Chest Medicine (all articles)
Target arterial PO2 according to the underlying pathology: a mini-review of the available data in mechanically ventilated patients.
4 Jun, 2021 | 10:26h | UTC
M-A: In hypoxemic non-hypercapnic patients, early extubation followed by noninvasive ventilation can reduce the total number of days of invasive mechanical ventilation (mean difference, − 2.04 days), without effects in ICU mortality.
4 Jun, 2021 | 10:27h | UTC
ANCA-Associated Vasculitis: An Update.
4 Jun, 2021 | 10:23h | UTCANCA-Associated Vasculitis: An Update – Journal of Clinical Medicine
RCT: Among patients with ANCA-associated vasculitis without severe glomerulonephritis or alveolar hemorrhage treated with Rituximab, a reduced-dose glucocorticoids regimen (prednisolone 0.5 mg/kg/d) was noninferior to a high-dose glucocorticoid regimen (prednisolone 1 mg/kg/d) for the induction of disease remission.
4 Jun, 2021 | 10:25h | UTC
Countries hit hardest by COVID-19 – estimated mortality countries will have on September 1, 2021.
3 Jun, 2021 | 11:09h | UTCCountries Hit Hardest by COVID-19 – Think Global Health
Commentary on Twitter (thread – click for more)
❓??? Which countries will have the highest mortality from COVID-19 come September 1, 2021? IHME researchers ran the numbers for a new article in @ThinkGlobalHlth ⤵️?https://t.co/d2CFHVzCYX
— Institute for Health Metrics and Evaluation (IHME) (@IHME_UW) June 2, 2021
What We Know About the Dangerous COVID B.1.617.2 (Delta) Variant – “the Delta variant may soon become the most dominant COVID strain in the world and lead to rapid outbreaks in countries without high vaccination rates”.
3 Jun, 2021 | 11:05h | UTCWhat We Know About the Dangerous COVID B.1.617.2 (Delta) Variant – Intelligencer
Commentary on Twitter
Good summary of what's presently known about the B.1.617.2 (Delta) variant @NYMag. Important to emphasize 2-dose vaccination effectiveness is high.https://t.co/8cKvR5eBMM w/ @jburnmurdoch @zeynep @macroliter by @chasdanner
— Eric Topol (@EricTopol) June 1, 2021
Israel reports link between rare cases of heart inflammation and COVID-19 vaccination in young men.
2 Jun, 2021 | 08:37h | UTCIsrael reports link between rare cases of heart inflammation and COVID-19 vaccination in young men – Science (a few articles per month are free)
Commentary on Twitter
?Paging @CDCgov and @US_FDA
“In a report submitted today to the Israeli Ministry of Health, they conclude that between one in 3000 and one in 6000 men ages 16 to 24 who received the vaccine developed the rare condition.” https://t.co/aoz2rkgdwO
— Ramin Farzaneh-Far MD (@rfsquared) June 1, 2021
WHO validates Sinovac-CoronaVac COVID-19 vaccine for emergency use and issues interim policy recommendations.
2 Jun, 2021 | 08:42h | UTCCommentary: WHO grants emergency approval to 2nd Chinese COVID vaccine – MedicalXpress
Commentary on Twitter (thread – click for more)
WHO today validated the Sinovac-CoronaVac #COVID19 vaccine for emergency use, giving countries, funders, procuring agencies & communities the assurance that it meets international standards for safety, efficacy and manufacturing.
More ⬇️ https://t.co/Uy0xmGlAIT— World Health Organization (WHO) (@WHO) June 1, 2021
Review: SARS-CoV-2 variants, spike mutations and immune escape.
2 Jun, 2021 | 08:33h | UTCSARS-CoV-2 variants, spike mutations and immune escape – Nature Reviews Microbiology
Commentary on Twitter
A new, exceptional review of the #SARSCoV2 major variants, zooming in on the culprit mutations, Δ epitopes/antigens.
It concludes there is a "high probability of future mutation-mediated escape from host immunity"https://t.co/D4mFot8Ot5@NatureRevMicro @_wharvey @robertson_lab pic.twitter.com/JgzAhpsviq— Eric Topol (@EricTopol) June 1, 2021
[Press release – not published yet] The city of Serrana in Brazil has seen a 95% drop in Covid-19 deaths after almost all adults were vaccinated with Chinese CoronaVac – The findings suggest the pandemic can be controlled after 75% of people are fully vaccinated.
2 Jun, 2021 | 08:39h | UTCCommentaries: Study in Brazilian town shows 95% efficacy of Sinovac’s vaccine in reducing death by COVID-19 – Global Times AND Brazil Covid: Deaths plunge after town’s adults vaccinated – BBC AND Sinovac vaccine restores a Brazilian city to near normal – Associated Press
WHO renames COVID-19 variants with the Greek alphabet (i.e., Alpha, Beta, Gamma, etc), making them simple, easy to say and remember. The naming system aims to prevent calling COVID-19 variants by the places where they are detected, which is stigmatizing & discriminatory.
1 Jun, 2021 | 08:26h | UTCTracking SARS-CoV-2 variants – World Health Organization
Commentaries: The name game for coronavirus variants just got a little easier – STAT AND Covid: WHO renames UK and other variants with Greek letters – BBC
Study shows low risk of SARS-CoV-2 reinfection 1 year after primary infection.
1 Jun, 2021 | 08:23h | UTCEditorial: Protection Because of Prior SARS-CoV-2 Infection
Commentary on Twitter
Lombardy, Italy was one of the worst-hit places in the world in the 1st wave of the pandemic. Now, a year later, how many had reinfections?
