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Chest Medicine (all articles)

Randomized Controlled Trial: Dupilumab in Glucocorticoid-Dependent Severe Asthma

23 May, 2018 | 12:39h | UTC

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma – New England Journal of Medicine (free)

Related Article: Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma – New England Journal of Medicine (free)

Editorial: New Biologics for Asthma (free)

Commentary: Dupilumab Improves Severe Asthma – NEJM Physician’s First Watch (free)


Perspective: E-cigarettes Are a Win or Loss for Public Health?

21 May, 2018 | 13:10h | UTC

E-cigarettes: A win or loss for public health? – Knowable Magazine (free)

Related Perspective: The Promise of Vaping and the Rise of Juul – The New Yorker (free)

See also: related guidelines, reports and commentaries on e-cigarettes (all free)

“Arguments over whether e-cigarettes are harmful or helpful seem gridlocked as emerging research underscores both the toxicity of vaping and its possible benefits”. (via @ghn_news see Tweet)

 


Randomized Controlled Trials: Treatments for Mild Asthma Compared

18 May, 2018 | 02:28h | UTC

Inhaled Combined Budesonide–Formoterol as Needed in Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Inhaled Combined Therapy as Needed in Mild Asthma (free)

Related Trial: As-Needed Budesonide–Formoterol versus Maintenance Budesonide in Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: International Study Suggests Alternative Treatment for Mild Asthma – McMaster University, via NewsWise (free) AND On Demand as Effective as Maintenance Therapy for Mild Asthma – Medscape (free registration required)

 


Review: Management of Acute Right Ventricle Failure

16 May, 2018 | 01:22h | UTC

Diagnostic workup, etiologies and management of acute right ventricle failure – Intensive Care Medicine (free for a limited period)

Source: Critical Care Reviews Newsletter

 


Acute Pulmonary Embolism Review: Focus on the Clinical Picture

16 May, 2018 | 00:49h | UTC

Acute Pulmonary Embolism: Focus on the Clinical Picture – Korean Circulatory Journal (free)

Source: Critical Care Reviews Newsletter

 


Review: Pulmonary Pearls & Pitfalls to Consider in Patients with Chest Trauma

9 May, 2018 | 16:24h | UTC

The Chest Bump: Pulmonary Pearls & Pitfalls to Consider in Patients with Chest Trauma – emDocs (free)

 


Meta-Analysis: Liberal vs Conservative Oxygen Therapy in Acutely ill Adults

4 May, 2018 | 02:13h | UTC

Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis – The Lancet (link to abstract – $ for full-text)

Commentary: Too liberal use of oxygen increases risk of death in acutely ill adult patients – McMaster University, via EurekAlert (free)

 


WHO Report: 9 out of 10 People Worldwide Breathe Polluted Air

4 May, 2018 | 02:08h | UTC

9 out of 10 people worldwide breathe polluted air, but more countries are taking action – World Health Organization (free)

Related Infographics: PHE Infographics: Air pollution (free)

Updated Fact Sheets: Ambient (outdoor) air quality and health (free) AND Household air pollution and health (free)

Commentaries: Air pollution inequality widens between rich and poor nations – The Guardian (free) AND Expert reaction to new WHO global air pollution data – Science Media Centre (free)

 


Randomized Controlled Trial: Once-Daily Single-Inhaler Triple vs Dual Therapy in Patients with COPD

4 May, 2018 | 01:55h | UTC

Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Single-Inhaler Triple Therapy in Patients with COPD (free)

 


Meta-Analysis: Direct Oral Anticoagulant vs Low-Molecular-Weight Heparin in Cancer Associated Thrombosis

4 May, 2018 | 01:59h | UTC

Direct oral anticoagulant (DOAC) versus low-molecular-weight heparin (LMWH) for treatment of cancer associated thrombosis (CAT): A systematic review and meta-analysis – Thrombosis Research (free)

Source: EvidenceAlerts

 


Summary: CHEST Guideline on Screening for Lung Cancer

4 May, 2018 | 01:54h | UTC

Screening for Lung Cancer: CHEST Guideline – American College of Cardiology (free)

Original Guideline: Screening for Lung Cancer: CHEST Guideline and Expert Panel Report (free)

 


Summary: AHA Scientific Statement on Right Heart Failure

4 May, 2018 | 01:53h | UTC

AHA Scientific Statement on Right Heart Failure – American College of Cardiology (free)

Original Guideline: Evaluation and Management of Right-Sided Heart Failure: A Scientific Statement From the American Heart Association (free PDF)

 


TOP Clinical Practice Guideline: Chronic Asthma

3 May, 2018 | 20:26h | UTC

Clinical Practice Guideline: Chronic Asthma – Toward Optimized Practice (free PDF)

See also: Summary (free PDF)

Related: see all TOP Clinical Practice Guidelines, a practical resource for Family Physicians at the point of care.

