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Chest Medicine (all articles)

RCT | Rituximab and MMF combo improves lung function vs. MMF in interstitial lung disease with NSIP pattern, but may increase infection risk

21 Jun, 2023 | 13:16h | UTC

Rituximab and mycophenolate mofetil combination in patients with interstitial lung disease (EVER-ILD): a double-blind, randomised, placebo-controlled trial – European Respiratory Journal (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Review | Ultrasonographic assessment of diaphragmatic function in the management of patients with acute respiratory failure

21 Jun, 2023 | 13:12h | UTC

Ultrasonographic Assessment of Diaphragmatic Function and Its Clinical Application in the Management of Patients with Acute Respiratory Failure – Diagnostics

 


Review | Pulmonary rehabilitation and physical interventions

21 Jun, 2023 | 13:11h | UTC

Pulmonary rehabilitation and physical interventions – European Respiratory Review

 

Commentary on Twitter

 


Guideline | Management of patients with primary spontaneous pneumothorax

20 Jun, 2023 | 12:46h | UTC

SPLF/SMFU/SRLF/SFAR/SFCTCV Guidelines for the management of patients with primary spontaneous pneumothorax: Endorsed by the French Speaking Society of Respiratory Diseases (SPLF), the French Society of Emergency Medicine (SFMU), the French Intensive Care Society (SRLF), the French Society of Anesthesia & Intensive Care Medicine (SFAR) and the French Society of Thoracic and Cardiovascular Surgery (SFCTCV) – Respiratory Medicine and Research

 


Review | Measuring exhaled nitric oxide when diagnosing and managing asthma

20 Jun, 2023 | 12:41h | UTC

Measuring exhaled nitric oxide when diagnosing and managing asthma – Cleveland Clinic Journal of Medicine

 


SR | Long‐acting muscarinic antagonist (LAMA) plus long‐acting beta‐agonist (LABA) vs. LABA plus inhaled corticosteroid (ICS) for COPD

20 Jun, 2023 | 12:26h | UTC

Long‐acting muscarinic antagonist (LAMA) plus long‐acting beta‐agonist (LABA) versus LABA plus inhaled corticosteroid (ICS) for stable chronic obstructive pulmonary disease – Cochrane Library

Summary: Which combination of inhaled medications are safe and effective for chronic obstructive pulmonary disease (COPD)? – Cochrane Library

 


ESICM guidelines on ARDS: definition, phenotyping and respiratory support strategies

19 Jun, 2023 | 14:18h | UTC

ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies – Intensive Care Medicine

See also: Caring for Patients With Acute Respiratory Distress Syndrome: Summary of the 2023 ESICM Practice Guidelines – JAMA (free for a limited period)

 

Commentary on Twitter

 


Review | The role of diet and nutrition in the management of COPD

19 Jun, 2023 | 13:47h | UTC

The role of diet and nutrition in the management of COPD – European Respiratory Review

 


M-A | Mechanical ventilation in patients with acute brain injury

16 Jun, 2023 | 14:03h | UTC

Mechanical ventilation in patients with acute brain injury: a systematic review with meta-analysis – Critical Care

 


ATS Report | Rehabilitation for people with respiratory disease and frailty

16 Jun, 2023 | 13:51h | UTC

Rehabilitation for People with Respiratory Disease and Frailty: An Official American Thoracic Society Workshop Report – Annals of the American Thoracic Society

 


Single-center cohort study | Low-risk PE patients with concerning CT findings – increased hospitalization, but no increased risk of mortality

16 Jun, 2023 | 13:49h | UTC

Adverse Clinical Outcomes Among Patients With Acute Low-risk Pulmonary Embolism and Concerning Computed Tomography Imaging Findings – JAMA Network Open

Commentary: Acute Low-Risk Pulmonary Embolism and Concerning CT Findings – American College of Cardiology

 


RCT | Nalbuphine reduces cough in idiopathic pulmonary fibrosis, despite adverse effects

15 Jun, 2023 | 14:55h | UTC

Nalbuphine Tablets for Cough in Patients with Idiopathic Pulmonary Fibrosis – NEJM Evidence

 


Review | Basic, translational and clinical aspects of bronchiectasis in adults

14 Jun, 2023 | 14:13h | UTC

Basic, translational and clinical aspects of bronchiectasis in adults – European Respiratory Review

 

Commentary on Twitter

 


M-A | Oseltamivir fails to lower hospitalization risk in adult and adolescent influenza patients

13 Jun, 2023 | 14:12h | UTC

Evaluation of Oseltamivir Used to Prevent Hospitalization in Outpatients With Influenza: A Systematic Review and Meta-analysis – JAMA Internal Medicine

 

Commentary on Twitter

 


