Critical Care
Guideline for the emergency management of anaphylaxis.
28 Jun, 2022 | 10:59h | UTCRelated:
EAACI guidelines: Anaphylaxis (2021 update) – European Journal of Allergy and Immunology
Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19.
27 Jun, 2022 | 11:49h | UTC
Commentary on Twitter
NEW Personal View—Use of pragmatic and explanatory trial designs in acute care research: lessons from #COVID19
From Jonathan Casey & colleagues https://t.co/3vJs5j6Q1Q pic.twitter.com/hEUFYxNKRf
— The Lancet Respiratory Medicine (@LancetRespirMed) June 14, 2022
M-A: Hypothermic vs. normothermic temperature control after cardiac arrest.
24 Jun, 2022 | 11:51h | UTCHypothermic versus Normothermic Temperature Control after Cardiac Arrest – NEJM Evidence
Related:
ERC-ESICM guidelines on temperature control after cardiac arrest in adults – Intensive Care Medicine (if the link is paywalled, try this one)
Systematic Review: Parenteral Vitamin C in patients with severe infection.
24 Jun, 2022 | 11:49h | UTCParenteral Vitamin C in Patients with Severe Infection: A Systematic Review – NEJM Evidence
Related:
Is shorter always better? The pros and cons of treating Gram-negative bloodstream infections with 7 days of antibiotics.
24 Jun, 2022 | 11:38h | UTC
Hemorrhagic fever with renal syndrome: literature review, epidemiology, clinical picture and pathogenesis.
24 Jun, 2022 | 11:02h | UTC
Study Commentary | How FAST can you spot a pneumothorax? breaking down a surprising result comparing ultrasound and chest radiograph in traumatic pneumothorax.
24 Jun, 2022 | 10:39h | UTCOriginal Study: Not so FAST—Chest ultrasound underdiagnoses traumatic pneumothorax – Journal of Trauma and Acute Care Surgery (link to abstract – $ for full-text)
Ivermectin for COVID-19 Cochrane review update: 11 trials and no evidence of benefit shown.
23 Jun, 2022 | 10:38h | UTCNews Release: Ivermectin for COVID-19 review update: 11 trials and no evidence of benefit shown – Liverpool School of Tropical Medicine
Original Article: Ivermectin for preventing and treating COVID‐19 – Cochrane Library
Summary: Ivermectin for preventing and treating COVID-19 – Cochrane Library
M-A: Early versus delayed complete revascularization in patients presenting with ST-segment elevation myocardial infarction and multivessel disease.
23 Jun, 2022 | 10:11h | UTC
Consensus Recommendations: Early management of patients with aneurysmal subarachnoid hemorrhage in a hospital with neurosurgical/neuroendovascular facilities.
22 Jun, 2022 | 11:25h | UTC
Position Paper: Diagnosis and management of infections caused by multidrug-resistant bacteria.
22 Jun, 2022 | 11:23h | UTCRelated Guideline:
Review: Advanced interventions in the pre-hospital resuscitation of patients with non-compressible hemorrhage after penetrating injuries.
22 Jun, 2022 | 11:21h | UTC
RCT: High-flow nasal cannula vs. conventional oxygen therapy in acute COPD exacerbation with mild hypercapnia.
22 Jun, 2022 | 11:09h | UTC
Randomized cross-over study: closed-loop oxygen control improves oxygen therapy in acute hypoxemic respiratory failure patients under high flow nasal oxygen.
22 Jun, 2022 | 11:08h | UTC
RCT: Low-dose methylprednisolone does not improve outcomes in critically ill patients with severe community-acquired pneumonia.
21 Jun, 2022 | 11:04h | UTC
Guidelines for the management of patients with severe acute pancreatitis.
21 Jun, 2022 | 10:57h | UTCRelated:
Evidence-Based Disposition of Acute Pancreatitis – emDocs
Pancreatitis – National Institute for Health and Care Excellence
Summary of the new 2022 AHA/ASA Guideline on intracerebral hemorrhage.
21 Jun, 2022 | 10:54h | UTCIntracerebral Hemorrhage 2022 Guideline Update – emDocs
Original Guideline: 2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association – Stroke
Top Things to Know: 2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage – American Heart Association
News Release: New guideline refines care for brain bleeds: compression socks, some meds not effective – American Heart Association
RCT: A restrictive intravenous fluid strategy does not improve outcomes in ICU patients with septic shock.
