Chest Medicine
[Preprint] The Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries.
14 May, 2021 | 08:34h | UTCThe Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries – The Lancet
Systematic review: Combination fixed‐dose beta-agonist and steroid inhaler as required is clinically effective in adults and adolescents with mild asthma.
14 May, 2021 | 08:23h | UTC
RCT: Tezepelumab can reduce exacerbations in adults and adolescents with severe, uncontrolled asthma.
14 May, 2021 | 08:25h | UTCCommentary: New drug shows promise against tough-to-manage asthma – MedicalXpress
[Not published yet] Observational study in Indonesia finds China’s Sinovac COVID-19 vaccine (CoronaVac) was 98% effective at preventing death and 96% effective at preventing hospitalization in healthcare workers
13 May, 2021 | 06:07h | UTCIndonesia study finds China’s Sinovac COVID-19 vaccine effective in medical staff – Reuters
[Preprint] Observational study finds single-dose Johnson & Johnson vaccine is 76.7% effective in preventing SARS-CoV-2 infection
13 May, 2021 | 06:06h | UTCReal-World Effectiveness of Ad26.COV2.S Adenoviral Vector Vaccine for COVID-19 – The Lancet
Commentary on Twitter
One of the first studies to assess real-world effectiveness of the J&J 1-dose vaccine, matches Phase 3 clinical trial, at 77%https://t.co/3YgcML9YSh @MayoClinic @MayoClinicHS preprint pic.twitter.com/XOjQlUaHK2
— Eric Topol (@EricTopol) May 11, 2021
Eight out of ten people hospitalized with COVID-19 develop neurological problems – the most common self-reported symptoms included headache (37%) and anosmia or ageusia (26%).
12 May, 2021 | 08:55h | UTC
Pfizer COVID-19 shot expanded to US children as young as 12.
12 May, 2021 | 08:53h | UTCPfizer COVID-19 shot expanded to US children as young as 12 – Associated Press
Counterpoint: Covid vaccines for children should not get emergency use authorization – The BMJ Opinion
Commentaries: Covid-19: FDA authorises Pfizer vaccine for children 12-15 – The BMJ AND Expert reaction to U.S. FDA authorising Pfizer-BioNTech COVID-19 vaccine for emergency use in adolescents – Science Media Centre
Most COVID-19 patients receiving home-based hospital care did not require escalation to traditional hospital setting – Approximately 1 in 5 were admitted within 14 days. Higher oxygen saturation was associated with decreased odds of transfer, whereas higher comorbidity burden was associated with increased risk.
12 May, 2021 | 08:50h | UTCOriginal study: Factors Associated With Risk for Care Escalation Among Patients With COVID-19 Receiving Home-Based Hospital Care – Annals of Internal Medicine
Related: Pandemic Boosts an Old Idea—Bringing Acute Care to the Patient
Population-based cohort study: Non-hospitalized COVID-19 patients have low-risk of serious long-term effects, but visits to general practitioners and outpatient hospital visits are increased.
12 May, 2021 | 08:47h | UTCCommentaries: Non-hospitalized COVID-19 patients: Low-risk of serious long-term effects, but more visits to doctor – The Lancet AND Any COVID-19 Infection Raises Odds for Lingering Symptoms, Study Finds – HealthDay AND Those with mild COVID-19 seek more primary care than uninfected peers – CIDRAP
M-A: Epidemiology and outcomes of COVID-19 in HIV-infected individuals – HIV is a significant risk factor for acquiring SARS-CoV-2 infection and is associated with a higher risk of mortality.
12 May, 2021 | 08:51h | UTCCommentary: People living with HIV more likely to get sick with, die from COVID-19 – Penn State
Coronavirus variants are spreading in India — what scientists know so far.
12 May, 2021 | 08:44h | UTCCoronavirus variants are spreading in India — what scientists know so far – Nature
[Preprint] Meta-analysis of risk of vaccine-induced immune thrombotic thrombocytopenia following ChAdOx1-S recombinant vaccine – Overall risk is 1 in 139,000; for age 65 and over, about 1 in 1,000,000; for age under 55, between 1 in 20,000 to 60,000.
12 May, 2021 | 08:45h | UTC
RCT: Among adults with idiopathic pulmonary fibrosis, antimicrobial therapy with co-trimoxazole or doxycycline is not associated with improved outcomes.
12 May, 2021 | 08:37h | UTCEffect of Antimicrobial Therapy on Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis: The CleanUP-IPF Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
Among adults with idiopathic pulmonary fibrosis, addition of co-trimoxazole or doxycycline compared with usual care did not significantly improve the time to nonrespiratory hospitalization or death https://t.co/t6WQ2sifx0
— JAMA (@JAMA_current) May 11, 2021
Ten simple steps to improve ventilation in healthcare facilities
11 May, 2021 | 09:27h | UTCTen simple steps to improve ventilation in healthcare facilities – Essential Critical Care
Commentary on Twitter
I've written ten simple steps to improve ventilation in healthcare facilities… with no jargon and loads of photos.
With expert input from @akm5376 @vfmcneill & @kartc from @IndiaCOVIDSOS.
Download here: https://t.co/OzsDXfPavm#COVIDisAirborne pic.twitter.com/UtsRO0IgWr
— Bex Sierra (@Global_ICU) May 5, 2021
Just 2% of SARS-CoV-2−positive individuals carry 90% of the virus circulating in communities
11 May, 2021 | 09:31h | UTC
Commentary on Twitter
Covid-19 is a supercarrier story. (!)
