Critical Care & Emergencies (all articles)
[Abstract Only] Randomized trial on strategies for tracheostomy decannulation
10 Sep, 2020 | 09:34h | UTC
Commentary on Twitter
New insigths in tracheostomy decannulation. A great pleasure to participate on this study leaded by Gonzalo Hernandez. High-Flow Oxygen with Capping or Suctioning for Tracheostomy Decannulation | NEJM https://t.co/103vhwWlvq @vallhebron @NEJM pic.twitter.com/DzyJSAgn1F
— Oriol Roca (@oriolrocag) September 10, 2020
WHO calls for global action on sepsis – cause of 1 in 5 deaths worldwide
10 Sep, 2020 | 09:27h | UTCWHO calls for global action on sepsis – cause of 1 in 5 deaths worldwide – World Health Organization
Report: Global report on the epidemiology and burden of sepsis – World Health Organization
Commentary on Twitter
Today the first Global report on #sepsis was launched, offering the most comprehensive evidence on the life-threatening condition
👉 https://t.co/sSLSPAQFv8 pic.twitter.com/iCv4n2Ux9n
— World Health Organization (WHO) (@WHO) September 9, 2020
Interactive calculator for interpreting Covid-19 antibody test results
9 Sep, 2020 | 09:12h | UTCTesting for SARS-CoV-2 antibodies – The BMJ
Commentary on Twitter
#BMJInfographic Try out this new interactive calculator for interpreting covid-19 antibody test results @will_s_t https://t.co/t0Ha5zMlg1 pic.twitter.com/TAjVLog3A1
— The BMJ (@bmj_latest) September 8, 2020
[Preprint] Randomized trial: Convalescent plasma not associated with improved outcomes in Covid-19
9 Sep, 2020 | 09:41h | UTC
Commentary on Twitter
Convalescent Plasma Randomized Controlled Trial (PLACID Trial) in the Management of Moderate #COVID19 (pre-print)
👉 “not associated with reduction in mortality or progression to severe COVID-19”
Link: https://t.co/2ZXnfemsas@GermHunterMD @MackayIM @CT_Bergstrom #IDTwitter pic.twitter.com/yZuOxVhbjL
— Alvin (@alvie_barr) September 8, 2020
IDSA Guidance on the treatment of antimicrobial resistant gram-negative infections
9 Sep, 2020 | 09:24h | UTCNews Release: IDSA Releases Guidance On Treatment Of Antimicrobial-Resistant Infections
Commentary on Twitter
The new @IDSAInfo guidance document on the treatment of MDR GN infections is 🔥🔥🔥. This a really practical/pragmatic document and will be of great use to frontline clinicianshttps://t.co/Eoz2vEHppb
— Mike Stevens (@Dr_Mike_Stevens) September 8, 2020
Guidelines for the management of intravascular catheters in the ICU
9 Sep, 2020 | 09:22h | UTC
Randomized trial: Out-of-hospital tranexamic acid does not improve neurologic outcomes in patients with traumatic brain injury
9 Sep, 2020 | 09:20h | UTCEditorial: Out-of-Hospital Tranexamic Acid for Traumatic Brain Injury
Commentary on Twitter
In this phase II RCT prehospital tranexamic acid, which inhibits breakdown of fibrin clot, did not improve neurologic outcomes at 6 months vs placebo in patients with moderate to severe TBI https://t.co/PHK91YYxK3 @SusanRowellMD
— JAMA (@JAMA_current) September 8, 2020
COVID-19 is, in the end, an endothelial disease
8 Sep, 2020 | 01:11h | UTCCOVID-19 is, in the end, an endothelial disease – European Heart Journal
Commentary on Twitter
COVID as an infectious disease of the “endothelium”, the lining of blood vessels, transmitted pre-sympyomatically. Explains the sepsis syndrome; explains the clotting/bleeding; explains the kidney failure.
What a nasty, nasty disease.https://t.co/5hlfL5Iik9
— David Fisman (@DFisman) September 7, 2020
Meta-analysis: Chloroquine and Hydroxychloroquine do not improve outcomes in COVID-19
8 Sep, 2020 | 01:08h | UTCRelated Meta-analysis: Antirheumatic Disease Therapies for the Treatment of COVID‐19: A Systematic Review and Meta‐analysis – Arthritis & Rheumatology
Review: Optimal management of acute coronary syndromes in the era of COVID-19
8 Sep, 2020 | 01:09h | UTCOptimal management of acute coronary syndromes in the era of COVID-19 – Heart
Podcast: Treatment of acute heart failure
8 Sep, 2020 | 01:00h | UTC#230 Kittleson Rules Acute Heart Failure – The Curbsiders Internal Medicine Podcast
Coalition Covid-19 Brazil – Randomized trial: Azithromycin not beneficial for patients admitted to the hospital with severe Covid-19
6 Sep, 2020 | 22:06h | UTCInvited Commentary: Azithromycin for severe COVID-19
Commentaries on Twitter
This network of Brazilian researchers has done an AMAZING job of getting organized & answering important ?s. In this Lancet article they show in a randomized trial that #azithromycin does not improve #Covid19 outcomes. @RenatoDLopes1 https://t.co/zL7GSaVqm8
— C. Michael Gibson MD (@CMichaelGibson) September 5, 2020
New trial @TheLancet does not support the routine use of azithromycin in combination with #Hydroxychloroquine in patients with severe #COVIDー19:https://t.co/vaj1XX3dSo
— Madhu Pai, MD, PhD (@paimadhu) September 6, 2020
Podcast: Hyponatremia deconstructed
8 Sep, 2020 | 01:01h | UTCREBOOT #48 Hyponatremia Deconstructed – The Curbsiders Internal Medicine Podcast
A living WHO guideline on drugs for Covid-19
6 Sep, 2020 | 22:04h | UTCA living WHO guideline on drugs for covid-19 – The BMJ
Commentary on Twitter
NEW #RapidRec makes a strong recommendation for systemic corticosteroids in patients with severe and critical #COVID19 and a weak or conditional recommendation against systemic corticosteroids in patients with non-severe covid-19 https://t.co/p7loBk95Vm
— The BMJ (@bmj_latest) September 5, 2020
Post-COVID syndrome severely damages children’s hearts; ‘immense inflammation’ causing cardiac blood vessel dilation
6 Sep, 2020 | 22:03h | UTCOriginal Study: Multisystem inflammatory syndrome in children: A systematic review – EClinicalMedicine
Commentary on Twitter
#COVID19 Multisystem inflammatory syndrome in children: A systematic review
An abnormal echocardiograph was observed in 314 of 581 patients (54·0%) with depressed ejection fraction (45·1%, n = 262 of 581) comprising the most common aberrancy.https://t.co/JqgETbH3DL pic.twitter.com/GqYtvGy0oP
— EPIDATUM (@epidatum) September 5, 2020
Does the COVID-19 cytokine storm exist?
