Critical Care
Teleneurology-enabled determination of death by neurologic criteria after cardiac arrest or severe neurologic injury
2 Mar, 2021 | 01:32h | UTCTeleneurology-Enabled Determination of Death by Neurologic Criteria After Cardiac Arrest or Severe Neurologic Injury – Neurology (link to abstract – $ for full-text)
M-A: Treatment with convalescent plasma is not associated with better outcomes in patients with Covid-19
28 Feb, 2021 | 21:51h | UTCEditorial: Emerging Lessons From COVID-19 for the US Clinical Research Enterprise
Commentary on Twitter
Just out: Our meta-analysis in @JAMA_current
"Among patients with COVID-19, treatment with convalescent plasma compared with control was not associated with improved survival or other positive clinical outcomes"https://t.co/tRqpd9v67m
— Lars G. Hemkens (@LGHemkens) February 26, 2021
Editorial | Twenty Lessons from 2020: With a Focus on the ICU Perspective
28 Feb, 2021 | 21:44h | UTCTwenty Lessons from 2020: With a Focus on the ICU Perspective – ICU Management & Practice
RCT: Baclofen reduces agitation in patients with unhealthy alcohol use receiving mechanical ventilation, but results in a longer time receiving mechanical ventilation and more extended ICU stay
28 Feb, 2021 | 21:09h | UTCEditorial: Baclofen to Prevent Agitation Caused by Alcohol Withdrawal in the ICU
Video presentation: Effect of Baclofen on Agitation-Related Events Among Mechanically Ventilated Patients With Alcohol Use Disorder
Commentary on Twitter
In this phase 3 RCT, high-dose baclofen reduced agitation-related events vs placebo in patients with unhealthy alcohol use receiving mechanical ventilation; considering the modest effect & secondary endpoints & adverse events, further research is needed https://t.co/gHWEqZKfFv
— JAMA (@JAMA_current) February 23, 2021
RCT: Balanced opioid-free anesthesia with Dexmedetomidine resulted in a greater incidence of serious adverse events, especially hypoxemia and bradycardia
28 Feb, 2021 | 21:03h | UTC
RCT: An intensive blood pressure lowering strategy after successful endovascular therapy in acute ischemic stroke did not reduce radiographic intraparenchymal hemorrhage rates
28 Feb, 2021 | 20:59h | UTCSafety and efficacy of intensive blood pressure lowering after successful endovascular therapy in acute ischaemic stroke (BP-TARGET): a multicentre, open-label, randomised controlled trial – The Lancet Neurology (link to abstract – $ for full-text)
Conflicting results from 2 randomized trials testing Tocilizumab for Covid-19
26 Feb, 2021 | 08:48h | UTC
Commentary on Twitter
Why do 2 randomized trials of tocilizumab, an interleukin-6 blocker, for severe covid-19, have opposite results?
Today @NEJMhttps://t.co/g8LCrhhpLyhttps://t.co/BcN3wOwsl0 pic.twitter.com/sLrQUYI1pf— Eric Topol (@EricTopol) February 25, 2021
PRO-CON Debate: Are Carbapenems necessary for all infections caused by ceftriaxone-resistant Enterobacterales?
28 Feb, 2021 | 20:43h | UTCEditorial: Navigating treatment approaches for presumed ESBL-producing infections
Commentary on Twitter (thread – click for more)
?NEW? PRO-CON Debate on the role of carbapenems in infections caused by Enterobacterales resistant to ceftriaxone. #AMR @BSACandJAC @IDdocAdi @ABsteward
— JAC-AMR (@jac_amr) February 24, 2021
Position Paper: Management of drug-induced liver injury
25 Feb, 2021 | 08:27h | UTC
ICU-based renal replacement therapy
25 Feb, 2021 | 08:23h | UTCICU-Based Renal Replacement Therapy – Critical Care Medicine
Commentary on Twitter
Renal Replacement in #ICU
?history/development
?(fast) evolution of tech & machines
?pivotal role of nursing
?mode: CRRT vs IHD
?CRRT & blood purification
?peds & neonates #PedsICU
?complications
?anticoagulation@CritCareMed #FOAMcc #FOANed #CCC50 https://t.co/NxC88pbIB6 pic.twitter.com/OGVkwkrjLi— M Velia Antonini (@FOAMecmo) February 4, 2021
Sepsis treatment: Another trial shows no benefit from the combination of Vitamin C, Thiamine, and Hydrocortisone
24 Feb, 2021 | 02:25h | UTCEffect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Hydrocortisone, Vitamin C, and Thiamine for Treatment of Sepsis: Making Evidence Matter
Related: The VITAMINS Randomized Clinical Trial: Vitamin C, Hydrocortisone, and Thiamine Not beneficial for Patients with Sepsis (study and commentaries)
Commentary on Twitter
VICTAS trial now in @JAMA_current. Is this the final nail in the coffin for HAT in sepsis? https://t.co/kDdmnIdC6s
— UGAC3 (@ugac3) February 23, 2021
How the COVID-19 pandemic will change the future of critical care
24 Feb, 2021 | 02:49h | UTCHow the COVID-19 pandemic will change the future of critical care – Intensive Care Medicine
Commentary on Twitter
Will #COVID19 change critical care?