90% of the virus load (circulating virions) is harbored by only 2% of individuals
[So much for the 80/20 Pareto principle]https://t.co/zidXh7DBjt@PNASNews by @Sara_Sawyer_ @CUBoulder @BioFrontiers and colleagues pic.twitter.com/xIPpgaGLTE— Eric Topol (@EricTopol) May 10, 2021
A global database of COVID-19 vaccinations
11 May, 2021 | 09:28h | UTCA global database of COVID-19 vaccinations – Nature Human Behaviour
See website: Statistics and Research: Coronavirus (COVID-19) Vaccinations – Our World in Data
Commentaries on Twitter
Since the beginning of the COVID vaccinations we brought together the global data.
It's the most cited resource that @OurWorldInData has ever produced. Thousands of citations every week.
Just now our vaccination dataset has been published in Nature!https://t.co/COmCMNSbw2
— Max Roser (@MaxCRoser) May 10, 2021
A stunner.
One of my favorite graphics from the pandemic: the story of the unprecedented #SARSCoV2 vaccines
Published today @NatureHumBehav @OurWorldInData https://t.co/raPq8H3DSq@redouad @MaxCRoser @_HannahRitchie @EOrtizOspina @lucasrodesg @lucasrodesg @JoeHasell @appel_cam pic.twitter.com/x1LYobAOkM— Eric Topol (@EricTopol) May 10, 2021
Mild COVID-19 infection is very unlikely to cause lasting heart damage
11 May, 2021 | 09:23h | UTCMild COVID-19 infection is very unlikely to cause lasting heart damage – Imperial College London
Commentary on Twitter
Mild Covid infection is unlikely to cause lasting heart damage, according to a study led by University College London. It's the largest & most detailed study to date into mild Covid infection and its longer-term impact on the heart https://t.co/pZ0Wgnf9zp pic.twitter.com/b1T9AClQeX
— delthia ricks 🔬 (@DelthiaRicks) May 9, 2021
Cohort study: Non-steroidal anti-inflammatory drug use is not associated with higher mortality or increased severity of COVID-19
11 May, 2021 | 09:25h | UTCCommentaries: Largest study to date confirms non-steroidal anti-inflammatory medications do not result in worse COVID-19 outcomes – The Lancet AND Non-steroidal anti-inflammatory drug use in COVID-19 – The Lancet Rheumatology AND Ibuprofen, other NSAIDs not tied to worse COVID illness, death – CIDRAP
Related study with similar findings: Nonsteroidal Antiinflammatory Drugs and Susceptibility to COVID‐19 – Arthritis & Rheumatism
Commentary on Twitter
NEW Research—Non-steroidal anti-inflammatory drugs (NSAIDs) do not increase the mortality or severity of #COVID19: findings from more than 72,000 people in the ISARIC @CCPUKstudy https://t.co/NPJzuS1wAx #LancetRheumatology #OpenAccess pic.twitter.com/LjG6O7e3F8
— The Lancet Rheumatology (@TheLancetRheum) May 7, 2021
Researchers tie severe immunosuppression to chronic COVID-19 and virus variants
11 May, 2021 | 09:21h | UTCResearchers Tie Severe Immunosuppression to Chronic COVID-19 and Virus Variants – JAMA
A ‘more rapidly spreading virus’ (B.1.617 variant) is fueling India’s mega COVID-19 surge, WHO chief scientist says
11 May, 2021 | 09:16h | UTCSee also: WHO Upgrades Virus Mutation Driving India’s COVID Surge To ‘Variant of Concern’ – Global Cases Start To ‘Plateau’ – Health Policy Watch AND Why India needs oxygen more urgently than vaccines – Vox AND WHO names B1617 fourth COVID-19 variant of concern – CIDRAP
Mucormycosis: The ‘black fungus’ maiming Covid patients in India
11 May, 2021 | 09:14h | UTCMucormycosis: The ‘black fungus’ maiming Covid patients in India – BBC
See also: Potentially fatal ‘black fungus’ infections on the rise in India’s COVID-19 patients – LiveScience AND A potentially fatal fungal infection is cropping up among India’s Covid patients. – The New York Times AND WHO says virus strain in India a ‘variant of concern’ as Europe eases curbs – MedicalXpress
Commentary on Twitter (thread – click for more)
Doctors in India are concerned about an increase in a highly fatal fungal infection affecting cases & recently recovered from #COVID19. Mucormycosis, is a mold that attacks the respiratory tract, potentially eroding facial structures & harming the brain.🧵https://t.co/1rHU2nM346
— Eric Feigl-Ding (@DrEricDing) May 10, 2021
New WHO Online Course: Initial approach to the acutely ill patient with COVID-19.
10 May, 2021 | 01:21h | UTC
WHO Infographic | How to care COVID-19 patients with mild symptoms at home: information for health care workers.
10 May, 2021 | 01:17h | UTCCOVID-19 home care bundle for health care workers – World Health Organization
Commentary on Twitter
How to care #COVID19 patients with mild symptoms at home: information for health care workershttps://t.co/r09i9k0zGl pic.twitter.com/i5ihXQrhzg
— World Health Organization (WHO) (@WHO) May 8, 2021
Covid-19: Most people admitted to hospital after vaccination were infected before immunity could develop, research shows.
10 May, 2021 | 01:14h | UTC
Commentary on Twitter
"#Covid19: Most people admitted to hospital after vaccination were infected before immunity could develop, research" https://t.co/wi30LkafC7
"…highlighting the importance of maintaining social distancing & understanding that immunity develops over time…"#ScienceUpFirst!
— Timothy Caulfield (@CaulfieldTim) May 7, 2021
Opinion | Aerosol generating procedures: are they of relevance for transmission of SARS-CoV-2?
10 May, 2021 | 01:16h | UTC
Commentary on Twitter
https://twitter.com/trishgreenhalgh/status/1390550428098699265