Cardiology (all articles)
Non-inferiority Trials in Cardiology: What Clinicians Need to Know
26 Nov, 2019 | 07:30h | UTCNon-inferiority trials in cardiology: what clinicians need to know – Heart (free)
Meta-Analysis: Bleeding and Ischemic Outcomes in Patients Treated with Dual vs. Triple Antithrombotic Therapy
22 Nov, 2019 | 08:26h | UTC
Cohort Study: Association of Troponin Level and Age with Mortality in Acute Care Centers
21 Nov, 2019 | 08:41h | UTCCommentary: Small rise in heart attack protein linked to increased risk of early death – Imperial College London (free)
Study: Switching from Tobacco Cigarettes to Electronic Cigarettes May Improve Cardiovascular Health
20 Nov, 2019 | 10:31h | UTCCommentaries: Smokers who switch to vaping could soon ‘have healthier hearts’ – NHS Choices (free) AND Vaping less harmful than smoking for vascular health, major study finds – University of Dundee (free) AND Switching from cigarettes to vapes may be better for heart health, study says – CNN (free)
Cohort Study: Association of Premature Natural and Surgical Menopause with Incident Cardiovascular Disease
19 Nov, 2019 | 08:01h | UTCAssociation of Premature Natural and Surgical Menopause With Incident Cardiovascular Disease – JAMA (free for a limited period)
#AHA19 – [Abstract Only] Randomized Trial: After an Ischemic Stroke or TIE a Lower LDL Treatment Target Reduces Cardiovascular Events
19 Nov, 2019 | 09:51h | UTCA Comparison of Two LDL Cholesterol Targets after Ischemic Stroke – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Treat Stroke to Target Finds Lower Risk of CV Events With Lower LDL-C Levels – American College of Cardiology (free) AND Treat Stroke to Target – Treat Stroke to Target – American College of Cardiology (free) AND Lower Cholesterol Cuts CV Events: Treat Stroke to Target Trial – TCTMD (free)
#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting
Related Commentary on Twitter
In patients with stroke and atherosclerosis randomly assigned to LDL targets of 70 mg/dl or 100 mg/dL, a composite CV endpoint was 12% lower over a median of 3.5 years in the lower LDL target group. #AHA19 https://t.co/l8vZ1M7XF6
— NEJM (@NEJM) November 18, 2019
#AHA19 – Randomized Trial: Phosphodiesterase 5 inhibitor Improves Exercise Capacity in Patients Who Have Undergone the Fontan Procedure
19 Nov, 2019 | 08:45h | UTCResults of the Fontan Udenafil Exercise Longitudinal (FUEL) Trial – Circulation (free for a limited period)
Commentaries: Teens with Heart Disease Improve Exercise Capacity in Large Clinical Trial – Children’s Hospital of Philadelphia (free) AND Pediatric drug trial finds benefit in teens with heart defect – NIH News Releases (free)
#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting
Related Commentary on Twitter
FUEL Trial- udenafil did not improve peak VO2, but did positively impact measures of exercise performance in pts w/FONTAN @PHNresearch @nih_nhlbi @HeartCare4Kids @ChildrensPhila #CircAHA19 #AHA19 #AHAJournals https://t.co/Kmt9GFASZR pic.twitter.com/WV0NITTg7y
— Circulation (@CircAHA) November 17, 2019
Review: Preoperative Evaluation Before Noncardiac Surgery
19 Nov, 2019 | 07:56h | UTCPreoperative Evaluation Before Noncardiac Surgery – Mayo Clinic Proceedings (free)
Related: Guideline: Preoperative Evaluation of Adult Patients Before Elective, Noncardiothoracic Surgery (free guidelines on the subject)
Review: Coronary Microvascular Dysfunction Causing Cardiac Ischemia in Women
19 Nov, 2019 | 07:41h | UTCCoronary Microvascular Dysfunction Causing Cardiac Ischemia in Women – JAMA (free for a limited period)
Related: Prognosis and Predictors of Mortality in Patients Suffering Myocardial Infarction With Non‐Obstructive Coronary Arteries (study, guidelines, and reviews on the subject)
Related Commentary on Twitter
2/3 of women with symptoms and signs of ischemia have no evidence of obstructive coronary artery disease (#INOCA). Many have coronary microvascular dysfunction, diagnosed by finding reduced coronary flow reserve on pharmacologic stress testing https://t.co/yNIFDVwNOm #AHA19
— JAMA (@JAMA_current) November 19, 2019
#AHA19 – [Not Published Yet] Landmark ISCHEMIA Trial: A Routine Invasive Strategy Does Not Reduce Cardiovascular Events in Patients with Stable Coronary Artery Disease