2ry Analysis of a RCT | Metformin linked to 41% reduction in long COVID incidence in outpatient treatment

12 Jun, 2023 | 13:55h | UTC

Outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months (COVID-OUT): a multicentre, randomised, quadruple-blind, parallel-group, phase 3 trial – The Lancet Infectious Diseases

News Release: Study shows metformin lowers the risk of getting long COVID – University of Minnesota Medical School

Commentary: Expert reaction to study on Metformin after testing positive for SARS-CoV-2 and risk of developing long COVID – Science Media Centre

 

Commentary on Twitter

 


Review | Acute dyspnea in the emergency department

12 Jun, 2023 | 13:33h | UTC

Acute dyspnea in the emergency department: a clinical review – Internal and Emergency Medicine

 


Cohort Study | Pulmonary hypertension post-VTE linked to a twofold increase in long-term mortality

12 Jun, 2023 | 13:27h | UTC

Long-Term Prognostic Impact of Pulmonary Hypertension After Venous Thromboembolism – American Journal of Cardiology

 


Review | Hemodynamic and respiratory support in pulmonary embolism

12 Jun, 2023 | 13:22h | UTC

Hemodynamic and respiratory support in pulmonary embolism: a narrative review – Frontiers in Medicine

 


RCT | Noninferiority shown between DOACs and LMWH for recurrent VTE prevention in cancer patients

5 Jun, 2023 | 13:50h | UTC

Summary: This unblinded, pragmatic, noninferiority randomized clinical trial aimed to assess the efficacy of direct oral anticoagulants (DOACs) against low-molecular-weight heparin (LMWH) in preventing recurrent venous thromboembolism (VTE) in patients with cancer. The study included 671 patients from 67 oncology centers, with a new clinical or radiological diagnosis of VTE.

Participants were randomly assigned to receive either a DOAC or LMWH for 6 months, and treating physicians selected and prescribed the drugs based on considerations like availability and drug-drug interactions. The primary outcome was the rate of recurrent VTE at 6 months. Findings revealed that the DOAC group had a recurrent VTE rate of 6.1% as compared to 8.8% in the LMWH group, showing noninferiority. Both groups had statistically similar rates of major bleeding and severe adverse events.

This pragmatic study included patients with advanced cancer and brain metastases, impaired performance status, and reduced liver or kidney function, making it more representative of routine oncology practice. Moreover, patient adherence to DOAC treatment was significantly higher than to LMWH. Nevertheless, the study had limitations, including the lack of blinding and underrepresentation of certain racial and ethnic groups.

In conclusion, this trial suggests that DOACs were noninferior to LMWH for preventing recurrent VTE in patients with cancer over a 6-month follow-up period, supporting the use of DOACs in this population for VTE prevention. Further research is needed to confirm these results and investigate long-term outcomes.

Article: Direct Oral Anticoagulants vs Low-Molecular-Weight Heparin and Recurrent VTE in Patients With Cancer: A Randomized Clinical Trial – JAMA (free for a limited period)

See also: Visual abstract

 

Commentary on Twitter

 


Systematic Review | Bupropion and nortriptyline: an assessment of their effectiveness in smoking cessation

2 Jun, 2023 | 12:28h | UTC

Antidepressants for smoking cessation – Cochrane Library

 


M-A | Residual respiratory disability after successful treatment of pulmonary tuberculosis

2 Jun, 2023 | 12:20h | UTC

Residual respiratory disability after successful treatment of pulmonary tuberculosis: a systematic review and meta-analysis – eClinicalMedicine

 


Review | Interventional therapies for pulmonary embolism

2 Jun, 2023 | 12:16h | UTC

Interventional therapies for pulmonary embolism – Nature Reviews Cardiology (if the link is paywalled, try this one)

 

Commentary on Twitter

 


Manual prone positioning in adults: reducing the risk of harm through evidence-based practices

2 Jun, 2023 | 12:14h | UTC

Manual Prone Positioning in Adults: Reducing the Risk of Harm Through Evidence-Based Practices – Critical Care Nurse

News Release: New guidance on manual prone positioning for patients with ARDS – American Association of Critical-Care Nurses

 


RCT | Dupilumab improves lung function and reduces exacerbations in COPD patients with elevated eosinophils

1 Jun, 2023 | 12:20h | UTC

Dupilumab for COPD with Type 2 Inflammation Indicated by Eosinophil Counts – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Dupilumab Improves Outcomes for COPD, Type 2 Inflammation in Randomized Trial – HCP Live

 

Commentary on Twitter

 


M-A | Noninvasive ventilation in patients with acute hypoxemic respiratory failure

1 Jun, 2023 | 12:11h | UTC

Noninvasive ventilation in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis of randomized controlled trials – Scientific Reports

 


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