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Chest Medicine

Clues to long Covid: Scientists strive to unravel what is driving disabling symptoms.

20 Jun, 2022 | 10:30h | UTC

Clues To Long Covid – Science

 

Case-control study: Risk of long COVID associated with delta vs. omicron variants of SARS-CoV-2.

20 Jun, 2022 | 10:34h | UTC

Risk of long COVID associated with delta versus omicron variants of SARS-CoV-2 – The Lancet

News Release: Long COVID risk less during Omicron compared to Delta, study finds – King’s College London

Commentaries:

Expert reaction to study looking at long COVID prevalence associated with delta versus omicron variants of SARS-CoV-2 – Science Media Centre

Omicron less likely to lead to long COVID, study finds – CIDRAP

Covid-19: Long covid risk is lower with omicron than delta, researchers find – The BMJ

 

Commentary on Twitter

 

[Preprint] Open-label RCT: Baricitinib noninferior to Tocilizumab in hospitalized patients with severe COVID-19.

20 Jun, 2022 | 10:28h | UTC

Tocilizumab versus baricitinib in hospitalized patients with severe COVID-19: an open label, randomized controlled trial – medRxiv

Related:

Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial – The Lancet Respiratory Medicine

Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis – medRxiv

WHO recommends two new drugs to treat COVID-19 – World Health Organization

Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial – The Lancet Respiratory Medicine

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 – New England Journal of Medicine

 

Commentary on Twitter

 

Brief Review: Helmet noninvasive support in hypoxemic respiratory failure.

20 Jun, 2022 | 01:13h | UTC

Helmet noninvasive support in hypoxemic respiratory failure – Intensive Care Medicine (if the link is paywalled, try this one)

 

Commentary on Twitter

 

#CCR22 – RCT: High-flow nasal cannula therapy met criteria for noninferiority compared to CPAP for the liberation from respiratory support in acutely ill children in the ICU.

16 Jun, 2022 | 11:10h | UTC

Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units: A Randomized Clinical Trial – JAMA (free for a limited period)

 

Commentary on Twitter

 

#CCR22 – RCT: Among critically ill patients undergoing tracheal intubation, administering a 500 ml fluid bolus did not decrease the incidence of severely low blood pressure, cardiac arrest, or death.

16 Jun, 2022 | 11:08h | UTC

Effect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial – JAMA (free for a limited period)

 

Commentary on Twitter

 

Perspective | Viruses that were on hiatus during Covid are back — and behaving in unexpected ways.

16 Jun, 2022 | 11:06h | UTC

Viruses that were on hiatus during Covid are back — and behaving in unexpected ways – STAT

 

Review: The physiological underpinnings of life-saving respiratory support.

16 Jun, 2022 | 11:03h | UTC

The physiological underpinnings of life-saving respiratory support – Intensive Care Medicine

 

Commentary on Twitter

 

Pfizer’s Paxlovid study fails to answer key questions over benefit for broader populations.

15 Jun, 2022 | 11:22h | UTC

Pfizer’s Paxlovid study fails to answer key questions over benefit for broader populations – STAT

 

RCT: Effect of varenicline added to counseling on smoking cessation among African American daily smokers.

15 Jun, 2022 | 11:18h | UTC

Effect of Varenicline Added to Counseling on Smoking Cessation Among African American Daily Smokers: The Kick It at Swope IV Randomized Clinical Trial – JAMA Network Open

Editorial: Helping African American Individuals Quit Smoking: Finally, Some Progress – JAMA

News Release: Varenicline Increases Smoking Cessation Rates for African American Smokers – University of Kansas Cancer Center

 

Commentary on Twitter

 

Analysis of thromboembolic and thrombocytopenic events after the AstraZeneca, Pfizer, and Moderna COVID-19 vaccines in 3 Nordic countries.

15 Jun, 2022 | 11:17h | UTC

Analysis of Thromboembolic and Thrombocytopenic Events After the AZD1222, BNT162b2, and MRNA-1273 COVID-19 Vaccines in 3 Nordic Countries – JAMA Network Open

 

M-A: Treatment outcomes among pregnant patients with multidrug-resistant tuberculosis.

