All Posts
Perspective: When Conventional Wisdom Is Put on Trial
5 Oct, 2018 | 02:40h | UTCWhen Conventional Wisdom Is Put on Trial – UNDark (free) (via @EricTopol)
“The author of “Randomistas” shows how randomized trials have overturned many popular findings, from hormone therapy to the benefits of multivitamins.”
Perspective: New Tools in the Ebola Arsenal
5 Oct, 2018 | 02:37h | UTCNew Tools in the Ebola Arsenal – New England Journal of Medicine (free)
Related: DRC Ebola cases rise as security concerns continue – CIDRAP (free) AND Officials fear Ebola epidemic may be spinning beyond their control, threatening regional spread – STAT (free) AND Ebola Likely to Spread From Congo to Uganda, W.H.O. Says – The New York Times (10 articles per month are free)
Study: Collaboration Between Academics and Industry in Clinical Trials
5 Oct, 2018 | 02:37h | UTCCommentaries: Shining a light on industry collaboration – The BMJ Opinion (free) AND Industry funders involved in most aspects of funded trials – OnMedica (free)
Meta-Analysis: Prescribed Exercise with Compression vs Compression Alone in Treating Patients With Venous Leg Ulcers
5 Oct, 2018 | 02:36h | UTCPrescribed Exercise With Compression vs Compression Alone in Treating Patients With Venous Leg Ulcers: A Systematic Review and Meta-analysis – JAMA Dermatology (link to abstract – $ for full-text)
Commentaries: Adding Exercise to Compression Improves Outcomes in Venous Leg Ulcers – Physcian’s First Watch (free) AND Compressions May Remedy Venous Leg Ulcers – MedPage Today (free)
Study: The Projected Timeframe Until Cervical Cancer Elimination in Australia
5 Oct, 2018 | 02:31h | UTCCommentaries: Modelling cervical cancer elimination – The Lancet Public Health (free) AND Australia on track to wipe out cervical cancer within 20 years – The Guardian (free) AND In Australia, Cervical Cancer Could Soon Be Eliminated – The New York Times (10 articles per month are free)
NICE Guideline: Renal Replacement Therapy
5 Oct, 2018 | 02:31h | UTC
Global, Regional, and National Burden of Parkinson’s Disease
5 Oct, 2018 | 02:30h | UTCInvited Commentary: The burden of Parkinson’s disease: a worldwide perspective (free)
“In 2016, 6·1 million people worldwide had Parkinson’s disease, 2·9 million (48%) women & 3·2 million (52%) men; the increase in burden since 1990 was not exclusively explained by an increasing number of older people” (via @TheLancet see Tweet)
Recommendations for the use of Electrophysiological Study
5 Oct, 2018 | 02:28h | UTC
Enhanced Recovery After Surgery Guidelines for Perioperative Care in Esophagectomy
5 Oct, 2018 | 02:29h | UTCGuidelines for Perioperative Care in Esophagectomy: Enhanced Recovery After Surgery (ERAS®) Society Recommendations – World Journal of Surgery (free for a limited period)
Study: Evaluating Progression-Free Survival as a Surrogate Outcome for Health-Related Quality of Life in Oncology
5 Oct, 2018 | 02:26h | UTCEvaluating Progression-Free Survival as a Surrogate Outcome for Health-Related Quality of Life in Oncology: A Systematic Review and Quantitative Analysis – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Health-related quality of life overlooked in cancer drug studies – McMaster University (free) AND Investigators Question the Use of PFS as a Surrogate End Point – Cancer Therapy Advisor (free) AND Preventing tumor spread may not improve quality of life – Reuters (free) AND Research: Consider quality of life when evaluating cancer drug studies – UPI (free)
Guideline: Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency
5 Oct, 2018 | 02:27h | UTCNews Release: Managing congenital adrenal hyperplasia requires shared decisions among patients, families, and heal – The Endocrine Society (free)
ACOG Committee Opinion: Well-Woman Visit
5 Oct, 2018 | 02:25h | UTCWell-Woman Visit – American College of Obstetrics and Gynecology (free)
News Release: ACOG and WPSI Release Materials to Support Women’s Preventive Care at Every Life Stage (free)
Commentary: ACOG Stresses Role of Ob/Gyns in Preventive Care For Women – Medscape (free registration required)
Study: Teen Cannabis Use and Cognitive Development
5 Oct, 2018 | 02:23h | UTCA Population-Based Analysis of the Relationship Between Substance Use and Adolescent Cognitive Development – American Journal of Psychiatry (link to abstract – $ for full-text)
Commentaries: Teen cannabis use is not without risk to cognitive development – Université de Montréal (free) AND Cannabis ‘more harmful than alcohol’ for teen brains – BBC (free)