20 Jun, 2022 | 10:51h | UTCRestriction of Intravenous Fluid in ICU Patients with Septic Shock – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: No Fewer Deaths Seen With Restricted IV Fluid for Septic Shock – HealthDay
Related:
Fluid administration and monitoring in ARDS: which management? – Intensive Care Medicine
Commentary on Twitter
In this trial, a restrictive approach to intravenous fluid administration in critically ill patients with septic shock did not reduce mortality. #CCR22 https://t.co/UfY1936Qwb pic.twitter.com/FtSaDIIroj
— NEJM (@NEJM) June 17, 2022
[Preprint] Open-label RCT: Baricitinib noninferior to Tocilizumab in hospitalized patients with severe COVID-19.
20 Jun, 2022 | 10:28h | UTCRelated:
WHO recommends two new drugs to treat COVID-19 – World Health Organization
Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 – New England Journal of Medicine
Commentary on Twitter
Preprint⚡⚡
Baricitinib Vs Tocilizumab open label RCT
Baricitinib was non-inferior to tocilizumab with regards to the composite outcome of mechanical ventilation or death by day 28 and the time to discharge by day 28 in patients with severe #COVID19 https://t.co/sQkhATkjEd— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) June 16, 2022
Brief Review: Helmet noninvasive support in hypoxemic respiratory failure.
20 Jun, 2022 | 01:13h | UTCHelmet noninvasive support in hypoxemic respiratory failure – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
Helmet noninvasive support in hypoxemic respiratory failure:
⚙️ set‐up
⛑ physiology of helmet interface: from most relevant feature to major drawbacks
💨 clinical implications
Free to read #FOAMcc on @yourICM
🖇 https://t.co/qNE4Id5oBg pic.twitter.com/b2auLLlW9z— Intensive Care Medicine (@yourICM) June 18, 2022
RCT: Immune enhancement with Thymosin alpha 1 does not improve outcomes in patients with predicted severe acute necrotizing pancreatitis.
20 Jun, 2022 | 01:11h | UTCImmune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double-blind randomised controlled trial – Intensive Care Medicine (if the link is paywalled, try this one)
Registry-based cohort study: Endovascular treatment vs. best medical management in acute basilar artery occlusion strokes.
17 Jun, 2022 | 11:03h | UTCEndovascular Treatment Versus Best Medical Management in Acute Basilar Artery Occlusion Strokes: Results From the ATTENTION Multicenter Registry – Circulation (free for a limited period)
Commentary on Twitter
#ResearchLetter In 2134 patients with basilar artery occlusion #stroke, endovascular treatment was associated with improved functional capacity. The effect was more pronounced in patients with more debilitating symptoms #AHAJournals https://t.co/wy4uFocYlR pic.twitter.com/TIBRVAXRhE
— Circulation (@CircAHA) June 10, 2022
#CCR22 – RCT: High-flow nasal cannula therapy met criteria for noninferiority compared to CPAP for the liberation from respiratory support in acutely ill children in the ICU.
16 Jun, 2022 | 11:10h | UTCEffect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
Among acutely ill children clinically assessed to require noninvasive respiratory support in a pediatric critical care unit, HFNC met the criterion for noninferiority compared with CPAP for time to liberation from respiratory support. https://t.co/WvU2fKLDOJ #CCR22
— JAMA (@JAMA_current) June 16, 2022
#CCR22 – RCT: Intravenous Vitamin C increases the risk of death or persistent organ dysfunction in adults with sepsis in the intensive care unit.
16 Jun, 2022 | 11:13h | UTCRelated:
Commentary on Twitter
https://twitter.com/NEJM/status/1536991910006468608
#CCR22 – RCT: Among critically ill patients undergoing tracheal intubation, administering a 500 ml fluid bolus did not decrease the incidence of severely low blood pressure, cardiac arrest, or death.
16 Jun, 2022 | 11:08h | UTCEffect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
In this randomized clinical trial, among critically ill adults undergoing tracheal intubation, administration of a fluid bolus did not significantly decrease the incidence of cardiovascular collapse. https://t.co/vPkfgLBF1n #CCR22
— JAMA (@JAMA_current) June 16, 2022