Chest Medicine
Analysis: Managing Mental Health Challenges Faced by Healthcare Workers During Covid-19 Pandemic
27 Mar, 2020 | 03:55h | UTCManaging mental health challenges faced by healthcare workers during covid-19 pandemic – The BMJ
Related Study: Factors Associated With Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019 – JAMA Network Open AND Commentary: Survey Finds COVID-19 Takes Heavy Psychological Toll on Health Care Workers – Psychiatric News Alert
BCCDC Position Statement on Unproven Therapies for COVID-19
27 Mar, 2020 | 03:48h | UTCRecommendation: Unproven Therapies for COVID-19 | March 24, 2020 – BC Centre for Disease Control
RSNA Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19
27 Mar, 2020 | 03:52h | UTCSee also: COVID-19: Updates for Radiologists
Analysis: What is the Risk of Dying from COVID-19?
26 Mar, 2020 | 02:23h | UTCWhat do we know about the risk of dying from COVID-19? – Our World in Data
Related: Global Covid-19 Case Fatality Rates – Centre for Evidence-Based Medicine, University of Oxford (free)
Postacute Care Preparedness for COVID-19: Thinking Ahead
26 Mar, 2020 | 01:52h | UTCPostacute Care Preparedness for COVID-19: Thinking Ahead – JAMA
“Post-acute care preparedness for COVID19: we need to strengthen capacity in primary and community care to deal with those discharged from hospital.” (via @trishgreenhalgh see Tweet)
CEBM: Assessing Dyspnea by Telephone or Video
26 Mar, 2020 | 01:42h | UTC
Practical Advice: PPE Pearls
26 Mar, 2020 | 01:49h | UTCPersonal Protective Equipment (PPE) Pearls – COVID-19 – emDocs
Hydroxychloroquine: Small Study Shows No Benefit
26 Mar, 2020 | 01:39h | UTCCommentary: Chloroquine Use For COVID-19 Shows No Benefit In First Small—But Limited—Controlled Trial – Forbes
Related: Coronavirus treatment hype can lead to harm – Lown Institute AND No, These Medicines Cannot Cure Coronavirus – The New York times
See also: Chloroquine for COVID-19: Cutting Through the Hype
New WHO Recommendations to Prevent Tuberculosis
25 Mar, 2020 | 02:55h | UTCNews Release: New WHO recommendations to prevent tuberculosis aim to save millions of lives – World Health Organization (free)
See also: Handbook (free)
Commentaries: Don’t forget chronic lung and immune conditions during covid-19, says WHO – The BMJ (free) AND As COVID-19 rages, WHO calls for more efforts to prevent TB – CIDRAP (free)
[Preprint] Incidence, Clinical Characteristics and Prognostic Factor of Patients with COVID-19: A Systematic Review and Meta-analysis
24 Mar, 2020 | 11:37h | UTCCommentary: Study Calculates Just How Much Age, Medical Conditions Raise Odds Of Severe COVID-19 – NPR (free)
Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019
23 Mar, 2020 | 01:37h | UTCInfographics: The Surviving Sepsis Campaign Rapid Guidelines on the Management of Critically Ill Adults with COVID-19 (free)
See also: COVID-19: Updates for Critical Care and Emergency Physicians (free resources)
NICE COVID-19 Rapid Guideline: Critical Care
23 Mar, 2020 | 01:32h | UTCCOVID-19 rapid guideline: critical care – National Institute for Health and Care Excellence (NICE)
See also: COVID-19: Updates for Critical Care and Emergency Physicians (free resources)
COVID-19: Updates for Critical Care and Emergency Physicians
25 May, 2020 | 00:01h | UTCGuidelines:
- NEW – Thromboembolism and anticoagulant therapy during the COVID-19 pandemic: interim clinical guidance from the anticoagulation forum – Journal of Thrombosis and Thrombolysis (05/2020)
- Tracheostomy in the COVID-19 era: global and multidisciplinary guidance – The Lancet Respiratory Medicine AND Commentary: Walking the line between benefit and harm from tracheostomy in COVID-19 – The Lancet Respiratory Medicine (05/2020)
- EAPCI Position Statement on Invasive Management of Acute Coronary Syndromes during the COVID-19 pandemic – European Heart Journal (05/2020)
- Management of acute ischemic stroke in patients with COVID-19 infection: Report of an international panel – International Journal of Stroke (05/2020)
- COVID-19 rapid guideline: acute kidney injury in hospital – National Institute for Health and Care Excellence (05/2020)
- Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19 (05/2020)
- Mechanical Thrombectomy in the Era of the COVID-19 Pandemic: Emergency Preparedness for Neuroscience Teams: A Guidance Statement From the Society of Vascular and Interventional Neurology – Stroke AND Commentaries: Guidance for Treating Stroke Patients During COVD-19 Crisis Developed – Boston University School of Medicine AND Mechanical Thrombectomy and Emergency Preparedness Guidance in COVID-19 Era – American College of Cardiology (05/2020)
- COVID-19 rapid guideline: antibiotics for pneumonia in adults in hospital – National Institute for Health and Care Excellence (05/2020)
- Infectious Diseases Society of America Guidelines on Infection Prevention in Patients with Suspected or Known COVID-19 (05/2020)
- Diagnosis, Prevention, and Treatment of Thromboembolic Complications in COVID-19: Report of the National Institute for Public Health of the Netherlands – Radiology (05/2020)
- Treatment of patients with nonsevere and severe coronavirus disease 2019: an evidence-based guideline – Canadian Medical Association Journal (05/2020)
- Regional Planning for Extracorporeal Membrane Oxygenation Allocation During COVID-19 – CHEST (05/2020)
- NIH Coronavirus Disease 2019 (COVID-19)
Treatment Guidelines – National Institutes of Health (04/2020) - COVID-19 rapid guideline: acute myocardial injury – National Institute for Health and Care Excellence (04/2020)
- ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic – European Society of Cardiology (04/2020)
- Respiratory Support in Novel Coronavirus Disease (COVID-19) Patients, with a Focus on Resource-Limited Settings – The American Society of Tropical Medicine and Hygiene (04/2020)
- Prevention and Treatment of Venous Thromboembolism Associated with Coronavirus Disease 2019 Infection: A Consensus Statement before Guidelines – Thrombosis and Haemostasis (04/2020)
- Hospital Preparedness for COVID-19: A Practical Guide from a Critical Care Perspective – American Journal of Respiratory and Critical Care Medicine (04/2020)
- ECMO Resource Planning in the Setting of Pandemic Respiratory Illness – Annals of the American Thoracic Society AND Commentary: ECMO physicians offer guidance in the context of resource-scarce COVID-19 treatment – American Thoracic Society (04/2020)
- Triage of scarce critical care resources in COVID-19: an implementation guide for regional allocation An expert panel report of the Task Force for Mass Critical Care and the American College of Chest Physicians – CHEST (04/2020)
- Practical guidance for the prevention of thrombosis and management of coagulopathy and disseminated intravascular coagulation of patients infected with COVID-19 – Thrombosis UK
- ISTH interim guidance on recognition and management of coagulopathy – Journal of Thrombosis and Haemostasis
- Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 Infection (04/2020)
- Optimizing Medication Management during the COVID-19 Pandemic: Implementation Guide for Post-Acute and Long-Term Care – University of Maryland School of Pharmacy (04/2020)
- Updated guidance on Personal Protective Equipment (PPE) for clinicians – Intensive Care Society AND Related: Clinical guidance for intensive care and anesthetics AND COVID-19: guidance for health professionals – GOV.UK (04/2020)
- Interim Guidance for Basic and Advanced Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19: From the Emergency Cardiovascular Care Committee and Get With the Guidelines®-Resuscitation Adult and Pediatric Task Forces of the American Heart Association in Collaboration with the American Academy of Pediatrics, American Association for Respiratory Care, American College of Emergency Physicians, The Society of Critical Care Anesthesiologists, and American Society of Anesthesiologists: Supporting Organizations: American Association of Critical Care Nurses and National EMS Physicians – Circulation AND News Release: Interim CPR guidelines address challenges of providing resuscitation during COVID-19 pandemic – American Heart Association (04/2020)
- Considerations for Drug Interactions on QTc in Exploratory COVID-19 (Coronavirus Disease 2019) Treatment – Circulation AND News Release: Caution recommended on COVID-19 treatment with hydroxychloroquine and azithromycin for patients with cardiovascular disease – American Heart Association AND Commentaries: Medical groups urge caution when using hydroxychloroquine, azithromycin to treat COVID-19 patients with CVD – Cardiovascular Business AND AHA, ACC, HRS Caution Use of COVID-19 Therapies Hydroxychloroquine and Azithromycin in Cardiac Patients – DAIC (04/2020)