Two Antiplatelet Drugs may Prevent Further Strokes but Increase Major Bleeds
5 Oct, 2018 | 02:24h | UTCTwo antiplatelet drugs may prevent further strokes but increase major bleeds – NIHR Signal (free)
Original Article: Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA – New England Journal of Medicine (link to abstract – $ for full-text)
Randomized Trial: Early Surgery vs Physical Therapy on Knee Function Among Patients With Nonobstructive Meniscal Tears
5 Oct, 2018 | 02:21h | UTCEffect of Early Surgery vs Physical Therapy on Knee Function Among Patients With Nonobstructive Meniscal Tears: The ESCAPE Randomized Clinical Trial – JAMA (free for a limited period)
Commentary: PT an Alternative to Surgery for Some Meniscal Tears – Physician’s First Watch (free)
Related: Adverse Outcomes After Arthroscopic Partial Meniscectomy (free study, commentary and guideline on the subject)
“Our Dutch multi center RCT demonstrates noninferiority of physical therapy compared with early surgery with arthroscopic partial meniscectomy for improving self-reported knee function in patients with nonobstructive meniscal tears.” (via @RudolfPoolman see Tweet)
Ten Principles for More Conservative, Care-Full Diagnosis
5 Oct, 2018 | 02:22h | UTCTen Principles for More Conservative, Care-Full Diagnosis – Annals of Internal Medicine (free) (via @EricTopol)
Guideline: Management of Malignant Pleural Effusions
5 Oct, 2018 | 02:21h | UTCRelated Guideline: ERS/EACTS statement on the management of malignant pleural effusions – European Respiratory Journal (free)
Sytematic Review: Antidepressant Withdrawal Effects
5 Oct, 2018 | 02:06h | UTCA systematic review into the incidence, severity and duration of antidepressant withdrawal effects: Are guidelines evidence-based? – Addictive Behaviours (free PDF)
Commentaries: Antidepressant withdrawal ‘hits millions’ – BBC (free) AND Antidepressant withdrawal symptoms severe, says new report – The Guardian (free)
Related: Antidepressant Withdrawal Syndrome (free review and NYT article)
Meta-Analysis: Treating Subclinical Hypothyroidism is Not Associated with Quality of Life and Thyroid-Related Symptoms
5 Oct, 2018 | 02:18h | UTCAssociation of Thyroid Hormone Therapy With Quality of Life and Thyroid-Related Symptoms in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)
Commentaries: Most Patients With Subclinical Hypothyroidism May Not Require Thyroid Medication – MedicalResearch.com (free) AND Hormone Tx May Not Benefit Subclinical Hypothyroidism – MedPage Today (free registration required) AND Treating Subclinical Hypothyroidism Is of Little Benefit – Medscape (free registration required)
Study: Fracture Prevention in Older Women with Osteopenia
5 Oct, 2018 | 02:03h | UTCEditorial: A Not-So-New Treatment for Old Bones (free)
Commentary: Study Suggests More Older Women May Benefit From Bone Drugs – The Associated Press (free)
Association is Not Causation: Treatment Effects Cannot be Estimated from Observational Data in Heart Failure
5 Oct, 2018 | 02:05h | UTC
Randomized Trial: Low-Dose Amitriptyline for Chronic Low Back Pain
5 Oct, 2018 | 02:00h | UTCEfficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Low-dose antidepressants ease back pain – Australian Hospital + Healthcare Bulletin (free) AND Antidepressant Amitriptyline Might Help Ease Low Back Pain – Physician’s First Watch (free)
Clinical Guide: Neuro-Ophthalmology at the Bedside
5 Oct, 2018 | 02:02h | UTCNeuro-Ophthalmology at the bedside: A clinical guide – Journal of Neurosciences in Rural Practice (free)
Randomized Trial: Six months versus 12 months dual antiplatelet therapy after drug-eluting stent implantation in ST-elevation myocardial infarction
5 Oct, 2018 | 01:59h | UTCRelated Research: 6-month versus 12-month or longer dual antiplatelet therapy after percutaneous coronary intervention in patients with acute coronary syndrome (link to abstract and commentaries)
In this study, DAPT for 6 months was non-inferior to DAPT for 12 months after drug-eluting stent implantation in ST-elevation myocardial infarction.
Randomized Trial: Drinking More Water Prevents Recurrent Cystitis
5 Oct, 2018 | 01:48h | UTCEditorial: Drinking More Water for Prevention of Recurrent Cystitis (free)
Commentaries: Drinking more water reduces bladder infections in women – UT Southwestern Medical Center (free) AND Drinking more water linked to fewer bladder infections in women – UPI (free)