6 Sep, 2020 | 21:55h | UTCDoes the COVID-19 cytokine storm exist? – Radboud University Medical Center
Original Study: Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions – JAMA
Commentary on Twitter
Study suggests #COVID19 may not be characterized by cytokine storm. Whether anticytokine therapies will benefit patients with COVID-19 remains to be determined https://t.co/alyFUwCYRC
— JAMA (@JAMA_current) September 4, 2020
Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline
6 Sep, 2020 | 21:43h | UTC
Invasive Fungal Disease complicating COVID-19: when it rains it pours
6 Sep, 2020 | 21:38h | UTCInvasive Fungal Disease complicating COVID-19: when it rains it pours – Clinical Infectious Diseases
Related study: A national strategy to diagnose COVID-19 associated invasive fungal disease in the ICU – Clinical Infectious Diseases
Commentary on Twitter
Read the fantastic editorial commentary by @martinhoenigl
Invasive Fungal Disease complicating COVID-19: when it rains it pours. #COVID19 @eurconfmedmycol #CID https://t.co/3M7NYI3zwk https://t.co/2YKpQ3x9TP— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) September 5, 2020
#ESCCongress – [Not Published Yet] Trial clarifies which patients with acute pulmonary embolism can be managed at home
6 Sep, 2020 | 21:36h | UTCNews Release: Trial clarifies which patients with acute pulmonary embolism can be managed at home – European Society of Cardiology
HESTIA Calculator: Hestia Criteria for Outpatient Pulmonary Embolism Treatment – MdCalc
sPESI Calculator: Simplified PESI (Pulmonary Embolism Severity Index) – MeCalc
Systematic review: Association between D-Dimer levels and mortality in patients with COVID-19
6 Sep, 2020 | 21:37h | UTC
Meta-analysis (randomized trials + cohort studies) suggests improved outcomes with early norepinephrine for septic shock
6 Sep, 2020 | 21:27h | UTCEarly Norepinephrine for Septic Shock – JournalFeed
Original Study: Timing of norepinephrine initiation in patients with septic shock: a systematic review and meta-analysis – Critical Care
“Further randomized clinical studies should be conducted in order to confirm the results.” (from Critical Care)
Review: Coagulopathy of Covid-19
4 Sep, 2020 | 02:14h | UTCCoagulopathy of Coronavirus Disease 2019 – Critical Care Medicine
Commentary on Twitter
What you need to know about #Covid19 #coagulopathy is all in one place – @CCM. This will help target your anticoagulation plans for COVID care. @SCCM https://t.co/gKUbc995ra
— Lauren R. Sorce, PhD, RN, CPNP-AC/PC, FAAN, FCCM (@SCCMPresident) September 1, 2020
Coalition Covid-19 Brazil – Randomized trial: Dexamethasone improves outcomes in patients with Acute Respiratory Distress Syndrome and COVID-19
3 Sep, 2020 | 11:24h | UTCEditorial: Corticosteroids in COVID-19 ARDS: Evidence and Hope During the Pandemic
Related studies: Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial – JAMA AND Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19: A Randomized Clinical Trial – JAMA
Commentary: Inexpensive Steroids Can Save Lives Of Seriously Ill COVID-19 Patients – NPR
Commentary on Twitter
In this RCT, IV #dexamethasone increased the number of ventilator-free days by day 28 vs standard care alone among patients with #COVID19 and moderate or severe ARDS https://t.co/RA9G6LVRlz @ICURevisited @FlaviaSepsis @israelmaia16
— JAMA (@JAMA_current) September 2, 2020
Video: Corticosteroids for COVID-19 – New Evidence of Benefit
3 Sep, 2020 | 11:21h | UTCCorticosteroids for COVID-19 – New Evidence of Benefit – JAMA
Meta-analysis: Corticosteroids for critically ill patients with COVID-19
3 Sep, 2020 | 11:23h | UTCEditorial: Corticosteroids in COVID-19 ARDS: Evidence and Hope During the Pandemic
Commentaries: Analysis of seven trials finds that corticosteroids reduce risk of death by 20 per cent in critically ill COVID-19 patients – University of Bristol AND Multiple studies confirm steroids can fight severe COVID-19 – MedicalXpress
Commentary on Twitter
1/8 Corticosteroids and COVID19
*Three* RCTs and a new @WHO meta-analysis add to #RECOVERY trial data that corticosteroids reduce mortality in critically ill #COVID19 patientshttps://t.co/H8c46Y5DTm— JAMA (@JAMA_current) September 2, 2020