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Chest Medicine

Six months of COVID vaccines: what 1.7 billion doses have taught scientists.

6 Jun, 2021 | 23:57h | UTC

Six months of COVID vaccines: what 1.7 billion doses have taught scientists – Nature

See also: Coronavirus (COVID-19) Vaccinations – Our World in Data

 

Related commentary on Twitter

 

Review: Management of patients with venous thromboembolism after the initial treatment period.

8 Jun, 2021 | 09:13h | UTC

Management of Patients With Venous Thromboembolism After the Initial Treatment Period – The Journal of the American Board of Family Medicine

 

WHO approval of Chinese CoronaVac COVID vaccine will be crucial to curbing pandemic.

6 Jun, 2021 | 23:56h | UTC

WHO approval of Chinese CoronaVac COVID vaccine will be crucial to curbing pandemic – Nature

Related: WHO validates Sinovac-CoronaVac COVID-19 vaccine for emergency use and issues interim policy recommendations. AND Brazilian town experiment shows mass vaccination can wipe out COVID-19.

 

Study shows reduced neutralizing antibody activity induced by Pfizer–BioNTech vaccine against SARS-CoV-2 variants of concern B.1.617.2 (Delta) and B.1.351 (Beta).

6 Jun, 2021 | 23:59h | UTC

Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2  and B.1.351 (Beta) by BNT162b2 vaccination – The Lancet

Commentary: Pfizer-BioNTech vaccine recipients have lower antibody levels targeting the Delta variant – The Francis Crick Institute

 

Commentary on Twitter (thread – click for more)

 

Case report: Successful treatment of vaccine-induced prothrombotic immune thrombocytopenia (VIPIT).

6 Jun, 2021 | 23:55h | UTC

Successful treatment of vaccine-induced prothrombotic immune thrombocytopenia (VIPIT) – Journal of Thrombosis and Haemostasis

Commentary: COVID-19 vaccination: Thrombosis can be prevented by prompt treatment, researchers report – Medical University of Vienna

 

2 new meta-analysis detail neurologic and psychiatric conditions in COVID-19.

6 Jun, 2021 | 23:54h | UTC

Neurologic, psychiatric conditions common in COVID-19 – CIDRAP

Meta-analysis 1: Neurology and neuropsychiatry of COVID-19: a systematic review and meta-analysis of the early literature reveals frequent CNS manifestations and key emerging narratives – Journal of Neurology, Neurosurgery & Psychiatry

Meta-analysis 2: Central and peripheral nervous system involvement by COVID-19: a systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings – BMC Infectious Diseases

Related: Large study finds 1 in 3 Covid-19 survivors have subsequent mental health and neurological conditions

 

Perspective | Could statins do more than lower cholesterol in patients with COVID-19? – “Don’t Start, Don’t Stop”.

6 Jun, 2021 | 23:49h | UTC

Could Statins Do More Than Lower Cholesterol in Patients With COVID-19? – JAMA

 

Investigation | Covid 19: How harm reduction advocates and the tobacco industry capitalized on the pandemic to promote nicotine.

6 Jun, 2021 | 23:51h | UTC

Covid 19: How harm reduction advocates and the tobacco industry capitalised on the pandemic to promote nicotine – The BMJ

Commentaries: Researchers report how the tobacco and e-cigarette industry capitalized on COVID-19 to promote smoking – News Medical AND Investigation discredits studies suggesting lower COVID-19 risk for smokers

 

Another study shows a high frequency of antibiotic use among patients hospitalized with Covid-19 (85.2%), despite low rates of confirmed secondary bacterial infections.

4 Jun, 2021 | 10:43h | UTC

Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study – The Lancet Microbe

Commentaries: Very high use of antibiotics in COVID-19 treatment could be reduced – University of Glasgow AND More evidence of frequent antibiotic use noted in COVID patients – CIDRAP AND Covid-19: Antimicrobial use was high during first wave despite bacterial co-infections being rare, study finds – The BMJ

Related: Many hospitalized Covid-19 patients are given antibiotics. That’s a problem – STAT

 

Commentary on Twitter (thread – click for more)

 

Cohort study: long working hours (more than 55 h/week) linked to increased risk of recurrent coronary events.

6 Jun, 2021 | 23:32h | UTC

Long Working Hours and Risk of Recurrent Coronary Events – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Working long hours may increase odds of second heart attack – American College of Cardiology AND Recurrent CHD Risk Up With Long Working Hours After First MI – HealthDay AND Longer Work Hours After MI Tied to Higher Risk of Recurrent Events – TCTMD

 

In a Mendelian randomization study, researchers found no genetic evidence to support an association between Vitamin D levels and COVID-19 susceptibility, severity, or hospitalization.

4 Jun, 2021 | 10:35h | UTC

Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study – PLOS Medicine

Commentary: Vitamin D may not provide protection from COVID-19 susceptibility or disease severity, study suggests – PLOS

Related: Living systematic review: The evidence is insufficient to determine the benefits and harms of vitamin D supplementation as a treatment of COVID‐19. AND RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19

 

RCT: Prophylactic post-exposure prophylaxis with Bamlanivimab reduced the incidence of Covid-19 among residents and staff of skilled nursing and assisted living facilities.

4 Jun, 2021 | 10:40h | UTC

Effect of Bamlanivimab vs Placebo on Incidence of COVID-19 Among Residents and Staff of Skilled Nursing and Assisted Living Facilities: A Randomized Clinical Trial – JAMA

Editorial: Bamlanivimab for Prevention of COVID-19

 

[Preprint] Covid-19 B.1.617.2 variant of concern (Delta) is associated with increased transmissibility compared to B.1.1.7 (Alpha) that will rapidly lead to B.1.617.2 becoming the prevailing variant in the UK.

