Chest Medicine (all articles)
Modeling study: Delaying second doses of Pfizer-BioNTech and Moderna mRNA vaccines could reduce deaths by up to 20% under certain conditions.
17 May, 2021 | 08:51h | UTCCommentaries: Expert reaction to study looking at the public health impact of delaying the second dose of the Pfizer-BioNTech and Moderna COVID-19 vaccines – Science Media Centre AND Delaying second Covid vaccine doses can save lives, study finds – The Guardian AND Delaying second COVID vaccine dose may prevent deaths under certain conditions – The BMJ
#ACC21 – [Not published yet] RCT: DARE-19: Dapagliflozin is safe, but did not significantly improve outcomes among high-risk patients hospitalized with COVID-19.
17 May, 2021 | 08:49h | UTC
Commentaries on Twitter
DARE-19 trial #ACC21 @ACCinTouch
Dapa did not reduce clinical endpoints in #COVID19, but excellent safety profile
? Do not discontinue SGLT2i in ? for #COVID19
Full slideset available in ?https://t.co/RPi5mpPbbN pic.twitter.com/B9VQdSSAFu
— Enrique Santas (@SantasEnrique) May 16, 2021
DARE-19 findings presented at #ACC21 show #dapagliflozin didn’t significantly ⬇️ risk of organ failure or death or improve recovery in patients hospitalized w/ #COVID19. However, data suggest the SGLT2 inhibitor was well tolerated in acutely ill patients. https://t.co/YjYxbuc952 pic.twitter.com/J4PqwvGpLJ
— American College of Cardiology (@ACCinTouch) May 16, 2021
‘It’s not over yet’: Uncertain protection from Covid vaccines leaves cancer patients in limbo.
17 May, 2021 | 08:45h | UTC‘It’s not over yet’: Uncertain protection from Covid vaccines leaves cancer patients in limbo – STAT
Perspective | New SARS-CoV-2 Variants — Clinical, Public Health, and Vaccine Implications.
14 May, 2021 | 08:43h | UTC
RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
14 May, 2021 | 08:46h | UTCHeterologous prime-boost COVID-19 vaccination: initial reactogenicity data – The Lancet
Commentaries: More side effects noted after using 2 different COVID vaccines – CIDRAP AND Covid vaccines: Mixing increases reports of mild side-effects – BBC
Perspective | Vaccines seem to work well against coronavirus variants. It’s also complicated.
14 May, 2021 | 08:41h | UTCVaccines seem to work well against coronavirus variants. It’s also complicated – STAT
CDC says fully vaccinated Americans can go indoors and outdoors without masks.
14 May, 2021 | 08:38h | UTCCDC Guidance: Interim Public Health Recommendations for Fully Vaccinated People – Centers for Disease Control and Prevention
Commentaries: CDC backtracks, saying fully vaccinated people can go maskless indoors – STAT AND Fully Vaccinated People Can Stop Wearing Masks Indoors And Outdoors, CDC Says – NPR AND CDC: No masks needed for COVID-vaccinated Americans – CIDRAP
Editorial: Vaccinating children against SARS-CoV-2 – “Hard to justify right now for most children in most countries”.
14 May, 2021 | 08:39h | UTCVaccinating children against SARS-CoV-2 – The BMJ
Related: Pfizer COVID-19 shot expanded to US children as young as 12.
What is mucormycosis, the fungal infection affecting COVID patients in India?
14 May, 2021 | 08:35h | UTCWhat is mucormycosis, the fungal infection affecting COVID patients in India? – The Conversation
Related: What Is ‘Black Fungus’? And Why Is It Spreading Among India’s COVID Patients? – NPR AND Mucormycosis: The ‘black fungus’ maiming Covid patients in India
Review: How to interpret and use COVID-19 serology and immunology tests.
14 May, 2021 | 08:36h | UTC
[Preprint] The Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries.
14 May, 2021 | 08:34h | UTCThe Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries – The Lancet
Systematic review: Combination fixed‐dose beta-agonist and steroid inhaler as required is clinically effective in adults and adolescents with mild asthma.
14 May, 2021 | 08:23h | UTC
RCT: Tezepelumab can reduce exacerbations in adults and adolescents with severe, uncontrolled asthma.
