Critical Care
[Preprint] RCT: non-invasive respiratory strategies in acute respiratory failure in patients with COVID-19 – CPAP reduced the composite outcome of intubation or death within 30 days; high-flow nasal oxygenation was not associated with better outcomes.
6 Aug, 2021 | 10:18h | UTCCommentary: Covid: Pressured oxygen reduces ventilator need – BBC
Commentary on Twitter (thread – click for more)
RECOVERY-RS results out, and confirm what most of us have been doing:
CPAP reduces intubation/mortality by 28% compared with no CPAP/HFNO (composite outcome, mostly intubation)
Nasal high flow not so successful1/https://t.co/bcB2sTdAsu pic.twitter.com/fvT8IbyxUr
— ??? ?????? ? (@LawtonTri) August 5, 2021
Review: Transmission of infections during cardiopulmonary resuscitation.
8 Aug, 2021 | 23:16h | UTCTransmission of Infections during Cardiopulmonary Resuscitation – Clinical Microbiology Reviews
Systematic Review: “Remdesivir probably has little or no effect on all‐cause mortality at up to 28 days in hospitalized adults with SARS‐CoV‐2 infection. We are uncertain about the effects of remdesivir on clinical improvement and worsening”.
6 Aug, 2021 | 10:15h | UTCRemdesivir for the treatment of COVID‐19 – Cochrane Library
Summary: Remdesivir for the treatment of COVID-19 – Cochrane Library
Commentary on Twitter (thread – click for more)
JUST PUBLISHED – Is #remdesivir an effective treatment for #COVID19? https://t.co/ntgfDQjMqs This @CochraneHaem systematic review looked at this antiviral medicine to see if it's an effective treatment for people in hospital w #COVID & if it causes unwanted effects. 1/5 pic.twitter.com/UtIW83uTtn
— The Cochrane Library (@CochraneLibrary) August 5, 2021
Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients.
6 Aug, 2021 | 10:13h | UTC
Clinical Picture: Mucormycosis after COVID-19 in a patient with diabetes.
6 Aug, 2021 | 10:09h | UTCMucormycosis after COVID-19 in a patient with diabetes – The Lancet
Related:
COVID-19 and mucormycosis superinfection: the perfect storm.
What is mucormycosis, the fungal infection affecting COVID patients in India?
[Preprint] The Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries.
Mucormycosis: The ‘black fungus’ maiming Covid patients in India
Global Guideline for the Diagnosis and Management of Mucormycosis
ESPEN practical guideline: Clinical nutrition in surgery – “Preoperative fasting from midnight is unnecessary in most patients. Patients undergoing surgery, who are considered to have no specific risk of aspiration, shall drink clear fluids until 2 h before anesthesia. Solids shall be allowed until 6 h before anesthesia.”
6 Aug, 2021 | 09:59h | UTCESPEN practical guideline: Clinical nutrition in surgery – Clinical Nutrition
Review: Rational fluid resuscitation in sepsis for the hospitalist.
6 Aug, 2021 | 09:53h | UTC
International, multicenter observational study: Outcomes with percutaneous dilatational tracheotomy in high-risk ICU patients.
6 Aug, 2021 | 08:59h | UTCPercutaneous dilatational tracheotomy in high-risk ICU patients – Annals of Intensive Care
Pre-post study: The implementation of a pathway and care bundle for the management of acute occlusive arterial mesenteric ischemia reduced mortality.
6 Aug, 2021 | 08:55h | UTC
Commentary on Twitter
Putting effort in the management of acute mesenteric ischemia seems worthwhile! How are these patients managed in your hospital? See our latest study. #EmergSurg #surgtwitter @villesallinen @JTraumAcuteSurg @me4_so @Me4Trauma https://t.co/iinp3HFBDw pic.twitter.com/njRQq3fpmp
— Matti Tolonen (@MattiTolon3n) August 4, 2021
M-A: Effects of early mobilization on the prognosis of critically ill patients.
6 Aug, 2021 | 08:57h | UTCEffects of early mobilization on the prognosis of critically ill patients: A systematic review and meta-analysis – International Journal of Nursing Studies (link to abstract – $ for full-text)
Commentary on Twitter
Effects of Early Mobilization on ICU patients: Meta-Analysis incl 39 studies (23 studies from China!) showed benefits for weaning, LOS, physical function and others, but not for mortality, delirium, handgrip strengthhttps://t.co/w8ZWNxyz8z pic.twitter.com/YA8cJDps9N
— Peter Nydahl (@NydahlPeter) July 29, 2021
RCT: In noncritically ill patients hospitalized with Covid-19, therapeutic-dose anticoagulation with heparin increased the probability of survival to hospital discharge compared with usual-care thromboprophylaxis.
5 Aug, 2021 | 09:07h | UTCEditorial: Surviving Covid-19 with Heparin?
Commentaries:
Therapeutic-Dose Heparin in COVID-19: Who Benefits, Who Doesn’t – TCTMD
Commentary on Twitter
In noncritically ill patients with #COVID19, anticoagulation increased the probability of survival to hospital discharge without organ support. https://t.co/3JzKdmL3SB #IDTwitter pic.twitter.com/iDjSelp2HL
— NEJM (@NEJM) August 4, 2021
RCT: In critically ill patients with Covid-19, therapeutic anticoagulation with heparin did not result in improved outcomes compared to usual-care pharmacologic thromboprophylaxis.
