Chest Medicine
Lung ultrasound for the early diagnosis of COVID-19 pneumonia: an international multicenter study
23 Mar, 2021 | 02:20h | UTC
Commentary on Twitter
Lung #ultrasound based approach for early diagnosis of #COVID19 pneumonia:
➡️20 US/European hospitals
➡️1462 pts
Combining #LUS patterns of probability + clinical characteristics allow to rapidly rule in/out #SARSCoV2 pneumonia at bedside w high accuracy!https://t.co/GqsOZoIdgc pic.twitter.com/eENciXi9Cf— Intensive Care Medicine (@yourICM) March 20, 2021
Expert consensus statements for the management of COVID-19-related acute respiratory failure
21 Mar, 2021 | 22:05h | UTC
Commentary on Twitter
👌Expert consensus statements for the management of 👍💥 COVID-19-related acute respiratory failure using a Delphi method.
👇👇👇👇👇https://t.co/ujt8669VAb pic.twitter.com/AlT0ZkdKSc— RECAT👩🏽⚕️🏥👨🏽⚕️🇲🇽🫀 (@LeslieMegom) March 17, 2021
Infection and mRNA vaccine-induced immunity may be retained against SARS-CoV-2 variant B.1.1.7
21 Mar, 2021 | 22:04h | UTCNeutralizing Antibodies Against SARS-CoV-2 Variants After Infection and Vaccination – JAMA
SARS-CoV-2 variants B.1.351 and P.1 can escape from therapeutic antibodies and evade antibodies induced by infection or mRNA vaccination
21 Mar, 2021 | 22:02h | UTCSARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies – Cell
[Preprint] Oxford/AstraZeneca and Pfizer/BioNTech vaccines probably can still neutralize P.1 strain of SARS-CoV-2, but at lower levels
21 Mar, 2021 | 21:55h | UTCAntibody evasion by the Brazilian P.1 strain of SARS-CoV-2 – bioRxiv
Commentary: Existing COVID vaccines may protect against Brazilian variant – Oxford study – Reuters
B.1.351 strain of SARS-CoV-2 neutralization titer reduced 8- to 9-fold for Pfizer and AstraZeneca vaccinees. Convalescent plasma and therapeutic antibodies were less effective against this variant as well.
21 Mar, 2021 | 21:52h | UTCEvidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera – Cell
Bioethics | “Europe’s Vaccine Ethics Call: Do No Harm and Let More Die?”
21 Mar, 2021 | 21:50h | UTCEurope’s Vaccine Ethics Call: Do No Harm and Let More Die? – The New York Times (free registration may be required)
Related opinion: Covid-19 vaccine adverse events: balancing monitoring with confidence in vaccines – The BMJ Opinion
See also: European Medicines Agency finds AstraZeneca vaccine is safe and benefits outweigh the risks (Statement and commentaries) AND Statement of the WHO Global Advisory Committee on Vaccine Safety (GACVS) COVID-19 subcommittee on safety signals related to the AstraZeneca COVID-19 vaccine – World Health Organization AND Update on the safety of COVID-19 Vaccine AstraZeneca (statement and commentaries)
Commentary on Twitter
Many bioethicists have a problem with how Europe halted use of the AstraZeneca vaccine. Keeping the vaccine available would have allowed people “to consensually protect themselves from a big risk by taking a very small one.” https://t.co/qctELhfFGI
— NYT Health (@NYTHealth) March 20, 2021
Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art Review
21 Mar, 2021 | 21:49h | UTC
Commentary on Twitter
@JACCJournals: We share a systematic summary of #anticcogulation,#antiplatelet, and #fibrinolysis #RCTs in #COVID19. Amazing work by @AzitaTalasaz and a stellar multidisciplinary team! Figs illustrate areas where we’ll have evidence, & the gaps. Link: https://t.co/t4ksxwjAze pic.twitter.com/0Th3OZBXOY
— Behnood Bikdeli (@bbikdeli) March 16, 2021
Modeling Study: Vaccination alone is unlikely to contain COVID-19 infections in UK
21 Mar, 2021 | 21:46h | UTCCommentaries: Risking further COVID-19 waves despite vaccination – The Lancet Infectious Diseases AND Vaccination alone is unlikely to contain COVID-19 infections in UK – The Lancet
Commentary on Twitter
Vaccination alone is unlikely to contain #COVID19 infections in UK, suggests modelling study in @TheLancetInfDis—gradual release of control measures, high vaccine uptake, and high efficacy vaccine essential to minimise future waves. https://t.co/zpbPsYVHS2 pic.twitter.com/v47v6ux4r6
— The Lancet (@TheLancet) March 19, 2021
RCT: Intermediate-dose enoxaparin (1 mg/kg/d) not better than standard-dose prophylactic anticoagulation in patients with Covid-19 admitted to the intensive care unit
19 Mar, 2021 | 08:42h | UTCEditorial: Finding the Optimal Thromboprophylaxis Dose in Patients With COVID-19 – JAMA
Commentary on Twitter
Intermediate-dose prophylactic enoxaparin (1 mg/kg/d) had no effect on a primary composite outcome of adjudicated venous or arterial thrombosis, ECMO, or 30-d mortality vs standard dose enoxaparin among ICU patients w #COVID19 https://t.co/L6UdB31J7V
— JAMA (@JAMA_current) March 18, 2021
European Medicines Agency finds AstraZeneca vaccine is safe and benefits outweigh the risks
