Chest Medicine (all articles)
Systematic Review: SARS‐CoV‐2‐neutralising monoclonal antibodies to prevent COVID‐19.
23 Jun, 2022 | 10:37h | UTCSARS‐CoV‐2‐neutralising monoclonal antibodies to prevent COVID‐19 – Cochrane Library
ASA and APSF statement on perioperative testing for the COVID-19 virus.
22 Jun, 2022 | 12:19h | UTCCommentary: ASA, APST Update Perioperative SARS-CoV-2 Testing Recommendations – HealthDay
Related:
Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery
BJS commission on surgery and perioperative care post-COVID-19.
ASA Guidance: Preoperative testing for COVID-19 is essential, regardless of vaccination.
Position statement: Perioperative management of post-COVID-19 surgical patients.
Review: Sex differences in sequelae from COVID-19 infection and in long COVID syndrome.
22 Jun, 2022 | 12:06h | UTCCommentary: Women more likely to have long COVID, different symptom profile – CIDRAP
RCT: Efficacy and safety of varenicline for smoking cessation in patients with type 2 diabetes.
22 Jun, 2022 | 11:16h | UTCAuthor Interview: Efficacy and Safety of Varenicline in Patients With Type 2 Diabetes – JAMA
Commentary on Twitter
This randomized clinical trial (CoEHAR) found the use of varenicline in smoking cessation programs for patients with diabetes resulted in prolonged abstinence. @CoeharUnict @RiccardoPolosa https://t.co/Sd57LMcsbJ
— JAMA Network Open (@JAMANetworkOpen) June 21, 2022
RCT: High-flow nasal cannula vs. conventional oxygen therapy in acute COPD exacerbation with mild hypercapnia.
22 Jun, 2022 | 11:09h | UTC
Randomized cross-over study: closed-loop oxygen control improves oxygen therapy in acute hypoxemic respiratory failure patients under high flow nasal oxygen.
22 Jun, 2022 | 11:08h | UTC
RCT: Low-dose methylprednisolone does not improve outcomes in critically ill patients with severe community-acquired pneumonia.
21 Jun, 2022 | 11:04h | UTC
How common is long COVID? Why studies give different answers.
21 Jun, 2022 | 11:03h | UTCHow common is long COVID? Why studies give different answers – Nature
WHO Interim statement on decision-making considerations for the use of variant updated COVID-19 vaccines.
20 Jun, 2022 | 10:42h | UTCSee also: Interim statement on the composition of current COVID-19 vaccines – World Health Organization
Commentary on Twitter (thread – click for more)
Current #COVID19 vaccines provide high levels of protection against severe disease and death from all variants. They should continue to be used.
? interim statement:https://t.co/bVzzx1HnG2 pic.twitter.com/CJlAJqFr3C
— World Health Organization (WHO) (@WHO) June 17, 2022
Consensus Study: A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research.
20 Jun, 2022 | 10:31h | UTCNews Release: Key outcomes of Long COVID identified in international consensus study – King’s College London
Invited Commentary: Post-COVID-19 condition in children: a COS is urgently needed – The Lancet Respiratory Medicine
Commentary on Twitter
NEW POSITION PAPER—A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research
From Daniel Munblit & co https://t.co/zAxQ1ww6bT pic.twitter.com/WIitohP3Xo
— The Lancet Respiratory Medicine (@LancetRespirMed) June 15, 2022
Clues to long Covid: Scientists strive to unravel what is driving disabling symptoms.
20 Jun, 2022 | 10:30h | UTC
Case-control study: Risk of long COVID associated with delta vs. omicron variants of SARS-CoV-2.
20 Jun, 2022 | 10:34h | UTCRisk of long COVID associated with delta versus omicron variants of SARS-CoV-2 – The Lancet
News Release: Long COVID risk less during Omicron compared to Delta, study finds – King’s College London
Commentaries:
Omicron less likely to lead to long COVID, study finds – CIDRAP
Covid-19: Long covid risk is lower with omicron than delta, researchers find – The BMJ
Commentary on Twitter
Substantial (~50-75%) reduction of #LongCovid with Omicron compared with Delta variant, magnitude influenced by age and time since vaccination @TheLancet https://t.co/shAzJn8WSj pic.twitter.com/bXoct0sXd1
— Eric Topol (@EricTopol) June 17, 2022
[Preprint] Open-label RCT: Baricitinib noninferior to Tocilizumab in hospitalized patients with severe COVID-19.
20 Jun, 2022 | 10:28h | UTCRelated:
WHO recommends two new drugs to treat COVID-19 – World Health Organization
Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 – New England Journal of Medicine
Commentary on Twitter
Preprint⚡⚡
Baricitinib Vs Tocilizumab open label RCT
Baricitinib was non-inferior to tocilizumab with regards to the composite outcome of mechanical ventilation or death by day 28 and the time to discharge by day 28 in patients with severe #COVID19 https://t.co/sQkhATkjEd— Antibiotic Steward Bassam Ghanem?? (@ABsteward) June 16, 2022
Brief Review: Helmet noninvasive support in hypoxemic respiratory failure.
