Critical Care | Page 30 of 78 | Links Medicus Content Curation & Alerts in Medicine

Cohort Study | Electrocardiographic findings associated with early clinical deterioration in acute pulmonary embolism.

31 Aug, 2022 | 11:30h | UTC

Electrocardiographic findings associated with early clinical deterioration in acute pulmonary embolism – Academic Emergency Medicine

Brief Review | Physiology of extracorporeal CO2 removal.

31 Aug, 2022 | 11:28h | UTC

Physiology of extracorporeal CO2 removal – Intensive Care Medicine

#ESCCongress | In critically ill patients with COVID-19, full-dose anticoagulation reduced thrombotic events but increased the risk of bleeding.

30 Aug, 2022 | 12:12h | UTC

Anticoagulation and Antiplatelet Therapy for Prevention of Venous and Arterial Thrombotic Events in Critically Ill Patients with COVID-19: COVID-PACT – Circulation

News Release: Trial supports full-dose anticoagulation to prevent blood clots in COVID-19 patients – European Society of Cardiology

Anticoagulants for people hospitalised with COVID‐19 – Cochrane Library

Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week – Journal of the American College of Cardiology

Efficacy and safety of heparin full-dose anticoagulation in hospitalized non-critically ill COVID-19 patients: a meta-analysis of multicenter randomized controlled trials – Journal of Thrombosis and Thrombolysis

Efficacy and safety of intensified versus standard prophylactic anticoagulation therapy in patients with Covid-19: a systematic review and meta-analysis – Open Forum Infectious Diseases

Point/Counterpoint: Should therapeutic heparin be administered to acutely ill hospitalized patients with COVID-19?

Commentary on Twitter

#OriginalResearch SimPub #ESCCongress: In the #COVID-PACT 2×2 factorial RCT, full-dose prophylactic anticoagulation, but not the addition of clopidogrel, reduced thrombotic complications but w/ increased bleeding among critically-ill patients w/ COVID-19 https://t.co/UNxFCIC5B9 pic.twitter.com/p5LGmpCGeL

— Circulation (@CircAHA) August 29, 2022

RCT | Acetazolamide resulted in faster decongestion in patients with acute decompensated heart failure with volume overload.

29 Aug, 2022 | 12:25h | UTC

Acetazolamide in Acute Decompensated Heart Failure with Volume Overload – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Acetazolamide improves decongestion in patients with acute decompensated heart failure – European Society of Cardiology

Commentary: Acetazolamide in Decompensated Heart Failure With Volume Overload – ADVOR – American College of Cardiology

Commentary on Twitter

ADVOR: In a placebo-controlled trial, patients with acute decompensated heart failure and volume overload who had been randomly assigned to receive IV acetazolamide plus a loop diuretic had a higher incidence of decongestion. #ESCCongress https://t.co/YeoffDhXwc pic.twitter.com/YV3gM3gxij

— NEJM (@NEJM) August 27, 2022

#ESCCongress | 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death.

29 Aug, 2022 | 12:21h | UTC

2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Developed by the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the European Society of Cardiology (ESC) Endorsed by the Association for European Paediatric and Congenital Cardiology (AEPC) – European Heart Journal

News Release: People of all ages should learn cardiopulmonary resuscitation – European Society of Cardiology

#ESCCongress – RCT | In comatose survivors of out-of-hospital cardiac arrest, targeting a mean arterial blood pressure of 77 mmHg vs. 63 mmHg did not result in different outcomes.

29 Aug, 2022 | 12:13h | UTC

Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Trial finds no benefit of raising blood pressure target in post cardiac arrest patients – European Society of Cardiology

Commentary: Blood Pressure Targets Show No Benefit in Comatose Survivors of Cardiac Arrest – HCPLive

Commentary on Twitter

BOX BP: This randomized trial found no difference in the rate of death or severe disability/coma when patients following out-of-hospital cardiac arrest were managed with higher or lower blood pressure targets. #ESCCongress https://t.co/5qOMtiPSck pic.twitter.com/QOl5KetTvn

— NEJM (@NEJM) August 27, 2022

#ESCCongress – RCT | In comatose survivors of out-of-hospital cardiac arrest, a restrictive vs. a liberal oxygenation strategy resulted in similar incidences of death, severe disability, and coma.

