Chest Medicine (all articles)
Systematic review of 45 studies including 9751 participants, most of which were hospitalized, found 73% had at least 1 persistent symptom for weeks after Covid-19.
27 May, 2021 | 08:37h | UTCCommentary: Seven out of ten hospitalized COVID-19 patients will have long-haul symptoms – MedicalXpress
Can people vaccinated against COVID-19 still spread the coronavirus? – “Preliminary evidence seems to suggest the COVID-19 vaccines make it less likely someone who’s vaccinated will transmit the coronavirus”.
27 May, 2021 | 08:27h | UTCCan people vaccinated against COVID-19 still spread the coronavirus? – The Conversation
Related: Indirect Protection by Reducing Transmission: Ending the Pandemic with SARS-CoV-2 Vaccination – “Tell the hesitant: the vaccines protect both you and protect others — a lot!”
[Preprint] More data showing a single-dose SARS-CoV-2 mRNA vaccine may be enough in individuals with previous COVID-19.
27 May, 2021 | 08:31h | UTCSingle-dose SARS-CoV-2 vaccine in a prospective cohort of COVID-19 patients – medRxiv
See also: SARS-CoV-2 vaccines for all but a single dose for COVID-19 survivors – EClinicalMedicine
Related: Another study shows a single dose of mRNA vaccine may be enough for patients with previous Covid-19
Commentaries on Twitter
If you had prior covid and you're wondering about getting vaccinated, here's a new prospective study showing single dose -> marked neutralizing antibody protection to the major variants AND again more than without prior covid and 2 mRNA doses https://t.co/k9v5gEDn2M pic.twitter.com/Z8nT3pL04v
— Eric Topol (@EricTopol) May 26, 2021
One dose of vaccine for prior covid.
Change the policy. Avoid unnecessary side effects and instead of wasting vaccine doses get them to the people around the world in needhttps://t.co/ODhx5kgAnq @EBioMedicine @MattFrieman @VivianaSimonLab @florian_krammer pic.twitter.com/oAeju9AASm— Eric Topol (@EricTopol) May 26, 2021
COVID Morbidity – The emerging burden of long COVID is significant, and needs to be considered when evaluating the risk vs. benefit of pandemic measures.
27 May, 2021 | 08:34h | UTCCOVID Morbidity – Science-Based Medicine
Moderna says its Covid vaccine is 100% effective in teens, plans to seek FDA OK in early June.
27 May, 2021 | 08:25h | UTCModerna says its Covid vaccine is 100% effective in teens, plans to seek FDA OK in early June – CNBC
Commentary on Twitter
BREAKING: Moderna study of more than 3,700 12- to 17-year olds found 100% effficacy in those who received 2-dose #covid19 #vaccine, no significant safety problems. Will apply for FDA authorization.https://t.co/l0MHiLjCcA
— Leana Wen, M.D. (@DrLeanaWen) May 25, 2021
Global cardiovascular organizations release joint opinion on achieving the ‘tobacco endgame’.
27 May, 2021 | 08:22h | UTCNews release: Global cardiovascular organizations release joint opinion on achieving the ‘tobacco endgame’ – American College of Cardiology
Commentary: The Tobacco Endgame—Eradicating a Worsening Epidemic – American College of Cardiology
COVID-19 in Amazonas, Brazil, was driven by the persistence of endemic lineages and P.1 emergence – “viral load was tenfold higher in P.1 infections than in non-P.1”.
26 May, 2021 | 08:42h | UTC
What scientists know about new, fast-spreading coronavirus variants.
26 May, 2021 | 08:45h | UTCWhat scientists know about new, fast-spreading coronavirus variants – Nature
[Preprint] Meta-analysis of RCT: Ivermectin for the treatment of COVID-19 – no effect on all-cause mortality, length of stay, or viral clearance
26 May, 2021 | 08:41h | UTC
Commentary on Twitter
???Preprint
Ivermectin for the treatment of #COVID19 : A systematic review & meta-analysis of RCTs
10 RCTs
1173 patients
8 RCTs➡️ Mild
1 RCT ➡️ Moderate
1 RCT➡️ Mild& mod
Ivermectin did not reduce all-cause mortality,length of stay or viral clearance https://t.co/QMx0wlfS8f pic.twitter.com/6yddqwqPF6— Antibiotic Steward ???Bassam Ghanem (@ABsteward) May 25, 2021
Estimating infectiousness throughout SARS-CoV-2 infection course – 8% of subjects had very high viral loads, one-third of whom had little to no symptoms; in individuals infected with the B.1.1.7 variant, average viral loads were 10 times higher.