- COVID‐19: Interim Guidance on Management Pending Empirical Evidence. From an American Thoracic Society‐led International Task Force AND Commentary: ATS publishes new guidance on COVID-19 management – American Thoracic Society (04/2020)
- N95 Re-Use Instructions – SAGES AND Related: Conserving Supply of Personal Protective Equipment—A Call for Ideas – JAMA AND N95 mask can be decontaminated without decreasing filtration efficiency – Stanford Medicine (03/2020)
- Practical guidance for the prevention of thrombosis and management of coagulopathy and disseminated intravascular coagulation of patients infected with COVID-19 – Thrombosis UK (04/2020)
- COVID-19 rapid guideline: severe asthma – National Institute for Health and Care Excellence (04/2020)
- COVID-19 rapid guideline: managing suspected or confirmed pneumonia in adults in the community – National Institute for Health and Care Excellence (04/2020)
- COVID-19 rapid guideline: managing symptoms (including at the end of life) in the community – National Institute for Health and Care Excellence (04/2020)
- Complete GUIDE to Lung Ultrasound in COVID-19 (Coronavirus) Patients – POCUS 101 (04/2020)
- European Society For Emergency Medicine position paper on emergency medical systems response to COVID-19 – European Journal of Emergency Medicine (04/2020)
- Personal Protective Equipment (PPE) for clinicians – Intensive Care Society (04/2020)
- Allocation of Scarce Critical Care Resources During a Public Health Emergency – University of Pittsburg AND Commentary: A system to allocate scarce ventilators and ICU beds gains traction for not counting any group out – STAT (04/2020)
- Temporary Emergency Guidance to US Stroke Centers During the COVID-19 Pandemic – American Heart Association / American Stroke Association AND News Release: Interim guidance issued on stroke care during COVID-19 pandemic – American Heart Association (04/2020)
- COVID-19: infection prevention and control – Public Health England (04/2020)
- Care of patients with liver disease during the COVID-19 pandemic: EASL-ESCMID Position Paper – European Association for the Study of the Liver (EASL) AND News Release: Patients with advanced liver disease and transplant recipients require specific care during COVID-19 – European Association for the Study of the Liver (EASL) (04/2020)
- Ethical guidance published for frontline staff dealing with pandemic – Royal College of Physicians (04/2020)
- Decontamination and Reuse of Filtering Facepiece Respirators using Contingency and Crisis Capacity Strategies – Centers for Disease Control and Prevention (04/2020)
- The Joint Commission issues statement supporting use of personal face masks provided from home amid COVID-19 pandemic (04/2020)
- Pandemic palliative care: beyond ventilators and saving lives – Canadian Medical Association Journal AND Commentary: A COVID-19 palliative care pandemic plan: An essential tool – Canadian Medical Association Journal (04/2020)
- Consensus guidelines for managing the airway in patients with COVID‐19 – Anaesthesia (04/2020)
- Recommendations from the Peking Union Medical College Hospital for the management of acute myocardial infarction during the COVID-19 outbreak – European Heart Journal (04/2020)
- COVID-19 in Older Adults: Key Points for Emergency Department Providers – Journal of Geriatric Emergency Medicine AND Commentary: Caring for seniors during COVID-19 pandemic – Regenstrief Institute (04/2020)
- Practical Manual: Severe Acute Respiratory Infections Treatment Centre – World Health Organization (03/2020)
- CSC Expert Consensus on Principles of Clinical Management of Patients with Severe Emergent Cardiovascular Diseases during the COVID-19 Epidemic – Circulation (03/2020)
- JAMA Guideline Summary: Management of Critically Ill Adults With COVID-19 – JAMA AND Editorial: Toward Universal Deployable Guidelines for the Care of Patients With COVID-19 AND Related Summary: Surviving Sepsis Campaign: COVID-19 Recommendations – CanadiEm (03/2020)
- Consensus Statement on Multiple Patients Per Ventilator – Society of Critical Care Medicine (03/2020)
- Interim Guidance for Healthcare Providers during COVID-19 Outbreak – American Heart Association AND News Release: Interim guidance to reduce COVID-19 transmission during resuscitation care – American Heart Association (03/2020)
- Interim Guidance for Emergency Medical Services (EMS) Systems and 911 Public Safety Answering Points (PSAPs) for COVID-19 in the United States – Centers for Disease Control and Prevention (03/2020)
- Report: N95 mask can be decontaminated without decreasing filtration efficiency – Stanford Medicine (03/2020)
- Ventilator Supply Mitigation Strategies: Letter to Health Care Providers – U.S. Food & Drug Administration (03/2020)
- Medical Glove Conservation Strategies: Letter to Health Care Providers – U.S. Food & Drug Administration (03/2020)
- FDA advises patients on use of non-steroidal anti-inflammatory drugs (NSAIDs) for COVID-19 – U.S. Food & Drug Administration (03/2020)
- Troponin and BNP Use in COVID-19 – Cardiology Magazine, American College of Cardiology (03/2020)
- Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19) – Intensive Care Medicine AND Infographics: The Surviving Sepsis Campaign Rapid Guidelines on the Management of Critically Ill Adults with COVID-19 (03/2020)
- COVID-19 rapid guideline: critical care – National Institute for Health and Care Excellence (NICE) (03/2020)
- Guidance: COVID-19 Airway Management Principles – Intensive Care Society; The Faculty of Intensive Care Management; Association of Anaesthetists; and Royal College of Anaesthetists (03/2020)
- Consensus statement: Safe Airway Society principles of airway management and tracheal intubation specific to the COVID-19 adult patient group – Medical Journal of Australia AND Summary: COVID-19 Airway Management Principles (03/2020)
- Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected – World Health Organization (03/2020)
- Strategies for Optimizing the Supply of Facemasks – Centers for Disease Control and Prevention (03/2020)
- Surgical Mask and Gown Conservation Strategies – Letter to Healthcare Providers – U.S. Food & Drug Administration (03/2020)
- Novel coronavirus (SARS-CoV-2) – Discharge criteria for confirmed COVID-19 cases – European Centre for Disease Prevention and Control (03/2020)
- COVID-19 Prioritization of Diagnostic Testing – Infectious Diseases Society of America AND Summary: IDSA Statement On COVID-19 Testing Recommendations – Infectious Diseases Society of America (03/2020)
- Interim Infection Prevention and Control Recommendations for Patients with Suspected or Confirmed Coronavirus Disease 2019 (COVID-19) in Healthcare Settings – Centers for Disease Control and Prevention (03/2020)
- Coronavirus disease 2019 (covid-19): a guide for UK GPs – The BMJ (03/2020)
- Chinese Clinical Guidance for COVID-19 Pneumonia Diagnosis and Treatment (7th edition) AND Commentary: Chinese Clinical Guidance For COVID-19 Pneumonia Diagnosis and Treatment – American College of Cardiology (03/2020)
Podcasts:
- Coronavirus (COVID-19) Update: Ventilatory Management for COVID-Related Respiratory Failure – JAMA (04/2020)
- Podcast 264: Is COVID-19 pushing MIs out of emergency departments? – NEJM Clinical Conversations (04/2020)
- #205 COVID Cakes and Hot Takes with Rahul Ganatra MD – The Curbsiders Internal Medicine Podcast (04/2020)
- Coronavirus (COVID-19) Update: Reusing Face Masks and N95 Respirators – JAMA (04/2020)
- Practice Made Perfect: What You Need to Know Now About Managing Individuals With COVID-19 – American College of Cardiology (04/2020)
- Audio Interview: Lessons from Covid-19 Hotspots – New England Journal of Medicine (04/2020)
- Episode 8 – Rapid Fire: COVID-19 Part 2 – HealthyDebate (04/2020)
- Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality – JAMA Cardiology (03/2020)
- EMCrit 268 – COVID Airway, Cardiac Arrest, Some Ethical Questions, etc. (03/2020)
Videos:
- NEW – Personal Protective Equipment and Covid-19 – New England Journal of Medicine (05/2020)
- Coronavirus (COVID-19) Update: Critical Care Management – JAMA (04/2020)
- Ways to Communicate Intensive Care Unit (ICU) Prognosis – JAMA (04/2020)
- Coronavirus (COVID-19) Update: Fairly Rationing ICU Care – JAMA (03/2020)
- COVID-19 Emergency Intubation Sim video by Glenfield Hospital – ICM Anaesthesia COVID-19 (03/2020)
- Coronavirus Testing – JAMA Network (03/2020)
