Allergy & Immunology
SARS-CoV-2 Infection Protects Against Rechallenge in Rhesus Macaques
21 May, 2020 | 09:27h | UTCSARS-CoV-2 infection protects against rechallenge in rhesus macaques – Science
Related Study: DNA vaccine protection against SARS-CoV-2 in rhesus macaques – Science
Commentaries: Infection With SARS-CoV-2 Protects Against Re-infection – At Least in Rhesus Macaques – Technology Networks AND Prototype Vaccine Protects Monkeys From Coronavirus – The New York Times
Serology for SARS-CoV-2: Apprehensions, Opportunities, and the Path Forward
20 May, 2020 | 09:53h | UTCSerology for SARS-CoV-2: Apprehensions, opportunities, and the path forward – Science Immunology
Case Series: Hyperinflammatory Shock in Children During COVID-19 Pandemic
7 May, 2020 | 09:21h | UTCHyperinflammatory shock in children during COVID-19 pandemic – The Lancet
Commentaries: Researchers report “unprecedented cluster” of inflammatory problems in children amid pandemic – CNN AND Expert reaction to report on 8 children with hyperinflammatory shock during the COVID-19 pandemic – Science Media Centre AND Mysterious inflammatory syndrome in children potentially linked to COVID-19 reported in Montreal – National Post AND A New Coronavirus Threat to Children – The New York Times AND What to Know About Kawasaki Disease, the Pediatric Inflammatory Condition Possibly Linked to COVID-19 – TIME AND Kawasaki Disease—The Latest Weird Illness From Coronavirus – Forbes
Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule
17 Mar, 2020 | 08:37h | UTCDevelopment and Validation of a Penicillin Allergy Clinical Decision Rule – JAMA Internal Medicine (free for a limited period)
FDA Safety Alert: Montelukast May Cause Serious Mental Health Side Effects
6 Mar, 2020 | 10:22h | UTCCommentary: Montelukast to Get Boxed Warning – NEJM Journal Watch (free)
[Abstract Only] Randomized Trial: Metformin May Reduce Metabolic Complications and Inflammation in Patients on Systemic Glucocorticoid Therapy
27 Feb, 2020 | 08:34h | UTCMetformin to reduce metabolic complications and inflammation in patients on systemic glucocorticoid therapy: a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2 trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentaries: Metformin could mitigate glucocorticoid-related complications – Medicine Matters (free) AND Metabolic effects of glucocorticoids reversed with metformin – Healio (free registration required) AND Diabetes Drug May Benefit Long-Term Steroid Users – MedPage Today (free registration required)
Cohort Study: Frequent Use of Household Cleaning Products in Early Life Linked to Increased Risk for Childhood Wheeze and Asthma at Age 3 Years
23 Feb, 2020 | 21:44h | UTCCommentaries: Cleaning products and asthma risk: a potentially important public health concern – Canadian Medical Association Journal (free) AND Exposure to cleaning products linked to asthma and wheezing in children – Health Europa (free) AND Cleaning Products May Raise Risk of Wheezing and Asthma in Young Children – MedicalResearch.com (free)
Clinical Updates: Management of Acute and Chronic Asthma in Adults in 2020
14 Feb, 2020 | 02:06h | UTCManagement of Acute Asthma in Adults in 2020 – JAMA (free for a limited period)
Related Article: Outpatient Management of Chronic Asthma in 2020 – JAMA (free for a limited period)
Editorial: New Therapeutic Strategies for Asthma – JAMA (free for a limited period)
Clinical Management of Seafood Allergy
21 Jan, 2020 | 01:11h | UTCClinical Management of Seafood Allergy – The Journal of Allergy and Clinical Immunology: In Practice (free)
Guidelines for Diagnosis, Management, Treatment and Prevention of DRESS syndrome
17 Jan, 2020 | 09:43h | UTC
Atrial Fibrillation: Current Evidence and Management Strategies During the Perioperative Period
9 Jan, 2020 | 23:36h | UTC
ASH Guideline: Immune Thrombocytopenia
5 Dec, 2019 | 11:19h | UTCAmerican Society of Hematology 2019 guidelines for immune thrombocytopenia – Blood Advances (free)
Related: Consensus Report: Investigation and Management of Primary Immune Thrombocytopenia (guidelines and reviews on the subject)
Study: Early Introduction of Allergenic Foods Can Prevent Food Allergies in High Risk Infants
5 Dec, 2019 | 10:28h | UTCSee also: Factors influencing adherence in a trial of early introduction of allergenic food – The Journal of Allergy and Clinical Immunology (free) AND Challenges experienced with early introduction and sustained consumption of allergenic foods in the Enquiring About Tolerance (EAT) study: A qualitative analysis – The Journal of Allergy and Clinical Immunology (free)
Original EAT Study: Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants – New England Journal of Medicine (free)