26 May, 2021 | 08:43h | UTCEstimating infectiousness throughout SARS-CoV-2 infection course – Science
Commentary: Estimating infectiousness of SARS-CoV-2: New study on viral load – Universitätsmedizin Berlin
Commentary on Twitter
Of 25,000+ people who tested positive for #COVID19 in Germany, 8% had very high viral loads; about a third of these had little to no symptoms. The results suggest asymptomatic people can be expected to be as infectious as hospitalized patients @c_drosten https://t.co/mRkzJrwFwU pic.twitter.com/vsrameCAWk
— Science Magazine (@ScienceMagazine) May 25, 2021
Short review: Diagnosis and management of acute respiratory distress syndrome
26 May, 2021 | 08:19h | UTC
Commentary on Twitter
#ARDS is an important priority in our ICUs at the moment. Our @CMAJ review looks at diagnosis, and provides a guideline-based approach to management, along with a discussion on #COVID19 ARDS.
A great primer for those new to ARDS!
OPEN ACCESS Link: https://t.co/saVdFT6Wyn pic.twitter.com/HbhoYbeG3u
— Shannon Fernando (@shanfernands) May 25, 2021
Admission respiratory status predicts mortality in COVID-19 – hypoxemic patients (oxygen saturation less than 92%) had a 1.8- to 4.0-fold increased mortality risk; those with respiratory rates over 22 breaths per minute were at 1.9- to 3.2-fold elevated mortality risk.
25 May, 2021 | 08:56h | UTCAdmission respiratory status predicts mortality in COVID-19 – Influenza and Other Respiratory Virus
Commentaries: COVID-19 mortality associated with 2 signs easily measured at home – University of Washington School of Medicine AND Low oxygen levels, shallow breathing tied to COVID death – CIDRAP
2 signs easily measured at home can indicate increased Covid mortality risk—respiration rate & blood-oxygen saturation. Both are distinctly predictive of higher mortality. Anyone receiving a positive Covid test can easily monitor for these signs at home https://t.co/8n7oc0d4E4 pic.twitter.com/02ysVaElsL
— delthia ricks ? (@DelthiaRicks) May 24, 2021
Living systematic review: The evidence is insufficient to determine the benefits and harms of vitamin D supplementation as a treatment of COVID‐19.
25 May, 2021 | 08:55h | UTCSummary: Is vitamin D an effective and safe treatment for COVID-19? – Cochrane Library
Perspective | Coronavirus: so many variants, but vaccines are still effective.
25 May, 2021 | 08:46h | UTCCoronavirus: so many variants, but vaccines are still effective – The Conversation
Secondary analysis of RCT finds Tocilizumab was beneficial to patients hospitalized with Covid-19 if CRP levels were greater than 15.0 mg/dL, but not if CRP levels were 15.0 mg/dL or less.
25 May, 2021 | 08:52h | UTC
Mild COVID-19 induces lasting antibody protection, study finds.
25 May, 2021 | 08:51h | UTCOriginal study: SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans – Nature
Commentary on Twitter (thread – click for more)
Just published @nature
After even mild covid infections there are, in addition to memory B cells, bone marrow plasma cells are induced to provide long-term protection > 1 yrhttps://t.co/zVfUFvciVk@TheBcellArtist @WUSTLmed
(NB vaccination still provides further protection) pic.twitter.com/rUd8pMAP1T— Eric Topol (@EricTopol) May 24, 2021
[Preprint] RCT: Both REGEN-COV 2400mg and 1200mg antibody cocktails significantly reduced Covid-19-related hospitalization or all-cause death compared to placebo (71.3% reduction and 70.4% reduction, respectively).