5 Aug, 2021 | 09:04h | UTCEditorial: Surviving Covid-19 with Heparin?
Commentaries:
Therapeutic-Dose Heparin in COVID-19: Who Benefits, Who Doesn’t – TCTMD
Commentary on Twitter
Anticoagulation did not improve hospital survival in critically Ill patients with #COVID19. https://t.co/E8RXE01jbF pic.twitter.com/9idGxgbUas
— NEJM (@NEJM) August 4, 2021
Myocarditis and pericarditis after vaccination for COVID-19.
5 Aug, 2021 | 08:57h | UTCMyocarditis and Pericarditis After Vaccination for COVID-19 – JAMA
Related:
Analysis finds benefits of COVID-19 vaccination outweigh risks of rare cases of myocarditis.
Case Series: Myocarditis following immunization with mRNA COVID-19 vaccines.
RCT: Similar outcomes with Milrinone vs. Dobutamine in the treatment of cardiogenic shock.
5 Aug, 2021 | 08:44h | UTCMilrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock – New England Journal of Medicine (link to abstract – $ for full-text)
Visual abstract: Milrinone vs. Dobutamine in Cardiogenic Shock
Commentary: Inotrope Showdown Leaves No Winner in Cardiogenic Shock – MedPage Today (link to abstract – $ for full-text)
Position statement: Perioperative management of post-COVID-19 surgical patients.
4 Aug, 2021 | 10:00h | UTCRelated:
Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery
Commentary on Twitter
Interesting position statement (from India) for perioperative management of post-COVID-19 surgical patients. Highlights important points to consider but appears overly cautious, recommending a lot of preop testing. #COVID19 https://t.co/oOR1ik21ha
— Steven Cohn, MD (@preopconsult) August 3, 2021
Antimicrobial stewardship in the ICU in COVID times: the known unknowns.
4 Aug, 2021 | 09:16h | UTCRelated:
Antimicrobial stewardship in ICUs during the COVID-19 pandemic: back to the 90s?
Too many COVID-19 patients get unneeded ‘just in case’ antibiotics
Spontaneous pneumomediastinum in patients diagnosed with covid-19: a case series with review of literature.
4 Aug, 2021 | 09:13h | UTC
Clinical practice recommendations on the management of perioperative cardiac arrest.
4 Aug, 2021 | 09:03h | UTC
2021 Update in the diagnosis and management of acute coronary syndromes for the perioperative clinician.
3 Aug, 2021 | 02:22h | UTC
Commentary on Twitter
Great review by @kjkunkelmd et al. 2021 Update in the Diagnosis and Management of Acute Coronary Syndromes For the Perioperative Clinician
? https://t.co/mPcUTX43TT@PedroMDMSc @HenryFordNews @JCVAonline pic.twitter.com/4K0XjO4kGK
— Alejandro Lemor MD, MS (@AlejandroLemor) July 24, 2021
What every intensivist should know about Tocilizumab.
2 Aug, 2021 | 00:25h | UTCWhat every intensivist should know about Tocilizumab – Critical Care
Related:
Tocilizumab in COVID-19 therapy: who benefits, and how?
NICE COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis.
30 Jul, 2021 | 12:14h | UTCNews release: NICE publishes new rapid guideline to diagnose and treat rare blood clotting condition associated with COVID-19 vaccination – National Institute for Health and Care Excellence
Related: Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)
Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.
30 Jul, 2021 | 12:12h | UTCVaccine-induced immune thrombotic thrombocytopenia: what we know and do not know – Blood
Related: Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)
Observational study: Positive Fluid balance linked to worse outcomes in critically ill patients with traumatic brain injury.
1 Aug, 2021 | 23:57h | UTCFluid balance and outcome in critically ill patients with traumatic brain injury (CENTER-TBI and OzENTER-TBI): a prospective, multicentre, comparative effectiveness study – The Lancet Neurology (link to abstract – $ for full-text)
Commentary: Traumatic Brain Injury: Fluid Overload Tied to Higher Mortality in ICU Patients – Physician’s Weekly
Commentary on Twitter
Happy with our paper in @TheLancetNeuro on comparative effectiveness of fluid management strategies in TBI patients in the ICU. Successful example of treatment effect estimation in observational data. @CenterTBI @Menon_Cambridge @Dr_Cit @ESteyerberghttps://t.co/TMzhkd1SZz
— Hester Lingsma (@hesterlingsma) July 23, 2021
Risk of acute myocardial infarction and ischemic stroke following COVID-19 in Sweden – “the true risk is increased by between three and eight times for acute myocardial infarction and by between three and seven times for ischaemic stroke following COVID-19.”
30 Jul, 2021 | 12:06h | UTCInvited commentary: What is the association of COVID-19 with heart attacks and strokes? – The Lancet
Commentary on Twitter
Is Covid a risk factor for heart attack and stroke?https://t.co/6KRaKzPgI5 @TheLancet
This new paper says yes, but the absolute increased risk is small, and likely due to predisposition to clotting in the post-infection phase pic.twitter.com/HQjxo63Yby— Eric Topol (@EricTopol) July 29, 2021
Study: Recommended approaches to minimize aerosol dispersion of SARS-CoV-2 during noninvasive ventilatory support can cause ventilator performance deterioration.
30 Jul, 2021 | 11:59h | UTC