden of sepsis: barriers and potential solutions – Critical Care (free)
Randomized Trial: Antibiotic Therapy Alone Seems Reasonable for Uncomplicated Appendicitis
28 Sep, 2018 | 00:55h | UTCFive-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Podcast: Treating Appendicitis Without Surgery – 5-Year Follow-up from a Randomized Clinical Trial of Antibiotic Treatment (free)
Video Summary: Five-Year Follow-up of Patients Given Antibiotic Therapy for Uncomplicated Acute Appendicitis (free)
Commentaries: Pills for appendicitis? Surgery often not needed, study says – STAT (free) AND Antibiotics Alone Seem Reasonable for Uncomplicated Appendicitis in Adults – Physician’s First Watch (free) AND Appendicitis? Antibiotics May Be All You Need – The New York Times (10 articles per month are free)
Related: Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis (link to abstract and commentaries) AND Antibiotics Versus Surgical Therapy for Uncomplicated Appendicitis (link to abstract and commentaries) AND Antibiotic Therapy versus Appendectomy for Acute Uncomplicated Appendicitis (free study and commentaries) AND New appendicitis guideline incorporates the possibility of non-operative treatment for uncomplicated disease (free guideline)
Review: Pharmacokinetics–Pharmacodynamics Issues Relevant for the Clinical use of Beta-lactams in Critically Ill Patients
27 Sep, 2018 | 23:02h | UTCRelated: Extended Antibiotic Infusions Could Save Lives: Here’s How to Do It (free commentary) AND Mortality lower with prolonged vs. short-term IV infusion of antipseudomonal beta-lactams (link to abstract and free commentary)
Review: Streptococcal Toxic Shock Syndrome in the Intensive Care Unit
27 Sep, 2018 | 22:46h | UTCStreptococcal toxic shock syndrome in the intensive care unit – Annals of Intensive Care (free)
Source: Critical Care Reviews Newsletter
Consensus: Targeted Temperature Management in Patients with Intracerebral Hemorrhage, Subarachnoid Hemorrhage, or Acute Ischemic Stroke
27 Sep, 2018 | 22:46h | UTCSource: Critical Care Reviews Newsletter
Refractory Septic Shock: Pragmatic Approach
21 Sep, 2018 | 01:55h | UTCRefractory septic shock: our pragmatic approach – Critical Care (free)
Review: Positive Pressure Ventilation in the Cardiac Intensive Care Unit
21 Sep, 2018 | 01:43h | UTCPositive Pressure Ventilation in the Cardiac Intensive Care Unit – Journal of the American College of Cardiology (free for a limited period) (via @Abraham_RMI)
Viewpoint: Antibiotics for Sepsis—Finding the Equilibrium
20 Sep, 2018 | 19:22h | UTCAntibiotics for Sepsis—Finding the Equilibrium – JAMA (free for a limited period)
Meta-Analysis: Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors
14 Sep, 2018 | 02:22h | UTCFatal Toxic Effects Associated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-analysis – JAMA Oncology (free for a limited period)
Commentaries: Study Discerns Rare Risks of Fatal Side Effects From Cancer Immunotherapy – AJMC (free) AND Fatal Toxicities Rare With Checkpoint Inhibitors – MedicalResearch.com (free)
Related Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)
Related Review: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)
Meta-Analysis: Restrictive vs. Liberal Transfusion Strategies in Cardiac Surgery
14 Sep, 2018 | 02:07h | UTCRelated study: Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery (link to abstract)
Randomized Trial: Piperacillin-Tazobactam vs for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance
14 Sep, 2018 | 02:03h | UTCEffect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Video Summary: Effect of Piperacillin-Tazobactam vs Meropenem on Mortality in Gram-Negative Bloodstream Infection – JAMA (free)
Commentaries: Combo antibiotic found inferior for MDR bloodstream infections – CIDRAP (free) AND Drug Combo No Better for Hard-to-Treat Bloodstream Infections – Medscape (free registration required)
“The results do not support the use of Pip/Tazo as 30 d mortality was 12.3% in Pip/Tazo vs 3.7% in Mero arms” (via @CarlosdelRio7 see Tweet)
Systematic Review: Antibiotics for Acute Rhinosinusitis in Adults
14 Sep, 2018 | 02:01h | UTCAntibiotics for acute rhinosinusitis in adults – Cochrane Library (free for a limited period)
Summary: Antibiotics for sinus infection of short duration in adults – Cochrane Library (free)
“Considering antibiotic resistance, and the very low incidence of serious complications, we conclude there is no place for antibiotics for people with uncomplicated acute rhinosinusitis.”
Guideline: Transfusion Practice in Critically Ill Children
14 Sep, 2018 | 01:34h | UTC
NICE Guideline: Pancreatitis
14 Sep, 2018 | 01:30h | UTCPancreatitis – National Institute for Health and Care Excellence (free)
The 2018 Surviving Sepsis Campaign’s Treatment Bundle: When Guidelines Outpace the Evidence Supporting Their Use
14 Sep, 2018 | 01:24h | UTCThe 2018 Surviving Sepsis Campaign’s Treatment Bundle: When Guidelines Outpace the Evidence Supporting Their Use – Annals of Emergency Medicine (free) (via @EMNerd)
Related Opinions: Petition to retire the surviving sepsis campaign guidelines – PulmCrit (free) AND The Surviving Sepsis Campaign: A Rush to Judgment – NEJM Journal Watch (free)
Original Guideline: The Surviving Sepsis Campaign Bundle: 2018 update – Intensive Care Medicine (free)
Subsegmental Pulmonary Embolism: Anticoagulation or Observation?
6 Sep, 2018 | 03:07h | UTCSubsegmental pulmonary embolism: anticoagulation or observation? – PulmCCM (free)
Guideline: Clinical Imaging for Hemoptysis
6 Sep, 2018 | 02:48h | UTC2018 Korean Clinical Imaging Guideline for Hemoptysis – Korean Journal of Radiology (free)
Review: Ischemia and No Obstructive Coronary Artery Disease (INOCA)
6 Sep, 2018 | 02:33h | UTC
Review: Use of Blood Cultures in the ED
2 Sep, 2018 | 02:28h | UTC“So, Blood Cultures… or No?” – Use of Blood Cultures in the ED – emDocs (free)
Related Review: How to Optimize the Use of Blood Cultures for the Diagnosis of Bloodstream Infections? A State-of-the Art – Frontiers in Microbiology (free)
Review: Cardiorenal Syndrome Revisited
2 Sep, 2018 | 02:26h | UTCCardiorenal Syndrome Revisited – Circulation (free) (via @Abraham_RMI)
Study: Performance of Electronic Prediction Rules for Prevalent Delirium at Hospital Admission
2 Sep, 2018 | 02:23h | UTCCommentary: New prediction rule may help detect delirium at hospital admission – ACP Hospitalist (free)
Palliative Care in Intensive Care Units: Why, Where, What, Who, When, How
2 Sep, 2018 | 02:13h | UTCPalliative care in intensive care units: why, where, what, who, when, how – BMC Anesthesiology (free)
Guideline: Periprocedural Antithrombotic Management for Lumbar Puncture
2 Sep, 2018 | 02:04h | UTC
Emergency Department Crowding: A Systematic Review of Causes, Consequences and Solutions
2 Sep, 2018 | 01:56h | UTCEmergency department crowding: A systematic review of causes, consequences and solutions – PLOS One (free)