Chest Medicine
Meta-analysis: Corticosteroids for critically ill patients with COVID-19
3 Sep, 2020 | 11:23h | UTCEditorial: Corticosteroids in COVID-19 ARDS: Evidence and Hope During the Pandemic
Commentaries: Analysis of seven trials finds that corticosteroids reduce risk of death by 20 per cent in critically ill COVID-19 patients – University of Bristol AND Multiple studies confirm steroids can fight severe COVID-19 – MedicalXpress
Commentary on Twitter
1/8 Corticosteroids and COVID19
*Three* RCTs and a new @WHO meta-analysis add to #RECOVERY trial data that corticosteroids reduce mortality in critically ill #COVID19 patientshttps://t.co/H8c46Y5DTm— JAMA (@JAMA_current) September 2, 2020
New WHO Guidance: Corticosteroids for COVID-19
3 Sep, 2020 | 11:20h | UTCCorticosteroids for COVID-19 – World Health Organization
News Release: WHO updates clinical care guidance with corticosteroid recommendations – World Health Organization
Commentaries: The WHO Now Recommends Cheap Steroids As a Life-Saving Treatment for Severe Covid-19 – Gizmodo AND Inexpensive steroids reduce deaths of hospitalized Covid-19 patients, WHO analysis confirms – STAT
Commentary on Twitter
🆕 guideline on use of dexamethasone & other corticosteroids advises:
✅ for oral or intravenous usage in treatment of patients with severe & critical #COVID19
❌ against usage in treatment of non-severe casesMore: https://t.co/eWHzRrYKvO
— World Health Organization (WHO) (@WHO) September 2, 2020
[Preprint] Randomized trial: Tocilizumab does not improve clinical status or mortality in hospitalized patients with COVID-19 pneumonia
3 Sep, 2020 | 11:19h | UTCTocilizumab in Hospitalized Patients With COVID-19 Pneumonia – medRxiv
Covid-19: Study found those younger than 40 had an infection fatality ratio (IFR) of 0.01%; those 60 or older had an IFR of 1.71%
3 Sep, 2020 | 11:18h | UTC
Commentary on Twitter
Age, sex, race affect death risk from #COVID-19. @FSPH_IUPUI study found those younger than 40 had fatality rate of 0.01%; those 60 or older 1.71%—2.5 times greater than #flu https://t.co/oT4BCVbVxe. @jblackburn_phd @aaronecarroll pic.twitter.com/wE6Ti0EG6E
— Annals of Int Med (@AnnalsofIM) September 2, 2020
Virus in the blood can predict severe COVID-19
3 Sep, 2020 | 11:11h | UTCVirus in the blood can predict severe COVID-19 – Karolinska Institutet
Original Study: SARS-CoV-2 RNA in serum as predictor of severe outcome in COVID-19: a retrospective cohort study – Clinical Infectious Diseases
IDSA Podcast – Managing patients post-COVID-19: From symptoms to lasting complications
3 Sep, 2020 | 11:08h | UTC
Combining PCR and antibody tests at point of care dramatically increases COVID-19 detection
3 Sep, 2020 | 11:10h | UTCOriginal Study: Combined point of care nucleic acid and antibody testing for SARS-CoV-2 following emergence of D614G Spike Variant – Cell Reports Medicine
Randomized trial: Effect of low tidal volume vs. conventional tidal volume on postoperative pulmonary complications in patients undergoing major surgery
3 Sep, 2020 | 10:57h | UTCEffect of Intraoperative Low Tidal Volume vs Conventional Tidal Volume on Postoperative Pulmonary Complications in Patients Undergoing Major Surgery: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
Normal lungs and the humans containing them don’t seem to mind how they’re ventilated (within reason). https://t.co/EdGVjm7esU
— Greg Bryson, MD, FRCPC (@glbryson) September 2, 2020
Study: Face shields, masks with valves ineffective against COVID-19 spread
2 Sep, 2020 | 09:55h | UTCFace Shields, Masks with Valves Ineffective Against COVID-19 Spread – American Institute of Physics
Original Study: Visualizing droplet dispersal for face shields and masks with exhalation valves – Physics of Fluids
Meta-analysis: Clinical manifestations, risk factors, and maternal and perinatal outcomes of Covid-19 in pregnancy
2 Sep, 2020 | 09:52h | UTC
#ESCCongress – [Not Published Yet] First randomized trial backs safety of ACE Inhibitors and ARBs in COVID-19 patients
2 Sep, 2020 | 09:48h | UTCNews Release: First randomised trial backs safety of common heart drugs in COVID-19 patients – European Society of Cardiology
Commentary on Twitter
Dr. Renato Lopes presents the BRACE CORONA trial: in patients hospitalized with COVID-19, suspending ACEI/ARB therapy for 30 days did not impact the number of days alive and out of hospital.