29 Aug, 2022 | 12:12h | UTC

Oxygen Targets in Comatose Survivors of Cardiac Arrest – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Restrictive oxygenation in post cardiac arrest patients is not harmful – European Society of Cardiology

Commentary on Twitter

BOX Oxygen: This RCT found no difference in the rate of death or severe disability/coma when mechanically ventilated patients following out-of-hospital cardiac arrest were managed with higher or lower oxygenation targets. #ESCCongress https://t.co/qqtd4SyVrl pic.twitter.com/q73gqSuAn4

— NEJM (@NEJM) August 27, 2022

Meta-analysis of randomized trials | Use of dexmedetomidine in patients with sepsis.

29 Aug, 2022 | 12:08h | UTC

Use of dexmedetomidine in patients with sepsis: a systematic review and meta-analysis of randomized-controlled trials – Annals of Intensive Care

A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial.

26 Aug, 2022 | 13:08h | UTC

A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial – Critical Care

Original Study: Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury – New England Journal of Medicine

Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta-analysis of randomised clinical trials – The Lancet

RCT: Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury – waiting too long can be deleterious

Meta-analysis: Early initiation of renal replacement therapy is not associated with survival benefit in critically ill patients with acute kidney injury

Consensus Document | Management of decompensated cirrhosis in the surgical ICU.

25 Aug, 2022 | 12:05h | UTC

Management of Decompensated Cirrhosis in the Surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document – Trauma Surgery & Acute Care Open

Commentary on Twitter

#TSACOTuesday ? !
Check out what the AAST Critical Care Committee has to say about the managing Decompensated Cirrhotics in the SICU! https://t.co/lKVn9Y50xO pic.twitter.com/A4MQzaDvTk

— Trauma Surgery & Acute Care Open (TSACO) (@TSACO_AAST) August 2, 2022

Brief Review | New drugs for acute kidney injury.

25 Aug, 2022 | 11:58h | UTC

New drugs for acute kidney injury – Intensive Care Medicine

Review | Subphenotypes in acute kidney injury.

25 Aug, 2022 | 11:50h | UTC

Subphenotypes in acute kidney injury: a narrative review – Critical Care

Long-term results of a RCT | Vasopressin and methylprednisolone did not improve outcomes in patients with in-hospital cardiac arrest.

24 Aug, 2022 | 14:15h | UTC

Effect of vasopressin and methylprednisolone vs. placebo on long-term outcomes in patients with in-hospital cardiac arrest a randomized clinical trial – Resuscitation

Original Study: RCT: Vasopressin + Methylprednisolone increase the likelihood of return of spontaneous circulation compared to placebo in patients with in-hospital cardiac arrest.

RCT | Rib fixation is not beneficial for non–ventilator-dependent chest wall injuries.

24 Aug, 2022 | 14:03h | UTC

Rib fixation in non–ventilator-dependent chest wall injuries: A prospective randomized trial – Journal of Trauma and Acute Care Surgery (link to abstract – $ for full-text)

Commentary on Twitter

Prospective randomized trial assessing #RibFixation in non ventilator dependent rib fracture patients compared to non operative management. Outcomes assessed were pain early, & at 3 & 6 months & quality of life. No benefit of rib fixation was demonstrated. https://t.co/0D9GbJ9Oye pic.twitter.com/b7G3wEPkxx

— Journal of Trauma and Acute Care Surgery (@JTraumAcuteSurg) June 7, 2022

Cluster RCT | Effect of antiseptic bathing with chlorhexidine or octenidine on central line–associated bloodstream infections in intensive care patients.

24 Aug, 2022 | 14:02h | UTC

Effect of antiseptic bathing with chlorhexidine or octenidine on central line–associated bloodstream infections in intensive care patients: a cluster-randomized controlled trial – Clinical Microbiology and Infection (link to abstract – $ for full-text)

Commentary on Twitter

Antiseptic bathing for CLABSI prevention:
SW-RCT incl 72 ICUs with 76,815 showed no significant differences between daily bathing with a) 2% chlorhexidine-impregnated cloths vs b) 0.08% octenidine vs c) water & soap in CLAPSI
Thanks to @CritCareReviews https://t.co/Ou3g3ptMLp

— Peter Nydahl (@NydahlPeter) May 30, 2022

Review | Dangerous causes of nausea/vomiting beyond the GI system.

