Critical Care
Long-term mortality of elderly patients after intensive care unit admission for COVID-19
14 Apr, 2021 | 02:09h | UTC
Commentary on Twitter
Long-term outcome of elderly (≥ 80y) #COVID19 pts admitted to #ICU: 6-month mortality ➡️ 72% (likely underestimated) at upper end of recent literature on older critical pts. Data supporting more informed goals-of-care decisions for this #SARSCoV2 cohort?https://t.co/mIKNxNpdC8 pic.twitter.com/OQS5SN5FXR
— Intensive Care Medicine (@yourICM) April 13, 2021
RCT: Inhaled budesonide shortens recovery time in non-hospitalized patients with COVID-19
13 Apr, 2021 | 05:30h | UTCOriginal study (preprint): Inhaled budesonide for COVID-19 in people at higher risk of adverse outcomes in the community: interim analyses from the PRINCIPLE trial – medRxiv
Commentary: Covid: Asthma drug ‘speeds up recovery at home’ – BBC
Related study: Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19 (study and commentaries)
M-A: Post-extubation oxygenation strategies in acute respiratory failure – NPPV or HFNC may reduce the risk of endotracheal reintubation but not mortality
12 Apr, 2021 | 00:42h | UTC
AHA/ASA Scientific Statement: Perioperative Neurological Evaluation and Management to Lower the Risk of Acute Stroke in Patients Undergoing Noncardiac, Nonneurological Surgery
12 Apr, 2021 | 00:50h | UTC
Commentary on Twitter
NEW GUIDELINE – now codifies what has been discussed for a while "If history of stroke exists, consider delaying elective surgery at least 6 mo
and preferably 9 mo from time of incident stroke." @SPAQIedu @LeeAFleisher @preopconsult @afedwardMD https://t.co/0ewdlPGVlj— Kurt Pfeifer (@KurtPfeifer) April 9, 2021
Cohort study: Postoperative in-hospital mortality of patients with COVID-19 infection was more than double that in patients without COVID-19
13 Apr, 2021 | 05:21h | UTCRelated: Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery AND Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk
Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients
12 Apr, 2021 | 01:23h | UTC
Commentary on Twitter
Prone position in #COVID19, use & effect:
➡️PP widely adopted, the more severe the respiratory failure, the more frequent the use
➡️PP improved oxygenation in most (better V/Q matching?)
➡️mortality of O2-Non-Responders significantly higher@Crit_Care https://t.co/Q2Z15a8Pvr pic.twitter.com/CZqshIfJrg— M Velia Antonini (@FOAMecmo) April 7, 2021
Another study shows intravenous radiocontrast use is not associated with reduced kidney function
12 Apr, 2021 | 00:44h | UTCCommentaries: Radiocontrast Exposure Safe for Kidney Function – HCP Live AND Exposure to contrast on CTPA doesn’t cause long-term kidney injury – AuntMinnie
Related: ACR/NKF Consensus Statement: “The Risk of Acute Kidney Injury Developing in Patients with Reduced Kidney Function Following Exposure to Intravenous Iodinated Contrast Media has Been Overstated” (Guideline and commentaries)
Commentary on Twitter (thread – click for more)
Our new paper in @JAMAInternalMed: is IV contrast nephrotoxic? Lots of studies say no, but have ⬆️risk of confounding: people who get contrast ≠ people who don't get it. We used a natural experiment to try to overcome this bias https://t.co/XWEEohAvK0 1/5
— Robert Goulden (@EMrobg) April 5, 2021
M-A: Treatment for bleeding esophageal varices in people with decompensated liver cirrhosis
12 Apr, 2021 | 00:39h | UTCRelated Cochrane Reviews: M-A: Secondary prevention of variceal bleeding in adults with previous esophageal variceal bleeding due to decompensated liver cirrhosis AND Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network meta‐analysis – Cochrane Library
Japanese doctors perform world’s first living donor lung transplant to a Covid-19 patient
12 Apr, 2021 | 01:12h | UTCJapanese doctors perform world’s first living donor lung transplant to a Covid-19 patient – CNN
Comprehensive Review | Pneumonia
9 Apr, 2021 | 03:14h | UTCPneumonia – Nature Reviews Disease Primers (free for a limited period)
Try this link if the above is paywalled.