Selected Articles:
- NEW – Remdesivir for the Treatment of Covid-19 — Preliminary Report – New England Journal of Medicine AND Commentaries: Preliminary report on NIAID trial of remdesivir – PulmCrit AND Peer-reviewed data shows remdesivir for COVID-19 improves time to recovery – National Institutes of Health AND Covid-19 study details benefits of treatment with remdesivir, and also its limitations – STAT (05/2020)
- NEW – Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis – The Lancet AND Commentaries: Chloroquine or hydroxychloroquine for COVID-19: why might they be hazardous? – The Lancet AND What a big new study on malaria drugs as Covid-19 treatments tells us — and what it doesn’t – STAT AND Hydroxychloroquine May Cause More Harm Than Benefit To COVID-19 Patients, Says New Lancet Study – Health Policy Watch (05/2020)
- NEW – Efficacy and safety of corticosteroids in COVID-19 based on evidence for COVID-19, other coronavirus infections, influenza, community-acquired pneumonia and acute respiratory distress syndrome: a systematic review and meta-analysis – Canadian Medical Association Journal (05/2020)
- NEW – Early Short Course Corticosteroids in Hospitalized Patients with COVID-19 – Clinical Infectious Diseases (05/2020)
- NEW – Unconventional approaches to mechanical ventilation—step-by-step through the COVID-19 crisis – Critical Care (05/2020)
- NEW – IL6 inhibition in critically ill COVID-19 patients is associated with increased secondary infections – medRxiv (05/2020)
- NEW – 15 drugs being tested to treat COVID-19 and how they would work – Nature (05/2020)
- NEW – Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19: A Living Systematic Review of Multiple Streams of Evidence – Annals of Internal Medicine (05/2020)
- NEW – SARS-CoV-2/COVID-19: Evidence-Based Recommendations on Diagnosis and Therapy – Geburtshilfe und Frauenheilkunde (05/2020)
- NEW – Emerging therapies for COVID-19 pneumonia – Expert Opinion on Investigational Drugs (05/2020)
- NEW – Generalized myoclonus in COVID-19 – Neurology (05/2020)
- NEW – COVID-19-Related Stroke – Translational Stroke Research (05/2020)
- NEW – Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 – New England Journal of Medicine AND Commentary: Lungs of deceased COVID-19 patients show distinctive features – Brigham and Women’s Hospital (05/2020)
- NEW – Postmortem Examination of Patients With COVID-19 – JAMA (05/2020)
- NEW – Choosing Wisely in the COVID-19 Era: Preventing Harm to Healthcare Workers – Journal of Hospital Medicine (05/2020)
- NEW – SARS2-CoV-2 and Stroke in a New York Healthcare System – Stroke AND News Release: Stroke rates among COVID-19 patients are low, but cases are more severe; overall stroke hospital admissions are down globally – American Heart Association (05/2020)
- NEW – Neurologic complications of COVID-19 – American Journal of Emergency Medicine (05/2020)
- NEW – Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study – The Lancet AND Commentaries: Critically ill patients with COVID-19 in New York City – The Lancet AND Nearly 40% of critically ill COVID-19 patients in New York City died, study finds – UPI (05/2020)
- NEW – Should azithromycin be used to treat COVID-19? A rapid review – BJGP Open (05/2020)
- NEW – Caring for Critically Ill Adults With Coronavirus Disease 2019 in a PICU: Recommendations by Dual Trained Intensivists – Pediatric Critical Care Medicine AND Related: Repurposing a Pediatric ICU for Adults – New England Journal of Medicine (05/2020)
- NEW – Safety considerations of chloroquine and hydroxychloroquine in treatment of COVID-19 – Clinical Microbiology and Infection (05/2020)
- Severe Covid-19 – New England Journal of Medicine (05/2020)
- Understanding pathophysiology of hemostasis disorders in critically ill patients with COVID-19 – Intensive Care Medicine (05/2020)
- Coagulation abnormalities and thrombosis in patients with COVID-19 – The Lancet (05/2020)
- Use of Prone Positioning in Nonintubated Patients With COVID-19 and Hypoxemic Acute Respiratory Failure – JAMA AND Related Study: Respiratory Parameters in Patients With COVID-19 After Using Noninvasive Ventilation in the Prone Position Outside the Intensive Care Unit – JAMA AND Editorial: Is the Prone Position Helpful During Spontaneous Breathing in Patients With COVID-19? (05/2020)
- Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial – The BMJ AND Commentary: Further evidence does not support hydroxychloroquine for patients with COVID-19 – BMJ (05/2020)
- Repurposing a Pediatric ICU for Adults – New England Journal of Medicine (05/2020)
- Chest CT findings of COVID-19 pneumonia by duration of symptoms – European Journal of Radiology (05/2020)
- Neurological Manifestations of COVID‐19: A review – Acta Neurologica Scandinavica (05/2020)
- Cytokine Release Syndrome in COVID-19 Patients, A New Scenario for an Old Concern: The Fragile Balance between Infections and Autoimmunity – International Journal of Molecular Sciences (05/2020)
- Convalescent plasma or hyperimmune immunoglobulin for people with COVID‐19: a rapid review – Cochrane Library AND Summary: Plasma from people who have recovered from COVID-19 to treat individuals with COVID-19 – Cochrane Library (05/2020)
- Should Clinicians Use Chloroquine or Hydroxychloroquine Alone or in Combination With Azithromycin for the Prophylaxis or Treatment of COVID-19? – Annals of Internal Medicine (05/2020)
- Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome: Results From a Prospective, Single-Center, Clinicopathologic Case Series – Annals of Internal Medicine (05/2020)
- Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data – British Journal of Medicine (05/2020)
- Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis – The Lancet Gastroenterology & Hepatology (05/2020)
- Endovascular Therapy for Patients With Acute Ischemic Stroke During the COVID-19 Pandemic: A Proposed Algorithm – Stroke AND Commentary: Endovascular Therapy for Acute Ischemic Stroke During COVID-19 Pandemic – American College of Cardiology (05/2020)
- Ethics of reallocating ventilators in the covid-19 pandemic – The BMJ (05/2020)
- Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 – European Heart Journal (05/2020)
- COVID‐19 and the Cerebro‐Cardiovascular Systems: What do we Know so Far? – Journal of the American Heart Association (05/2020)
- Subphenotyping ARDS in COVID-19 Patients: Consequences for Ventilator Management – Annals of the American Thoracic Society (05/2020)
- Recruitability and effect of PEEP in SARS-Cov-2-associated acute respiratory distress syndrome – Annals of Intensive Care (05/2020)
- Preparing your intensive care unit for the COVID-19 pandemic: practical considerations and strategies – Critical Care (05/2020)
- Simultaneous ventilation of two simulated ARDS patients in COVID-19 pandemic – Critical Care (05/2020)
- Inpatient Use of Inhaled Pulmonary Vasodilator Therapy in Patients Infected With COVID-19 – American College of Cardiology (05/2020)
- Severe COVID-19: A Review of Recent Progress With a Look Toward the Future – Frontiers in Public Health (05/2020)
- Development and Validation of a Clinical Risk Score to Predict the Occurrence of Critical Illness in Hospitalized Patients With COVID-19 – JAMA Internal Medicine (05/2020)
- Hydroxychloroquine in patients with COVID-19: A Systematic Review and meta-analysis. – Diabetes & Metabolic Syndrome: Clinical Research & Reviews (05/2020)
- A Beacon for Dark Times: Palliative Care Support During the Coronavirus Pandemic – NEJM Catalyst (05/2020)
- Guillain‐Barre syndrome during SARS‐CoV‐2 pandemic: a case report and review of recent literature – Journal of the Peripheral Nervous System (05/2020)
- Recognizing COVID-19-related myocarditis: the possible pathophysiology and proposed guideline for diagnosis and management – Heart Rhythm (05/2020)
- Our recommendations for acute management of COVID-19 – Critical Care (05/2020)
- Avoiding hospital-related infections during the COVID-19 epidemic – Critical Care (05/2020)
- COVID-19 and ECMO: the interplay between coagulation and inflammation—a narrative review – Critical Care (05/2020)
- Lymphopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A systemic review and meta-analysis – International Journal of Infectious Diseases (05/2020)
- Liver injury is associated with severe Coronavirus disease 2019 (COVID‐19) infection: a systematic review and meta‐analysis of retrospective studies – Hepatology Research (05/2020)
- QT Interval Prolongation and Torsade De Pointes in Patients with COVID-19 treated with Hydroxychloroquine/Azithromycin – Heart Rhythm (05/2020)