➡️approach to crises
➡️flexible #ICU capacity/staff & safer design
➡️efficient supply/use of PPE, devices, consumables, meds
➡️triage principles
➡️communication
➡️end‐of‐life
➡️#AI, registries, agile collaborative RCTshttps://t.co/0aWmhQxItm pic.twitter.com/qFZCi4eYwM— Intens Care Med (@yourICM) February 23, 2021
M-A: The diagnostic accuracy of noninvasive methods to measure the intracranial pressure
23 Feb, 2021 | 01:14h | UTC
FDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias
23 Feb, 2021 | 02:03h | UTCFDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias – STAT
FDA Safety Alert: Pulse Oximeter Accuracy and Limitations: FDA Safety Communication – U.S. Food & Drug Administration
Related: “Racial Bias in Pulse Oximetry Measurement”. In two large cohorts, Black patients had nearly three times the frequency of occult hypoxemia that was not detected by pulse oximetry as White patients – New England Journal of Medicine (study and commentaries)
Editorial: Prophylactic anticoagulation for patients in hospital with covid-19
23 Feb, 2021 | 01:59h | UTCProphylactic anticoagulation for patients in hospital with covid-19 – The BMJ
Related: Full-dose Heparin best for moderate COVID-19 regardless of D-dimer — Data released from ACTIV-4a, ATTACC, and REMAP-CAP trials AND Cohort study: Early initiation of prophylactic anticoagulation linked to reduced mortality in patients admitted to hospital with Covid-19
Intensive care management of patients with COVID-19: a practical approach
21 Feb, 2021 | 22:34h | UTCRelated Guideline: Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update AND Infographic
SOFA score is not accurate enough for mortality prediction in severely ill patients with COVID-19 pneumonia
19 Feb, 2021 | 02:44h | UTC
Commentary on Twitter
'The discriminant accuracy of the #SOFA score for
mortality prediction in patients prior to intubation for#COVID-19 pneumonia was poor and significantly inferior to simply using age.' Age, apparently can't be used because 'discrimination'. #bioethics https://t.co/QJIxqupoVx— udo schuklenk ?️??????? (@schuklenk) February 17, 2021
Review: Oxygen administration for patients with ARDS
19 Feb, 2021 | 02:24h | UTCOxygen administration for patients with ARDS – Journal of Intensive Care
RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19
18 Feb, 2021 | 03:20h | UTCEditorial: Vitamin D3 to Treat COVID-19: Different Disease, Same Answer
In this RCT a single high dose of #vitaminD3 (100K IU) raised mean serum 25OH D levels but had no effect on hospital LOS (primary outcome), in-hospital mortality, ICU admission, or need for mechanical ventilation (secondary outcomes) https://t.co/eozVaYnb25
— JAMA (@JAMA_current) February 17, 2021
M-A: The effect of convalescent plasma therapy on COVID-19 patient mortality
18 Feb, 2021 | 03:07h | UTCRelated study (not published yet) with conflicting results: RECOVERY trial: No Benefit from convalescent plasma in hospitalized patients with Covid-19 (news release and commentary)
Video: Emergency intubation in Covid-19
18 Feb, 2021 | 03:16h | UTCEmergency Intubation in Covid-19 – New England Journal of Medicine
Patient characteristics and clinical outcomes of Type 1 vs. Type 2 myocardial infarction
18 Feb, 2021 | 02:54h | UTCPatient Characteristics and Clinical Outcomes of Type 1 Versus Type 2 Myocardial Infarction – Journal of the American Academy of Cardiology (link to abstract – $ for full-text)
Commentary on Twitter
What are the patient characteristics & clinical outcomes of type 1 vs type 2 #cvMI in the U.S.? Over 200K+ are analyzed. Find out in this week’s issue of #JACC: https://t.co/trgZtKgbOy @CianPMcCarthy @mvaduganathan @JJheart_doc #HFWeek2021 #HeartMonth #CardioTwitter pic.twitter.com/dCdinfeNwE
— JACC Journals (@JACCJournals) February 16, 2021
Short review: Acute CV complications of hematopoietic stem cell transplantation
18 Feb, 2021 | 02:40h | UTCAcute CV Complications of Hematopoietic Stem Cell Transplantation – American College of Cardiology
Ocular MRI findings in patients with severe COVID-19
17 Feb, 2021 | 01:42h | UTCCommentaries: New COVID-19 side effect: MRI links severe infection to dangerous eye problems – Health Imaging AND MRI illuminates COVID-19’s negative impact on the eyes – AuntMinnie AND Windows of Infection: MRI Reveals COVID-19-Linked Eye Abnormalities – Diagnostic Imaging
Cardiac arrest in COVID-19: characteristics and outcomes of in- and out-of-hospital cardiac arrest
17 Feb, 2021 | 01:32h | UTC
Commentary on Twitter
#COVID19 was involved in at least 10% of all out-of-hospital cardiac arrests (OHCA) and 16% of intra-hospital cardiac arrests (IHCA) and, among #COVID_19 cases, 30-day mortality was increased 3.4-fold in OHCA & 2.3-fold in IHCA https://t.co/uS6rzTXuew#EHJ #ESCYoung @ehj_ed pic.twitter.com/QisuU9rsLT
— European Society of Cardiology Journals (@ESC_Journals) February 5, 2021