19 Mar, 2021 | 08:37h | UTCCommentaries: Restoring confidence after the covid-19 Oxford/AstraZeneca vaccine pause will be an uphill battle – The BMJ Opinion AND European Medicines Agency: AstraZeneca Vaccine Safe – Benefits Outweigh Risks – Despite Possible Rare Events – Health Policy Watch AND Expert reaction to announcement from EMA on Oxford-AstraZeneca vaccine and blood clots – Science Media Centre AND European regulators say AstraZeneca vaccine safe, but can’t rule out rare events – CIDRAP AND AstraZeneca vaccine safe, but rare risk of blood clots not ruled out, EU regulator says – LiveScience AND European Medicines Agency Finds AstraZeneca Vaccine Safe And Effective – NPR
Current evidence for COVID-19 therapies: a systematic literature review
19 Mar, 2021 | 08:36h | UTC
SARS-CoV-2 transmission without symptoms
19 Mar, 2021 | 08:30h | UTCSARS-CoV-2 transmission without symptoms – Science (a few articles per month are free)
How do you treat coronavirus? Here are physicians’ best strategies
19 Mar, 2021 | 08:33h | UTCHow do you treat coronavirus? Here are physicians’ best strategies – Science (a few articles per month are free)
CDC: SARS-CoV-2 Variants of Concern
19 Mar, 2021 | 08:28h | UTCSARS-CoV-2 Variants – Centers for Disease Control and Prevention
Commentaries: Coronavirus strains first detected in California are officially ‘variants of concern,’ CDC says – CNN AND CDC IDs new COVID-19 variants of concern as hot spots reemerge – CIDRAP
Leprosy drug holds promise as at-home treatment for COVID-19
19 Mar, 2021 | 08:22h | UTCOriginal article: Clofazimine broadly inhibits coronaviruses including SARS-CoV-2 – Nature
Perspective | Five reasons why COVID herd immunity is probably impossible
19 Mar, 2021 | 08:19h | UTCFive reasons why COVID herd immunity is probably impossible – Nature
The use of extracorporeal CO2 removal in acute respiratory failure
18 Mar, 2021 | 08:47h | UTCThe use of extracorporeal CO2 removal in acute respiratory failure – Annals of Intensive Care
Opinion | “’It’s a very special picture.’ Why vaccine safety experts put the brakes on AstraZeneca’s COVID-19 vaccine”
18 Mar, 2021 | 09:14h | UTC‘It’s a very special picture.’ Why vaccine safety experts put the brakes on AstraZeneca’s COVID-19 vaccine – Science (a few articles per month are free)
Related: Update on the safety of COVID-19 Vaccine AstraZeneca (statement and commentaries)
WHO Statement | The benefits of the AstraZeneca vaccine outweigh its risks – vaccinations should continue
18 Mar, 2021 | 09:17h | UTCWHO statement on AstraZeneca COVID-19 vaccine safety signals – World Health Organization
Related: Update on the safety of COVID-19 Vaccine AstraZeneca (statement and commentaries)
Commentary on Twitter (thread – click for more)
At this time, WHO considers that the benefits of the AstraZeneca vaccine outweigh its risks and recommends that vaccinations continue.
Full statement on AstraZeneca #COVID19 vaccine safety signals:
👉 https://t.co/9J6MtxXWK8 pic.twitter.com/fWGzqbjMuE— World Health Organization (WHO) (@WHO) March 17, 2021
Opinion | “The zero-risk mentality stifling Europe is now killing its people”
18 Mar, 2021 | 09:11h | UTCThe zero-risk mentality stifling Europe is now killing its people – The Sidney Morning Herald
Related: Update on the safety of COVID-19 Vaccine AstraZeneca (statement and commentaries)
Systematic Review: Thoracic imaging tests for the diagnosis of COVID‐19
18 Mar, 2021 | 09:05h | UTCThoracic imaging tests for the diagnosis of COVID‐19 – Cochrane Library
Opinion | “Oxford-AstraZeneca Vaccine Safety: Reports of blood clots after receiving the AstraZeneca COVID-19 vaccine are very likely just background events.”
18 Mar, 2021 | 09:09h | UTCRelated: Update on the safety of COVID-19 Vaccine AstraZeneca (statement and commentaries) AND What is Going on With the AstraZeneca/Oxford Vaccine? – Science Translational Medicine
Just How Do Deaths Due to COVID-19 Stack Up?
18 Mar, 2021 | 09:03h | UTCJust How Do Deaths Due to COVID-19 Stack Up? – Think Global Health
Commentary on Twitter (thread – click for more)
The Americas and Europe accounted for 80% of COVID-19 deaths globally, even though they represent only a quarter of the world's population. @ThinkGlobalHlth launches a tracker of COVID as a cause of death globally and the factors driving those trends 1/https://t.co/t6xp2yAWA4 pic.twitter.com/SJ9DRdlu1e
— Tom Bollyky (@TomBollyky) March 17, 2021
Long Covid | Four-month clinical status of a cohort of patients after hospitalization for COVID-19
18 Mar, 2021 | 09:00h | UTCFour-Month Clinical Status of a Cohort of Patients After Hospitalization for COVID-19 – JAMA
Editorial: Outcomes for Patients Following Hospitalization for COVID-19