Commentaries: Introducing peanuts and eggs early can prevent food allergies in high risk infants – King’s College London (free) AND Expert reaction to three studies looking at early introduction of allergenic foods to infants – Science Media Centre (free)
Related Guidelines: AAP Updated Recommendations for Dietary Interventions to Prevent Atopic Disease (free guidance and commentaries) AND Timing of introduction of allergenic solids for infants at high risk – Canadian Paediatric Society (free)
#KidneyWk – [Abstract Only] Randomized Trial: New Drug May Reduce Itch Intensity in Hemodialysis Patients
10 Nov, 2019 | 14:34h | UTCA Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Novel Drug Eases Uremic Pruritus – Renal & Urology News (free)
#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019
Review: Eosinophilic Gastrointestinal Diseases in Childhood
22 Oct, 2019 | 07:18h | UTCEosinophilic Gastrointestinal Diseases in Childhood – Annals of Nutrition & Metabolism (free)
CSACI Position Statement: Newer Generation H1-Antihistamines are Safer than First-generation H1-Antihistamines
16 Oct, 2019 | 10:32h | UTC
[Abstract Only] Randomized Trial: Monoclonal Anti-IgE Antibody for Chronic Spontaneous Urticaria
7 Oct, 2019 | 00:47h | UTCLigelizumab for Chronic Spontaneous Urticaria – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Ligelizumab safely, effectively treats hives – MedicalXpress (free) AND Ligelizumab May Improve Response in Chronic Urticaria – Medscape (free registration required)
[Abstract Only] Randomized Trial: Monoclonal Antibody for Patients with Severe Chronic Rhinosinusitis with Nasal Polyps
2 Oct, 2019 | 22:17h | UTCEfficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials – The Lancet (link to abstract – $ for full-text)
Related Commentary on Twitter
NEW Research—Efficacy & safety of dupilumab in patients w/ severe chronic #rhinosinusitis w/ #nasalpolyps (LIBERTY NP SINUS-24 & LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials https://t.co/YH5khPeHxz pic.twitter.com/PR12UBV6Kf
— The Lancet (@TheLancet) September 20, 2019
Short Review: Food Allergy Prevention with Early Food Introduction
16 Sep, 2019 | 02:16h | UTCOriginal Guideline: Timing of introduction of allergenic solids for infants at high risk – Canadian Paediatric Society (free)
See also: AAP Updated Recommendations for Dietary Interventions to Prevent Atopic Disease (free guideline and commentary)
Evaluation and Management of Angioedema in the Emergency Department
15 Sep, 2019 | 23:43h | UTCSource: Medscape
[Abstract Only] Study: Few People with Peanut Allergy Tolerate Peanut After Stopping Oral Immunotherapy
15 Sep, 2019 | 23:32h | UTCFew people with peanut allergy tolerate peanut after stopping oral immunotherapy – NIH News Releases (free)
Original Study: Sustained outcomes in oral immunotherapy for peanut allergy (POISED study): a large, randomised, double-blind, placebo-controlled, phase 2 study – The Lancet (link to abstract – $ for full-text)
Related: Meta-Analysis: Oral Immunotherapy for Peanut Allergy INCREASES Allergic and Anaphylactic Reactions (link to abstract and commentaries)
Guideline: Management of Chronic Urticaria in Children
18 Aug, 2019 | 21:34h | UTCManagement of chronic urticaria in children: a clinical guideline – Italian Journal of Pediatrics (free)
Related Guidelines: BSACI guideline for the management of chronic urticaria and angioedema (free) AND The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria (free) AND The diagnosis and management of acute and chronic urticaria: 2014 update – American Academy of Allergy, Asthma & Immunology (AAAAI) (free) AND ASCIA Chronic Spontaneous Urticaria (CSU) Position Paper and Treatment Guidelines (free)
Study: High Gluten Intake During Childhood May Increase the Risk of Celiac Disease in Genetically Predisposed Children
15 Aug, 2019 | 08:12h | UTCAssociation of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk – JAMA (free for a limited period)
Editorial: Gluten and Celiac Disease Risk: Is It Just a Matter of Quantity? (free for a limited period)
Commentaries: Association between coeliac disease risk and gluten intake confirmed – Lund University (free) High Gluten Diet Adds to Risk of Celiac Disease In Genetically Predisposed Children – MedicalResearch.com (free) AND Eating more gluten early in life is tied to children’s higher risk of celiac disease, a study says – CNN (free)
Expert Consensus: Management of Hypersensitivity Reactions to Intravenous Iron in Adults
2 Aug, 2019 | 00:05h | UTC
Observational Study Suggests Use of Acid-Suppressing Drugs May Increase the Risk of Allergies
1 Aug, 2019 | 07:37h | UTCCommentaries: Stomach-protecting medicines can trigger allergies – Medical University of Vienna (free) AND Acid-Suppressing Drugs Tied to Later Use of Anti-Allergy Drugs – NEJM Journal Watch (free) AND Your heartburn drugs may be giving you allergies, study suggests – CNN (free)