24 May, 2021 | 08:46h | UTCREGEN-COV Antibody Cocktail Clinical Outcomes Study in Covid-19 Outpatients – medRxiv
Commentary on Twitter
REGEN-COV Antibody Cocktail(casirivimab with imdevimab) Clinical Outcomes Study in Covid-19 Outpatients: N:>4000 pts
Both 1200mg IV&2400mg REGEN-COV led to a ≥70% ⬇️ (vs placebo) in Covid-19 hospitalization or all-cause death over 28 days after treatmenthttps://t.co/NJxF4BjZRs pic.twitter.com/CFdvEEIWEL— Antibiotic Steward ???Bassam Ghanem (@ABsteward) May 21, 2021
[Preprint] Pfizer and AstraZeneca Vaccines effective against B.1.617.2 variant after 2 doses.
24 May, 2021 | 08:42h | UTCNews release: Vaccines highly effective against B.1.617.2 variant after 2 doses – Public Health England
Original study: Effectiveness of COVID-19 vaccines against the B.1.617.2 variant – Public Health England
Commentary: Covid: Pfizer and AstraZeneca jabs effective against Indian variant – study – BBC
[Preprint] Effectiveness of the CoronaVac vaccine in the elderly population during a P.1 variant-associated epidemic of COVID-19 in Brazil – “CoronaVac was 42% effective in the real-world setting of extensive P.1 transmission, but significant protection was not observed until completion of the two-dose regimen”.
24 May, 2021 | 08:43h | UTC
M-A: Tocilizumab in COVID-19 – “For hospitalized COVID-19 patients, there is some evidence that tocilizumab use may be associated with a short-term mortality benefit, but further high-quality data are required”.
24 May, 2021 | 08:39h | UTC
Commentary on Twitter
Tocilizumab as IL-6 antagonist in hospitalized #COVID19 pts, SR/MA/TSA:
➡️10 RCTs/6493 pts (52.2% ➡️ tocilizumab)
➡️some evidence suggests tocilizumab may be associated with short-term mortality benefit
➡️tocilizumab may prevent disease progression to MVhttps://t.co/sWR4Y351sl pic.twitter.com/JPD31Nb5rn— Intens Care Med (@yourICM) May 22, 2021
WHO: The impact of COVID-19 on global health goals – COVID-19 responsible for at least 3 million excess deaths in 2020.
24 May, 2021 | 08:49h | UTCThe impact of COVID-19 on global health goals – World Health Organization
Related: Covid-19 pandemic: approximately one million excess deaths occurred in 2020 in 29 high income countries. AND Perspective | Tracking lives we’ve lost to COVID-19. AND COVID-19 has caused 6.9 million deaths globally, more than double what official reports show
Commentary on Twitter (thread – click for more)
? The latest World Health Statistics report finds that #COVID19 is responsible for at least 3 million excess deaths in 2020 ? https://t.co/yAXB5bzx1g#HealthData pic.twitter.com/DMd9fg69I2
— World Health Organization (WHO) (@WHO) May 21, 2021
Using resources wisely in the COVID-19 pandemic: an international list of Choosing Wisely recommendations.
24 May, 2021 | 08:36h | UTC
Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection.
24 May, 2021 | 08:38h | UTCCommentary: Scientists find new way of predicting COVID-19 vaccine efficacy – University of New South Wales
Commentary on Twitter (thread – click for more)
Just published @NatureMedicine: For 7 vaccines, the neutralizing antibody levels are highly predictive of the magnitude of clinical efficacy, support long term protection vs severe illness, and preserved efficacy vs variantshttps://t.co/ZQIrTQErMm pic.twitter.com/rUl9TMbVrC
— Eric Topol (@EricTopol) May 17, 2021
Risk factors for illness severity among pregnant women with confirmed SARS-CoV-2 infection – moderate-to-severe COVID-19 was associated with age 25 years and older, healthcare occupation, pre-pregnancy obesity, chronic lung disease, chronic hypertension, and pregestational diabetes mellitus.
24 May, 2021 | 08:34h | UTC
Indirect Protection by Reducing Transmission: Ending the Pandemic with SARS-CoV-2 Vaccination – “Tell the hesitant: the vaccines protect both you and protect others — a lot!”
24 May, 2021 | 08:31h | UTC
Commentary on Twitter
*Strongly* recommend this comprehensive review of just how much COVID19 vaccines reduce the risk of transmitting the virus to others. Tell the hesitant: the vaccines protect both you and protect others — a lot! @mugecevik @AaronRichterman @EricMeyerowitz https://t.co/Cv3t3zNMRL pic.twitter.com/sOLAKKIJnQ
— Paul Sax (@PaulSaxMD) May 21, 2021