0.3%
And 13-15 X infections for those who did not have covidhttps://t.co/ewpMRcPIMB @JAMAInternalMed pic.twitter.com/I7z2L04Evp— Eric Topol (@EricTopol) May 28, 2021
Perspective | Can I get AstraZeneca now and Pfizer later? Why mixing and matching COVID vaccines could help solve many rollout problems.
1 Jun, 2021 | 08:20h | UTC
M-A: Triple vs. dual inhaler therapy in patients with moderate to severe asthma – fewer severe asthma exacerbations, but without significant differences in quality of life or mortality.
1 Jun, 2021 | 08:12h | UTCTriple vs Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma: A Systematic Review and Meta-analysis – JAMA (free for a limited period)
Commentary on Twitter
Among patients with moderate to severe asthma, triple therapy compared with dual therapy was significantly associated with fewer severe asthma exacerbations and modest improvements in asthma control but no significant difference in quality of life https://t.co/icKsWu0Md9 #ATS2021
— JAMA (@JAMA_current) May 19, 2021
Opinion | 7 reasons why we should not need boosters for COVID-19.
31 May, 2021 | 08:21h | UTC7 Reasons Why We Should Not Need Boosters for COVID-19 – by Monica Ghandi, MD
No COVID-19 cases found after a well-controlled indoor concert.
31 May, 2021 | 08:24h | UTCNo COVID-19 cases found after well-controlled indoor concert – CIDRAP
Invited Commentary: Innovations in COVID-19 testing: the road from pandemic response to control – The Lancet Infectious Diseases
Commentary on Twitter (thread – click for more)
Report of the Barcelona music event out here. These are difficult studies to do – and you need to carefully review them.
Same-day SARS-CoV-2 antigen test screening in an indoor mass-gathering live music event: a randomised controlled trial https://t.co/KDMtsGD23v
— Jon Deeks FMedSci ? (@deeksj) May 28, 2021
New IDSA Guidelines on antigen testing for the diagnosis of COVID-19.
31 May, 2021 | 08:25h | UTC
Covid-19 vaccination prevents transmission from vaccinated to unvaccinated household members.
31 May, 2021 | 08:18h | UTCThe indirect effect of mRNA-based Covid-19 vaccination on unvaccinated household members – medRxiv
Commentary on Twitter
More on less transmission, yet another incentive:
"Our results suggest that mRNA-based vaccines do not only prevent #SARSCoV2 infections among vaccinated individuals but lead to a substantial reduction in infections among unvaccinated household members"https://t.co/sIqoOLiH3b pic.twitter.com/6rv2tojR2m— Eric Topol (@EricTopol) May 29, 2021
Vietnam finds new rapidly spreading SARS-CoV-2 variant, hybrid of B.1.617.2 and B.1.1.7 strains.
31 May, 2021 | 08:16h | UTCVietnam finds new virus variant, hybrid of India, UK strains – Associated Press
See also: Covid: Vietnam detects new UK-Indian variant, health officials say – BBC AND Vietnam says new Covid variant is hybrid of India and UK strains – The Guardian
[Not published yet] Observational study in Uruguay found CoronaVac reduced mortality by 97 percent – “In people who had received two doses, it reduced infection with the coronavirus by 57 percent and intensive care admissions by 95 percent”.
31 May, 2021 | 08:14h | UTCCoronaVac reduces mortality by 97 percent: Uruguay study – Associated Press
Lab study found CoronaVac serum neutralization efficiency was significantly decreased against B.1.526, P.1, and B1.351 SARS-CoV-2 variants.
28 May, 2021 | 08:26h | UTC
COLCORONA RCT: Colchicine for community-treated patients with COVID-19 – findings suggest it may lower death and hospital admission rates, but further studies are required.
28 May, 2021 | 08:27h | UTCInvited Commentary: Exploiting an early immunological window of opportunity in COVID-19 – The Lancet Respiratory Medicine
The global burden of smoking tobacco and attributable disease in 204 countries and territories – “In the absence of intervention, the annual toll of 7.69 million deaths and 200 million disability-adjusted life-years attributable to smoking will increase over the coming decades”.
28 May, 2021 | 08:19h | UTCRelated studies: Spatial, temporal, and demographic patterns in prevalence of chewing tobacco use in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019 – The Lancet Public Health AND Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and initiation among young people in 204 countries and territories, 1990–2019 – The Lancet Public Health
RCT: Pfizer-BioNTech Covid-19 vaccine shows 100% efficacy in adolescents – mainly transient mild-to-moderate reactogenicity was frequently observed, such as injection-site pain (in 79 to 86% of participants), fatigue (in 60 to 66%), and headache (in 55 to 65%).
28 May, 2021 | 08:24h | UTC
Commentary on Twitter
The 12-15 year-olds mRNA vaccine randomized, placebo-controlled clinical trial is published @NEJM today [@BioNTech_Group/@Pfizer]https://t.co/7GlgC9xdd0
—100% efficacy (95% CI 75,100)
—1.8 X higher levels of neutralizing antibodies than 16-25 yr olds
—very good safety profile pic.twitter.com/hQzkpuA5Nu— Eric Topol (@EricTopol) May 27, 2021
Covid-19: Pfizer-BioNTech vaccine is “likely” responsible for deaths of some elderly patients, Norwegian review finds.
28 May, 2021 | 08:22h | UTC
Commentary on Twitter
The Pfizer-BioNTech covid-19 vaccine is “likely” to have been responsible for at least 10 deaths of frail elderly people in nursing homes in Norway, an expert review concluded, although it emphasised considerable uncertainty around its conclusionshttps://t.co/w32jH6MtRH
— The BMJ (@bmj_latest) May 27, 2021