4 Jun, 2021 | 10:36h | UTC

Interim estimates of increased transmissibility, growth rate, and reproduction number of the Covid-19 B.1.617.2 variant of concern in the United Kingdom – medRxiv

Related: Covid: Indian variant ‘now dominant’ in the UK – BBC

 

Target arterial PO2 according to the underlying pathology: a mini-review of the available data in mechanically ventilated patients.

4 Jun, 2021 | 10:26h | UTC

Target arterial PO2 according to the underlying pathology: a mini-review of the available data in mechanically ventilated patients – Annals of Intensive Care

 

M-A: In hypoxemic non-hypercapnic patients, early extubation followed by noninvasive ventilation can reduce the total number of days of invasive mechanical ventilation (mean difference, − 2.04 days), without effects in ICU mortality.

4 Jun, 2021 | 10:27h | UTC

Effects of early extubation followed by noninvasive ventilation versus standard extubation on the duration of invasive mechanical ventilation in hypoxemic non-hypercapnic patients: a systematic review and individual patient data meta-analysis of randomized controlled trials – Critical Care

 

ANCA-Associated Vasculitis: An Update.

4 Jun, 2021 | 10:23h | UTC

ANCA-Associated Vasculitis: An Update – Journal of Clinical Medicine

 

RCT: Among patients with ANCA-associated vasculitis without severe glomerulonephritis or alveolar hemorrhage treated with Rituximab, a reduced-dose glucocorticoids regimen (prednisolone 0.5 mg/kg/d) was noninferior to a high-dose glucocorticoid regimen (prednisolone 1 mg/kg/d) for the induction of disease remission.

4 Jun, 2021 | 10:25h | UTC

Effect of Reduced-Dose vs High-Dose Glucocorticoids Added to Rituximab on Remission Induction in ANCA-Associated Vasculitis: A Randomized Clinical Trial – JAMA

 

Countries hit hardest by COVID-19 – estimated mortality countries will have on September 1, 2021.

3 Jun, 2021 | 11:09h | UTC

Countries Hit Hardest by COVID-19 – Think Global Health

 

Commentary on Twitter (thread – click for more)

 

What We Know About the Dangerous COVID B.1.617.2 (Delta) Variant – “the Delta variant may soon become the most dominant COVID strain in the world and lead to rapid outbreaks in countries without high vaccination rates”.

3 Jun, 2021 | 11:05h | UTC

What We Know About the Dangerous COVID B.1.617.2 (Delta) Variant – Intelligencer

 

Commentary on Twitter

 

Israel reports link between rare cases of heart inflammation and COVID-19 vaccination in young men.

2 Jun, 2021 | 08:37h | UTC

Israel reports link between rare cases of heart inflammation and COVID-19 vaccination in young men – Science (a few articles per month are free)

Related: CDC is investigating several reports that teenagers and young adults may have developed myocarditis after receiving mRNA vaccines. Most cases were mild, more often in males than females, more often following dose 2 than dose 1, and typically, within 4 days after vaccination.

 

Commentary on Twitter

https://twitter.com/rfsquared/status/1399803644288061442

 

WHO validates Sinovac-CoronaVac COVID-19 vaccine for emergency use and issues interim policy recommendations.

2 Jun, 2021 | 08:42h | UTC

WHO validates Sinovac COVID-19 vaccine for emergency use and issues interim policy recommendations – World Health Organization

Commentary: WHO grants emergency approval to 2nd Chinese COVID vaccine – MedicalXpress

 

Commentary on Twitter (thread – click for more)

Review: SARS-CoV-2 variants, spike mutations and immune escape.

2 Jun, 2021 | 08:33h | UTC

SARS-CoV-2 variants, spike mutations and immune escape – Nature Reviews Microbiology

 

Commentary on Twitter

 

[Press release – not published yet] The city of Serrana in Brazil has seen a 95% drop in Covid-19 deaths after almost all adults were vaccinated with Chinese CoronaVac – The findings suggest the pandemic can be controlled after 75% of people are fully vaccinated.

2 Jun, 2021 | 08:39h | UTC

Immunization of Serrana´s population with Butantan´s vaccine has a high decrease of 80% cases and 95% in deaths by COVID – Instituto Butantan

Commentaries: Study in Brazilian town shows 95% efficacy of Sinovac’s vaccine in reducing death by COVID-19 – Global Times AND Brazil Covid: Deaths plunge after town’s adults vaccinated – BBC AND Sinovac vaccine restores a Brazilian city to near normal – Associated Press

 

WHO renames COVID-19 variants with the Greek alphabet (i.e., Alpha, Beta, Gamma, etc), making them simple, easy to say and remember. The naming system aims to prevent calling COVID-19 variants by the places where they are detected, which is stigmatizing & discriminatory.

1 Jun, 2021 | 08:26h | UTC

Tracking SARS-CoV-2 variants – World Health Organization

Commentaries: The name game for coronavirus variants just got a little easier – STAT AND Covid: WHO renames UK and other variants with Greek letters – BBC

 

Study shows low risk of SARS-CoV-2 reinfection 1 year after primary infection.

1 Jun, 2021 | 08:23h | UTC

Assessment of SARS-CoV-2 Reinfection 1 Year After Primary Infection in a Population in Lombardy, Italy – JAMA Internal Medicine

Editorial: Protection Because of Prior SARS-CoV-2 Infection

 

Commentary on Twitter

 

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