[Preprint] CoronaVac is 50% effective for reducing symptomatic SARS-CoV-2 infection after the first dose in the setting of high P.1 variant transmission in Brazil
9 Apr, 2021 | 03:36h | UTC
Commentary on Twitter (thread – click for more)
New 50% efficacy study of Brazil-predominant vaccine CoronaVac (by Sinovac) in Manaus 🇧🇷 among healthcare workers when #P1 ~75% dominant. Not a trial, but the study found a 1st dose >=14-days efficacy of 50% on symptomatic #COVID19, ~32% if +asymptomatic. https://t.co/YMmZ3mmSDI pic.twitter.com/jwx5R627ys
— Eric Feigl-Ding (@DrEricDing) April 8, 2021
Commentary | Distinguishing the real from the hyperglycemia: does COVID-19 induce diabetes?
9 Apr, 2021 | 03:28h | UTC
The NIH COVID-19 Treatment Guidelines Panel’s Statement on the Emergency Use Authorization of Anti-SARS-CoV-2 Monoclonal Antibodies for the Treatment of COVID-19
9 Apr, 2021 | 03:35h | UTC
Review: Care for the organ transplant recipient on the intensive care unit
8 Apr, 2021 | 08:36h | UTCCare for the organ transplant recipient on the intensive care unit – Journal of Critical Care
Guidance on syndrome of Thrombosis and Thrombocytopenia occurring after coronavirus Vaccination
7 Apr, 2021 | 01:48h | UTC
Commentary on Twitter
https://twitter.com/trishgreenhalgh/status/1379414362700517385
Large study showed no association between blood group types and increased risk of Covid-19
7 Apr, 2021 | 01:41h | UTC
Commentary on Twitter
This case-control study found blood type A was not associated with higher nor type O with lower COVID-19 susceptibility or severity. Blood types were not prognostically useful. https://t.co/P8VpvQWuwE
— JAMA Network Open (@JAMANetworkOpen) April 6, 2021
Diagnostic Test Interpretation: Evaluation of Hypokalemia
6 Apr, 2021 | 01:07h | UTCEvaluation of Hypokalemia – JAMA (free for a limited period)
Consensus Statement: Perioperative management of patients with pulmonary hypertension undergoing non-cardiothoracic, non-obstetric surgery
6 Apr, 2021 | 00:54h | UTC
M-A: Colchicine administration for percutaneous coronary intervention
6 Apr, 2021 | 00:58h | UTCColchicine administration for percutaneous coronary intervention: A meta-analysis of randomized controlled trials – The American Journal of Emergency Medicine (link to abstract – $ for full-text)
Related: Efficacy and safety of low-dose colchicine in patients with coronary disease: a systematic review and meta-analysis of randomized trials – European Heart Journal (link to abstract – $ for full-text)
M-A: High versus low PEEP levels for mechanically ventilated adult patients with acute lung injury and ARDS
5 Apr, 2021 | 01:19h | UTC
Cohort study: High thrombotic risk in cancer patients receiving immunotherapy
5 Apr, 2021 | 01:08h | UTCHigh thrombotic risk in cancer patients receiving immunotherapy – Medical University of Vienna
Original study: Incidence, risk factors, and outcomes of venous and arterial thromboembolism in immune checkpoint inhibitor therapy – Blood
Early outcomes after lung transplantation for severe COVID-19: a series of the first consecutive cases from four countries
5 Apr, 2021 | 01:49h | UTCCommentary: Criteria for selecting COVID-19 patients for lung lung transplantation – Medical University of Vienna
Commentary on Twitter
NEW Research—Lung transplantation is the only option for survival in some patients with severe, unresolving #COVID19-associated #ARDS
From Ankit Bharat & colleagues https://t.co/7u52IJSOIn, including a fantastic video abstract https://t.co/2cjfTLXR8R
— The Lancet Respiratory Medicine (@LancetRespirMed) April 1, 2021
Exceedingly rare side effects reported with AstraZeneca vaccine in the UK – 22 cases of cerebral venous sinus thrombosis with low levels of platelets out of 18 million vaccinated individuals
5 Apr, 2021 | 01:45h | UTCCovid-19: Seven UK blood clot deaths after AstraZeneca vaccine – BBC
Original report: Coronavirus vaccine – weekly summary of Yellow Card reporting – Medicines and Healthcare products Regulatory Agency
Related opinion: Undermining the AstraZeneca jab is a dangerous act of political folly – The Guardian
“Based on current experience, the expected benefits of both COVID-19 vaccines in preventing COVID-19 and its serious complications far outweigh any known side effects”
Many hospitalized Covid-19 patients are given antibiotics. That’s a problem
5 Apr, 2021 | 01:33h | UTCMany hospitalized Covid-19 patients are given antibiotics. That’s a problem – STAT
RCT: Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury – waiting too long can be deleterious
2 Apr, 2021 | 09:17h | UTCComparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial – The Lancet (link to abstract – $ for full-text)