18 Nov, 2019 | 01:13h | UTCCommentaries: International Study of Comparative Health Effectiveness With Medical and Invasive Approaches – ISCHEMIA – American College of Cardiology (free) AND ISCHEMIA Trial Examines Invasive vs. Conservative Strategy in SIHD Patients – American College of Cardiology (free) AND ISCHEMIA: Invasive Strategy No Better Than Meds for CV Events – TCTMD (free) AND Surgery for Blocked Arteries Is Often Unwarranted, Researchers Find – The New York Times (free) AND ISCHEMIA Trial Finds No Evidence of Lower Cardiac Event Rates in Patients Treated with Heart Procedures, but Better Quality of Life – PR Newswire (free) AND Big study casts doubt on need for many heart procedures – Associated Press (free) AND Stents no better than drugs for many heart patients: U.S. study – Reuters (free) AND Stents, bypass surgery show no benefit in heart disease mortality rates among stable patients – Stanford Medicine (free)
#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting
#AHA19 – [Abstract Only] Practice Changing? – Randomized Trial: Low-Dose Colchicine Improves Outcomes after Myocardial Infarction
18 Nov, 2019 | 01:11h | UTCEfficacy and Safety of Low-Dose Colchicine after Myocardial Infarction – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Colchicine Cardiovascular Outcomes Trial – COLCOT – American College of Cardiology (free) AND COLCOT Renews Hope for Anti-inflammatory in Secondary Prevention: Colchicine – TCTMD (free)
#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting
Related Commentary on Twitter
In a randomized, placebo-controlled trial of 4745 patients with recent myocardial infarction, low-dose colchicine (0.5 mg once daily) prevented ischemic cardiovascular events. See the COLCOT trial. #AHA19 https://t.co/H2eubZ6HRD
— NEJM (@NEJM) November 16, 2019
#AHA19 – [Abstract Only] Randomized Trial: An Antiplatelet-based Strategy is Associated with Better Outcomes vs. Anticoagulation After Transcatheter Aortic-Valve Replacement
18 Nov, 2019 | 01:08h | UTCA Controlled Trial of Rivaroxaban after Transcatheter Aortic-Valve Replacement – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: GALILEO Trial Finds Higher Risk of Death, Bleeding With Rivaroxaban After TAVR – American College of Cardiology (free) AND Global Study Comparing a Rivaroxaban-based Antithrombotic Strategy to an Antiplatelet-based Strategy After TAVR – GALILEO – American College of Cardiology (free) AND GALILEO: Rivaroxaban-Based Antithrombotic Strategy or Antiplatelet-Based Strategy After TAVR? – Docwire (free)
#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting
Related Commentary on Twitter
Patients who had had successful TAVR randomized to either a rivaroxaban-based antithrombotic regimen or an antiplatelet-based regimen. At 17 mos, death or thromboembolic complications occurred more frequently w/ rivaroxaban. See the GALILEO trial. #AHA19 https://t.co/boQo9SbGKe
— NEJM (@NEJM) November 16, 2019
AHA Updates on Advanced Cardiovascular Life Support (ACLS)
18 Nov, 2019 | 01:00h | UTC– 2019 American Heart Association and American Red Cross Focused Update for First Aid: Presyncope – Circulation (free PDF)
#AHA19 – [Abstract Only] Randomized Trial: Early Surgery Improves Outcomes in Asymptomatic Patients with Very Severe Aortic Stenosis
18 Nov, 2019 | 01:09h | UTCEarly Surgery or Conservative Care for Asymptomatic Aortic Stenosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: RECOVERY Finds Early Surgery Beneficial For Asymptomatic Severe AS Patients – American College of Cardiology (free) AND Randomized Comparison of Early Surgery Versus Conventional Treatment in Very Severe Aortic Stenosis – RECOVERY – American College of Cardiology (free) AND Early Surgery Beats a Conservative Approach in Asymptomatic AS: RECOVERY – TCTMD (free)
#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting
Related Commentary on Twitter
At a median of 6 years of follow-up, operative mortality or CV death occurred less frequently in asymptomatic patients with very severe aortic stenosis who received early valve replacement surgery than in those conservatively managed. #AHA19 https://t.co/hcQeoRqseJ
— NEJM (@NEJM) November 16, 2019
Summary of Recommendations: International Consensus on CPR and Emergency Cardiovascular Care for Children and Adults
18 Nov, 2019 | 00:52h | UTC
Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass
15 Nov, 2019 | 10:40h | UTC
[Abstract Only] Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation
14 Nov, 2019 | 10:37h | UTCLarge-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: What Can We Learn From The Apple Heart Study? – Cardiobrief (free)