15 Jun, 2022 | 10:47h | UTC

Treatment Outcomes Among Pregnant Patients With Multidrug-Resistant Tuberculosis: A Systematic Review and Meta-analysis – JAMA Network Open

 

Commentary on Twitter

 

Cohort Study | Intermediate-risk pulmonary embolism: echocardiography predictors of clinical deterioration.

15 Jun, 2022 | 10:34h | UTC

Intermediate-risk pulmonary embolism: echocardiography predictors of clinical deterioration – Critical Care

 

Systematic Review: Janus kinase inhibitors for the treatment of COVID‐19.

14 Jun, 2022 | 11:14h | UTC

Janus kinase inhibitors for the treatment of COVID‐19 – Cochrane Library

Summary: Are systemic Janus kinase inhibitors an effective treatment for people with COVID-19? – Cochrane Library

 

[Preprint] RCT: Ivermectin does not benefit patients with mild-to-moderate COVID-19 in the outpatient setting.

14 Jun, 2022 | 11:12h | UTC

Ivermectin for Treatment of Mild-to-Moderate COVID-19 in the Outpatient Setting: A Decentralized, Placebo-controlled, Randomized, Platform Clinical Trial – medRxiv

Commentary: Study finds no benefit to taking ivermectin for COVID-19 symptoms – Duke University

 

Study among patients with sleep apnea showed multimorbidity was present in two-thirds of individuals at the time of diagnosis.

14 Jun, 2022 | 10:47h | UTC

Multimorbidity and overall comorbidity of sleep apnoea: a Finnish nationwide study – ERJ Open Research

Commentary: Study Highlights Prevalence of OSA and Overall Burden of Comorbidities – AJMC

 

Commentary on Twitter

 

M-A: Respiratory viral co-infections in patients with COVID-19 and associated outcomes.

13 Jun, 2022 | 10:41h | UTC

Respiratory viral co-infections in patients with COVID-19 and associated outcomes: A systematic review and meta-analysis – Reviews in Medical Virology

 

NIH Updated Guideline: Oxygenation and ventilation for adults with Covid-19.

13 Jun, 2022 | 10:44h | UTC

Oxygenation and Ventilation for Adults – National Institutes of Health

 

RCT: Intramuscular tixagevimab–cilgavimab may benefit non-hospitalized unvaccinated adults with Covid-19.

13 Jun, 2022 | 10:39h | UTC

Efficacy and safety of intramuscular administration of tixagevimab–cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trial – The Lancet Respiratory Medicine

Commentaries:

Safety and efficacy of tixagevimab–cilgavimab in preventing severe COVID – News Medical

Expert reaction to results of the TACKLE Phase 3 trial of Evusheld (tixagevimab and cilgavimab) for treating early COVID-19 in outpatients – Science Media Centre

 

Commentary on Twitter

 

Brief Review: How to manage anticoagulation during extracorporeal membrane oxygenation.

13 Jun, 2022 | 08:03h | UTC

How to manage anticoagulation during extracorporeal membrane oxygenation – Intensive Care Medicine (if the link is paywalled, try this one)

Related: 2021 ELSO Adult and Pediatric Anticoagulation Guidelines – ASAIO Journal

 

Canada to require a warning be printed on every cigarette.

13 Jun, 2022 | 07:58h | UTC

Canada to require a warning be printed on every cigarette – Associated Press

 

M-A: Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections.

10 Jun, 2022 | 12:00h | UTC

Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: Update of a living systematic review and meta-analysis – PLOS Medicine

 

Guidance Statement: Surgical triage and timing for patients with COVID undergoing thoracic surgery.

10 Jun, 2022 | 11:58h | UTC

Surgical Triage and Timing for Patients with COVID: A Guidance Statement from the Society of Thoracic Surgeons – Annals of Thoracic Surgery

 

Review: Pathophysiology and mechanism of long COVID.

10 Jun, 2022 | 11:55h | UTC

Pathophysiology and mechanism of long COVID: a comprehensive review – Annals of Medicine

 

[Preprint] Largest study to date on long COVID identifies a broad list of diagnoses.

10 Jun, 2022 | 11:53h | UTC

Study Commentary: Largest study to date on long COVID identifies a broad list of diagnoses – News Medical

Original Study: Understanding Post-Acute Sequelae of SARS-CoV-2 Infection through Data-Driven Analysis with Longitudinal Electronic Health Records: Findings from the RECOVER Initiative – medRxiv

 

Commentary on Twitter

 

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