23 Aug, 2022 | 13:13h | UTC

Dangerous Causes of Nausea/Vomiting Beyond the GI System – emDocs

Review | Inadequate practices for hepatic encephalopathy management in the inpatient setting.

23 Aug, 2022 | 12:57h | UTC

Inadequate practices for hepatic encephalopathy management in the inpatient setting – Journal of Hospital Medicine

Review | Blood transfusion reactions.

23 Aug, 2022 | 12:50h | UTC

Blood Transfusion Reactions—A Comprehensive Review of the Literature including a Swiss Perspective – Journal of Clinical Medicine

Review | Drug regimens of novel antibiotics in critically ill patients with varying renal functions.

23 Aug, 2022 | 12:49h | UTC

Drug Regimens of Novel Antibiotics in Critically Ill Patients with Varying Renal Functions: A Rapid Review – Antibiotics

How to improve intubation in the intensive care unit | Update on knowledge and devices.

22 Aug, 2022 | 12:15h | UTC

How to improve intubation in the intensive care unit. Update on knowledge and devices – Intensive Care Medicine (free for a limited period)

Commentary on Twitter

Tracheal intubation in #ICU
➡️ preoxygenation & apneic oxygenation
➡️ devices for ETT positioning & airway management algorithms
➡️ tube position confirmation
➡️ hemodynamic optimization/choice of drugs
➡️ bundle to limit complications #FOAMcc @yourICM
? https://t.co/Bn5F5aRsHK pic.twitter.com/vWgJh5z8Vl

— Intensive Care Medicine (@yourICM) August 20, 2022

Review | Hemoperfusion in the intensive care unit.

22 Aug, 2022 | 11:56h | UTC

Hemoperfusion in the intensive care unit – Intensive Care Medicine

Review | Manipulating temperature: devices for targeted temperature management in brain injury.

22 Aug, 2022 | 11:55h | UTC

Manipulating temperature: devices for targeted temperature management (TTM) in brain injury – Intensive Care Medicine (if the link is paywalled, try this one)

M-A | The accuracy of pulse oximetry in measuring oxygen saturation by levels of skin pigmentation.

19 Aug, 2022 | 16:15h | UTC

The accuracy of pulse oximetry in measuring oxygen saturation by levels of skin pigmentation: a systematic review and meta-analysis – BMC Medicine

Impact of ethnicity on the accuracy of measurements of oxygen saturations: A retrospective observational cohort study – eClinicalMedicine

Racial and Ethnic Discrepancy in Pulse Oximetry and Delayed Identification of Treatment Eligibility Among Patients With COVID-19 – JAMA Internal Medicine

Racial Bias in Pulse Oximetry Measurement – New England Journal of Medicine

Pulse Oximetry for Monitoring Patients with Covid-19 at Home — A Pragmatic, Randomized Trial – New England Journal of Medicine

Effectiveness and safety of pulse oximetry in remote patient monitoring of patients with COVID-19: a systematic review – The Lancet Digital Health

FDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias – STAT

Pulse Oximeter Accuracy and Limitations: FDA Safety Communication – U.S. Food & Drug Administration

Consensus Guideline | Preventing unrecognized esophageal intubation.

19 Aug, 2022 | 16:16h | UTC

Preventing unrecognised oesophageal intubation: a consensus guideline from the Project for Universal Management of Airways and international airway societies* – Anaesthesia

News Release: New guidance to prevent the tragedy of unrecognized esophageal intubation – Association of Anaesthetists of Great Britain and Ireland

Commentary on Twitter

?New #FreeForever @UniversalAirway guidelines!@NicholasChrimes @AndyHiggsGAA @CarinHagberg @PaulBakerORSIM @gaspasser @jadamlaw @hypoxicchicken @SheilaMyatra @ProfEllenO @AirwayOnDemand @crossermed @JohnCSakles @SorbelloMax @doctimcook

?https://t.co/UkOWKhFyBG pic.twitter.com/rnvEdsgRDs

— ??????????? (@Anaes_Journal) August 18, 2022