Full slide deck: https://t.co/avSK41bGSj#ESCCongress pic.twitter.com/2p0FH9U2RG
— C. Michael Gibson MD (@CMichaelGibson) September 1, 2020
Pulmonary hypertension: A brief guide for clinicians
2 Sep, 2020 | 09:34h | UTCPulmonary Hypertension: A Brief Guide for Clinicians – Mayo Clinic Proceedings
Position Paper: Diagnosis and treatment of pulmonary embolism during the COVID-19 pandemic
1 Sep, 2020 | 06:27h | UTC
Anticoagulation in COVID-19: A systematic review, meta-analysis and rapid guidance from the Mayo Clinic
1 Sep, 2020 | 06:26h | UTC
Cases of SARS-CoV-2 reinfection highlight the limitations — and the mysteries — of our immune system
1 Sep, 2020 | 06:18h | UTC
Asthma in COVID-19 hospitalizations: An overestimated risk factor?
1 Sep, 2020 | 06:22h | UTC
Commentary on Twitter
https://twitter.com/holguinf01/status/1300505812473843713
Scientists are reporting several cases of Covid-19 reinfection — but the implications are complicated
1 Sep, 2020 | 06:20h | UTC
What Is the predictive value of a single nasopharyngeal SARS-CoV-2 PCR swab test in a patient with COVID-like symptoms and / or significant COVID-19 exposure?
1 Sep, 2020 | 06:12h | UTC
Commentary on Twitter
What Is the Predictive Value of a Single Nasopharyngeal SARS-CoV-2 PCR Swab Test in a Patient with COVID-like Symptoms and / or Significant #COVID19 Exposure?
The PCR-test was found to be 87% sensitive, 97% specific, a PPV of 0.98, and a NPV of 0.80 #ofid https://t.co/MGQdzDsd8k— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) August 31, 2020
Choosing Wisely: Five low-value or harmful practices that should be avoided in pediatric pulmonology and sleep medicine
1 Sep, 2020 | 05:57h | UTCCommentary: Choosing Wisely: 5 Practices to Avoid in Pediatric Pulmonology and Sleep Medicine – NEJM Journal Watch
See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
Perspective: COVID-19 vaccine trials should seek worthwhile efficacy
31 Aug, 2020 | 01:45h | UTCCOVID-19 vaccine trials should seek worthwhile efficacy – The Lancet
Commentary: Covid vaccine rush could make pandemic worse, say scientists – The Guardian
Commentary on Twitter
"Although efficacy far greater than 50% would be better, efficacy of about 50% would represent substantial progress"
Philip Krause et al for the @WHO Solidarity Vaccines Trial Expert Group on why #COVID19 vaccine trials should seek worthwhile efficacy https://t.co/2VWas8YU7L pic.twitter.com/RjbeZkeAE0
— The Lancet (@TheLancet) August 28, 2020
Study: Saliva or nasopharyngeal swab specimens for detection of SARS-CoV-2
31 Aug, 2020 | 01:47h | UTCRelated study: Salivary Detection of COVID-19 – Annals of Internal Medicine
Commentary on Twitter
Just published @NEJM
Strong support for saliva as an alternative to nasopharyngeal swab samples to detect #SARSCoV2
by @awyllie13 @YaleSPH and team @YaleMed https://t.co/waF5ODmiV8 pic.twitter.com/zw1D2JqW0y— Eric Topol (@EricTopol) August 28, 2020
A national strategy to diagnose COVID-19 associated invasive fungal disease in the ICU
31 Aug, 2020 | 01:44h | UTC
Updated Covid-19 Reviews: Hydroxychloroquine or Chloroquine / Masks / ACE Inhibitors or ARBs
28 Aug, 2020 | 08:54h | UTC- Update Alert 2: Hydroxychloroquine or Chloroquine for the Treatment or Prophylaxis of COVID-19
- Update Alert 2: Masks for Prevention of Respiratory Virus Infections, Including SARS-CoV-2, in Health Care and Community Settings
- Update Alert 3: Risks and Impact of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers on SARS-CoV-2 Infection in Adults
Pathophysiology of COVID-19-associated acute respiratory distress syndrome: A multicenter prospective observational study
28 Aug, 2020 | 08:50h | UTC
Individuals with obesity and COVID‐19: A global perspective on the epidemiology and biological relationships
27 Aug, 2020 | 09:57h | UTCCommentaries: Obesity increases risk of complications from Covid-19, damages vaccine efficacy, study finds – CNN AND Obesity increases risk of Covid-19 death by 48%, study finds – The Guardian AND Obesity linked with higher risk for COVID-19 complications – University of North Carolina at Chapel Hill