- Association of Treatment with Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State – JAMA (05/2020)
- Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial – The Lancet AND Commentaries: Interferon beta-1b for COVID-19 – The Lancet AND New triple antiviral drug combination shows early promise for treating COVID-19 in phase 2 randomized trial – The Lancet AND A Drug Cocktail Hastens Recovery in Some Coronavirus Patients – The New York Times AND Triple drug therapy helps coronavirus patients recover more quickly, study finds – CNN (05/2020)
- Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19 – New England Journal of Medicine AND Editorial: The Urgency of Care during the Covid-19 Pandemic — Learning as We Go
- Association of Treatment Dose Anticoagulation with In-Hospital Survival Among Hospitalized Patients with COVID-19 – Journal of the American College of Cardiology AND Commentaries: Giving blood thinners to severely ill Covid-19 patients is gaining ground – STAT AND Blood thinners may improve survival among hospitalized COVID-19 patients – Mount Sinai Hospital AND Anticoagulation Associated With Improved Outcomes in Hospitalized COVID-19 Patients – American College of Cardiology AND Expert reaction to study looking at blood thinners in hospitalised patients with COVID-19 – Science Media Centre (05/2020)
- Awake Proning for COVID-19 – PulmCrit (05/2020)
- Interpreting Diagnostic Tests for SARS-CoV-2 – JAMA (05/2020)
- Treatment of Community-Acquired Pneumonia During the Coronavirus Disease 2019 (COVID-19) Pandemic – Annals of Internal Medicine (05/2020)
- Cardiovascular Collapse in COVID-19 Infection: The Role of Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) – CJC Open (05/2020)
- Editorial: Psychological stress of ICU nurses in the time of COVID-19 – Critical Care (05/2020)
- Editorial: Ethics guidelines on COVID-19 triage—an emerging international consensus – Critical Care (05/2020)
- Can computed tomography be a primary tool for COVID-19 detection? Evidence appraisal through meta-analysis – Critical Care (05/2020)
- Acute respiratory failure in COVID-19: is it “typical” ARDS? – Critical Care (05/2020)
- Performing tracheostomy during the Covid-19 pandemic: guidance and recommendations from the Critical Care and Acute Care Surgery Committees of the American Association for the Surgery of Trauma – Trauma Surgery & Acute Care Open (05/2020)
- Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study – The Lancet Rheumatology AND Commentaries: Expert reaction to study looking at use of arthritis drug anakinra in hospitalised patients with severe COVID-19 – Science Media Centre AND Small study of patients with severe COVID-19 treated with the arthritis drug anakinra finds clinical improvements – The Lancet (05/2020)
- Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia – The Lancet Rheumatology (05/2020)
- Arterial thromboembolic complications in COVID‐19 in low risk patients despite prophylaxis – British Journal of Haematology (05/2020)
- Multivessel coronary thrombosis in a patient with COVID-19 pneumonia – European Heart Journal (05/2020)
- RCEM Position Statement COVID-19: Resetting Emergency Department Care – The Royal College of Emergency Medicine AND Commentary: Emergency departments must not return to pre-covid days of overcrowding and lack of safety, says college – The BMJ (05/2020)
- Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study – Annal of Internal Medicine (05/2020)
- Acute limb ischaemia in two young, non-atherosclerotic patients with COVID-19 – The Lancet (05/2020)
- Acute Cor Pulmonale in Critically Ill Patients with Covid-19 – New England Journal of Medicine (05/2020)
- Estimated Demand for US Hospital Inpatient and Intensive Care Unit Beds for Patients With COVID-19 Based on Comparisons With Wuhan and Guangzhou, China – JAMA Network Open (05/2020)
- [Preprint] Risk Factors of the Severity of COVID-19: A Meta-Analysis – medRxiv (05/2020)
- A Rapid Systematic Review of Clinical Trials Utilizing Chloroquine and Hydroxychloroquine as a Treatment for COVID‐19 – Academic Emergency Medicine (05/2020)
- High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study – Intensive Care Medicine (05/2020)
- Severe ARDS in COVID-19-infected pregnancy: obstetric and intensive care considerations – American Journal of Obstetrics & Gynecology MFM (05/2020)
- COVID-19, superinfections and antimicrobial development: What can we expect? – Clinical Infectious Diseases (05/2020)
- COVID-19: don’t neglect antimicrobial stewardship principles! – Clinical Microbiology and Infection (05/2020)
- The Use of Bronchoscopy during the COVID-19 Pandemic: CHEST/AABIP Guideline and Expert Panel Report – CHEST (05/2020)
- Tracheal intubation in patients with COVID-19 – Canadian Medical Association Journal (05/2020)
- Maximising application of the Aerosol Box in protecting healthcare workers during the covid-19 pandemic – Anaesthesia (05/2020)
- Respiratory Pathophysiology of Mechanically Ventilated Patients with COVID-19: A Cohort Study – American Journal of Respiratory and Critical Care Medicine AND Commentary: PulmCrit – Is COVID-19 ARDS, pseudoARDS, L, or H? Physiology data from Boston – PulmCrit (05/2020)
- Treatment Considerations for COVID-19: A Critical Review of the Evidence (or Lack Thereof) – Mayo Clinic Proceedings (05/2020)
- Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial – The Lancet AND Commentaries: First randomized trial of remdesivir suggests antiviral drug is not associated with significant clinical benefits, more research needed – The Lancet AND Expert reaction to trial of remdesivir in adults – Science Media Centre (05/2020)
- Characteristics of ischaemic stroke associated with COVID-19 – Journal of Neurology, Neurosurgery, and Psychiatry AND Commentary: Expert reaction to study looking at COVID-19, ischaemic stroke and blood clots – Science media Centre (05/2020)
- Coagulopathy associated with COVID-19 – Canadian Medical Association Journal (05/2020)
- Cytokine release syndrome in severe COVID-19 – Science (05/2020)
- Cardiovascular manifestations and treatment considerations in covid-19 – Heart (05/2020)
- Neurological Implications of COVID-19 Infections – Neurocritical Care (05/2020)
- Bacterial and fungal co-infection in individuals with coronavirus: A rapid review to support COVID-19 antimicrobial prescribing – Clinical Infectious Diseases (05/2020)
- Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy – Thrombosis Research (05/2020)
- COVID‐19 Coagulopathy in Caucasian patients – British Journal of Haematology (05/2020)
- COVID-19 and the Cardiovascular System: Implications for Risk Assessment, Diagnosis, and Treatment Options – Cardiovascular Research (05/2020)
- Scoping review of prevalence of neurologic comorbidities in patients hospitalized for COVID-19 – Neurology (05/2020)
- COVID-19: ICU delirium management during SARS-CoV-2 pandemic – Critical Care (05/2020)
- Clinical determinants for fatality of 44,672 patients with COVID-19 – Critical Care (05/2020)
- Pulmonary Embolism or Pulmonary Thrombosis in COVID-19? Is the Recommendation to Use High-Dose Heparin for Thromboprophylaxis Justified? – Thrombosis and Haemostasis (05/2020)
- COVID‐19 diagnosis and management: a comprehensive review – Journal of Internal Medicine (05/2020)
- Clinical characteristics and outcomes of patients with severe covid-19 with diabetes – BMJ Open Diabetes Research & Care (05/2020)
- Pharmacotherapy in COVID-19; A narrative review for emergency providers – American Journal of Emergency Medicine (05/2020)
- Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young – New England Journal of Medicine (05/2020)
- Lung pathology of COVID-19: is AFOP in play? – PulmCrit (05/2020)
- Inpatient Care of Patients with COVID-19: A Guide for Hospitalists – The American Journal of Medicine (05/2020)
- Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation – Intensive Care Medicine (05/2020)
- COVID-19 cytokine storm: the interplay between inflammation and coagulation – The Lancet Respiratory Medicine (05/2020)
- Acute Stroke Care in the Coronavirus Disease 2019 Pandemic – Journal of Stroke and Cardiovascular Diseases (05/2020)
- COVID‐19 Associated Pulmonary Aspergillosis – Mycosis (05/2020)
- Exposure to a Surrogate Measure of Contamination From Simulated Patients by Emergency Department Personnel Wearing Personal Protective Equipment – JAMA AND Editorial: COVID-19 and Risks Posed to Personnel During Endotracheal Intubation – JAMA (05/2020)
- Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis – American Journal of Emergency Medicine (05/2020)
- Lung Ultrasound in COVID-19 – emDocs (05/2020)
- The role of extracorporeal life support for patients with COVID‐19: Preliminary results from a statewide experience – Journal of Cardiac Surgery (05/2020)
- Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis – Journal of Infection (05/2020)
- A Call for Rational Intensive Care in the Era of COVID-19 – American Journal of Respiratory Cell and Molecular Biology (04/2020)
- Management of COVID-19 Respiratory Distress – JAMA (04/2020)
- Transforming ORs into ICUs – New England Journal of Medicine (04/2020)
- The QT interval in patients with COVID-19 treated with hydroxychloroquine and azithromycin – Nature Medicine AND Commentary: Expert reaction to paper looking at cardiac abnormalities in patients with COVID-19 treated with hydroxychloroquine and azithromycin – Science Media Centre (04/2020)
- High incidence of venous thromboembolic events in anticoagulated severe COVID‐19 patients – Journal of Thrombosis and Haemostasis (04/2020)
- Chinese expert consensus on diagnosis and treatment of coagulation dysfunction in COVID-19 – Military Medical Research (04/2020)
- Some take-home messages about the COVID experience in New York – PulmCrit (04/2020)
- Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial – JAMA Network Open AND Editorial: Caution Needed on the Use of Chloroquine and Hydroxychloroquine for Coronavirus Disease 2019 – JAMA Network Open (04/2020)
- Cardiovascular Complications in Patients with COVID-19: Consequences of Viral Toxicities and Host Immune Response – Current Cardiovascular Reports (04/2020)
- COVID-19 in cardiac arrest and infection risk to rescuers: A systematic review – Resuscitation (04/2020)
- COVID-19 Lung Injury and High Altitude Pulmonary Edema: A False Equation with Dangerous Implications – Annals of the American Thoracic Society (04/2020)
- Pulmonary Embolism in COVID-19 Patients: Awareness of an Increased Prevalence – Circulation (04/2020)
- Myocarditis in a patient with COVID-19: a cause of raised troponin and ECG changes – The Lancet (04/2020)
- The effect of corticosteroid treatment on patients with coronavirus infection: a systematic review and meta-analysis – Journal of Infection (04/2020)
- Neurological Insights of COVID-19 Pandemic – ACS Publications (04/2020)
- High-flow nasal cannula may be no safer than non-invasive positive pressure ventilation for COVID-19 patients – Critical Care (04/2020)
- Sonographic signs and patterns of COVID-19 pneumonia – The Ultrasound Journal (04/2020)
- In Defense of Evidence-Based Medicine for the Treatment of COVID-19 ARDS – Annals of the American Thoracic Society (04/2020)
- Is it wrong to prioritise younger patients with covid-19? – The BMJ AND Commentary: Should age be a prioritizing factor in deciding who gets treated for COVID-19? – News Medical (04/2020)
- Cardiovascular complications in COVID-19 – American Journal of Emergency Medicine (04/2020)
- Extracorporeal Membrane Oxygenation in the Treatment of Severe Pulmonary and Cardiac Compromise in COVID-19: Experience with 32 patients – ASAIO Journal (04/2020)
- Elevated troponin in patients with Coronavirus Disease 2019 (COVID-19): possible mechanisms – Journal of Cardiac Failure (04/2020)
- Potential for Lung Recruitment and Ventilation-Perfusion Mismatch in Patients With the Acute Respiratory Distress Syndrome From Coronavirus Disease 2019 – Critical Care Medicine (04/2020)
- Editorial: Delivering extracorporeal membrane oxygenation for patients with COVID‐19: what, who, when and how? – Anaesthesia (04/2020)
- The Obstacle Course of Reperfusion for STEMI in the COVID-19 Pandemics – Circulation (04/2020)
- Management of Acute Myocardial Infarction During the COVID-19 Pandemic – Journal of the American Academy of Cardiology (04/2020)
- Description and Proposed Management of the Acute COVID-19 Cardiovascular Syndrome – Circulation (04/2020)
- Therapeutic strategies for critically ill patients with COVID-19 – Annals of Intensive Care (04/2020)
- Timed & titrated use of steroid in COVID-19? – PulmCrit (04/2020)
- D‐dimer levels on admission to predict in‐hospital mortality in patients with Covid‐19 – Journal of Thrombosis and Haemostasis (04/2020)
- Thrombocytopenia and Its Association with Mortality in Patients with COVID‐19 – Journal of Thrombosis and Haemostasis (04/2020)
- Miller Fisher Syndrome and polyneuritis cranialis in COVID-19 – Neurology (04/2020)
- Editorial: COVID-19 pneumonia: ARDS or not? – Critical Care (04/2020)
- Basing Respiratory Management of Coronavirus on Physiological Principles – American Journal of Respiratory and Critical Care Medicine (04/2020)
- Defining ARDS & recruitability, with implications for COVID treatment – PulmCrit (04/2020)
- How does coronavirus kill? Clinicians trace a ferocious rampage through the body, from brain to toes – Science (04/2020)
- Acute kidney injury in SARS-CoV-2 infected patients – Critical Care
- The Science Underlying COVID-19: Implications for the Cardiovascular System – Circulation (04/2020)
- COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up – Journal of the American College of Cardiology AND Commentary: JACC Paper Outlines Implications, Considerations For Thrombotic Disease Patients During COVID-19 Pandemic – American College of Cardiology (04/2020)
- Priorities for Cath labs in the COVID-19 tsunami: Roberto Ferrari and co-authors present a procedure to follow subsequent to the outbreak in Italy – European Heart Journal AND Commentaries: Priorities for Cath Labs in the COVID-19 Tsunami – American College of Cardiology (04/2020)
- Related: Reperfusion of STEMI in the COVID-19 Era – Business as Usual? – Circulation AND As COVID-19 Spreads, US Cath Labs Ponder Fibrinolytics for STEMI – TCTMD (04/2020)
- Disruptive Modifications to Cardiac Critical Care Delivery During the Covid-19 Pandemic: An International Perspective – Journal of the American College of Cardiology (04/2020)
- Guillain–Barré Syndrome Associated with SARS-CoV-2 – New England Journal of Medicine (04/2020)
- Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis – Clinical Chemistry and Laboratory Medicine (04/2020)
- German recommendations for critically ill patients with COVID‑19 – Medizinische Klinik – Intensivmedizin und Notfallmedizin (04/2020)
- End-stage Heart Failure with COVID-19: Strong Evidence of Myocardial Injury by 2019-nCoV – JACC: Heart Failure (04/2020)
- Conservative management of Covid-19 patients – emergency palliative care in action – Journal of Pain and Symptom Management AND Commentary: Call for palliative care to be adapted for severely ill COVID-19 patients – Lancaster University (04/2020)
- Neurologic Features in Severe SARS-CoV-2 Infection – New England Journal of Medicine (04/2020)
- Hematological findings and complications of COVID‐19 – American Journal of Hematology (04/2020)
- Encephalitis as a clinical manifestation of COVID-19 – Brain, Behavior and Immunity (04/2020)
- Cardiovascular Considerations in Treating Patients with Coronavirus (COVID-19) – Journal of Cardiovascular Pharmacology (04/2020)
- COVID-19, Arrhythmic Risk and Inflammation: Mind the Gap! – Circulation (04/2020)
- Perspective: cardiovascular disease and the Covid-19 pandemic – Basic Research in Cardiology (04/2020)
- COVID-19 and Kidney Failure in the Acute Care Setting: Our Experience From Seattle – American Journal of Kidney Diseases (04/2020)
- Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review – JAMA (04/2020)
- D-dimer cutoffs to predict thrombosis in COVID-19 – PulmCrit
- Prediction for Progression Risk in Patients with COVID-19 Pneumonia: the CALL Score – Clinical Infectious Diseases
- Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations – The Lancet Respiratory Medicine AND Commentary: Understanding pathways to death in patients with COVID-19 – The Lancet Respiratory Medicine (04/2020)
- Compassionate Use of Remdesivir for Patients with Severe Covid-19 – New England Journal of Medicine AND Commentaries: PulmCrit – Eleven reasons the NEJM paper on remdesivir reveals nothing AND Expert reaction to a study about compassionate use of remdesivir for patients with severe COVID-19 – Science Media Centre AND What Do the New Remdesivir Data Mean? – Science Translational Medicine (04/2020)
- Editorial: Cardiopulmonary Resuscitation after Hospital Admission with Covid-19 – The BMJ (04/2020)
“This pandemic has changed the risk-benefit balance for CPR: from “there is no harm in trying” to “there is little benefit to the patient, and potentially significant harm to staff.””
- Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China – JAMA Neurology AND Editorial: The Spectrum of Neurologic Disease in the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic Infection: Neurologists Move to the Frontlines AND Commentaries: 40% of people with severe COVID-19 experience neurological complications – UPI AND Expert reaction to paper on neurological manifestations of patients hospitalised with COVID-19 in Wuhan, China – Science Media Centre (04/2020)
- Preparing a neurology department for SARS-CoV-2 (COVID-19): Early experiences at Columbia University Irving Medical Center and the New York Presbyterian Hospital in New York City – Neurology (04/2020)
- Acute stroke management pathway during Coronavirus-19 pandemic – Neurological Sciences (04/2020)
- Incidence of thrombotic complications in critically ill ICU patients with COVID-19 – Thrombosis Research (04/2020)
- High prevalence of obesity in severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) requiring invasive mechanical ventilation – Obesity (04/2020)
- Obesity in patients younger than 60 years is a risk factor for Covid-19 hospital admission – Clinical Infectious Diseases AND Commentary: In New York, obesity appears to raise COVID-19 risk – CIDRAP (04/2020)
- Prevalence and impact of diabetes among people infected with SARS-CoV-2 – Journal of Endocrinological Investigation AND Commentary: Diabetes Could Increase Severity of COVID-19, Including Risk of ICU Admission and Death – MedicalResearch.com (04/2020)
- Evidence Reviews: Diabetes and risks from COVID-19 – CEBM University of Oxford AND Managing diabetes during the COVID-19 pandemic – CEBM University of Oxford (04/2020)
- [Preprint] Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City – medRxiv (04/2020)
- COVID-19 with Different Severity: A Multi-center Study of Clinical Features – American Journal of Respiratory and Critical Care Medicine (04/2020)
- Point‐of‐care lung ultrasound in patients with COVID‐19 – a narrative review – Anaesthesia (04/2020)
- Battling COVID‐19: Critical care and peri‐operative healthcare resource management strategies in a tertiary academic medical centre in Singapore – Anaesthesia (04/2020)
- COVID‐19: The Uninvited Guest in the Intensive Care Unit (ICU) Implications for Pharmacotherapy – Pharmacotherapy (04/2020)
- [Preprint] Classification of COVID-19 in intensive care patients: towards rational and effective clinical triage – medRxiv (04/2020)
- ST-segment Elevation, Myocardial Injury, and Suspected or Confirmed COVID-19 Patients: Diagnostic and Treatment Uncertainties – Mayo Clinic Proceedings AND News Release: Mayo Clinic experts offer guidance on treating COVID-19 patients with signs of acute heart attack – Mayo Clinic (04/2020)
- Managing the supportive care needs of those affected by COVID-19 – European Respiratory Journal (04/2020)
- Review: Should chloroquine and hydroxychloroquine be used to treat COVID-19? A rapid review – BJGP Open (04/2020)
- Complete Guide to CARDIAC Ultrasound in COVID-19 (Coronavirus) – POCUS 101 (04/2020)
- Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence? – The Lancet Neurology (04/2020)
- Predictors of Mortality for Patients with COVID-19 Pneumonia Caused by SARS-CoV-2: A Prospective Cohort Study – European Respiratory Journal AND Commentary: Studies: Smoking, age, other factors raise risk of COVID-19 death – CIDRAP (04/2020)
- Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19 – New England Journal of Medicine (04/2020)
- For survivors of severe COVID-19, beating the virus is just the beginning – Science (04/2020)
- Acute myocarditis presenting as a reverse Tako-Tsubo syndrome in a patient with SARS-CoV-2 respiratory infection – European Heart Journal (04/2020)
- Extracorporeal membrane oxygenation (ECMO): does it have a role in the treatment of severe COVID-19? – International Journal of Infectious Diseases (04/2020)
- A first Case of Meningitis/Encephalitis associated with SARS-Coronavirus-2 – International Journal of Infectious Diseases (04/2020)
- The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease – Autoimmunity Reviews (04/2020)
- Effectiveness of convalescent plasma therapy in severe COVID-19 patients – Proceedings of the National Academy of Sciences (04/2020)
- Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy – JAMA AND Editorial: Critical Illness in Patients With COVID-19: Mounting an Effective Clinical and Research Response – JAMA (04/2020)
- Coronavirus Disease 2019 (COVID-19): Epidemiology, Clinical Spectrum and Implications for the Cardiovascular Clinician – American College of Cardiology (04/2020)
- Personal protective equipment during the COVID‐19 pandemic – a narrative review – Anaesthesia (04/2020)
- The use of high-flow nasal oxygen in COVID-19 – Anaesthesia (04/2020)
- COVID-19 pneumonia: different respiratory treatment for different phenotypes? – Intensive Care Medicine (04/2020)
- Covid-19 Does Not Lead to a “Typical” Acute Respiratory Distress Syndrome – American Journal of Respiratory and Critical Care Medicine (04/2020)
- “After considering that, all we can do ventilating these patients is “buying time” with minimum additional damage: the lowest possible PEEP and gentle ventilation. We need to be patient.”
- Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy – Journal of Thrombosis and Haemostasis (04/2020)
- Q & A: COVID-19 and Coagulopathy: Frequently Asked Questions – American Society of Hematology (04/2020)
- The Variety of Cardiovascular Presentations of COVID-19 – Circulation AND News Release: New York City physicians note multiple cardiovascular presentations of COVID-19, impact of pre-existing CVD – American Heart Association (04/2020)
- Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan: A Retrospective Observational Study – American Journal of Respiratory and Critical Care Medicine AND Commentary: New Study Identifies Characteristics of Patients With Fatal COVID-19 – American Thoracic Society (04/2020)
- Editorial: Covid-19 in China: ten critical issues for intensive care medicine – Critical Care (04/2020)
- Barrier Enclosure during Endotracheal Intubation – New England Journal of Medicine (04/2020)
- Editorial: Neurologists and Covid-19: A note on courage in a time of uncertainty – Neurology (04/2020)
- Nervous system involvement after infection with COVID-19 and other coronaviruses – Brain, Behavior, and Immunity (04/2020)
- COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies – Journal of Clinical and Translational Hepatology (04/2020)
- How Hospitals Can Protect Frontline Healthcare Workers From COVID-19 – Medium (04/2020)
- Universal Masking in Hospitals in the Covid-19 Era – New England Journal of Medicine (04/2020)
- Treatment with convalescent plasma for critically ill patients with SARS-CoV-2 infection – CHEST (04/2020)
- Covid-19 Does Not Lead to a “Typical” Acute Respiratory Distress Syndrome – American Journal of Respiratory and Critical Care Medicine (04/2020)
- Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know – Annals of Internal Medicine (04/2020)
- Resident Response During Pandemic: This Is Our Time – Annals of Internal Medicine (04/2020)
- Potential Legal Liability for Withdrawing or Withholding Ventilators During COVID-19: Assessing the Risks and Identifying Needed Reforms – JAMA (04/2020)
- Strategies for the prevention and management of coronavirus disease 2019 – European Respiratory Journal (04/2020)
- Acute pulmonary embolism and COVID-19 pneumonia: a random association? – European Heart Journal (04/2020)
- Timely Diagnosis and Treatment Shortens the Time to Resolution of Coronavirus Disease (COVID-19) Pneumonia and Lowers the Highest and Last CT Scores From Sequential Chest CT – American Journal of Roentgenology AND Commentary: New CT scoring criteria for timely diagnosis, treatment of coronavirus disease (COVID-19) – American Roentgen Ray Society (04/2020)
- Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 2019 — United States, February 12–March 28, 2020 – CDC Morbidity and Mortality Weekly Report (04/2020)
- Pragmatic Recommendations for Intubating Critically Ill Patients with Suspected COVID‐19 – Journal of the American College of Emergency Physicians Open (04/2020)
- Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China – JAMA Ophthalmology AND Commentary: Humans, Viruses, and the Eye—An Early Report From the COVID-19 Front Line – JAMA Ophthalmology (04/2020)
- COVID-19–associated Acute Hemorrhagic Necrotizing Encephalopathy: CT and MRI Features – Radiology (04/2020)
- Neuroinfection may potentially contribute to pathophysiology and clinical manifestations of COVID‐19 – Acta Physiologica (04/2020)
- Physiotherapy management for COVID-19 in the acute hospital setting: clinical practice recommendations – Journal of Physiotherapy (04/2020)
- Clinical and immunologic features in severe and moderate Coronavirus Disease 2019 – The Journal of Clinical Investigation AND Commentary: SARS-CoV-2: A Storm is Raging – The Journal of Clinical Investigation (04/2020)
- Review article: gastrointestinal features in COVID‐19 and the possibility of faecal transmission – Alimentary Pharmacology and Therapeutics (04/2020)
- Association of radiologic findings with mortality of patients infected with 2019 novel coronavirus in Wuhan, China – PLOS One (04/2020)
- Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial – medRxiv (03/2020)
- Ventricular Arrhythmia Risk Due to Hydroxychloroquine-Azithromycin Treatment For COVID-19 – American College of Cardiology (03/2020)
- Covid-19 in Critically Ill Patients in the Seattle Region — Case Series – New England Journal of Medicine (03/2020)
- The Italian coronavirus disease 2019 outbreak: recommendations from clinical practice – Anaesthesia (03/2020)
- Special attention to nurses’ protection during the COVID-19 epidemic – Critical Care (03/2020)
- Ethical considerations in the allocation of critical care resources when capacity is overwhelmed – Canadian Journal of Emergency Medicine (03/2020)
- The Importance of Addressing Advance Care Planning and Decisions About Do-Not-Resuscitate Orders During Novel Coronavirus 2019 (COVID-19) – JAMA (03/2020)
- Novel 2019 Coronavirus SARS-CoV-2 (COVID-19): An Updated Overview for Emergency Clinicians – 03-23-20 – Emergency Medicine Practice (03/2020)
- A Framework for Rationing Ventilators and Critical Care Beds During the COVID-19 Pandemic – JAMA (03/2020)
- Recommendations for Endotracheal Intubation of COVID-19 Patients – Anesthesia & Analgesia (03/2020)
- Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis – Clinica Chimica Acta (03/2020)
- Disseminated intravascular coagulation in patients with 2019‐nCoV pneumonia – Journal of Thrombosis and Haemostasia
- Editorial: Sourcing Personal Protective Equipment During the COVID-19 Pandemic – JAMA (03/2020)
- Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma – JAMA AND Editorial: Convalescent Plasma to Treat COVID-19: Possibilities and Challenges AND Commentaries: A new report raises hope that the blood of recovered patients can help treat severe coronavirus cases – Business Insider AND Plasma transfusion shows promise for COVID-19 treatment, says China study – UPI (03/2020)
- Managing mental health challenges faced by healthcare workers during covid-19 pandemic – The BMJ (03/2020)
- Rising to the Challenge of the Novel SARS-coronavirus-2 (SARS-CoV-2): Advice for Pulmonary and Critical Care and an Agenda for Research – American Journal of Respiratory and Critical Care Medicine (03/2020)
- Lung Recruitability in SARS-CoV-2 Associated Acute Respiratory Distress Syndrome: A Single-center, Observational Study – American Journal of Respiratory and Critical Care Medicine AND Commentary: Wuhan study shows lying face down improves breathing in severe COVID-19 – American Thoracic Society (03/2020)
- Time Kinetics of Viral Clearance and Resolution of Symptoms in Novel Coronavirus Infection – American Journal of Respiratory and Critical Care Medicine (03/2020)
- Ventilatory Ratio in Hypercapnic Mechanically Ventilated Patients with COVID-19 Associated ARDS – American Journal of Respiratory and Critical Care Medicine (03/2020)
- Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19): Evidence from a meta-analysis – Progress in Cardiovascular Diseases AND Commentary: Meta-Analysis on Troponin I in Patients With Coronavirus – Latest in Cardiology (03/2020)
- Policies on the use of respiratory protection for hospital health workers to protect from coronavirus disease (COVID-19) – International Journal of Nursing Sciences (03/2020)
- Effect of gastrointestinal symptoms on patients infected with COVID-19 – Gastroenterology (03/2020)
- Preprint: The feasibility of convalescent plasma therapy in severe COVID-19 patients: a pilot study – medRxiv (03/2020)
- Preprint: Incidence, clinical characteristics and prognostic factor of patients with COVID-19: a systematic review and meta-analysis – medRxiv (PDF) AND Commentary: Study Calculates Just How Much Age, Medical Conditions Raise Odds Of Severe COVID-19 – NPR (03/2020)
- The Toughest Triage — Allocating Ventilators in a Pandemic – New England Journal of Medicine (03/2020)
- Fair Allocation of Scarce Medical Resources in the Time of Covid-19 – New England Journal of Medicine AND Commentary: Life, or death? Experts guide pandemic medical equipment decisions – CIDRAP (03/2020)
- Planning and provision of ECMO services for severe ARDS during the COVID-19 pandemic and other outbreaks of emerging infectious diseases – The Lancet Respiratory Medicine (03/2020)
- Rational use of face masks in the COVID-19 pandemic – The Lancet Respiratory Medicine (03/2020)
- More awareness is needed for severe acute respiratory syndrome coronavirus 2019 transmission through exhaled air during non-invasive respiratory support: experience from China – European Respiratory Review (03/2020)
- Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy – JAMA (03/2020)