20 Jun, 2022 | 01:13h | UTCHelmet noninvasive support in hypoxemic respiratory failure – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
Helmet noninvasive support in hypoxemic respiratory failure:
⚙️ set‐up
⛑ physiology of helmet interface: from most relevant feature to major drawbacks
? clinical implications
Free to read #FOAMcc on @yourICM
? https://t.co/qNE4Id5oBg pic.twitter.com/b2auLLlW9z— Intensive Care Medicine (@yourICM) June 18, 2022
#CCR22 – RCT: High-flow nasal cannula therapy met criteria for noninferiority compared to CPAP for the liberation from respiratory support in acutely ill children in the ICU.
16 Jun, 2022 | 11:10h | UTCEffect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
Among acutely ill children clinically assessed to require noninvasive respiratory support in a pediatric critical care unit, HFNC met the criterion for noninferiority compared with CPAP for time to liberation from respiratory support. https://t.co/WvU2fKLDOJ #CCR22
— JAMA (@JAMA_current) June 16, 2022
#CCR22 – RCT: Among critically ill patients undergoing tracheal intubation, administering a 500 ml fluid bolus did not decrease the incidence of severely low blood pressure, cardiac arrest, or death.
16 Jun, 2022 | 11:08h | UTCEffect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
In this randomized clinical trial, among critically ill adults undergoing tracheal intubation, administration of a fluid bolus did not significantly decrease the incidence of cardiovascular collapse. https://t.co/vPkfgLBF1n #CCR22
— JAMA (@JAMA_current) June 16, 2022
Perspective | Viruses that were on hiatus during Covid are back — and behaving in unexpected ways.
16 Jun, 2022 | 11:06h | UTCViruses that were on hiatus during Covid are back — and behaving in unexpected ways – STAT
Review: The physiological underpinnings of life-saving respiratory support.
16 Jun, 2022 | 11:03h | UTCThe physiological underpinnings of life-saving respiratory support – Intensive Care Medicine
Commentary on Twitter
Physiology of life-saving respiratory support:
➡️historical overview
➡️pathophysiology of respiratory failure
Invasive mechanical ventilation & extracorporeal support #ECLS #ECMO:
➡️rationale
➡️implementation
➡️iatrogenic consequences
➡️future#FOAMcc
? https://t.co/EEvfpqVKIa pic.twitter.com/4t7wl53Jpz— Intensive Care Medicine (@yourICM) June 12, 2022
Pfizer’s Paxlovid study fails to answer key questions over benefit for broader populations.
15 Jun, 2022 | 11:22h | UTCPfizer’s Paxlovid study fails to answer key questions over benefit for broader populations – STAT
RCT: Effect of varenicline added to counseling on smoking cessation among African American daily smokers.
15 Jun, 2022 | 11:18h | UTCEditorial: Helping African American Individuals Quit Smoking: Finally, Some Progress – JAMA
News Release: Varenicline Increases Smoking Cessation Rates for African American Smokers – University of Kansas Cancer Center
Commentary on Twitter
Study found that, among African American adults who were daily smokers, counseling + 12 weeks of varenicline treatment, vs counseling + placebo, showed a significant improvement in rates of 7-day point prevalence smoking abstinence at week 26. https://t.co/fK4NUWgkJO
— JAMA (@JAMA_current) June 14, 2022
Analysis of thromboembolic and thrombocytopenic events after the AstraZeneca, Pfizer, and Moderna COVID-19 vaccines in 3 Nordic countries.
15 Jun, 2022 | 11:17h | UTC
M-A: Treatment outcomes among pregnant patients with multidrug-resistant tuberculosis.
15 Jun, 2022 | 10:47h | UTC
Commentary on Twitter
This meta-analysis of pregnant patients treated for multi-drug-resistant tuberculosis (MDR-TB) found 73% treatment success and 73% favorable pregnancy outcomes, with adverse events (incl liver/kidney impairment, hearing loss) in more than half of patients. https://t.co/Mx5RLiwhU9
— JAMA Network Open (@JAMANetworkOpen) June 10, 2022
Cohort Study | Intermediate-risk pulmonary embolism: echocardiography predictors of clinical deterioration.
15 Jun, 2022 | 10:34h | UTC
Systematic Review: Janus kinase inhibitors for the treatment of COVID‐19.
14 Jun, 2022 | 11:14h | UTCJanus kinase inhibitors for the treatment of COVID‐19 – Cochrane Library
[Preprint] RCT: Ivermectin does not benefit patients with mild-to-moderate COVID-19 in the outpatient setting.
14 Jun, 2022 | 11:12h | UTCCommentary: Study finds no benefit to taking ivermectin for COVID-19 symptoms – Duke University