14 May, 2021 | 08:25h | UTCCommentary: New drug shows promise against tough-to-manage asthma – MedicalXpress
[Not published yet] Observational study in Indonesia finds China’s Sinovac COVID-19 vaccine (CoronaVac) was 98% effective at preventing death and 96% effective at preventing hospitalization in healthcare workers
13 May, 2021 | 06:07h | UTCIndonesia study finds China’s Sinovac COVID-19 vaccine effective in medical staff – Reuters
[Preprint] Observational study finds single-dose Johnson & Johnson vaccine is 76.7% effective in preventing SARS-CoV-2 infection
13 May, 2021 | 06:06h | UTCReal-World Effectiveness of Ad26.COV2.S Adenoviral Vector Vaccine for COVID-19 – The Lancet
Commentary on Twitter
One of the first studies to assess real-world effectiveness of the J&J 1-dose vaccine, matches Phase 3 clinical trial, at 77%https://t.co/3YgcML9YSh @MayoClinic @MayoClinicHS preprint pic.twitter.com/XOjQlUaHK2
— Eric Topol (@EricTopol) May 11, 2021
Eight out of ten people hospitalized with COVID-19 develop neurological problems – the most common self-reported symptoms included headache (37%) and anosmia or ageusia (26%).
12 May, 2021 | 08:55h | UTC
Pfizer COVID-19 shot expanded to US children as young as 12.
12 May, 2021 | 08:53h | UTCPfizer COVID-19 shot expanded to US children as young as 12 – Associated Press
Counterpoint: Covid vaccines for children should not get emergency use authorization – The BMJ Opinion
Commentaries: Covid-19: FDA authorises Pfizer vaccine for children 12-15 – The BMJ AND Expert reaction to U.S. FDA authorising Pfizer-BioNTech COVID-19 vaccine for emergency use in adolescents – Science Media Centre
Most COVID-19 patients receiving home-based hospital care did not require escalation to traditional hospital setting – Approximately 1 in 5 were admitted within 14 days. Higher oxygen saturation was associated with decreased odds of transfer, whereas higher comorbidity burden was associated with increased risk.
12 May, 2021 | 08:50h | UTCOriginal study: Factors Associated With Risk for Care Escalation Among Patients With COVID-19 Receiving Home-Based Hospital Care – Annals of Internal Medicine
Related: Pandemic Boosts an Old Idea—Bringing Acute Care to the Patient
Population-based cohort study: Non-hospitalized COVID-19 patients have low-risk of serious long-term effects, but visits to general practitioners and outpatient hospital visits are increased.
12 May, 2021 | 08:47h | UTCCommentaries: Non-hospitalized COVID-19 patients: Low-risk of serious long-term effects, but more visits to doctor – The Lancet AND Any COVID-19 Infection Raises Odds for Lingering Symptoms, Study Finds – HealthDay AND Those with mild COVID-19 seek more primary care than uninfected peers – CIDRAP
M-A: Epidemiology and outcomes of COVID-19 in HIV-infected individuals – HIV is a significant risk factor for acquiring SARS-CoV-2 infection and is associated with a higher risk of mortality.
12 May, 2021 | 08:51h | UTCCommentary: People living with HIV more likely to get sick with, die from COVID-19 – Penn State
Coronavirus variants are spreading in India — what scientists know so far.
12 May, 2021 | 08:44h | UTCCoronavirus variants are spreading in India — what scientists know so far – Nature
[Preprint] Meta-analysis of risk of vaccine-induced immune thrombotic thrombocytopenia following ChAdOx1-S recombinant vaccine – Overall risk is 1 in 139,000; for age 65 and over, about 1 in 1,000,000; for age under 55, between 1 in 20,000 to 60,000.
12 May, 2021 | 08:45h | UTC
RCT: Among adults with idiopathic pulmonary fibrosis, antimicrobial therapy with co-trimoxazole or doxycycline is not associated with improved outcomes.
12 May, 2021 | 08:37h | UTCEffect of Antimicrobial Therapy on Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis: The CleanUP-IPF Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
Among adults with idiopathic pulmonary fibrosis, addition of co-trimoxazole or doxycycline compared with usual care did not significantly improve the time to nonrespiratory hospitalization or death https://t.co/t6WQ2sifx0
— JAMA (@JAMA_current) May 11, 2021
Ten simple steps to improve ventilation in healthcare facilities
11 May, 2021 | 09:27h | UTCTen simple steps to improve ventilation in healthcare facilities – Essential Critical Care
Commentary on Twitter
I've written ten simple steps to improve ventilation in healthcare facilities… with no jargon and loads of photos.
With expert input from @akm5376 @vfmcneill & @kartc from @IndiaCOVIDSOS.
Download here: https://t.co/OzsDXfPavm#COVIDisAirborne pic.twitter.com/UtsRO0IgWr
— Bex Sierra (@Global_ICU) May 5, 2021
Just 2% of SARS-CoV-2−positive individuals carry 90% of the virus circulating in communities
11 May, 2021 | 09:31h | UTC
Commentary on Twitter
Covid-19 is a supercarrier story. (!)
90% of the virus load (circulating virions) is harbored by only 2% of individuals
[So much for the 80/20 Pareto principle]https://t.co/zidXh7DBjt@PNASNews by @Sara_Sawyer_ @CUBoulder @BioFrontiers and colleagues pic.twitter.com/xIPpgaGLTE— Eric Topol (@EricTopol) May 10, 2021