“…nearly half a million people were required to identify a few hundred people with AF. (It should further be noted that we have no idea whether the patients identified in this group will even benefit from their diagnosis, since they may differ in important ways from AF patients identified by traditional means.)” (from Cardiobrief)
Review: Adjunctive Antithrombotic Therapy for Patients with Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement
14 Nov, 2019 | 10:21h | UTCAdjunctive Antithrombotic Therapy for Patients with Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement – JAMA Cardiology (free for a limited period)
[Abstract Only] Cohort Study: Interplay of Coronary Artery Calcium and Risk Factors for Predicting CVD/CHD Mortality
14 Nov, 2019 | 10:17h | UTCInterplay of Coronary Artery Calcium and Risk Factors for Predicting CVD/CHD Mortality: The CAC Consortium – JACC: Cardiovascular Imaging (link to abstract – $ for full-text)
Commentary: Coronary Artery Calcium and Risk Factors for Predicting Mortality – American College of Cardiology (free)
Related Study: Association of Coronary Artery Calcium With Long-term, Cause-Specific Mortality Among Young Adults (free study and commentary)
2019 AHA/ACC Clinical Performance and Quality Measures for Adults With High Blood Pressure
13 Nov, 2019 | 10:48h | UTCCommentaries: New Performance and Quality Measures For High BP Released – American College of Cardiology (free) AND Heart Groups Publish New Performance, Quality Measures for BP Management – NEJM Journal Watch (free)
Related AHA/ACC Guideline and Summaries: 2017 ACC/AHA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults (free) AND Executive Summary (free) AND Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Synopsis of the 2017 ACC/AHA Hypertension Guideline – Annals of Internal Medicine (free)
[Abstract Only] Small Randomized Trial Suggests an Initial Imaging-Guided Strategy May Reduce Invasive Coronary Angiograms in Patients with Non–ST-Segment Elevation Myocardial Infarction and Inconclusive ECGs
13 Nov, 2019 | 10:43h | UTCInitial Imaging-Guided Strategy Versus Routine Care in Patients with Non–ST-Segment Elevation Myocardial Infarction – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Upfront Imaging Reduces Invasive Angiography in Patients With Unclear NSTEMI Diagnosis – TCTMD (free) AND Imaging-Guided Strategy vs. Routine Care for NSTEMI Patients – American College of Cardiology (free)
[Not Published Yet] Artificial Intelligence Examining ECGs Predicts Irregular Heartbeat, Death Risk
13 Nov, 2019 | 10:40h | UTCRelated Study: Artificial Intelligence Algorithm Can Detect Patients with Atrial Fibrillation from a Sinus Rhythm ECG (link to abstract and commentaries)
Guideline Summary: Drugs for Atrial Fibrillation
13 Nov, 2019 | 10:36h | UTCDrugs for Atrial Fibrillation – JAMA (free for a limited period)
Podcast: Review of Atrial Fibrillation Treatment – JAMA (free audio)
Original Guideline: 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation (free)
Meta-Analysis: Aspirin for Primary Prevention of Cardiovascular Disease with a Particular Focus on Subgroups
12 Nov, 2019 | 11:19h | UTCRelated: Acetylsalicylic acid for primary prevention of cardiovascular events – Canadian Family Physician (free) AND Evidence evolving on aspirin as prevention – ACP Internist (free) AND Benefits and Harms of Aspirin for Primary Prevention of Cardiovascular Disease – Annals of Internal Medicine (link to abstract and commentaries) AND Aspirin for Primary Prevention: Is This the End of the Road? (selection of resources on the subject)
Randomized Trial: 0/1-hour High-sensitivity Cardiac Troponin T Protocol Enables Faster Discharge of Patients with Suspected Acute Coronary Syndrome
12 Nov, 2019 | 11:20h | UTCA Randomized Trial of a 1-Hour Troponin T Protocol in Suspected Acute Coronary Syndromes – Circulation (free for a limited period)
Commentaries: World-First Trial Cuts ED Wait Times and Admissions – Flinders University (free) AND Ruling Out MI Safe With 0/1-Hour High-Sensitivity Troponin: RAPID-TNT – TCTMD (free)
Related Studies/Commentaries Highlighting Problems with High-sensitivity Cardiac Troponin: Myths in Emergency Medicine: Is hs-cTnT Worth the Downstream Testing? – Emergency Medicine News (free) AND Randomized Trial: High-Sensitivity Troponin in the Evaluation of Suspected Acute Coronary Syndrome – The Lancet (free study and commentaries) AND Cohort Study: The Introduction of High-sensitive Troponins Had No Impact on Survival – Journal of the American College of Cardiology (free) AND Cohort Study: High Sensitivity Cardiac Troponin May Result in Misdiagnosis of Acute Myocardial Infarction – The BMJ (free)