- COVID-19 Treatment: A Review of Early and Emerging Options – Open Forum Infectious Diseases (03/2020)
- Coronaviruses and immunosuppressed patients. The facts during the third epidemic – Liver Transplantation (03/2020)
- Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19) — United States, February 12–March 16, 2020 – CDC Morbidity and Mortality Weekly Report AND Commentary: US studies offer clues to COVID-19 swift spread, severity – CIDRAP (03/2020)
- Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy: Early Experience and Forecast During an Emergency Response – JAMA (03/2020)
- Protecting Health Care Workers during the COVID-19 Coronavirus Outbreak –Lessons from Taiwan’s SARS response – Clinical Infectious Diseases (03/2020)
- COVID-19 and the Risk to Health Care Workers: A Case Report – Annals of Internal Medicine (03/2020)
- Can Lung US Help Critical Care Clinicians in the Early Diagnosis of Novel Coronavirus (COVID-19) Pneumonia? – Radiology (03/2020)
- Treatment of COVID-19: old tricks for new challenges – Critical Care (03/2020)
- Safe patient transport for COVID-19 – Critical Care (03/2020)
- Preparing for COVID-19: early experience from an intensive care unit in Singapore – Critical Care (03/2020)
- How to balance acute myocardial infarction and COVID-19: the protocols from Sichuan Provincial People’s Hospital – Intensive Care Medicine (03/2020)
- People at Risk for Serious Illness from COVID-19 – Centers for Disease Control and Prevention AND Commentaries: COVID-19 continues spread in U.S., CDC issues recommendations for high-risk patients – ACP Internist AND Are You At Higher Risk For Serious COVID-19 Illness? Here Is What To Do – Forbes (03/2020)
- Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study – The Lancet AND Commentaries: First study identifies risk factors associated with death in adults hospitalised with new coronavirus disease in Wuhan – The Lancet (free) AND Older age, history of sepsis, heart trouble elevate COVID-19 death risk – UPI (03/2020)
- Comorbidities and multi-organ injuries in the treatment of COVID-19 – The Lancet (03/2020)
- Respiratory support for patients with COVID-19 infection – The Lancet Respiratory Medicine (03/2020)
- Clinical Characteristics of Coronavirus Disease 2019 in China – New England Journal of Medicine (03/2020)
- Personal Protective Equipment (PPE) Pearls – COVID-19 – emDocs (03/2020)
- Coronavirus disease 2019 (COVID-19): update for anesthesiologists and intensivists March 2020 – Der Anaesthesist (03/2020)
- The Importance of Addressing Advance Care Planning and Decisions About Do-Not-Resuscitate Orders During Novel Coronavirus 2019 (COVID-19) – JAMA (03/2020)
- Potential Effects of Coronaviruses on the Cardiovascular System: A Review – JAMA Cardiology AND Editorial: Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality (03/2020)
- Coronavirus Disease 2019 (COVID-19) and Cardiovascular Disease – Circulation (03/2020)
- Care for Critically Ill Patients With COVID-19 – JAMA (03/2020)
- COVID 19 – BMJ Best Practice (03/2020)
- Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the Coronavirus Disease 2019 (COVID-19) Pandemic – Journal of the American College of Cardiology AND Commentary: CVD in the Setting of COVID-19: Considerations to Prepare Patients, Providers, Health Systems – American College of Cardiology (03/2020)
- Novel Coronavirus COVID-19: An Overview for Emergency Clinicians – EXTRA Supplement – Emergency Medicine Practice (03/2020)
- Treatment for severe acute respiratory distress syndrome from COVID-19 – The Lancet Respiratory Medicine (03/2020)
- The impact of high-flow nasal cannula (HFNC) on coughing distance: implications on its use during the novel coronavirus disease outbreak – Canadian Journal of Anesthesia (03/2020)
News & Perspectives:
- These Coronavirus Exposures Might Be the Most Dangerous – The New York Times (04/2020)
- The Coronavirus Patients Betrayed by Their Own Immune Systems – The New York Times (04/2020)
- Lessons from a different war for preventing moral injury among clinicians treating Covid-19 – STAT (04/2020)
- ‘Panic Prescribing’ Untested Coronavirus Treatments: A Danger To Patients Today and Tomorrow – Health Affairs (04/2020)
- We shouldn’t rush to use an unproven malaria drug to treat the coronavirus – STAT (04/2020)
- A new Covid-19 problem: Shortages of medicines needed for placing patients on ventilators – STAT (04/2020)
- If You Get Critically Ill With COVID-19, How Far Should Doctors Go To Keep You Alive? – wbur (04/2020)
- How would overwhelmed hospitals decide who to treat first? – Associated Press (04/2020)
- Experts Race to Set Rules For Deciding Who Lives and Who Dies – Undark (04/2020)
- ICU doctors now face the toughest decisions they will ever have to make – The Guardian
- Who Should Be Saved First? Experts Offer Ethical Guidance – The New York Times
COVID-19 Critical Care: This page will be updated as often as necessary and will be fixed in the right column on our homepage.
CEBM Estimates Infection Rate Fatality (IFR) of COVID-19 at 0,20%
23 Mar, 2020 | 01:16h | UTCGlobal Covid-19 Case Fatality Rates – Centre for Evidence-Based Medicine, University of Oxford (free)
[Preprint] Randomized Trial: Favipiravir vs. Arbidol for COVID-19
23 Mar, 2020 | 01:18h | UTCFavipiravir versus Arbidol for COVID-19: A Randomized Clinical Trial – medRxiv
Loss of Smell and Taste Could be a Sign of COVID-19
23 Mar, 2020 | 01:11h | UTCPosition Statement: Loss of sense of smell as marker of COVID-19 infection – ENT-UK
See also: There’s An Unexpected Loss Of Smell And Taste In Coronavirus Patients – Forbes AND If you’ve lost your sense of smell or taste, you could be a ‘hidden carrier’ of the coronavirus – Business Insider
IDSA Statement: COVID-19 Prioritization of Diagnostic Testing
20 Mar, 2020 | 11:01h | UTCCOVID-19 Prioritization of Diagnostic Testing – Infectious Diseases Society of America (free PDF)
Summary: IDSA Statement On COVID-19 Testing Recommendations – Infectious Diseases Society of America (free)
Editorial by John P.A. Ioannidis: COVID-19: The Harms of Exaggerated Information and Non‐evidence‐based Measures
23 Mar, 2020 | 01:08h | UTCRelated Opinion Piece: A fiasco in the making? As the coronavirus pandemic takes hold, we are making decisions without reliable data – STAT (free)
Rebuttal 1: We know enough now to act decisively against Covid-19. Social distancing is a good place to start – STAT (free)
Rebuttal 2: A Rebuttal to “A Fiasco in the Making?” – Hilda Bastian (Free)
New Preliminary Studies with Hydroxychloroquine:
20 Mar, 2020 | 10:57h | UTCThis was an open-label study with only 42 patients without patient-relevant endpoints. The 6 patients that received Hydroxychloroquine + Azithromycin achieved more efficient virus elimination than control patients.
New in Vitro Study: Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro – Cell Discovery (free)
Related Articles: In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) – Clinical Infectious Diseases (free PDF) AND New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? – International Journal of Antimicrobial Agents (free) AND A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19 – Journal of Critical Care (free) AND Of chloroquine and COVID-19 – Antiviral Research (free)
CDC Guideline: Strategies for Optimizing the Supply of Facemasks
20 Mar, 2020 | 11:03h | UTCStrategies for Optimizing the Supply of Facemasks – Centers for Disease Control and Prevention (free)
Video: Coronavirus Update with Anthony Fauci, MD
19 Mar, 2020 | 11:04h | UTCCoronavirus Update with Anthony Fauci, MD – March 18, 2020 – JAMA (free)
Podcast: New Research on Possible Treatments for Covid-19
19 Mar, 2020 | 10:57h | UTC
State of the Art Review: Management of ANCA Associated Vasculitis
19 Mar, 2020 | 10:54h | UTCManagement of ANCA associated vasculitis – The BMJ (free)
Interim Guidance: Clinical Management of Severe Acute Respiratory Infection When Novel Coronavirus (nCoV) Infection is Suspected
16 Mar, 2020 | 08:01h | UTCRelated: Severe SARS-CoV-2 Infections: Practical Considerations and Management Strategy for Intensivists (free studies and reviews)
Related Commentary on Twitter
Updated #COVID19 clinical guidance covers:
🔹Early case recognition
🔹Guidance for care of children, pregnant women, adults & older people
🔹Managing cases
🔹Infection prevention & control
🔹Sample collection & an update on investigational therapeutics
👉https://t.co/ZVaiu2C19V pic.twitter.com/yyOzIbtbEO— World Health Organization (WHO) (@WHO) March 15, 2020
Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy: Early Experience and Forecast During an Emergency Response
16 Mar, 2020 | 07:55h | UTCRelated Video: Coronavirus in Italy – Report From The Front Lines – JAMA (free)