 


Review: Goodpasture’s syndrome (anti-GBM disease) in the ED

3 May, 2018 | 19:22h | UTC

Goodpasture’s syndrome (anti-GBM disease): ED presentations, evaluation, and management – emDocs (free)

 


Debate: Should we Recommend e-Cigarettes to Help Smokers Quit?

27 Apr, 2018 | 01:36h | UTC

Should we recommend e-cigarettes to help smokers quit? – The BMJ (free)

See also: related guidelines, reports and commentaries on e-cigarettes

“Experts debate: Should doctors recommend e-cigarettes to help smokers quit? Revelation in harm reduction or a way to keep people addicted and gateway to youth smoking?” (via @rich_hurley see Tweet)

 


Cohort Study: Proton‐Pump Inhibitors and Risk of Pneumonia in Older Adults

24 Apr, 2018 | 19:29h | UTC

Proton‐Pump Inhibitors and Long‐Term Risk of Community‐Acquired Pneumonia in Older Adults – Journal of the American Geriatrics Society (free)

Commentary: Commonly prescribed heartburn drug linked to Pneumonia in Older Adults – University of Exeter (free)

Related: Proton Pump Inhibitors: Review of Emerging Concerns – Mayo Clinic Proceedings (free) AND Complications of Proton Pump Inhibitor Therapy – Gastroenterology (free) AND Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence – Therapeutic Advances in Drug Safety (free) AND Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free)

Source: Hospital Medicine Virtual Journal Club

 


Review: Management of Dyspnea in the Terminally Ill

24 Apr, 2018 | 18:03h | UTC

Management of Dyspnea in the Terminally Ill – CHEST (free PDF)

Source: Hospital Medicine Virtual Journal Club

 


Randomized Controlled Trial: Home vs Hospital Treatment of COPD Exacerbation

24 Apr, 2018 | 18:01h | UTC

Home treatment of COPD exacerbation selected by DECAF score: a non-inferiority, randomised controlled trial and economic evaluation -Thorax (free)

Source: Hospital Medicine Virtual Journal Club

 


Report: Role of Immunotherapy in the Treatment of Asthma

23 Apr, 2018 | 21:15h | UTC

Role of Immunotherapy in the Treatment of Asthma – Agency for Healthcare Research and Quality (free)

Source: EvidenceAlerts

 


BTS Quality Standards for Acute Non-invasive Ventilation in Adults

20 Apr, 2018 | 01:32h | UTC

British Thoracic Society Quality Standards for acute non-invasive ventilation in adults – BMJ Open Respiratory Research (free)

Related Guidelines: Clinical practice guidelines for the use of noninvasive positive-pressure ventilation and noninvasive continuous positive airway pressure in the acute care setting – Canadian Medical Association Journal (free) AND BTS/ICS guideline for the ventilatory management of acute hypercapnic respiratory failure in adults – Thorax (free)

Source: Critical Care Reviews Newsletter

 


Research: ECMO versus Prone Position in ARDS

20 Apr, 2018 | 00:51h | UTC

Unproven and Expensive before Proven and Cheap: Extracorporeal Membrane Oxygenation versus Prone Position in Acute Respiratory Distress Syndrome – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)

Commentary: Few patients with ARDS in ECMO trials undergo prone positioning, though it saves lives – Univadis (free registration required)

 


Perspective: Smoking Even One Cigarette a Day Raises Risk for Coronary Heart Disease

18 Apr, 2018 | 01:11h | UTC

Smoking even one cigarette a day raises risk for coronary heart disease – The Washington Post (a few articles per month are free) (via @DrFrieden see Tweet)

See original article: Meta-Analysis: Just One Cigarette a Day Seriously Elevates Cardiovascular Risk (free article and commentaries)

 


Meta-Analysis: Lung Ultrasound vs Chest Radiograph in Critically Ill Patients With Respiratory Symptoms

17 Apr, 2018 | 20:04h | UTC

Diagnostic Accuracy of Chest Radiograph, and When Concomitantly Studied Lung Ultrasound, in Critically Ill Patients With Respiratory Symptoms: A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)

Commentary: Lung ultrasound accuracy beats X-ray in critically ill patients with respiratory symptoms – Univadis (free registration required)

 


Report: State of Global Air 2018

18 Apr, 2018 | 00:59h | UTC

State of Global Air 2018 (free report and interactive website)

Commentaries: Over 7 Billion People Face Unsafe Air: State of Global Air 2018 – Institute for Health Metrics and Evaluation (free) AND More than 95% of world’s population breathe dangerous air, major study finds – The Guardian (free) AND More than 95% of world’s population breathing unhealthy air, says new report – CNN (free)

 


Randomized Controlled Trial: Combination Therapy with Immunotherapy Increases Overall Survival in Patients with Lung Cancer

16 Apr, 2018 | 16:34h | UTC

Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer – New England Journal of Medicine (free)

Commentaries: AACR 2018: Combination therapy doubles survival in metastatic lung cancer – eCancer News (free) AND Lung Cancer Patients Live Longer With Immune Therapy – New York Times (10 articles per month are free)

 


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